Downregulation of pro-inflammatory mediators by a water extract of Schisandra chinensis (Turcz.) Baill fruit in lipopolysaccharide-stimulated RAW 264.7 macrophage cells

Environmental Toxicology and Pharmacology

Volumn 36, Issue 2, 2013, Pages 256-264

  Dilshara, Matharage Gayani ^a   Jayasooriya, Rajapaksha Gedara Prasad Tharanga ^a   Kang, Chang Hee ^a   Lee, Seungheon ^a   Park, Sang Rul ^a   Jeong, Jin Woo ^b   Choi, Yung Hyun ^b   Seo, Yong Taek ^c   Jang, Young Pyo ^c   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Dong Eui University   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

Akt; Nitric oxide; Nuclear factor B; Prostaglandin E2; Schisandra chinensis; Tumor necrosis factor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE B; PYRROLIDINE DITHIOCARBAMATE; SCHISANDRA CHINENSIS EXTRACT; SHIZANDRIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WATER;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FRUIT; GENE; GENE EXPRESSION REGULATION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN SYNTHESIS; RNA SYNTHESIS; SCHISANDRA CHINENSIS; TUMOR NECROSIS FACTOR ALPHA GENE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AKT; NITRIC OXIDE; NUCLEAR FACTOR-ΚB; PROSTAGLANDIN E2; SCHISANDRA CHINENSIS; TUMOR NECROSIS FACTOR-Α;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FRUIT; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SCHISANDRA; SOLVENTS; TUMOR NECROSIS FACTOR-ALPHA; WATER;

EID: 84878141338     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2013.04.005     Document Type: Article

References (34)

1. Baldwin A.S. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 1996, 14:649-683.
2. Bendtzen K. Anti-TNF-α biotherapies: perspectives for evidence-based personalized medicine. Immunotherapy 2012, 4:1167-1179.
3. Buzzo C.L., Campopiano J.C., Massis L.M., Lage S.L., Cassado A.A., Leme-Souza R., Cunha L.D., Russo M., Zamboni D.S., Amarante-Mendes G.P., Bortoluci K.R. A novel pathway for inducible nitric-oxide synthase activation through inflammasomes. J. Biol. Chem. 2010, 285:32087-32095.
4. Chen Y., Vallee S., Wu J., Vu D., Sondek J., Ghosh G. Inhibition of NF-κB activity by IκBβ in association with κB-Ras. Mol. Cell. Biol. 2004, 24:3048-3056.
5. Chiu P.Y., Mak D.H., Poon M.K., Ko K.M. In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin. Planta Med. 2002, 68:951-956.
6. Choi Y.W., Takamatsu S., Khan S.I., Srinivas P.V., Ferreira D., Zhao J., Khan I.A. Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J. Nat. Prod. 2006, 69:356-359.
7. Dan H.C., Cooper M.J., Cogswell P.C., Duncan J.A., Ting J.P., Baldwin A.S. Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008, 22:1490-1500.
8. Davies M.G., Hagen P.O. Systemic inflammatory response syndrome. Br. J. Surg. 1997, 84:920-935.
9. Dretzke J., Edlin R., Round J., Connock M., Hulme C., Czeczot J., Fry-Smith A., McCabe C., Meads C. A systematic review and economic evaluation of the use of tumour necrosis factor-alpa (TNF-α) inhibitors, adalimumab and infliximab, for Crohn's disease. Health Technol. Assess. 2011, 15:1-244.
10. Duffield J.S. The inflammatory macrophage: a story of Jekyll and Hyde. Clin. Sci. 2003, 104:27-38.
11. 2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems. J. Pharmacol. Exp. Ther. 2002, 303:1001-1006.
12. Hale S., Lightman S. Anti-TNF therapies in the management of acute and chronic uveitis. Cytokine 2006, 33:231-237.
13. Höcherl K., Dreher F., Kurtz A., Bucher M. Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure. Hypertension 2002, 40:947-953.
14. Huang T., Shen P., Shen Y. Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography. J. Chromatogr. A 2005, 1066:239-242.
15. Khan S., Shin E.M., Choi R.J., Jung Y.H., Kim J., Tosun A., Kim Y.S. Suppression of LPS-induced inflammatory and NF-κB responses by anomalin in RAW 264.7 macrophages. J. Cell. Biochem. 2011, 112:2179-2188.
16. 2 in rat mesangial cells by a nonsteroidal anti-inflammatory drug: the role of cyclic AMP. Mol. Pharmacol. 1998, 53:385-391.
17. Kwon D.Y., Kim da S., Yang H.J., Park S. The lignin-rich fractions of Fructus Schisandrae improve sensitivity via the PPAR-γ pathway in in vitro and in vivo studies. J. Ethnopharmacol. 2011, 135:455-462.
18. Landry D.W., Oliver J.A. The pathogenesis of vasodilatory shock. N. Engl. J. Med. 2001, 345:588-595.
19. Lee M.S., Chao J., Yen J.C., Lin L.W., Tsai F.S., Hsieh M.T., Peng W.H., Cheng H.Y. Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the MAPK family and the mitochondria dependent pathway. Molecules 2012, 18:354-372.
20. Li X.N., Pu J.X., Du X., Yang L.M., An H.M., Lei C., He F., Luo X., Zheng Y.T., Lu Y., Xiao W.L., Sun H.D. Lignans with anti-HIV activity from Schisandra propinqua var. sinensis. J. Nat. Prod. 2009, 72:1133-1141.
21. Lipsky P.E. The clinical potential of cyclooxygenase-2-specific inhibitor. Am. J. Med. 1999, 106:51S-57S.
22. Llesuy S.F., Tomaro M.L. Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim. Biophys. Acta 1994, 1223:9-14.
23. MacMicking J., Xie Q.W., Nathan C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 1997, 15:323-350.
24. Pahl H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 1999, 18:6853-6866.
25. Plevy S.E., Landers C.J., Prehn J., Carramanzana N.M., Deem R.L., Shealy D., Targan S.R. A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J. Immunol. 1997, 159:6276-6282.
26. Rubio-Perez J.M., Morillas-Ruiz J.M. A review: inflammatory process in Alzheimer's disease, role of cytokines. Scientific World J. 2012, 2012:756357.
27. Stalińska K., Guzdek A., Rokicki M., Koj A. Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants. J. Physiol. Pharmacol. 2005, 56:157-169.
28. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat. Res. 2001, 480-481:243-268.
29. Tak P.P., Firestein G.S. NF-κB: a key role in inflammatory diseases. J. Clin. Invest. 2001, 107:7-11.
30. Tracey K.J., Cerami A. Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu. Rev. Med. 1994, 45:491-503.
31. Xu X., Zhou X., Zhou X.W., Zhang Z., Liao M.J., Gao Q., Luo H.M. Schizandrin prevents dexamethasone-induced cognitive deficits. Neurosci. Bull. 2012, 28:532-540.
32. Yasukawa K., Ikeya Y., Mitsuhashi H., Iwasaki M., Aburada M., Nakagawa S., Takeuchi M., Takido M. Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 1992, 49:68-71.
33. Zhang W., He X.J., Ma Y.Y., Wang H.J., Xia Y.J., Zhao Z.S., Ye Z.Y., Tao H.Q. Inducible nitric oxide synthase expression correlates with angiogenisis, lymphangiogenisis, and poor prognosis in gastric cancer patients. Hum. Pathol. 2001, 42:1275-1282.
34. Zhao T., Mao G., Mao R., Zou Y., Zheng D., Feng W., Ren Y., Wang W., Zheng W., Song J., Chen Y., Yang L., Wu X. Antitumor and immunomodulatory activity of a water-soluble low molecular weight polysaccharide from Schisandra chinensis (Turcz.) Baill. Food Chem. Toxicol. 2013, 55:609-616.