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Volumn 20, Issue 6, 2013, Pages 622-630

One-carbon metabolism, spermatogenesis, and male infertility

Author keywords

male infertility; methylation; MTHFR; oxidative damage; spermatogenesis

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CARBON; DNA; HISTONE; HOMOCYSTEINE; METHIONINE SYNTHASE; METHIONINE SYNTHASE REDUCTASE;

EID: 84878191137     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719112459232     Document Type: Review
Times cited : (57)

References (72)
  • 3
    • 2442686408 scopus 로고    scopus 로고
    • Genomic imprinting in disruptive spermatogenesis
    • DOI 10.1016/S0140-6736(04)16256-9, PII S0140673604162569
    • Marques CJ, Carvalho F, Sousa M, Barros MA. Genomic imprinting in disruptive spermatogenesis. Lancet. 2004 ; 363: 1700-1702 (Pubitemid 38670329)
    • (2004) Lancet , vol.363 , Issue.9422 , pp. 1700-1702
    • Marques, C.J.1    Carvalho, F.2    Sousa, M.3    Barros, A.4
  • 4
    • 79955668953 scopus 로고    scopus 로고
    • Redox regulation of fertilization and the spermatogenic process
    • Fujii J, Tsunoda S. Redox regulation of fertilization and the spermatogenic process. Asian J Androl. 2011 ; 13 (3). 420-423
    • (2011) Asian J Androl , vol.13 , Issue.3 , pp. 420-423
    • Fujii, J.1    Tsunoda, S.2
  • 5
    • 77954603078 scopus 로고    scopus 로고
    • Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice
    • Chan D, Cushnie DW, Neaga OR, Lawrance AK, Rozen R, Trasler JK. Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice. Endocrinology. 2010 ; 151 (7). 3363-3373
    • (2010) Endocrinology , vol.151 , Issue.7 , pp. 3363-3373
    • Chan, D.1    Cushnie, D.W.2    Neaga, O.R.3    Lawrance, A.K.4    Rozen, R.5    Trasler, J.K.6
  • 6
    • 78649817579 scopus 로고    scopus 로고
    • Determination of glutation peroxidase and superoxide dismutase activities in canine seminal plasma and its relation with sperm quality and lipid peroxidation post thaw
    • Neagu VR, García BM, Rodríguez AM, et al. Determination of glutation peroxidase and superoxide dismutase activities in canine seminal plasma and its relation with sperm quality and lipid peroxidation post thaw. Theriogenology. 2011 ; 75 (1). 10-16
    • (2011) Theriogenology , vol.75 , Issue.1 , pp. 10-16
    • Neagu, V.R.1    García, B.M.2    Rodríguez, A.M.3
  • 7
    • 0023118495 scopus 로고
    • Effects of the transmethylation inhibitor S-adenosyl-homocysteine and of the methyl donor S-adenosyl-methionine on rat Leydig cell function in vitro
    • DOI 10.1016/0022-4731(87)90035-5
    • Papadopoulos V, Kamtchouing P, Drosdowsky MA, Carreau S. Effects of the transmethylation inhibitor S-adenosyl-homocysteine and of the methyl donor S-adenosyl-methionine on rat Leydig cell function in vitro. J Steroid Biochem. 1987 ; 26 (1). 93-98 (Pubitemid 17034692)
    • (1987) Journal of Steroid Biochemistry , vol.26 , Issue.1 , pp. 93-98
    • Papadopoulos, V.1    Kamtchouing, P.2    Drosdowsky, M.A.3    Carreau, S.4
  • 8
    • 0020655439 scopus 로고
    • Transcobalamin II deficiency associated with unusual bone marrow findings and chromosomal abnormalities
    • DOI 10.1002/ajh.2830140111
    • Rana SR, Colman N, Goh KO, Herbert V, Klemperer MR. Transcobalamin II deficiency associated with unusual bone marrow findings and chromosomal abnormalities. Am J Hematol. 1983 ; 14 (1). 89-96 (Pubitemid 13192225)
    • (1983) American Journal of Hematology , vol.14 , Issue.1 , pp. 89-96
    • Rana, S.R.1    Colman, N.2    Goh, K.O.3    Herbert, V.4    Klemperer, M.R.5
  • 9
    • 21744462251 scopus 로고    scopus 로고
    • Homocysteine: Overview of biochemistry, molecular biology, and role in disease processes
    • DOI 10.1055/s-2005-872394
    • Fowler B. Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin Vasc Med. 2005 ; 5 (2). 77-86 (Pubitemid 40944284)
    • (2005) Seminars in Vascular Medicine , vol.5 , Issue.2 , pp. 77-86
    • Fowler, B.1
  • 10
    • 77954303577 scopus 로고    scopus 로고
    • Antioxidant levels in blood and seminal plasma and their impact on sperm parameters in infertile men
    • Shamsi MB, Venkatesh S, Kumar R, et al. Antioxidant levels in blood and seminal plasma and their impact on sperm parameters in infertile men. Indian J Biochem Biophys. 2010 ; 47 (1). 38-43
    • (2010) Indian J Biochem Biophys , vol.47 , Issue.1 , pp. 38-43
    • Shamsi, M.B.1    Venkatesh, S.2    Kumar, R.3
  • 11
    • 0033970043 scopus 로고    scopus 로고
    • Folate and carcinogenesis: An integrated scheme
    • Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000 ; 130 (2). 129-132 (Pubitemid 30073783)
    • (2000) Journal of Nutrition , vol.130 , Issue.2 , pp. 129-132
    • Choi, S.-W.1    Mason, J.B.2
  • 12
    • 0035122292 scopus 로고    scopus 로고
    • The folate cycle and disease in humans
    • Fowler B. The folate cycle and disease in humans. Kidney Int Suppl. 2001 ; 78: S221 - S229
    • (2001) Kidney Int Suppl , vol.78
    • Fowler, B.1
  • 13
    • 0035225593 scopus 로고    scopus 로고
    • Plasma homocysteine level in relation to folate and vitamin B6 status in apparently normal men
    • Lakshmi AV, Maniprabha C, Krishna TP. Plasma homocysteine level in relation to folate and vitamin B6 status in apparently normal men. Asia Pac J Clin Nutr. 2001 ; 10 (3). 194-196 (Pubitemid 33739354)
    • (2001) Asia Pacific Journal of Clinical Nutrition , vol.10 , Issue.3 , pp. 194-196
    • Lakshmi, A.V.1
  • 15
    • 0034692453 scopus 로고    scopus 로고
    • Aberrant methylation of gene promoters in cancer - Concepts, misconcepts, and promise
    • Baylin SB, Belinsky SA, Herman JG. Aberrant methylation of gene promoters in cancer - concepts, misconcepts, and promise. J Natl Cancer Inst. 2000 ; 92 (18). 1460-1461
    • (2000) J Natl Cancer Inst , vol.92 , Issue.18 , pp. 1460-1461
    • Baylin, S.B.1    Belinsky, S.A.2    Herman, J.G.3
  • 16
    • 0028809885 scopus 로고
    • 5-Aza deoxyCytidine-induced inhibition of differentiation of spermatogonia into spermatocytes in the mouse
    • Raman R. Narayan G. 5-Aza deoxyCytidine-induced inhibition of differentiation of spermatogonia into spermatocytes in the mouse. Mol Reprod Dev. 1995 ; 42: 284-290
    • (1995) Mol Reprod Dev , vol.42 , pp. 284-290
    • Raman, R.1    Narayan, G.2
  • 17
    • 0035876883 scopus 로고    scopus 로고
    • Free radical scavenging behavior of folic acid: Evidence for possible antioxidant activity
    • DOI 10.1016/S0891-5849(01)00543-3, PII S0891584901005433
    • Joshi R, Adhikari S, Patro BS, Chattopadhyay S, Mukherjee T. Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radic Biol Med. 2001 ; 30 (12). 1390-1399 (Pubitemid 32522954)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.12 , pp. 1390-1399
    • Joshi, R.1    Adhikari, S.2    Patro, B.S.3    Chattopadhyay, S.4    Mukherjee, T.5
  • 18
  • 20
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • DOI 10.1016/S0092-8674(00)81656-6
    • Okano M, Bell DW, Haber DA, Li E. DNA methyl-transferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999 ; 99 (3). 247-257 (Pubitemid 29519904)
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 21
    • 0034305821 scopus 로고    scopus 로고
    • DNA methylation in health and disease
    • Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet. 2000 ; 1 (1). 11-19
    • (2000) Nat Rev Genet , vol.1 , Issue.1 , pp. 11-19
    • Robertson, K.D.1    Wolffe, A.P.2
  • 22
    • 0033805888 scopus 로고    scopus 로고
    • Genomic DNA methylation decreases in response to moderate folate depletion in elderly women
    • Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ, Bailey LB.. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr. 2000 ; 72 (4). 998-1003
    • (2000) Am J Clin Nutr , vol.72 , Issue.4 , pp. 998-1003
    • Rampersaud, G.C.1    Kauwell, G.P.2    Hutson, A.D.3    Cerda, J.J.4    Bailey, L.B.5
  • 23
    • 0027326933 scopus 로고
    • DNA methylation in folate deficiency use of CpG methylase
    • DOI 10.1006/bbrc.1993.1750
    • Balaghi M, Wagner C. DNA methylation in folate deficiency: use of CpG methylase. Biochem Biophys Res Commun. 1993 ; 193 (3). 1184-1190 (Pubitemid 23209719)
    • (1993) Biochemical and Biophysical Research Communications , vol.193 , Issue.3 , pp. 1184-1190
    • Balaghi, M.1    Wagner, C.2
  • 24
    • 0028925741 scopus 로고
    • Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats
    • Pogribny IP, Basnakian AG, Miller BJ, Lopatina NG, Poirier LA, James SJ. Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res. 1995 ; 55 (9). 1894-1901
    • (1995) Cancer Res , vol.55 , Issue.9 , pp. 1894-1901
    • Pogribny, I.P.1    Basnakian, A.G.2    Miller, B.J.3    Lopatina, N.G.4    Poirier, L.A.5    James, S.J.6
  • 25
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A. 1997 ; 94: 3290-3295
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3290-3295
    • Blount, B.C.1    MacK, M.M.2    Wehr, C.M.3
  • 26
    • 77954303577 scopus 로고    scopus 로고
    • Antioxidant levels in blood and seminal plasma and their impact on sperm parameters in infertile men
    • Shamsi MB, Venkatesh S, Kumar R, et al. Antioxidant levels in blood and seminal plasma and their impact on sperm parameters in infertile men. Indian J Biochem Biophys. 2010 ; 47 (1). 38-43
    • (2010) Indian J Biochem Biophys , vol.47 , Issue.1 , pp. 38-43
    • Shamsi, M.B.1    Venkatesh, S.2    Kumar, R.3
  • 27
    • 77956189400 scopus 로고    scopus 로고
    • Increased levels of oxidants and reduced antioxidants in semen of infertile men with varicocele
    • Abd-Elmoaty MA, Saleh R, Sharma R, Agarwal A. Increased levels of oxidants and reduced antioxidants in semen of infertile men with varicocele. Fertil Steril. 2010 ; 94 (4). 1531-1534
    • (2010) Fertil Steril , vol.94 , Issue.4 , pp. 1531-1534
    • Abd-Elmoaty, M.A.1    Saleh, R.2    Sharma, R.3    Agarwal, A.4
  • 28
    • 0028939847 scopus 로고
    • Molecular localization of free thiols in human sperm chromatin
    • Rousseaux J, Rousseaux-Prevost R. Molecular localization of free thiols in human sperm chromatin. Biol Reprod. 1995 ; 52: 1066-1072
    • (1995) Biol Reprod , vol.52 , pp. 1066-1072
    • Rousseaux, J.1    Rousseaux-Prevost, R.2
  • 29
    • 0035906343 scopus 로고    scopus 로고
    • DNA damage from micronutrient deficiencies is likely to be a major cause of cancer
    • DOI 10.1016/S0027-5107(01)00070-7, PII S0027510701000707
    • Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res. 2001 ; 475 (1-2). 7-20 (Pubitemid 32284938)
    • (2001) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.475 , Issue.1-2 , pp. 7-20
    • Ames, B.N.1
  • 30
    • 0035849145 scopus 로고    scopus 로고
    • Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility [7]
    • DOI 10.1056/NEJM200104123441517
    • Bezold G, Lange M, Peter RU. Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility. New Engl J Med. 2001 ; 344 (15). 1172-1173 (Pubitemid 32285246)
    • (2001) New England Journal of Medicine , vol.344 , Issue.15 , pp. 1172-1173
    • Bezold, G.1    Lange, M.2    Peter, R.U.3
  • 31
    • 0242661475 scopus 로고    scopus 로고
    • C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration
    • DOI 10.1016/S0015-0282(03)02157-5
    • Ebisch IM, van Heerde WL, Thomas CM, van der Put N, Wong WY, Steegers-Theunissen RP. C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration. Fertil Steril. 2003 ; 80 (5). 1190-1194 (Pubitemid 37377749)
    • (2003) Fertility and Sterility , vol.80 , Issue.5 , pp. 1190-1194
    • Ebisch, I.M.W.1    Van Heerde, W.L.2    Thomas, C.M.G.3    Van Der Put, N.4    Wong, W.Y.5    Steegers-Theunissen, R.P.M.6
  • 33
    • 16244371735 scopus 로고    scopus 로고
    • Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population
    • DOI 10.1111/j.1365-2605.2004.00513.x
    • Singh K, Singh SK, Sah R, Singh I, Raman R. Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population. Int J Androl. 2005 ; 28 (2). 115-119 (Pubitemid 40461182)
    • (2005) International Journal of Andrology , vol.28 , Issue.2 , pp. 115-119
    • Singh, K.1    Singh, S.K.2    Sah, R.3    Singh, I.4    Raman, R.5
  • 35
    • 32844467372 scopus 로고    scopus 로고
    • MTHFR C677T polymorphism, GSTM1 deletion and male infertility: A possible suggestion of a gene-gene interaction?
    • DOI 10.1080/13547500500442050, PII T1778711571682
    • Paracchini V, Garte S, Taioli E. MTHFR, C677T polymorphism. GSTM1 deletion and male infertility: a possible suggestion of a gene-gene interaction?. Biomarkers. 2006 ; 11 (1). 53-60 (Pubitemid 43250551)
    • (2006) Biomarkers , vol.11 , Issue.1 , pp. 53-60
    • Paracchini, V.1    Garte, S.2    Taioli, E.3
  • 36
    • 33846083097 scopus 로고    scopus 로고
    • Single nucleotide polymorphism C677T in the methylenete-trahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia
    • DOI 10.1111/j.1745-7262.2007.00225.x
    • A ZC, Yang Y, Zhang SZ, Li N, Zhang W. Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for male infertility for Chinese men with azoospermia or severe oligozoospermia. Asian J Androl. 2007 ; 9 (1). 57-62 (Pubitemid 46061025)
    • (2007) Asian Journal of Andrology , vol.9 , Issue.1 , pp. 57-62
    • Yang, Y.1    Zhang, S.-Z.2    Li, N.3    Zhang, W.4
  • 37
    • 33751380396 scopus 로고    scopus 로고
    • Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility
    • DOI 10.1093/humrep/del280
    • Lee HC, Jeong YM, Lee SH, et al. Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility. Hum Reprod. 2006 ; 21 (12). 3162-3170 (Pubitemid 44811619)
    • (2006) Human Reproduction , vol.21 , Issue.12 , pp. 3162-3170
    • Lee, H.-C.1    Jeong, Y.-M.2    Lee, S.H.3    Cha, K.Y.4    Song, S.-H.5    Kim, N.K.6    Lee, K.W.7    Lee, S.8
  • 38
    • 34147103978 scopus 로고    scopus 로고
    • Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men
    • DOI 10.1093/molehr/gal118
    • Dhillon VS, Shahid M, Husain SA. Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men. Mol Hum Reprod. 2007 ; 13 (4). 213-222 (Pubitemid 46554738)
    • (2007) Molecular Human Reproduction , vol.13 , Issue.4 , pp. 213-222
    • Dhillon, V.S.1    Shahid, M.2    Husain, S.A.3
  • 39
    • 68449090625 scopus 로고    scopus 로고
    • Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts
    • Ravel C, Chantot-Bastaraud S, Chalmey C, et al. Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts. PLoS One. 2009 ; 4 (8). e6540
    • (2009) PLoS One , vol.4 , Issue.8 , pp. 6540
    • Ravel, C.1    Chantot-Bastaraud, S.2    Chalmey, C.3
  • 40
    • 84891493190 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase A1298C polymorphism and male infertility in a Romanian population group
    • Farcas MF, Trifa AP, Militaru M, et al. Methylenetetrahydrofolate reductase A1298C polymorphism and male infertility in a Romanian population group. J Clin Med. 2009 ; 4: 4
    • (2009) J Clin Med , vol.4 , pp. 4
    • Farcas, M.F.1    Trifa, A.P.2    Militaru, M.3
  • 41
    • 78751569721 scopus 로고    scopus 로고
    • Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts
    • Montjean D, Benkhalifa M, Dessolle L, et al. Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts. Fertil Steril. 2011 ; 95 (2). 635-640
    • (2011) Fertil Steril , vol.95 , Issue.2 , pp. 635-640
    • Montjean, D.1    Benkhalifa, M.2    Dessolle, L.3
  • 42
    • 77957988161 scopus 로고    scopus 로고
    • MTHFR A1298C polymorphism and idiopathic male infertility
    • Singh K, Singh SK, Raman R. MTHFR A1298C polymorphism and idiopathic male infertility. J Postgrad Med. 2010 ; 56 (4). 267-269
    • (2010) J Postgrad Med , vol.56 , Issue.4 , pp. 267-269
    • Singh, K.1    Singh, S.K.2    Raman, R.3
  • 43
    • 84891484560 scopus 로고    scopus 로고
    • Cystathionine β-Synthase 844ins68 gene variant and idiopathic male infertility [published online August 5, 2009]
    • Singh K, Agrawal NK, Khanna A, Jain M, Pandey S.. Cystathionine β-Synthase 844ins68 gene variant and idiopathic male infertility [published online August 5, 2009]. Reprod Sci. 2009 ;:
    • (2009) Reprod Sci
    • Singh, K.1    Agrawal, N.K.2    Khanna, A.3    Jain, M.4    Pandey, S.5
  • 44
    • 79952126454 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms are related to male infertility in Brazilian men
    • Gava MM, Chagas Ede O, Bianco B, et al. Methylenetetrahydrofolate reductase polymorphisms are related to male infertility in Brazilian men. Genet Test Mol Biomarkers. 2011 ; 15 (3). 153-157
    • (2011) Genet Test Mol Biomarkers , vol.15 , Issue.3 , pp. 153-157
    • Gava, M.M.1    Chagas Ede, O.2    Bianco, B.3
  • 45
    • 79952503528 scopus 로고    scopus 로고
    • Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility
    • Safarinejad MR, Shafiei N, Safarinejad S.. Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility. Reprod Sci. 2011 ; 18 (3). 304-315
    • (2011) Reprod Sci , vol.18 , Issue.3 , pp. 304-315
    • Safarinejad, M.R.1    Shafiei, N.2    Safarinejad, S.3
  • 46
    • 84861499663 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism is not associated with male infertility in a South Indian population
    • Vani GT, Mukesh N, Rama Devi P, Usha Rani P, Reddy PP. Methylenetetrahydrofolate reductase C677T polymorphism is not associated with male infertility in a South Indian population. Andrologia. 2012 ; 44 (suppl 1). 252-259
    • (2012) Andrologia , vol.44 , Issue.SUPPL. 1 , pp. 252-259
    • Vani, G.T.1    Mukesh, N.2    Rama Devi, P.3    Usha Rani, P.4    Reddy, P.P.5
  • 47
    • 79960581001 scopus 로고    scopus 로고
    • Strong association of 677 C>T substitutions in the MTHFR gene with male infertility - A study on an Indian population and a meta-analysis
    • Gupta N, Gupta S, Dama M, et al. Strong association of 677 C>T substitutions in the MTHFR gene with male infertility - a study on an Indian population and a meta-analysis. PLoS One. 2011 ; 6 (7). e22277
    • (2011) PLoS One , vol.6 , Issue.7 , pp. 22277
    • Gupta, N.1    Gupta, S.2    Dama, M.3
  • 48
    • 5644243210 scopus 로고    scopus 로고
    • Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults
    • DOI 10.1016/j.atherosclerosis.2004.05.014, PII S0021915004002825
    • Romerio SC, Linder L, Nyfeler J, et al. Acute hyperhomocysteinaemia decreases NO bioavailability in healthy adults. Atherosclerosis. 2004 ; 176 (2). 337-344 (Pubitemid 39369524)
    • (2004) Atherosclerosis , vol.176 , Issue.2 , pp. 337-344
    • Romerio, S.C.1    Linder, L.2    Nyfeler, J.3    Wenk, M.4    Litynsky, P.5    Asmis, R.6    Haefeli, W.E.7
  • 50
    • 0031923571 scopus 로고    scopus 로고
    • Role of nitric oxide in the biology, physiology and pathophysiology of reproduction
    • DOI 10.1093/humupd/4.1.3
    • Rosselli M, Keller PJ, Dubey RK. Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum Reprod Update. 1998 ; 4 (1). 3-24 (Pubitemid 28223052)
    • (1998) Human Reproduction Update , vol.4 , Issue.1 , pp. 3-24
    • Rosselli, M.1    Keller, P.J.2    Dubey, R.K.3
  • 51
    • 0037244912 scopus 로고    scopus 로고
    • Nitric oxide is a signaling molecule in spermatozoa
    • DOI 10.2174/1381612033391720
    • Herrero MB, deLamirande E, Gagnon C. Nitric oxide is a signaling molecule in spermatozoa. Curr Pharm Des. 2003 ; 9: 419-425 (Pubitemid 36131733)
    • (2003) Current Pharmaceutical Design , vol.9 , Issue.5 , pp. 419-425
    • Herrero, M.B.1    De Lamirande, E.2    Gagnon, C.3
  • 52
    • 0742306236 scopus 로고    scopus 로고
    • Nitric Oxide/Nitric Oxide Synthase, Spermatogenesis, and Tight Junction Dynamics
    • DOI 10.1095/biolreprod.103.021329
    • Lee NP, Cheng CY. Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics. Biol Reprod. 2004 ; 70: 267-276 (Pubitemid 38160083)
    • (2004) Biology of Reproduction , vol.70 , Issue.2 , pp. 267-276
    • Lee, N.P.Y.1    Cheng, C.Y.2
  • 53
    • 27944478245 scopus 로고    scopus 로고
    • DNA damage to spermatozoa has impacts on fertilization and pregnancy
    • DOI 10.1007/s00441-005-1097-5
    • Lewis SE, Aitken RJ. DNA damage to spermatozoa has impacts on fertilization and pregnancy. Cell Tissue Res. 2005 ; 322: 33-41 (Pubitemid 41677654)
    • (2005) Cell and Tissue Research , vol.322 , Issue.1 , pp. 33-41
    • Lewis, S.E.M.1    Aitken, R.J.2
  • 54
    • 14044276314 scopus 로고    scopus 로고
    • Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function
    • DOI 10.2174/1389200052997357
    • Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr Drug Metab. 2005 ; 6 (1). 27-36 (Pubitemid 40277879)
    • (2005) Current Drug Metabolism , vol.6 , Issue.1 , pp. 27-36
    • Weiss, N.1
  • 55
    • 30344464729 scopus 로고    scopus 로고
    • What an andrologist/urologist should know about free radicals and why
    • DOI 10.1016/j.urology.2005.07.012, PII S009042950501006X
    • Agarwal A, Prabakaran S, Allamaneni S. What an andrologist/urologist should know about free radicals and why. Urology. 2006 ; 67 (1). 2-8 (Pubitemid 43069245)
    • (2006) Urology , vol.67 , Issue.1 , pp. 2-8
    • Agarwal, A.1    Prabakaran, S.2    Allamaneni, S.3
  • 56
    • 51849127760 scopus 로고    scopus 로고
    • Folate-mediated one-carbon metabolism
    • Fox JT, Stover PJ. Folate-mediated one-carbon metabolism. Vitam Horm. 2008 ; 79: 1-44
    • (2008) Vitam Horm , vol.79 , pp. 1-44
    • Fox, J.T.1    Stover, P.J.2
  • 58
    • 34250747441 scopus 로고    scopus 로고
    • Origins and consequences of DNA damage in male germ cells
    • Aitken RJ, De Iuliis GN. Origins and consequences of DNA damage in male germ cells. Reprod Biomed Online. 2007 ; 14 (6). 727-733 (Pubitemid 46951708)
    • (2007) Reproductive BioMedicine Online , vol.14 , Issue.6 , pp. 727-733
    • Aitken, R.J.1    De Iuliis, G.N.2
  • 60
    • 78349304922 scopus 로고    scopus 로고
    • Seminal plasma homocysteine, folate and cobalamin in men with obstructive and non-obstructive azoospermia
    • Crha I, Kralikova M, Melounova J, et al. Seminal plasma homocysteine, folate and cobalamin in men with obstructive and non-obstructive azoospermia. J Assist Reprod Genet. 2010 ; 27 (9-10). 533-538
    • (2010) J Assist Reprod Genet , vol.27 , Issue.910 , pp. 533-538
    • Crha, I.1    Kralikova, M.2    Melounova, J.3
  • 61
    • 14044257216 scopus 로고    scopus 로고
    • Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation
    • DOI 10.1095/biolreprod.104.035238
    • Kelly TL, Neaga OR, Schwahn BC, Rozen R, Trasler JM. Infertility in 5,10-methylenetetra hydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by life time dietary betaine supplementation. Biol Reprod. 2005 ; 72 (3). 667-677 (Pubitemid 40279846)
    • (2005) Biology of Reproduction , vol.72 , Issue.3 , pp. 667-677
    • Kelly, T.L.J.1    Neaga, O.R.2    Schwahn, B.C.3    Rozen, R.4    Trasler, J.M.5
  • 62
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995 ; 10 (1). 111-113
    • (1995) Nat Genet , vol.10 , Issue.1 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 65
    • 68949208601 scopus 로고    scopus 로고
    • MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: The role of epigenetics in male infertility
    • Khazamipour N, Noruzinia M, Fatehmanesh P, Keyhanee M, Pujol P. MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility. Human Reprod. 2009 ; 24 (9). 2361-2364
    • (2009) Human Reprod , vol.24 , Issue.9 , pp. 2361-2364
    • Khazamipour, N.1    Noruzinia, M.2    Fatehmanesh, P.3    Keyhanee, M.4    Pujol, P.5
  • 66
    • 78649730409 scopus 로고    scopus 로고
    • Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR)
    • Wu W, Shen O, Qin Y, et al. Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR). PLoS One. 2010 ; 5 (11). e13884
    • (2010) PLoS One , vol.5 , Issue.11 , pp. 13884
    • Wu, W.1    Shen, O.2    Qin, Y.3
  • 68
    • 0033427561 scopus 로고    scopus 로고
    • Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers
    • Kawakami K, Omura K, Kanehira E, Watanabe Y. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res. 1999 ; 19 (4B). 3249-3252 (Pubitemid 30042617)
    • (1999) Anticancer Research , vol.19 , Issue.4 B , pp. 3249-3252
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3    Watanabe, Y.4
  • 69
    • 0036322745 scopus 로고    scopus 로고
    • In the cystathionine β-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific
    • Choumenkovitch SF, Selhub J, Bagley PJ, et al. In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific. J Nutr. 2002 ; 132 (8). 2157-2160 (Pubitemid 34851643)
    • (2002) Journal of Nutrition , vol.132 , Issue.8 , pp. 2157-2160
    • Choumenkovitch, S.F.1    Selhub, J.2    Bagley, P.J.3    Maeda, N.4    Nadeau, M.R.5    Smith, D.E.6    Choi, S.-W.7
  • 70
    • 0002942853 scopus 로고
    • Bailey LB, ed. New York, NY: Marcel Dekker;
    • Wagner C. Folate in Health and Disease. Bailey LB, ed. New York, NY: Marcel Dekker ; 1995: 23-42.
    • (1995) Folate in Health and Disease , pp. 23-42
    • Wagner, C.1
  • 71
    • 55449126945 scopus 로고    scopus 로고
    • Pharmacogenetic relevance of MTHFR polymorphisms
    • Toffoli G, De Mattia E. Pharmacogenetic relevance of MTHFR polymorphisms. Pharmacogenomics. 2008 ; 9 (9). 1195-206
    • (2008) Pharmacogenomics , vol.9 , Issue.9 , pp. 1195-1206
    • Toffoli, G.1    De Mattia, E.2


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