High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin

Journal of Biological Chemistry

Volumn 288, Issue 21, 2013, Pages 14709-14715

  Tobe, Ryuta ^a   Naranjo Suarez, Salvador ^a   Everley, Robert A ^b   Carlson, Bradley A ^a   Turanov, Anton A ^c   Tsuji, Petra A ^d   Yoo, Min Hyuk ^a   Gygi, Steven P ^b   Gladyshev, Vadim N ^c   Hatfield, Dolph L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d TOWSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC TREATMENT; ENZYMATIC ACTIVITIES; GLUTATHIONE PEROXIDASE; MAMMALIAN CELLS; SELENOCYSTEINE; SELENOPROTEIN EXPRESSION; SELENOPROTEINS; THIOREDOXIN REDUCTASE 1;

ARGININE; ERRORS; PEPTIDES;

ANTIBIOTICS;

ANTIBIOTIC G 418; ARGININE; CHLORAMPHENICOL; CYSTEINE; DOXYCYCLINE; GLUTATHIONE PEROXIDASE 1; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SELENOCYSTEINE; SELENOCYSTEINE TRANSFER RNA; THIOREDOXIN REDUCTASE 1; TRANSFER RNA; TRYPTOPHAN; UNCLASSIFIED DRUG;

ACCURACY; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL LABELING; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE INSERTION; GENE MUTATION; MAMMAL CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA TRANSLATION; STOP CODON;

MISREADING; PROTEIN SYNTHESIS; SELENOCYSTEINE; SELENOPROTEIN; TRANSFER RNA (TRNA); TRANSLATION; UGA CODON;

AMEBICIDES; AMINO ACID SUBSTITUTION; ANIMALS; ANTI-BACTERIAL AGENTS; ARGININE; CELL LINE, TUMOR; CHLORAMPHENICOL; DOXYCYCLINE; GENTAMICINS; GLUTATHIONE PEROXIDASE; HUMANS; MICE; RNA, TRANSFER, AMINO ACID-SPECIFIC; SELENOCYSTEINE; SELENOPROTEINS; THIOREDOXINS;

EID: 84878224706     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.446666     Document Type: Article

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