-
1
-
-
0033017570
-
The effect of age on the pharmacokinetics and pharmacodynamics of midazolam
-
Albrecht S, Ihmsen H, Hering W et al (1999) The effect of age on the pharmacokinetics and pharmacodynamics of midazolam. Clin Pharmacol Ther 65:630-639
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 630-639
-
-
Albrecht, S.1
Ihmsen, H.2
Hering, W.3
-
2
-
-
0344943299
-
Bioavailability of dexmedetomidine after extravascular doses in healthy subjects
-
Anttila M, Penttila J, Helminen A et al (2003) Bioavailability of dexmedetomidine after extravascular doses in healthy subjects. Br J Clin Pharmacol 56:691-693
-
(2003)
Br J Clin Pharmacol
, vol.56
, pp. 691-693
-
-
Anttila, M.1
Penttila, J.2
Helminen, A.3
-
3
-
-
0030805186
-
In-use contamination of propofol. A clinical study
-
Bach A, Motsch J, Schmidt H et al (1997) In-use contamination of propofol. A clinical study. Eur J Anaesthesiol 14:178-183
-
(1997)
Eur J Anaesthesiol
, vol.14
, pp. 178-183
-
-
Bach, A.1
Motsch, J.2
Schmidt, H.3
-
4
-
-
33847632825
-
Dexmedetomidine for the treatment of postanesthesia shivering in children
-
Blaine Easley R, Brady KM, Tobias JD (2007) Dexmedetomidine for the treatment of postanesthesia shivering in children. Paediatr Anaesth 17:341-346
-
(2007)
Paediatr Anaesth
, vol.17
, pp. 341-346
-
-
Blaine Easley, R.1
Brady, K.M.2
Tobias, J.D.3
-
5
-
-
84864209239
-
Dexmedetomidine use in pediatric intensive care and procedural sedation
-
Buck ML (2010) Dexmedetomidine use in pediatric intensive care and procedural sedation. J Pediatr Pharmacol Ther 15:17-29
-
(2010)
J Pediatr Pharmacol Ther
, vol.15
, pp. 17-29
-
-
Buck, M.L.1
-
6
-
-
0028271008
-
Dexmedetomidine decreases thiopental dose requirement and alters distribution pharmacokinetics
-
Buhrer M, Mappes A, Lauber R et al (1994) Dexmedetomidine decreases thiopental dose requirement and alters distribution pharmacokinetics. Anesthesiology 80:1216-1227
-
(1994)
Anesthesiology
, vol.80
, pp. 1216-1227
-
-
Buhrer, M.1
Mappes, A.2
Lauber, R.3
-
7
-
-
7244220115
-
Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers
-
Cortinez LI, Hsu YW, Sum-Ping ST et al (2004) Dexmedetomidine pharmacodynamics: Part II: crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 101:1077-1083
-
(2004)
Anesthesiology
, vol.101
, pp. 1077-1083
-
-
Cortinez, L.I.1
Hsu, Y.W.2
Sum-Ping, S.T.3
-
8
-
-
68849097671
-
The use of dexmedetomidine in critically ill children
-
Czaja AS, Zimmerman JJ (2009) The use of dexmedetomidine in critically ill children. Pediatr Crit Care Med 10:381-386
-
(2009)
Pediatr Crit Care Med
, vol.10
, pp. 381-386
-
-
Czaja, A.S.1
Zimmerman, J.J.2
-
9
-
-
0034761921
-
The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment
-
De Wolf AM, Fragen RJ, Avram MJ et al (2001) The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment. Anesth Analg 93:1205-1209
-
(2001)
Anesth Analg
, vol.93
, pp. 1205-1209
-
-
De Wolf, A.M.1
Fragen, R.J.2
Avram, M.J.3
-
10
-
-
26044479381
-
Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: An analysis of frequency and risk factors
-
Devlin JW, Lau AK, Tanios MA (2005) Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors. Pharmacotherapy 25:1348-1352
-
(2005)
Pharmacotherapy
, vol.25
, pp. 1348-1352
-
-
Devlin, J.W.1
Lau, A.K.2
Tanios, M.A.3
-
11
-
-
77953036827
-
Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive care unit
-
Devlin JW, Mallow-Corbett S, Riker RR (2010) Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive care unit. Crit Care Med 38:231-243
-
(2010)
Crit Care Med
, vol.38
, pp. 231-243
-
-
Devlin, J.W.1
Mallow-Corbett, S.2
Riker, R.R.3
-
12
-
-
79953878354
-
Analytic reviews: Propofol infusion syndrome in the ICU
-
Diedrich DA, Brown DR (2011) Analytic reviews: propofol infusion syndrome in the ICU. J Intensive Care Med 26:59-72
-
(2011)
J Intensive Care Med
, vol.26
, pp. 59-72
-
-
Diedrich, D.A.1
Brown, D.R.2
-
13
-
-
0033811109
-
Influence of cardiac output on dexmedetomidine pharmacokinetics
-
Dutta S, Lal R, Karol MD et al (2000) Influence of cardiac output on dexmedetomidine pharmacokinetics. J Pharm Sci 89:519-527
-
(2000)
J Pharm Sci
, vol.89
, pp. 519-527
-
-
Dutta, S.1
Lal, R.2
Karol, M.D.3
-
14
-
-
0027217287
-
Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers
-
Dyck JB, Maze M, Haack C et al (1993) Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology78:821-828
-
(1993)
Anesthesiology78
, pp. 821-828
-
-
Dyck, J.B.1
Maze, M.2
Haack, C.3
-
15
-
-
0027299384
-
The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers
-
Dyck JB, Maze M, Haack C et al (1993) The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology 78:813-820
-
(1993)
Anesthesiology
, vol.78
, pp. 813-820
-
-
Dyck, J.B.1
Maze, M.2
Haack, C.3
-
16
-
-
0033860761
-
The effects of increasing plasma concentrations of dexmedetomidine in humans
-
Ebert TJ, Hall JE, Barney JA et al (2000) The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 93:382-394
-
(2000)
Anesthesiology
, vol.93
, pp. 382-394
-
-
Ebert, T.J.1
Hall, J.E.2
Barney, J.A.3
-
17
-
-
41549149971
-
Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy
-
Elvan EG, Oc B, Uzun S et al (2008) Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy. Eur J Anaesthesiol 25:357-364
-
(2008)
Eur J Anaesthesiol
, vol.25
, pp. 357-364
-
-
Elvan, E.G.1
Oc, B.2
Uzun, S.3
-
18
-
-
0030754859
-
Pharmacokinetics and pharmacodynamics of midazolam given via continuous intravenous infusion in intensive care units
-
discussion 367-408
-
Fragen RJ (1997) Pharmacokinetics and pharmacodynamics of midazolam given via continuous intravenous infusion in intensive care units. Clin Ther 19:405-419, discussion 367-408
-
(1997)
Clin Ther
, vol.19
, pp. 405-419
-
-
Fragen, R.J.1
-
19
-
-
75149143531
-
Dexmedetomidine sedation in children after cardiac surgery
-
Hosokawa K, Shime N, Kato Y et al (2010) Dexmedetomidine sedation in children after cardiac surgery. Pediatr Crit Care Med 11:39-43
-
(2010)
Pediatr Crit Care Med
, vol.11
, pp. 39-43
-
-
Hosokawa, K.1
Shime, N.2
Kato, Y.3
-
20
-
-
38149016800
-
Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep
-
Huupponen E, Maksimow A, Lapinlampi P et al (2008) Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand 52:289-294
-
(2008)
Acta Anaesthesiol Scand
, vol.52
, pp. 289-294
-
-
Huupponen, E.1
Maksimow, A.2
Lapinlampi, P.3
-
21
-
-
84857320674
-
Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients
-
Iirola T, Ihmsen H, Laitio R et al (2012) Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients. Br J Anaesth 108:460-468
-
(2012)
Br J Anaesth
, vol.108
, pp. 460-468
-
-
Iirola, T.1
Ihmsen, H.2
Laitio, R.3
-
22
-
-
79952982795
-
Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers
-
Iirola T, Vilo S, Aantaa R et al (2011) Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers. Br J Anaesth 106:522-527
-
(2011)
Br J Anaesth
, vol.106
, pp. 522-527
-
-
Iirola, T.1
Vilo, S.2
Aantaa, R.3
-
23
-
-
84858657050
-
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: Two randomized controlled trials
-
Jakob SM, Ruokonen E, Grounds RM et al (2012) Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 307:1151-1160
-
(2012)
JAMA
, vol.307
, pp. 1151-1160
-
-
Jakob, S.M.1
Ruokonen, E.2
Grounds, R.M.3
-
24
-
-
0032589056
-
Alpha2-adrenoceptor agonists stimulate high-affinity GTPase activity in a receptor subtype-selective manner
-
Jansson CC, Pohjanoksa K, Lang J et al (1999) Alpha2-adrenoceptor agonists stimulate high-affinity GTPase activity in a receptor subtype-selective manner. Eur J Pharmacol 374:137-146
-
(1999)
Eur J Pharmacol
, vol.374
, pp. 137-146
-
-
Jansson, C.C.1
Pohjanoksa, K.2
Lang, J.3
-
25
-
-
0033742791
-
Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans
-
Karol MD, Maze M (2000) Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans. Baillieres Best Pract Res Clin Anaesthesiol 14:261-269
-
(2000)
Baillieres Best Pract Res Clin Anaesthesiol
, vol.14
, pp. 261-269
-
-
Karol, M.D.1
Maze, M.2
-
26
-
-
0025891337
-
Effect of systemic medetomidine, an alpha 2 adrenoceptor agonist, on experimental pain in humans
-
Kauppila T, Kemppainen P, Tanila H et al (1991) Effect of systemic medetomidine, an alpha 2 adrenoceptor agonist, on experimental pain in humans. Anesthesiology 74:3-8
-
(1991)
Anesthesiology
, vol.74
, pp. 3-8
-
-
Kauppila, T.1
Kemppainen, P.2
Tanila, H.3
-
27
-
-
0026064736
-
Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism
-
Kharasch ED, Hill HF, Eddy AC (1991) Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism. Anesthesiology 75:520-524
-
(1991)
Anesthesiology
, vol.75
, pp. 520-524
-
-
Kharasch, E.D.1
Hill, H.F.2
Eddy, A.C.3
-
28
-
-
0028338772
-
Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine
-
Kivisto KT, Kallio A, Neuvonen PJ (1994) Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine. Eur J Clin Pharmacol 46:345-349
-
(1994)
Eur J Clin Pharmacol
, vol.46
, pp. 345-349
-
-
Kivisto, K.T.1
Kallio, A.2
Neuvonen, P.J.3
-
29
-
-
74749090954
-
Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception
-
Kohli U, Muszkat M, Sofowora GG et al (2010) Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception. Eur J Pain 14:154-159
-
(2010)
Eur J Pain
, vol.14
, pp. 154-159
-
-
Kohli, U.1
Muszkat, M.2
Sofowora, G.G.3
-
30
-
-
79751493114
-
Pharmacokinetics of dexmedetomidine in Chinese post-surgical intensive care unit patients
-
Lin L, Guo X, Zhang MZ et al (2011) Pharmacokinetics of dexmedetomidine in Chinese post-surgical intensive care unit patients. Acta Anaesthesiol Scand 55:359-367
-
(2011)
Acta Anaesthesiol Scand
, vol.55
, pp. 359-367
-
-
Lin, L.1
Guo, X.2
Zhang, M.Z.3
-
31
-
-
57349146913
-
Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia
-
Lin TF, Yeh YC, Lin FS et al (2009) Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia. Br J Anaesth 102:117-122
-
(2009)
Br J Anaesth
, vol.102
, pp. 117-122
-
-
Lin, T.F.1
Yeh, Y.C.2
Lin, F.S.3
-
32
-
-
0029739504
-
Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c
-
Link RE, Desai K, Hein L et al (1996) Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c. Science 273:803-805
-
(1996)
Science
, vol.273
, pp. 803-805
-
-
Link, R.E.1
Desai, K.2
Hein, L.3
-
33
-
-
0025908613
-
Pharmacokinetic model driven infusion of propofol in children
-
Marsh B, White M, Morton N et al (1991) Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 67:41-48
-
(1991)
Br J Anaesth
, vol.67
, pp. 41-48
-
-
Marsh, B.1
White, M.2
Morton, N.3
-
34
-
-
38049096672
-
Changes in sedation management in German intensive care units between 2002 and 2006: A national follow-up survey
-
Martin J, Franck M, Sigel S et al (2007) Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey. Crit Care 11:R124
-
(2007)
Crit Care
, vol.11
-
-
Martin, J.1
Franck, M.2
Sigel, S.3
-
35
-
-
31344440159
-
Practice of sedation and analgesia in German intensive care units: Results of a national survey
-
Martin J, Parsch A, Franck M et al (2005) Practice of sedation and analgesia in German intensive care units: results of a national survey. Crit Care 9: R117-123
-
(2005)
Crit Care
, vol.9
-
-
Martin, J.1
Parsch, A.2
Franck, M.3
-
36
-
-
0037241146
-
Propofol: A review of its use in intensive care sedation of adults
-
McKeage K, Perry CM (2003) Propofol: a review of its use in intensive care sedation of adults. CNS Drugs 17:235-272
-
(2003)
CNS Drugs
, vol.17
, pp. 235-272
-
-
McKeage, K.1
Perry, C.M.2
-
37
-
-
33745684466
-
A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients: Preliminary study
-
Memis D, Dokmeci D, Karamanlioglu B et al (2006) A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients: preliminary study. Eur J Anaesthesiol 23:700-704
-
(2006)
Eur J Anaesthesiol
, vol.23
, pp. 700-704
-
-
Memis, D.1
Dokmeci, D.2
Karamanlioglu, B.3
-
38
-
-
34247551128
-
Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: A randomised, open-label, pharmacoeconomic trial
-
Muellejans B, Matthey T, Scholpp J et al (2006) Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial. Crit Care 10:R91
-
(2006)
Crit Care
, vol.10
-
-
Muellejans, B.1
Matthey, T.2
Scholpp, J.3
-
39
-
-
0037313063
-
The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects
-
Nelson LE, Lu J, Guo T et al (2003) The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology 98:428-436
-
(2003)
Anesthesiology
, vol.98
, pp. 428-436
-
-
Nelson, L.E.1
Lu, J.2
Guo, T.3
-
40
-
-
84863585302
-
Dexmedetomidine and clonidine from second- to first-line sedative agents in the critical care setting?
-
Pichot C, Ghignone M, Quintin L (2012) Dexmedetomidine and clonidine: from second- to first-line sedative agents in the critical care setting? J Intensive Care Med 27:219-237
-
(2012)
J Intensive Care Med
, vol.27
, pp. 219-237
-
-
Pichot, C.1
Ghignone, M.2
Quintin, L.3
-
41
-
-
70350552006
-
Dexmedetomidine pharmacokinetics in pediatric intensive care-A pooled analysis
-
Potts AL, Anderson BJ, Warman GR et al (2009) Dexmedetomidine pharmacokinetics in pediatric intensive care-a pooled analysis. Paediatr Anaesth 19:1119-1129
-
(2009)
Paediatr Anaesth
, vol.19
, pp. 1119-1129
-
-
Potts, A.L.1
Anderson, B.J.2
Warman, G.R.3
-
42
-
-
59649127447
-
Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial
-
Riker RR, Shehabi Y, Bokesch PM et al (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301:489-499
-
(2009)
JAMA
, vol.301
, pp. 489-499
-
-
Riker, R.R.1
Shehabi, Y.2
Bokesch, P.M.3
-
43
-
-
0037111193
-
The Richmond Agitation-Sedation Scale: Validity and reliability in adult intensive care unit patients
-
Sessler CN, Gosnell MS, Grap MJ et al (2002) The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 166:1338-1344
-
(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 1338-1344
-
-
Sessler, C.N.1
Gosnell, M.S.2
Grap, M.J.3
-
44
-
-
0030862290
-
Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine
-
Talke P, Richardson CA, Scheinin M, Fisher DM (1997) Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg 85:1136-1142
-
(1997)
Anesth Analg
, vol.85
, pp. 1136-1142
-
-
Talke, P.1
Richardson, C.A.2
Scheinin, M.3
Fisher, D.M.4
-
45
-
-
77954459092
-
Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: A meta-analysis
-
Tan JA, Ho KM (2010) Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis. Intensive Care Med 36:926-939
-
Intensive Care Med
, vol.36
, pp. 926-939
-
-
Tan, J.A.1
Ho, K.M.2
-
46
-
-
0032705173
-
Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit
-
Venn RM, Bradshaw CJ, Spencer R et al (1999) Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 54:1136-1142
-
(1999)
Anaesthesia
, vol.54
, pp. 1136-1142
-
-
Venn, R.M.1
Bradshaw, C.J.2
Spencer, R.3
-
47
-
-
0035167022
-
Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: Patient and clinician perceptions
-
Venn RM, Grounds RM (2001) Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth 87:684-690
-
(2001)
Br J Anaesth
, vol.87
, pp. 684-690
-
-
Venn, R.M.1
Grounds, R.M.2
-
48
-
-
0033803263
-
Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care
-
Venn RM, Hell J, Grounds RM (2000) Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care 4:302-308
-
(2000)
Crit Care
, vol.4
, pp. 302-308
-
-
Venn, R.M.1
Hell, J.2
Grounds, R.M.3
-
49
-
-
0036257713
-
Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care
-
Venn RM, Karol MD, Grounds RM (2002) Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care. Br J Anaesth 88:669-675
-
(2002)
Br J Anaesth
, vol.88
, pp. 669-675
-
-
Venn, R.M.1
Karol, M.D.2
Grounds, R.M.3
-
50
-
-
0023903938
-
Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist
-
Virtanen R, Savola JM, Saano V et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 150:9-14
-
(1988)
Eur J Pharmacol
, vol.150
, pp. 9-14
-
-
Virtanen, R.1
Savola, J.M.2
Saano, V.3
|