A new cyclooxygenase-2 inhibitor, (1E,4E)-1,5-bis(2-bromophenyl)penta- 1,4-dien-3-one (GL63) suppresses cyclooxygenase-2 gene expression in human lung epithelial cancer cells: Coupled mRNA stabilization and posttranscriptional inhibition

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 7, 2010, Pages 1170-1175

  Xiao, Jian ^a,b   Tan, Yi ^b,c   Pan, Yunbao ^a   Liang, Guang ^b   Qu, Changju ^a   Zhang, Xie ^b   Zhang, Yi ^b   Li, Xiaokun ^b   Yang, Huiling ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c University of Louisville School of Medicine   (United States)

Author keywords

Curcumin analogue; Cyclooxygenase 2; Human antigen R; Posttranscription

Indexed keywords

(1E,4E) 1,5 BIS (2 BROMOPHENYL) PENTA 1,4 DIEN 3 ONE; CURCUMIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GL 63; HUR PROTEIN; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LUNG CARCINOMA; PROTEIN EXPRESSION; REPORTER GENE; RNA DEGRADATION; RNA PROCESSING; RNA STABILITY; TRANSCRIPTION TERMINATION;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; BROMOBENZENES; CELL LINE; CELL PROLIFERATION; CURCUMIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DNA PRIMERS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LUNG; PENTANONES; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER;

EID: 77954463609     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1170     Document Type: Article

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