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Volumn 4, Issue 1, 2013, Pages

Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length

Author keywords

Aging; HMEC; Human mammary epithelial cell; Telomerase; Telomere

Indexed keywords

CELL PROTEIN; PROTEIN CD227; STEM CELL FACTOR; TELOMERASE; UNCLASSIFIED DRUG;

EID: 84878240997     PISSN: None     EISSN: 20419414     Source Type: Journal    
DOI: 10.1186/2041-9414-4-4     Document Type: Article
Times cited : (6)

References (34)
  • 1
    • 84863915064 scopus 로고    scopus 로고
    • Accumulation of multi potent progenitors with a basal differentiation bias during aging of human mammary epithelia
    • 10.1158/0008-5472.CAN-12-0157, 22552289
    • Garbe JC, Pepin F, Pelissier FA, Sputova K, Fridriksdottir AJ, et al. Accumulation of multi potent progenitors with a basal differentiation bias during aging of human mammary epithelia. Cancer Res 2012, 72:3687-3701. 10.1158/0008-5472.CAN-12-0157, 22552289.
    • (2012) Cancer Res , vol.72 , pp. 3687-3701
    • Garbe, J.C.1    Pepin, F.2    Pelissier, F.A.3    Sputova, K.4    Fridriksdottir, A.J.5
  • 2
    • 0036153330 scopus 로고    scopus 로고
    • Normal and tumour-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition
    • 2933194, 11801722
    • Gudjonsson T, Ronnov-Jessen L, Villadsen R, Rank F, Bissell MJ, et al. Normal and tumour-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci 2002, 115:39-50. 2933194, 11801722.
    • (2002) J Cell Sci , vol.115 , pp. 39-50
    • Gudjonsson, T.1    Ronnov-Jessen, L.2    Villadsen, R.3    Rank, F.4    Bissell, M.J.5
  • 3
    • 42949121126 scopus 로고    scopus 로고
    • Regulation of in situ to invasive breast carcinoma transition
    • 10.1016/j.ccr.2008.03.007, 18455123
    • Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, et al. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 2008, 13:394-406. 10.1016/j.ccr.2008.03.007, 18455123.
    • (2008) Cancer Cell , vol.13 , pp. 394-406
    • Hu, M.1    Yao, J.2    Carroll, D.K.3    Weremowicz, S.4    Chen, H.5
  • 4
    • 38549131901 scopus 로고    scopus 로고
    • GATA-3 links tumour differentiation and dissemination in a luminal breast cancer model
    • 10.1016/j.ccr.2008.01.011, 2262951, 18242514
    • Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, et al. GATA-3 links tumour differentiation and dissemination in a luminal breast cancer model. Cancer Cell 2008, 13:141-152. 10.1016/j.ccr.2008.01.011, 2262951, 18242514.
    • (2008) Cancer Cell , vol.13 , pp. 141-152
    • Kouros-Mehr, H.1    Bechis, S.K.2    Slorach, E.M.3    Littlepage, L.E.4    Egeblad, M.5
  • 5
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumour development in BRCA1 mutation carriers
    • 10.1038/nm.2000, 19648928
    • Lim E, Vaillant F, Wu D, Forrest NC, Pal B, et al. Aberrant luminal progenitors as the candidate target population for basal tumour development in BRCA1 mutation carriers. Nat Med 2009, 15:907-913. 10.1038/nm.2000, 19648928.
    • (2009) Nat Med , vol.15 , pp. 907-913
    • Lim, E.1    Vaillant, F.2    Wu, D.3    Forrest, N.C.4    Pal, B.5
  • 6
    • 77956218241 scopus 로고    scopus 로고
    • BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    • 10.1016/j.stem.2010.07.010, 20804975
    • Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 2010, 7:403-417. 10.1016/j.stem.2010.07.010, 20804975.
    • (2010) Cell Stem Cell , vol.7 , pp. 403-417
    • Molyneux, G.1    Geyer, F.C.2    Magnay, F.A.3    McCarthy, A.4    Kendrick, H.5
  • 7
    • 79551614327 scopus 로고    scopus 로고
    • Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate
    • 10.1016/j.stem.2010.12.007, 3050563, 21295272
    • Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, et al. Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate. Cell Stem Cell 2011, 8:149-163. 10.1016/j.stem.2010.12.007, 3050563, 21295272.
    • (2011) Cell Stem Cell , vol.8 , pp. 149-163
    • Proia, T.A.1    Keller, P.J.2    Gupta, P.B.3    Klebba, I.4    Jones, A.D.5
  • 8
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • 10.1038/345458a0, 2342578
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460. 10.1038/345458a0, 2342578.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 9
    • 34447306620 scopus 로고    scopus 로고
    • Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
    • 10.1016/j.humpath.2006.11.023, 17588641
    • Aida J, Izumiyama-Shimomura N, Nakamura K, Ishii A, Ishikawa N, et al. Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol 2007, 38:1192-1200. 10.1016/j.humpath.2006.11.023, 17588641.
    • (2007) Hum Pathol , vol.38 , pp. 1192-1200
    • Aida, J.1    Izumiyama-Shimomura, N.2    Nakamura, K.3    Ishii, A.4    Ishikawa, N.5
  • 10
    • 49649125535 scopus 로고    scopus 로고
    • Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    • 10.1016/j.exger.2008.06.001, 18590810
    • Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SS, et al. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol 2008, 43:833-839. 10.1016/j.exger.2008.06.001, 18590810.
    • (2008) Exp Gerontol , vol.43 , pp. 833-839
    • Aida, J.1    Izumiyama-Shimomura, N.2    Nakamura, K.3    Ishikawa, N.4    Poon, S.S.5
  • 12
    • 0012950854 scopus 로고    scopus 로고
    • Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age
    • Son NH, Murray S, Yanovski J, Hodes RJ, Weng N. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J Immunol 2000, 165:1191-1196.
    • (2000) J Immunol , vol.165 , pp. 1191-1196
    • Son, N.H.1    Murray, S.2    Yanovski, J.3    Hodes, R.J.4    Weng, N.5
  • 13
    • 13144305133 scopus 로고    scopus 로고
    • The rate of telomere sequence loss in human leukocytes varies with age
    • 10.1073/pnas.95.10.5607, 20425, 9576930
    • Frenck RW, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA 1998, 95:5607-5610. 10.1073/pnas.95.10.5607, 20425, 9576930.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5607-5610
    • Frenck, R.W.1    Blackburn, E.H.2    Shannon, K.M.3
  • 14
    • 0345643319 scopus 로고    scopus 로고
    • Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
    • 10.1084/jem.190.2.157, 2195579, 10432279
    • Rufer N, Brummendorf TH, Kolvraa S, Bischoff C, Christensen K, et al. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 1999, 190:157-167. 10.1084/jem.190.2.157, 2195579, 10432279.
    • (1999) J Exp Med , vol.190 , pp. 157-167
    • Rufer, N.1    Brummendorf, T.H.2    Kolvraa, S.3    Bischoff, C.4    Christensen, K.5
  • 15
    • 0028077099 scopus 로고
    • Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age
    • 10.1073/pnas.91.21.9857, 44916, 7937905
    • Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, et al. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994, 91:9857-9860. 10.1073/pnas.91.21.9857, 44916, 7937905.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9857-9860
    • Vaziri, H.1    Dragowska, W.2    Allsopp, R.C.3    Thomas, T.E.4    Harley, C.B.5
  • 16
    • 0036164074 scopus 로고    scopus 로고
    • Telomere lengths are characteristic in each human individual
    • 10.1016/S0531-5565(01)00218-2, 11830355
    • Takubo K, Izumiyama-Shimomura N, Honma N, Sawabe M, Arai T, et al. Telomere lengths are characteristic in each human individual. Exp Gerontol 2002, 37:523-531. 10.1016/S0531-5565(01)00218-2, 11830355.
    • (2002) Exp Gerontol , vol.37 , pp. 523-531
    • Takubo, K.1    Izumiyama-Shimomura, N.2    Honma, N.3    Sawabe, M.4    Arai, T.5
  • 17
    • 0034152198 scopus 로고    scopus 로고
    • Telomerase activity in normal ovaries and premature ovarian failure
    • 10.1620/tjem.190.231, 10778807
    • Kinugawa C, Murakami T, Okamura K, Yajima A. Telomerase activity in normal ovaries and premature ovarian failure. Tohoku J Exp Med 2000, 190:231-238. 10.1620/tjem.190.231, 10778807.
    • (2000) Tohoku J Exp Med , vol.190 , pp. 231-238
    • Kinugawa, C.1    Murakami, T.2    Okamura, K.3    Yajima, A.4
  • 18
    • 0031922795 scopus 로고    scopus 로고
    • Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals
    • 10.1007/s004390050711, 9600234
    • Iwama H, Ohyashiki K, Ohyashiki JH, Hayashi S, Yahata N, et al. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet 1998, 102:397-402. 10.1007/s004390050711, 9600234.
    • (1998) Hum Genet , vol.102 , pp. 397-402
    • Iwama, H.1    Ohyashiki, K.2    Ohyashiki, J.H.3    Hayashi, S.4    Yahata, N.5
  • 19
    • 53849110244 scopus 로고    scopus 로고
    • Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts
    • 10.1016/j.humpath.2008.04.005, 18656239
    • Kurabayashi R, Takubo K, Aida J, Honma N, Poon SS, et al. Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts. Hum Pathol 2008, 39:1647-1655. 10.1016/j.humpath.2008.04.005, 18656239.
    • (2008) Hum Pathol , vol.39 , pp. 1647-1655
    • Kurabayashi, R.1    Takubo, K.2    Aida, J.3    Honma, N.4    Poon, S.S.5
  • 20
    • 1242338876 scopus 로고    scopus 로고
    • Telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma
    • 10.1016/S0002-9440(10)63180-X, 1614707, 14982846
    • Meeker AK, Hicks JL, Gabrielson E, Strauss WM, De Marzo AM, et al. Telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma. Am J Pathol 2004, 164:925-935. 10.1016/S0002-9440(10)63180-X, 1614707, 14982846.
    • (2004) Am J Pathol , vol.164 , pp. 925-935
    • Meeker, A.K.1    Hicks, J.L.2    Gabrielson, E.3    Strauss, W.M.4    De Marzo, A.M.5
  • 21
    • 70350223685 scopus 로고    scopus 로고
    • Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells
    • 10.1158/0008-5472.CAN-09-0270, 2782785, 19773443
    • Garbe JC, Bhattacharya S, Merchant B, Bassett E, Swisshelm K, et al. Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res 2009, 69:7557-7568. 10.1158/0008-5472.CAN-09-0270, 2782785, 19773443.
    • (2009) Cancer Res , vol.69 , pp. 7557-7568
    • Garbe, J.C.1    Bhattacharya, S.2    Merchant, B.3    Bassett, E.4    Swisshelm, K.5
  • 22
    • 0030668750 scopus 로고    scopus 로고
    • Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells
    • 25715, 9398663
    • Stampfer MR, Bodnar A, Garbe J, Wong M, Pan A, et al. Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells. Mol Biol Cell 1997, 8:2391-2405. 25715, 9398663.
    • (1997) Mol Biol Cell , vol.8 , pp. 2391-2405
    • Stampfer, M.R.1    Bodnar, A.2    Garbe, J.3    Wong, M.4    Pan, A.5
  • 23
    • 10344229954 scopus 로고    scopus 로고
    • Accelerated telomere shortening in response to life stress
    • 10.1073/pnas.0407162101, 534658, 15574496
    • Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 2004, 101:17312-17315. 10.1073/pnas.0407162101, 534658, 15574496.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17312-17315
    • Epel, E.S.1    Blackburn, E.H.2    Lin, J.3    Dhabhar, F.S.4    Adler, N.E.5
  • 24
    • 71749089585 scopus 로고    scopus 로고
    • Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance
    • 10.1016/j.jim.2009.09.012, 3280689, 19837074
    • Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, et al. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods 2010, 352:71-80. 10.1016/j.jim.2009.09.012, 3280689, 19837074.
    • (2010) J Immunol Methods , vol.352 , pp. 71-80
    • Lin, J.1    Epel, E.2    Cheon, J.3    Kroenke, C.4    Sinclair, E.5
  • 25
    • 0035836727 scopus 로고    scopus 로고
    • Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells
    • 10.1073/pnas.071483998, 31863, 11287649
    • Stampfer MR, Garbe J, Levine G, Lichtsteiner S, Vasserot AP, et al. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci USA 2001, 98:4498-4503. 10.1073/pnas.071483998, 31863, 11287649.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4498-4503
    • Stampfer, M.R.1    Garbe, J.2    Levine, G.3    Lichtsteiner, S.4    Vasserot, A.P.5
  • 26
    • 84055207463 scopus 로고    scopus 로고
    • Separation of telomerase functions by reverse genetics
    • 10.1073/pnas.1112414108, 3250197, 21949400
    • Mukherjee S, Firpo EJ, Wang Y, Roberts JM. Separation of telomerase functions by reverse genetics. Proc Natl Acad Sci USA 2011, 108:E1363-1371. 10.1073/pnas.1112414108, 3250197, 21949400.
    • (2011) Proc Natl Acad Sci USA , vol.108
    • Mukherjee, S.1    Firpo, E.J.2    Wang, Y.3    Roberts, J.M.4
  • 27
    • 0037068753 scopus 로고    scopus 로고
    • Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
    • 10.1038/sj.onc.1205780, 12214273
    • Olsen CL, Gardie B, Yaswen P, Stampfer MR. Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 2002, 21:6328-6339. 10.1038/sj.onc.1205780, 12214273.
    • (2002) Oncogene , vol.21 , pp. 6328-6339
    • Olsen, C.L.1    Gardie, B.2    Yaswen, P.3    Stampfer, M.R.4
  • 28
    • 81155148160 scopus 로고    scopus 로고
    • Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells
    • 10.1111/j.1474-9726.2011.00736.x, 3433764, 21824272
    • Sherman MY, Meng L, Stampfer M, Gabai VL, Yaglom JA. Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. Aging Cell 2011, 10:949-961. 10.1111/j.1474-9726.2011.00736.x, 3433764, 21824272.
    • (2011) Aging Cell , vol.10 , pp. 949-961
    • Sherman, M.Y.1    Meng, L.2    Stampfer, M.3    Gabai, V.L.4    Yaglom, J.A.5
  • 29
    • 0036606952 scopus 로고    scopus 로고
    • A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
    • 10.1016/S0168-9525(02)02696-3, 12044358
    • Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet 2002, 18:295-301. 10.1016/S0168-9525(02)02696-3, 12044358.
    • (2002) Trends Genet , vol.18 , pp. 295-301
    • Carter, C.S.1    Ramsey, M.M.2    Sonntag, W.E.3
  • 30
    • 14844293962 scopus 로고    scopus 로고
    • The role of insulin and IGF-1 signalling in longevity
    • 10.1007/s00018-004-4297-y, 15723168
    • Katic M, Kahn CR. The role of insulin and IGF-1 signalling in longevity. Cell Mol Life Sci 2005, 62:320-343. 10.1007/s00018-004-4297-y, 15723168.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 320-343
    • Katic, M.1    Kahn, C.R.2
  • 31
    • 46749152214 scopus 로고    scopus 로고
    • Actions of human telomerase beyond telomeres
    • 10.1038/cr.2008.74, 18574498
    • Cong Y, Shay JW. Actions of human telomerase beyond telomeres. Cell Res 2008, 18:725-732. 10.1038/cr.2008.74, 18574498.
    • (2008) Cell Res , vol.18 , pp. 725-732
    • Cong, Y.1    Shay, J.W.2
  • 32
    • 0019172106 scopus 로고
    • Growth of normal human mammary epithelial cells in culture
    • 10.1007/BF02618365, 6993343
    • Stampfer MR, Hallowes R, Hackett AJ. Growth of normal human mammary epithelial cells in culture. In Vitro 1980, 16:415-425. 10.1007/BF02618365, 6993343.
    • (1980) In Vitro , vol.16 , pp. 415-425
    • Stampfer, M.R.1    Hallowes, R.2    Hackett, A.J.3
  • 33
    • 84875797871 scopus 로고    scopus 로고
    • Processing of human reduction mammoplasty and mastectomy tissues for cell culture
    • LaBarge MA, Garbe JC, Stampfer MR. Processing of human reduction mammoplasty and mastectomy tissues for cell culture. J Vis Exp 2013, (71):e50011.
    • (2013) J Vis Exp , Issue.71
    • LaBarge, M.A.1    Garbe, J.C.2    Stampfer, M.R.3
  • 34
    • 0032529451 scopus 로고    scopus 로고
    • Telomere analysis by fluorescence in situ hybridization and flow cytometry
    • 10.1093/nar/26.16.3651, 147775, 9685479
    • Hultdin M, Gronlund E, Norrback K, Eriksson-Lindstrom E, Just T, et al. Telomere analysis by fluorescence in situ hybridization and flow cytometry. Nucleic Acids Res 1998, 26:3651-3656. 10.1093/nar/26.16.3651, 147775, 9685479.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3651-3656
    • Hultdin, M.1    Gronlund, E.2    Norrback, K.3    Eriksson-Lindstrom, E.4    Just, T.5


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