-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
77956627711
-
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
-
Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010; 29: 4989-5005.
-
(2010)
Oncogene
, vol.29
, pp. 4989-5005
-
-
Whittaker, S.1
Marais, R.2
Zhu, A.X.3
-
4
-
-
32944480899
-
Opportunities for targeted therapies in hepatocellular carcinoma
-
Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 2005; 23: 8093-108.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8093-8108
-
-
Thomas, M.B.1
Abbruzzese, J.L.2
-
5
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-90.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
7
-
-
77951915307
-
Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy
-
Villanueva A, Minguez B, Forner A, Reig M, Llovet JM. Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy. Annu Rev Med 2010; 61: 317-28.
-
(2010)
Annu Rev Med
, vol.61
, pp. 317-328
-
-
Villanueva, A.1
Minguez, B.2
Forner, A.3
Reig, M.4
Llovet, J.M.5
-
8
-
-
64249135764
-
Novel agents on the horizon for cancer therapy
-
Ma WW, Adjei AA. Novel agents on the horizon for cancer therapy. CA Cancer J Clin 2009; 59: 111-37.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 111-137
-
-
Ma, W.W.1
Adjei, A.A.2
-
9
-
-
0036830642
-
Role of histone H3 lysine 27 methylation in Polycomb-group silencing
-
Cao R, Wang L, Wang H et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298: 1039-43.
-
(2002)
Science
, vol.298
, pp. 1039-1043
-
-
Cao, R.1
Wang, L.2
Wang, H.3
-
10
-
-
1942503942
-
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
-
Cao R, Zhang Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev 2004; 14: 155-64.
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 155-164
-
-
Cao, R.1
Zhang, Y.2
-
11
-
-
73649102464
-
EZH2 is essential for glioblastoma cancer stem cell maintenance
-
Suva ML, Riggi N, Janiszewska M et al. EZH2 is essential for glioblastoma cancer stem cell maintenance. Cancer Res 2009; 69: 9211-8.
-
(2009)
Cancer Res
, vol.69
, pp. 9211-9218
-
-
Suva, M.L.1
Riggi, N.2
Janiszewska, M.3
-
12
-
-
19944397508
-
Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma
-
Sudo T, Utsunomiya T, Mimori K et al. Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma. Br J Cancer 2005; 92: 1754-8.
-
(2005)
Br J Cancer
, vol.92
, pp. 1754-1758
-
-
Sudo, T.1
Utsunomiya, T.2
Mimori, K.3
-
13
-
-
29344439946
-
Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
-
Weikert S, Christoph F, Kollermann J et al. Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med 2005; 16: 349-53.
-
(2005)
Int J Mol Med
, vol.16
, pp. 349-353
-
-
Weikert, S.1
Christoph, F.2
Kollermann, J.3
-
14
-
-
33644822360
-
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
-
Bachmann IM, Halvorsen OJ, Collett K et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006; 24: 268-73.
-
(2006)
J Clin Oncol
, vol.24
, pp. 268-273
-
-
Bachmann, I.M.1
Halvorsen, O.J.2
Collett, K.3
-
15
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
Kleer CG, Cao Q, Varambally S et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003; 100: 11606-11.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
Cao, Q.2
Varambally, S.3
-
16
-
-
0142105414
-
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
-
Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003; 22: 5323-35.
-
(2003)
EMBO J
, vol.22
, pp. 5323-5335
-
-
Bracken, A.P.1
Pasini, D.2
Capra, M.3
Prosperini, E.4
Colli, E.5
Helin, K.6
-
17
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally S, Dhanasekaran SM, Zhou M et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419: 624-9.
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
-
18
-
-
48749104292
-
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma
-
Sasaki M, Ikeda H, Itatsu K et al. The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma. Lab Invest 2008; 88: 873-82.
-
(2008)
Lab Invest
, vol.88
, pp. 873-882
-
-
Sasaki, M.1
Ikeda, H.2
Itatsu, K.3
-
19
-
-
34748893835
-
Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma
-
Chen Y, Lin MC, Wang H et al. Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma. Proteomics 2007; 7: 3097-104.
-
(2007)
Proteomics
, vol.7
, pp. 3097-3104
-
-
Chen, Y.1
Lin, M.C.2
Wang, H.3
-
20
-
-
84855191863
-
The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2
-
Zheng F, Liao YJ, Cai MY et al. The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 2012; 61: 278-89.
-
(2012)
Gut
, vol.61
, pp. 278-289
-
-
Zheng, F.1
Liao, Y.J.2
Cai, M.Y.3
-
21
-
-
79957912993
-
EZH2-mediated concordant repression of Wnt antagonists promotes beta-catenin-dependent hepatocarcinogenesis
-
Cheng AS, Lau SS, Chen Y et al. EZH2-mediated concordant repression of Wnt antagonists promotes beta-catenin-dependent hepatocarcinogenesis. Cancer Res 2011; 71: 4028-39.
-
(2011)
Cancer Res
, vol.71
, pp. 4028-4039
-
-
Cheng, A.S.1
Lau, S.S.2
Chen, Y.3
-
22
-
-
84864344679
-
Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs to promote liver cancer metastasis
-
Au SL, Wong CC, Lee JM et al. Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs to promote liver cancer metastasis. Hepatology 2012; 56: 622-31.
-
(2012)
Hepatology
, vol.56
, pp. 622-631
-
-
Au, S.L.1
Wong, C.C.2
Lee, J.M.3
-
23
-
-
34547487035
-
Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin
-
Chen Y, Lin MC, Yao H et al. Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. Hepatology 2007; 46: 200-8.
-
(2007)
Hepatology
, vol.46
, pp. 200-208
-
-
Chen, Y.1
Lin, M.C.2
Yao, H.3
-
24
-
-
80055046798
-
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
-
Yang F, Zhang L, Huo XS et al. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology 2011; 54: 1679-89.
-
(2011)
Hepatology
, vol.54
, pp. 1679-1689
-
-
Yang, F.1
Zhang, L.2
Huo, X.S.3
-
25
-
-
79958279832
-
p53-paralog DNp73 oncogene is repressed by IFNalpha/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor
-
Testoni B, Schinzari V, Guerrieri F, Gerbal-Chaloin S, Blandino G, Levrero M. p53-paralog DNp73 oncogene is repressed by IFNalpha/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. Oncogene 2011; 30: 2670-8.
-
(2011)
Oncogene
, vol.30
, pp. 2670-2678
-
-
Testoni, B.1
Schinzari, V.2
Guerrieri, F.3
Gerbal-Chaloin, S.4
Blandino, G.5
Levrero, M.6
-
26
-
-
84859157028
-
3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells
-
Chiba T, Suzuki E, Negishi M et al. 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells. Int J Cancer 2012; 130: 2557-67.
-
(2012)
Int J Cancer
, vol.130
, pp. 2557-2567
-
-
Chiba, T.1
Suzuki, E.2
Negishi, M.3
-
27
-
-
34247625135
-
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
-
Tan J, Yang X, Zhuang L et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 2007; 21: 1050-63.
-
(2007)
Genes Dev
, vol.21
, pp. 1050-1063
-
-
Tan, J.1
Yang, X.2
Zhuang, L.3
-
28
-
-
84255200363
-
Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway
-
Liu H, Xu J, Zhou L et al. Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. Cancer Res 2011; 71: 7547-57.
-
(2011)
Cancer Res
, vol.71
, pp. 7547-7557
-
-
Liu, H.1
Xu, J.2
Zhou, L.3
-
29
-
-
4143054651
-
Activated p53 suppresses the histone methyltransferase EZH2 gene
-
Tang X, Milyavsky M, Shats I, Erez N, Goldfinger N, Rotter V. Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene 2004; 23: 5759-69.
-
(2004)
Oncogene
, vol.23
, pp. 5759-5769
-
-
Tang, X.1
Milyavsky, M.2
Shats, I.3
Erez, N.4
Goldfinger, N.5
Rotter, V.6
-
30
-
-
77954230484
-
Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage
-
Xu J, Yun X, Jiang J et al. Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. Hepatology 2010; 52: 142-54.
-
(2010)
Hepatology
, vol.52
, pp. 142-154
-
-
Xu, J.1
Yun, X.2
Jiang, J.3
-
31
-
-
84862742319
-
Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1
-
Xu J, Liu H, Chen L et al. Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1. Gastroenterology 2012; 143: 199-212.
-
(2012)
Gastroenterology
, vol.143
, pp. 199-212
-
-
Xu, J.1
Liu, H.2
Chen, L.3
-
32
-
-
80051921285
-
Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component
-
Zhang W, Xu W, Xiong S. Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol 2011; 187: 1764-77.
-
(2011)
J Immunol
, vol.187
, pp. 1764-1777
-
-
Zhang, W.1
Xu, W.2
Xiong, S.3
-
33
-
-
77953474634
-
Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization
-
Zhang W, Xu W, Xiong S. Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol 2010; 184: 6465-78.
-
(2010)
J Immunol
, vol.184
, pp. 6465-6478
-
-
Zhang, W.1
Xu, W.2
Xiong, S.3
-
34
-
-
54449083925
-
Molecular targeted therapies in hepatocellular carcinoma
-
Llovet JM, Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 2008; 48: 1312-27.
-
(2008)
Hepatology
, vol.48
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
35
-
-
85027937746
-
MEK-ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes
-
Fujii S, Tokita K, Wada N et al. MEK-ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes. Oncogene 2011; 30: 4118-28.
-
(2011)
Oncogene
, vol.30
, pp. 4118-4128
-
-
Fujii, S.1
Tokita, K.2
Wada, N.3
-
36
-
-
80054991835
-
PDGF signalling controls age-dependent proliferation in pancreatic beta-cells
-
Chen H, Gu X, Liu Y et al. PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. Nature 2011; 478: 349-55.
-
(2011)
Nature
, vol.478
, pp. 349-355
-
-
Chen, H.1
Gu, X.2
Liu, Y.3
-
37
-
-
77955541508
-
Regulation of tumor angiogenesis by EZH2
-
Lu C, Han HD, Mangala LS et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell 2011; 18: 185-97.
-
(2011)
Cancer Cell
, vol.18
, pp. 185-197
-
-
Lu, C.1
Han, H.D.2
Mangala, L.S.3
-
38
-
-
80051496158
-
Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability
-
Wu SC, Zhang Y. Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability. J Biol Chem 2011; 286: 28511-9.
-
(2011)
J Biol Chem
, vol.286
, pp. 28511-28519
-
-
Wu, S.C.1
Zhang, Y.2
-
39
-
-
35648993596
-
Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization
-
Meng XW, Lee SH, Dai H et al. Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization. J Biol Chem 2007; 282: 29831-46.
-
(2007)
J Biol Chem
, vol.282
, pp. 29831-29846
-
-
Meng, X.W.1
Lee, S.H.2
Dai, H.3
-
40
-
-
79955087925
-
Sorafenib inhibits transforming growth factor beta1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes
-
Chen YL, Lv J, Ye XL et al. Sorafenib inhibits transforming growth factor beta1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 2011; 53: 1708-18.
-
(2011)
Hepatology
, vol.53
, pp. 1708-1718
-
-
Chen, Y.L.1
Lv, J.2
Ye, X.L.3
-
41
-
-
84984559474
-
Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
-
Chen KF, Tai WT, Liu TH et al. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. Clin Cancer Res 2010; 16: 5189-99.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5189-5199
-
-
Chen, K.F.1
Tai, W.T.2
Liu, T.H.3
-
42
-
-
84867408207
-
Sorafenib-Induced Hepatocellular Carcinoma Cell Death Depends on Reactive Oxygen Species Production in vitro and in vivo
-
Coriat R, Nicco C, Chereau C et al. Sorafenib-Induced Hepatocellular Carcinoma Cell Death Depends on Reactive Oxygen Species Production in vitro and in vivo. Mol Cancer Ther 2012; 11: 2284-93.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2284-2293
-
-
Coriat, R.1
Nicco, C.2
Chereau, C.3
-
43
-
-
35748937338
-
Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
-
Yu J, Cao Q, Mehra R et al. Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell 2007; 12: 419-31.
-
(2007)
Cancer Cell
, vol.12
, pp. 419-431
-
-
Yu, J.1
Cao, Q.2
Mehra, R.3
-
44
-
-
77749297990
-
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB
-
Min J, Zaslavsky A, Fedele G et al. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med 2010; 16: 286-94.
-
(2010)
Nat Med
, vol.16
, pp. 286-294
-
-
Min, J.1
Zaslavsky, A.2
Fedele, G.3
-
45
-
-
47949125993
-
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor
-
Herranz N, Pasini D, Diaz VM et al. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol 2008; 28: 4772-81.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4772-4781
-
-
Herranz, N.1
Pasini, D.2
Diaz, V.M.3
-
46
-
-
33846148370
-
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene
-
Kotake Y, Cao R, Viatour P et al. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev 2007; 21: 49-54.
-
(2007)
Genes Dev
, vol.21
, pp. 49-54
-
-
Kotake, Y.1
Cao, R.2
Viatour, P.3
|