In vitro repair of DNA hairpins containing various numbers of CAG/CTG trinucleotide repeats

DNA Repair

Volumn 11, Issue 2, 2012, Pages 201-209

  Zhang, Tianyi ^a,b   Huang, Jian ^a   Gu, Liya ^b   Li, Guo Min ^a,b  

^a WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Endonucleolytic incision; Hairpin repair; MutS ; Trinucleotide repeats

Indexed keywords

DNA; PROTEIN MUTS; PROTEIN MUTS ALPHA; PROTEIN MUTS BETA; UNCLASSIFIED DRUG;

ARTICLE; CAG REPEAT; CONTROLLED STUDY; DNA HAIRPIN; DNA METABOLISM; DNA REPAIR; DNA STRAND; DNA STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IN VITRO STUDY; MISMATCH REPAIR; MOLECULAR DYNAMICS; PRIORITY JOURNAL; TRINUCLEOTIDE REPEAT;

BASE SEQUENCE; CELL NUCLEUS; DNA REPAIR; HELA CELLS; HUMANS; INVERTED REPEAT SEQUENCES; MOLECULAR SEQUENCE DATA; MUTS DNA MISMATCH-BINDING PROTEIN; TRINUCLEOTIDE REPEATS;

EID: 84855860798     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2011.10.020     Document Type: Article

References (28)

1. Lopez Castel A., Cleary J.D., Pearson C.E. Repeat instability as the basis for human diseases and as a potential target for therapy. Nat. Rev. Mol. Cell. Biol. 2010, 11:165-170.
2. Mirkin S.M. Expandable DNA repeats and human disease. Nature 2007, 447:932-940.
3. Pearson C.E., Nichol Edamura K., Cleary J.D. Repeat instability: mechanisms of dynamic mutations. Nat. Rev. Genet. 2005, 6:729-742.
4. Gordenin D.A., Kunkel T.A., Resnick M.A. Repeat expansion-all in a flap?. Nat. Genet. 1997, 16:116-118.
5. Kang S., Jaworski A., Ohshima K., Wells R.D. Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli. Nat. Genet. 1995, 10:213-218.
6. Miret J.J., Pessoa-Brandao L., Lahue R.S. Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:12438-12443.
7. McMurray C.T. Mechanisms of trinucleotide repeat instability during human development. Nat. Rev. Genet. 2010, 11:786-799.
8. Richards R.I., Sutherland G.R. Simple repeat DNA is not replicated simply. Nat. Genet. 1994, 6:114-116.
9. Gacy A.M., Goellner G., Juranic N., Macura S., McMurray C.T. Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell 1995, 81:533-540.
10. Liu G., Chen X., Bissler J.J., Sinden R.R., Leffak M. Replication-dependent instability at (CTG)×(CAG) repeat hairpins in human cells. Nat. Chem. Biol. 2010, 6:652-659.
11. Pearson C.E., Tam M., Wang Y.H., Montgomery S.E., Dar A.C., Cleary J.D., Nichol K. Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions. Nucl. Acids Res. 2002, 30:4534-4547.
12. Petruska J., Arnheim N., Goodman M.F. Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. Nucl. Acids Res. 1996, 24:1992-1998.
13. Hou C., Chan N.L., Gu L., Li G.M. Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts. Nat. Struct. Mol. Biol. 2009, 16:869-875.
14. Panigrahi G.B., Lau R., Montgomery S.E., Leonard M.R., Pearson C.E. Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair. Nat. Struct. Mol. Biol. 2005, 12:654-662.
15. n DNA hairpins. Cell Biosci. 2011, 1:11.
16. Manley K., Shirley T.L., Flaherty L., Messer A. Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nat. Genet. 1999, 23:471-473.
17. Owen B.A., Yang Z., Lai M., Gajek M., Badger J.D., Hayes J.J., Edelmann W., Kucherlapati R., Wilson T.M., McMurray C.T. (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat. Struct. Mol. Biol. 2005, 12:663-670.
18. Panigrahi G.B., Slean M.M., Simard J.P., Gileadi O., Pearson C.E. Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:12593-12598.
19. Owen B.A., McMurray H.L.W.C.T. The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent. Nat. Struct. Mol. Biol. 2009, 16:550-557.
20. n hairpin repair in vitro. J. Biol. Chem. 2009, 284:20452-20456.
21. McMurray C.T. Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease. DNA Repair (Amst.) 2008, 7:1121-1134.
22. Holmes J., Clark S., Modrich P. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:5837-5841.
23. Zhang Y., Yuan F., Presnell S.R., Tian K., Gao Y., Tomkinson A.E., Gu L., Li G.M. Reconstitution of 5'-directed human mismatch repair in a purified system. Cell 2005, 122:693-705.
24. McCulloch S.D., Gu L., Li G.M. Bi-directional processing of DNA loops by mismatch repair-dependent and -independent pathways in human cells. J. Biol. Chem. 2003, 278:3891-3896.
25. Gomes-Pereira M., Fortune M.T., Ingram L., McAbney J.P., Monckton D.G. Pms2 is a genetic enhancer of trinucleotide CAG·CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion. Hum. Mol. Genet. 2004, 13:1815-1825.
26. Kovtun I.V., McMurray C.T. Features of trinucleotide repeat instability in vivo. Cell Res. 2008, 18:198-213.
27. Gu L., Cline-Brown B., Zhang F., Qiu L., Li G.M. Mismatch repair deficiency in hematological malignancies with microsatellite instability. Oncogene 2002, 21:5758-5764.
28. Li G.M. Mechanisms and functions of DNA mismatch repair. Cell Res. 2008, 18:85-98.