A new curcumin analogue exhibits enhanced antitumor activity in nasopharyngeal carcinoma

Oncology Reports

Volumn 30, Issue 1, 2013, Pages 239-245

  Pan, Yunbao ^a   Xiao, Jian ^b   Liang, Guang ^b   Wang, Mengyao ^a   Wang, Dujuan ^a   Wang, Sumei ^a   Yang, Huiling ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Curcumin; Endoplasmic reticulum stress; Epstein Barr virus associated malignancy; Nasopharyngeal carcinoma

Indexed keywords

1,5 BIS(2 BROMOPHENYL)PENTA 1,4 DIEN 3 ONE; ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; CURCUMIN; GL 63; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CARCINOGENICITY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BROMOBENZENES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CURCUMIN; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MICE; MICE, NUDE; NASOPHARYNGEAL NEOPLASMS; PENTANONES; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84878178044     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2457     Document Type: Article

References (29)

1. Lo KW, Chung GT and To KF: Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches. Semin Cancer Biol 22: 79-86, 2012.
2. Hui EP, Ma BB, Leung SF, et al: Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma. J Clin Oncol 27: 242-249, 2009.
3. Yip KW, Mocanu JD, Au PY, et al: Combination Bcl-2 antisense and radiation therapy for nasopharyngeal cancer. Clin Cancer Res 11: 8131-8144, 2005. (Pubitemid 41698758)
4. Lev-Ari S, Lichtenberg D and Arber N: Compositions for treatment of cancer and inflammation. Recent Pat Anticancer Drug Discov 3: 55-62, 2008. (Pubitemid 351223210)
5. Gandhy SU, Kim K, Larsen L, Rosengren RJ and Safe S: Curcumin and synthetic analogs induce reactive oxygen species and decrease specificity protein (Sp) transcription factors by targeting microRNAs. BMC Cancer 12: 564, 2012.
6. Binion DG, Otterson MF and Rafiee P: Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut 57: 1509-1517, 2008.
7. Anand P, Kunnumakkara AB, Newman RA and Aggarwal BB: Bioavailability of curcumin: problems and promises. Mol Pharm 4: 807-818, 2007.
8. Pae HO, Jeong SO, Jeong GS, et al: Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells. Biochem Biophys Res Commun 353: 1040-1045, 2007.
9. Isohashi F, Endo H, Mukai M, Inoue T and Inoue M: Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions. Cancer Sci 99: 2395-2401, 2008.
10. Yogosawa S, Yamada Y, Yasuda S, Sun Q, Takizawa K and Sakai T: Dehydrozingerone, a structural analogue of curcumin, induces cell-cycle arrest at the G2/M phase and accumulates intracellular ROS in HT-29 human colon cancer cells. J Nat Prod 75: 2088-2093, 2012.
11. Subramaniam D, May R, Sureban SM, et al: Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. Cancer Res 68: 1962-1969, 2008. (Pubitemid 351416583)
12. Liang G, Yang S, Zhou H, et al: Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues. Eur J Med Chem 44: 915-919, 2009.
13. Liang G, Shao L, Wang Y, et al: Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents. Bioorg Med Chem 17: 2623-2631, 2009.
14. Xiao J, Chu Y, Hu K, et al: Synthesis and biological analysis of a new curcumin analogue for enhanced anti-tumor activity in HepG 2 cells. Oncol Rep 23: 1435-1441, 2010.
15. Xiao J, Tan Y, Pan Y, et al: A new cyclooxygenase-2 inhibitor, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63) suppresses cyclooxygenase-2 gene expression in human lung epithelial cancer cells: coupled mRNA stabilization and posttranscriptional inhibition. Biol Pharm Bull 33: 1170-1175, 2010.
16. Qu C, Liang Z, Huang J, et al: miR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell Cycle 11: 785-796, 2012.
17. Pan Y, Zhang Q, Tian L, et al: Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma. Cancer Res 72: 1890-1900, 2012.
18. Pan Y, Zhang Q, Atsaves V, Yang H and Claret FX: Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways. Oncogene: Jul 16, 2012 (Epub ahead of print).
19. Yang H, Wen YY, Zhao R, et al: DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer. Cancer Res 66: 3096-3105, 2006.
20. Matsuo K, Gray MJ, Yang DY, et al: The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol 128: 552-559, 2012.
21. Eizirik DL, Miani M and Cardozo AK: Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 56: 234-241, 2012.
22. Hutzen B, Friedman L, Sobo M, et al: Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Int J Oncol 35: 867-872, 2009.
23. Friedman L, Lin L, Ball S, et al: Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. Anticancer Drugs 20: 444-449, 2009.
24. Naidu MD, Mason JM, Pica RV, Fung H and Pena LA: Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1. J Radiat Res 51: 393-404, 2010.
25. Zou W, Yue P, Khuri FR and Sun SY: Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation. Cancer Res 68: 7484-7492, 2008.
26. Zhang K and Kaufman RJ: Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 279: 25935-25938, 2004. (Pubitemid 38798732)
27. Liu D, Yin H and Zhang M: Signaling pathways involved in endoplasmic reticulum stress-induced neuronal apoptosis. Int J Neurosci 123: 155-162, 2012.
28. Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, et al: PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene 29: 3881-3895, 2010.
29. Yamazaki T, Sasaki N, Nishi M and Takeshima H: Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23. Biochem Biophys Res Commun 392: 196-200, 2010.