Novel methodology to identify TRPV1 antagonists independent of capsaicin activation

Journal of Biomolecular Screening

Volumn 18, Issue 5, 2013, Pages 544-555

  Zicha, Stephen ^a   Radresa, Olivier ^a   Laplante, Patricia ^a   Morton, Michael ^a   Jones, Karen ^a   Main, Martin ^a   Trivedi, Shephali ^a   Julien, Ron P ^a   Griffin, Andrew ^a   Labrecque, Jean ^a   Ahmad, Sultan ^a   Brown, William ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

automated patch clamp; electrophysiology; ligand gated ion channel; pain; TRPV1

Indexed keywords

CAPSAICIN; RUBIDIUM; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL CELL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; DEPOLARIZATION; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MEMBRANE STEADY POTENTIAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AUTOMATED PATCH CLAMP; ELECTROPHYSIOLOGY; LIGAND-GATED ION CHANNEL; PAIN; TRPV1;

ANIMALS; CAPSAICIN; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; SENSORY SYSTEM AGENTS; TRPV CATION CHANNELS;

EID: 84878167981     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112470563     Document Type: Article

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