Coordinated processing of 3′ slipped (CAG)n/(CTG) n hairpins by DNA polymerases β and δ preferentially induces repeat expansions

Journal of Biological Chemistry

Volumn 288, Issue 21, 2013, Pages 15015-15022

  Chan, Nelson L S ^a,e   Guo, Jinzhen ^a,b   Zhang, Tianyi ^a,c   Mao, Guogen ^a   Hou, Caixia ^a   Yuan, Fenghua ^d   Huang, Jian ^c   Zhang, Yanbin ^d   Wu, Jianxin ^b   Gu, Liya ^a   Li, Guo Min ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b CAPITAL INSTITUTE OF PEDIATRICS   (China)

^c WUHAN UNIVERSITY   (China)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY SEQUENCES; DNA POLYMERASE; DNA SYNTHESISS; HAIRPIN FORMATION; HAIRPIN STRUCTURES; NEUROLOGICAL DISORDERS; TRINUCLEOTIDE;

DNA; EXPANSION; NUCLEOTIDES; POLYMERS; SYNTHESIS (CHEMICAL);

COORDINATION REACTIONS;

ADENINE; CYTOSINE; DNA; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE DELTA; EXONUCLEASE; GUANINE; THYMINE;

ARTICLE; DNA STRUCTURE; DNA SYNTHESIS; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PROCESSING; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; TRINUCLEOTIDE REPEAT;

DNA ENZYMES; DNA POLYMERASE; DNA REPAIR; GENOMIC INSTABILITY; NUCLEOTIDE REPEAT DISEASE;

DNA; DNA POLYMERASE BETA; DNA POLYMERASE III; DNA REPLICATION; HELA CELLS; HUMANS; INVERTED REPEAT SEQUENCES;

EID: 84878235563     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.464370     Document Type: Article

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