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Volumn 73, Issue 6, 2013, Pages 719-725

Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESD; PLACEBO; PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; WNT INDUCED SIGNALING PROTEIN 1; WNT PROTEIN;

EID: 84878182321     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2013.42     Document Type: Article
Times cited : (30)

References (40)
  • 2
    • 70449130481 scopus 로고    scopus 로고
    • Epidemiology of bronchopulmonary dysplasia
    • Van Marter LJ. Epidemiology of bronchopulmonary dysplasia. Semin Fetal Neonatal Med 2009;14:358-66
    • (2009) Semin Fetal Neonatal Med , vol.14 , pp. 358-366
    • Van Marter, L.J.1
  • 3
    • 66249126322 scopus 로고    scopus 로고
    • Pitfalls, problems, and progress in bronchopulmonary dysplasia
    • Bhandari A, Bhandari V. Pitfalls, problems, and progress in bronchopulmonary dysplasia. Pediatrics 2009;123:1562-73
    • (2009) Pediatrics , vol.123 , pp. 1562-1573
    • Bhandari, A.1    Bhandari, V.2
  • 4
    • 15544380502 scopus 로고    scopus 로고
    • Lung vascular development: Implications for the pathogenesis of bronchopulmonary dysplasia
    • Stenmark KR, Abman SH. Lung vascular development: Implications for the pathogenesis of bronchopulmonary dysplasia. Annu Rev Physiol 2005; 67:623-61
    • (2005) Annu Rev Physiol , vol.67 , pp. 623-661
    • Stenmark, K.R.1    Abman, S.H.2
  • 5
    • 0031843337 scopus 로고    scopus 로고
    • Functional and pathological effects of prolonged hyperoxia in neonatal mice
    • Warner BB, Stuart LA, Papes RA, Wispe Jr. Functional and pathological effects of prolonged hyperoxia in neonatal mice. Am J Physiol 1998;275(1 P 1):L110-7
    • (1998) Am J Physiol , vol.275 , Issue.1 P1
    • Warner, B.B.1    Stuart, L.A.2    Papes, R.A.3    Wispe, J.R.4
  • 6
    • 0032778616 scopus 로고    scopus 로고
    • Pathways to cell death in hyperoxia
    • Horowitz S. Pathways to cell death in hyperoxia. Chest 1999;116:SUPPL 1:64S-7S.
    • (1999) Chest , vol.116 , Issue.SUPPL. 1
    • Horowitz, S.1
  • 7
    • 77955055436 scopus 로고    scopus 로고
    • Hyperoxia-derived lung damage in preterm infants
    • Bhandari V. Hyperoxia-derived lung damage in preterm infants. Semin Fetal Neonatal Med 2010;15:223-9
    • (2010) Semin Fetal Neonatal Med , vol.15 , pp. 223-229
    • Bhandari, V.1
  • 8
    • 0037408422 scopus 로고    scopus 로고
    • Wnt signaling and pulmonary fibrosis
    • Morrisey EE. Wnt signaling and pulmonary fibrosis. Am J Pathol 2003;162:1393-7
    • (2003) Am J Pathol , vol.162 , pp. 1393-1397
    • Morrisey, E.E.1
  • 10
    • 73949090577 scopus 로고    scopus 로고
    • WNT signaling in lung disease a failure or a regeneration signal?
    • Konigshoff M, Eickelberg O. WNT signaling in lung disease: A failure or a regeneration signal? Am J Respir Cell Mol Biol 2010;42:21-31
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 21-31
    • Konigshoff, M.1    Eickelberg, O.2
  • 11
    • 0242500879 scopus 로고    scopus 로고
    • Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
    • Chilosi M, Poletti V, Zamo A, et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 2003;162: 1495-502
    • (2003) Am J Pathol , vol.162 , pp. 1495-1502
    • Chilosi, M.1    Poletti, V.2    Zamo, A.3
  • 12
    • 47749101725 scopus 로고    scopus 로고
    • Functional Wnt signaling is increased in idiopathic pulmonary fibrosis
    • Konigshoff M, Balsara N, Pfaff EM, et al. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS ONE 2008;3:e2142
    • (2008) PLoS ONE , vol.3
    • Konigshoff, M.1    Balsara, N.2    Pfaff, E.M.3
  • 13
    • 70349211744 scopus 로고    scopus 로고
    • Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
    • Cohen ED, Ihida-Stansbury K, Lu MM, Panettieri RA, Jones PL, Morrisey EE. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest 2009; 119:2538-49
    • (2009) J Clin Invest , vol.119 , pp. 2538-2549
    • Cohen, E.D.1    Ihida-Stansbury, K.2    Lu, M.M.3    Panettieri, R.A.4    Jones, P.L.5    Morrisey, E.E.6
  • 14
    • 0034727104 scopus 로고    scopus 로고
    • LDL-receptor-related proteins in Wnt signal transduction
    • Tamai K, Semenov M, Kato Y, et al. LDL-receptor-related proteins in Wnt signal transduction. Nature 2000;407:530-5
    • (2000) Nature , vol.407 , pp. 530-535
    • Tamai, K.1    Semenov, M.2    Kato, Y.3
  • 16
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao B, Wu W, Li Y, et al. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 2001;411:321-5
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3
  • 17
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    • Mao J, Wang J, Liu B, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 2001;7:801-9
    • (2001) Mol Cell , vol.7 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3
  • 18
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way
    • He X, Semenov M, Tamai K, Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way. Development 2004;131:1663-77
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 19
    • 9344261834 scopus 로고    scopus 로고
    • LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells
    • Wang X, Adhikari N, Li Q, Hall JL. LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2004;287: H2376-83
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Wang, X.1    Adhikari, N.2    Li, Q.3    Hall, J.L.4
  • 20
    • 82755165212 scopus 로고    scopus 로고
    • Connective tissue growth factor antibody therapy attenuates hyperoxia-induced lung injury in neonatal rats
    • Alapati D, Rong M, Chen S, et al. Connective tissue growth factor antibody therapy attenuates hyperoxia-induced lung injury in neonatal rats. Am J Respir Cell Mol Biol 2011;45:1169-77
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 1169-1177
    • Alapati, D.1    Rong, M.2    Chen, S.3
  • 21
    • 67049171435 scopus 로고    scopus 로고
    • Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone
    • Dasgupta C, Sakurai R, Wang Y, et al. Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone. Am J Physiol Lung Cell Mol Physiol 2009;296:L1031-41
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296
    • Dasgupta, C.1    Sakurai, R.2    Wang, Y.3
  • 22
    • 0037423222 scopus 로고    scopus 로고
    • Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    • Hsieh JC, Lee L, Zhang L, et al. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell 2003;112:355-67
    • (2003) Cell , vol.112 , pp. 355-367
    • Hsieh, J.C.1    Lee, L.2    Zhang, L.3
  • 23
    • 77953100335 scopus 로고    scopus 로고
    • Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells
    • Lu W, Liu CC, Thottassery JV, Bu G, Li Y. Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry 2010;49:4635-43
    • (2010) Biochemistry , vol.49 , pp. 4635-4643
    • Lu, W.1    Liu, C.C.2    Thottassery, J.V.3    Bu, G.4    Li, Y.5
  • 24
    • 0018835695 scopus 로고
    • Value of echocardiography in assessing the outcome of bronchopulmonary dysplasia of the newborn
    • Fouron JC, Le Guennec JC, Villemant D, Perreault G, Davignon A. Value of echocardiography in assessing the outcome of bronchopulmonary dysplasia of the newborn. Pediatrics 1980;65:529-35
    • (1980) Pediatrics , vol.65 , pp. 529-535
    • Fouron, J.C.1    Le Guennec, J.C.2    Villemant, D.3    Perreault, G.4    Davignon, A.5
  • 25
    • 34248384848 scopus 로고    scopus 로고
    • Bronchopulmonary dysplasia: Where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease
    • Thebaud B, Abman SH. Bronchopulmonary dysplasia: Where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease. Am J Respir Crit Care Med 2007;175:978-85
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 978-985
    • Thebaud, B.1    Abman, S.H.2
  • 26
    • 65249088418 scopus 로고    scopus 로고
    • WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    • Konigshoff M, Kramer M, Balsara N, et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 2009;119:772-87
    • (2009) J Clin Invest , vol.119 , pp. 772-787
    • Konigshoff, M.1    Kramer, M.2    Balsara, N.3
  • 27
    • 33845620229 scopus 로고    scopus 로고
    • Regulation of smooth muscle cell proliferation by beta-catenin/ T-cell factor signaling involves modulation of cyclin D1 and p21 expression
    • Quasnichka H, Slater SC, Beeching CA, Boehm M, Sala-Newby GB, George SJ. Regulation of smooth muscle cell proliferation by beta-catenin/ T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ Res 2006;99:1329-37
    • (2006) Circ Res , vol.99 , pp. 1329-1337
    • Quasnichka, H.1    Slater, S.C.2    Beeching, C.A.3    Boehm, M.4    Sala-Newby, G.B.5    George, S.J.6
  • 28
    • 80053276370 scopus 로고    scopus 로고
    • Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo
    • Lin C, Lu W, Zhai L, et al. Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo. FEBS Lett 2011;585:3120-5
    • (2011) FEBS Lett , vol.585 , pp. 3120-3125
    • Lin, C.1    Lu, W.2    Zhai, L.3
  • 29
    • 33748807230 scopus 로고    scopus 로고
    • Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd
    • Li Y, Lu W, He X, Bu G. Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd. FEBS Lett 2006;580:5423-8
    • (2006) FEBS Lett , vol.580 , pp. 5423-5428
    • Li, Y.1    Lu, W.2    He, X.3    Bu, G.4
  • 30
    • 20344377886 scopus 로고    scopus 로고
    • Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1
    • Wang Z, Shu W, Lu MM, Morrisey EE. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol 2005;25:5022-30
    • (2005) Fzd10, and LRP5. Mol Cell Biol , vol.25 , pp. 5022-5030
    • Wang, Z.1    Shu, W.2    Lu, M.M.3    Morrisey, E.E.4
  • 31
    • 66049144587 scopus 로고    scopus 로고
    • The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension
    • Laumanns IP, Fink L, Wilhelm J, et al. The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension. Am J Respir Cell Mol Biol 2009;40:683-91
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 683-691
    • Laumanns, I.P.1    Fink, L.2    Wilhelm, J.3
  • 32
    • 0023867690 scopus 로고
    • Pulmonary vascular remodeling in neonatal pulmonary hypertension
    • Haworth SG. Pulmonary vascular remodeling in neonatal pulmonary hypertension. State of the art. Chest 1988;93:SUPPL 3:133S-8S.
    • (1988) State of the art. Chest , vol.93 , Issue.SUPPL. 3
    • Haworth, S.G.1
  • 33
    • 2942541475 scopus 로고    scopus 로고
    • Cellular and molecular pathobiology of pulmonary arterial hypertension
    • Humbert M, Morrell NW, Archer SL, et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 2004;43:SUPPL 12 S:13S-24S.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL. 12
    • Humbert, M.1    Morrell, N.W.2    Archer, S.L.3
  • 34
    • 33749345684 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms
    • Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms. Circ Res 2006; 99:675-91
    • (2006) Circ Res , vol.99 , pp. 675-691
    • Stenmark, K.R.1    Fagan, K.A.2    Frid, M.G.3
  • 35
    • 78649745131 scopus 로고    scopus 로고
    • Reversible or irreversible remodeling in pulmonary arterial hypertension
    • Sakao S, Tatsumi K, Voelkel NF. Reversible or irreversible remodeling in pulmonary arterial hypertension. Am J Respir Cell Mol Biol 2010;43: 629-34
    • (2010) Am J Respir Cell Mol Biol , vol.43 , pp. 629-634
    • Sakao, S.1    Tatsumi, K.2    Voelkel, N.F.3
  • 36
    • 77958450885 scopus 로고    scopus 로고
    • The role of wnt signaling in physiological and pathological angiogenesis
    • Dejana E. The role of wnt signaling in physiological and pathological angiogenesis. Circ Res 2010;107:943-52
    • (2010) Circ Res , vol.107 , pp. 943-952
    • Dejana, E.1
  • 38
    • 0035891595 scopus 로고    scopus 로고
    • Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia
    • Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM. Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;164(10 Pt 1): 1971-80
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.10 PART 1 , pp. 1971-1980
    • Bhatt, A.J.1    Pryhuber, G.S.2    Huyck, H.3    Watkins, R.H.4    Metlay, L.A.5    Maniscalco, W.M.6
  • 40
    • 79954997910 scopus 로고    scopus 로고
    • CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: Implication in the pathogenesis of severe bronchopulmonary dysplasia
    • Chen S, Rong M, Platteau A, et al. CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: Implication in the pathogenesis of severe bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 2011;300:L330-40
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300
    • Chen, S.1    Rong, M.2    Platteau, A.3


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