Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: Relationship with interleukin-6

Brain, Behavior, and Immunity

Volumn 31, Issue , 2013, Pages 48-53

  Lotrich, Francis E ^a   Sears, Barry ^b   McNamara, Robert K ^c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b The Inflammation Research Foundation   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Arachidonic acid; C reactive protein; Cytokine; Inflammation; Interleukin 6; Major depressive disorder; Omega 3 fatty acids

Indexed keywords

ARACHIDONIC ACID; C REACTIVE PROTEIN; DOCOSAHEXAENOIC ACID; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 6; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN;

ADULT; AGED; ARTICLE; DEPRESSION; FEMALE; HEPATITIS C; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RACE; SLEEP QUALITY; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ARACHIDONIC ACID; C-REACTIVE PROTEIN; DEPRESSIVE DISORDER; FATTY ACIDS, OMEGA-3; FEMALE; HEPATITIS C; HUMANS; INFLAMMATION; INTERFERON-ALPHA; INTERLEUKIN-6; MALE; MIDDLE AGED;

EID: 84878154348     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.08.007     Document Type: Article

References (52)

1. Adams P.B., Lawson S., Sanigorski A., Sinclair A.J. Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996, 31:S157-S161.
2. Akhondzadeh S., Jafari S., Faisi F. Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial. Depress. Anxiety 2009, 26:607-611.
3. Bull S.J., Huezo-Diaz P., Binder E.B., Cubells J.F., Ranjith G., Maddock C., Miyazaki C., Alexander N., Hotopf M., Cleare A.J., Norris S., Cassidy E., Aitchison K.J., Miller A.H., Pariante C.M. Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-a and ribavirin treatment. Mol. Psychiatry 2008, 14:1095-1104.
4. Buysse D.J., Reynolds C.F., Monk T.H., Berman S.R., Kupfer D.J. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989, 28:193-213.
5. Calder P.C. The relationship between the fatty acid composition of immune cells and their function. Prostagl. Leukotr. Essent. Fatty Acids 2008, 79:101-108.
6. Capuron L., Miller A.H. Cytokines and psychopathology: lessons from interferon-alpha. Biol. Psychiatry 2004, 56:819-824.
7. Capuron L., Gumnick J.F., Musselman D.L., Lawson D.H., Reemsnyder A., Nemeroff C.B., Miller A.H. Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 2002, 26:643-652.
8. Cleland L.G., Gibson R.A., Neumann M., French J.K. The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids. Prostagl. Leukotr. Essent. Fatty Acids 1990, 40:9-12.
9. Conklin S.M., Manuck S.B., Yao J.K., Flory J.D., Hibbeln J.R., Muldoon M.F. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosomat. Med. 2007, 69:932-934.
10. Decsi T., Kennedy K. Sex-specific differences in essential fatty acid metabolism. Am. J. Clin. Nutr. 2011, 94:1914S-1919S.
11. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E., Lanctot K. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67:446-457.
12. Franzen P.L., Buysse D.J., Rabinovitz M., Pollock B.G., Lotrich F.E. Poor sleep quality predicts onset of either major depression or subsyndromal depression with irritability during interferon-alpha treatment. J. Psychiatry Res. 2009, 177:240-245.
13. Frasur-Smith N., Lesperance F., Julien P. Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes. Biol. Psychiatry 2004, 55:891-896.
14. Freeman M.P., Hibbeln J.R., Wisner K.L., et al. Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J. Clin. Psychiatry 2006, 67:1954-1967.
15. Hofacer R., Rider T., Jandacek R., Tso P., Magrisso I.J., Benoit S.C., McNamara R.K. Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status. Nutr. Res. 2011, 31:715-722.
16. Hong S., Gronert K., Devchand P., Moussignac R.L., Serhan C.N. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J. Biol. Chem. 2003, 278:14677-14687.
17. Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomat. Med. 2009, 71:171-186.
18. Igarashi M., Ma K., Chang L., Bell J.M., Rapoport S.I. Dietary n-3 PUFA deprivation for 15weeks upregulates elongase and desaturase expression in rat liver but not brain. J. Lipid Res. 2007, 48:2463-2470.
19. Kodas E., Galineau L., Bodard S., Vancassel S., Guilloteau D., Besnard J.C., Chalon S. Serotoninergic neurotransmission is affected by n-3 polyunsaterated fatty acids in the rat. J. Neurochem. 2004, 89:695-702.
20. Kozak W., Soszynski D., Rudolph K., Conn D.A., Kluger M.J. Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation. Am. J. Physiol. 1997, 272:R1298-R1307.
21. Lemaitre R.N., Tanaka T., Tang W., Manichaikul A., Foy M., Kabagambe E.K., Nettleton J.A., King I.B., Weng L.-C., Bhattacharya S., Bandinelli S., Bis J.C., Rich S.S., Jacobs D.R.J., Cherubini A., et al. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genetics 2011, 7:e1002193.
22. Lin P.Y., Su K.P. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J. Clin. Psychiatry 2007, 68:1056-1061.
23. Lin P.Y., Huang S.Y., Su K.P. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol. Psychiatry 2010, 68:140-147.
24. Linthorst A.C.E., Flachskamm C., Holsboer F., Reul J.M.H.M. Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway. Neuroscience 1996, 72:989-997.
25. Liu Q., Bengmark S., Qu S. Nutrigenomics therapy of hepatisis C virus induced-hepatosteatosis. BMC Gastroenterology 2010, 10:49.
26. Lotrich F.E. Inflammatory cytokines, growth factors, and depression. Curr. Pharmaceut. Des. 2012, 18.
27. Lotrich F.E., Rabinovitz F., Gironda P., Pollock B.G. Depression following pegylated interferon-alpha: characteristics and vulnerability. J. Psychosomat. Res. 2007, 63:131-135.
28. Lotrich F.E., Ferrell R.E., Rabinovitz M., Pollock B.G. Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism. Biol. Psychiatry 2009, 65:344-348.
29. Lotrich F.E., Ferrell R.F., Rabinovitz M., Pollock B.G. Labile anger during interferon-alpha treatment is associated with a polymorphism in tumor necrosis factor-alpha. Clin. Neuropharmacol. 2010, 33:191-197.
30. Maes M., Smith R., Christophe A., Cosyns P., Desnyder R., Meltzer H. Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20:4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J. Affect Dis. 1996, 38:35-46.
31. Mamalakis G., Kiriakakis M., Tsibinos G., Hatzis C., Flouri S., Mantzoros C., Kafatos A. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharm. Biochem. Behav. 2006, 85:474-479.
32. McNamara R.K., Jandacek R., Rider T., Tso P., Cole-Strauss A., Lipton J.W. Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. Prostag. Leukotr. Essent. Fatty Acids 2010, 83:185-191.
33. McNamara R.K., Jandacek R., Rider T., Tso P., Dwivedi Y., Pandey G.N. Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J. Affect Dis. 2010, 126:303-311.
34. Mingam R., Moranis A., Bluthe R.-M., De Smedt-Peyrusse V., Kelley K.W., Guesnet P., Lavialle M., Dantzer R., Laye S. Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice. Eur. J. Neurosci. 2008, 28:1877-1886.
35. Montgomery S.A., Asberg M. A new depression scale designed to be sensitive to change. Br. J. Psychiatry 1979, 134:382-389.
36. Musselman D.L., Lawson D.H., Gumnick J.F., Manatunga A.K., Penna S., Goodkin R.S., Greiner K., Nemeroff C.B., Miller A.H. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N Engl. J. Med. 2001, 344:961-966.
37. Novak T.E., Babcock T.A., Jho D.H., al e. NF-kB inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNF-a transcription. Am. J. Physiol. Cell Mol. Physiol. 2003, 284:L84-L89.
38. Portanova J.P., Zhang Y., Anderson G.D., Houser S.D., Masferrer J.L., Seibert K., Gregory S.A., Isakson P.C. Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. J. Exp. Med. 1998, 184:883-891.
39. Prather A.A., Rabinovitz M., Pollock B.G., Lotrich F.E. Cytokine-induced depression during IFN-α treatment: the role of IL-6 and sleep quality. Br. Behav. Immun. 2009, 23:1109-1116.
40. Raison C.L., Capuron L., Miller A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006, 27:24-31.
41. Raison C.L., Borisov A.S., Woolwine B.J., Massung B., Vogt G., Miller A.H. Interferon-[alpha] effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol. Psychiatry 2010, 15:535-547.
42. Rao J.S., Ertley R.N., DeMar J.C., Rapoport S.I., Bazinet R.P., Lee H.J. Dietary n-3 PUFA deprovation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol. Psychiatry 2007, 12:151-157.
43. Sergeant S., Hugenschmidt C.E., Rudock M.E., Ziegler J.T., Ivester P., Ainsworth H.C., Vaidya D., Case L.D., Langefeld C.D., Freedman B.I., Bowden D.W., Mathias R.A., Chilton F.H. Difference in arachidonic acid levels and fatty acid desaturase (FAD5) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br. J. Nutr. 2012, 107:547-555.
44. Simopoulos A.P. The importance of the omega-6/omega-3 fatty acid raion in cardiovascular disease and other chronic diseases. Exp. Biol. Med. 2008, 233:674-688.
45. Song C., Li X., Leonard B.E., Horrobin D.F. Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. J. Lipid Res. 2003, 44:1984-1991.
46. Song C., Leonard B.E., Horrobin D.F. Dietary ethyl-eicosapentaenoic acid but not soybean oil reverses central interleukin-1-induced changes in behavior, coricosterone and immune responses in rats. Stress 2004, 7:43-54.
47. Su K.-P., Huang S.-Y., Peng C.-Y., Lai H.-C., Huang C.-L., Chen Y.-C., Aitchison K.J., Pariante C.M. Phospholipase A2 and cycloxygenase 2 genes influence the risk of interferon-a-induced depression by regulating polyunsaturated faty acids levels. Biol. Psychiatry 2010, 67:550-557.
48. Sublette M.E., Hibbeln J.R., Galfalvy H., Oquendo M.A., Mann J.J. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am. J. Psychiatry 2006, 163:1100-1102.
49. Tiemeier H., van Tuijl H.R., Hofman A., Kiliaan A.J., Breteler M.M. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam study. Am. J. Clin. Nutr. 2003, 78:40-46.
50. Vedin I., Cederholm T., Levi Y.F., Basun H., Garlind A., Faxén Irving G., Jönhagen M.E., Vessby B., Wahlund L.-O., Palmblad J. Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. Am. J. Clin. Nutr. 2008, 87:1616-1622.
51. Wang P., Zhu F., Konstantopoulos K. Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation. Am. J. Physiol. Cell Physiol. 2010, 298:C1445-1456.
52. Zorrilla E.P., Luborsky L., McKay J.R., Rosenthal R., Houldin A., Tax A., McCorkle R., Seligman D.A., Schmidt K. The relationship of depression and stressors to immunological assays: a meta-analytic review. Br. Behav. Immun. 2001, 15:199-226.