Dendritic cell function in the host response to Helicobacter pylori infection of the gastric mucosa

Pathogens and Disease

Volumn 67, Issue 1, 2013, Pages 46-53

  Shiu, Jessica ^a   Blanchard, Thomas G ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Dendritic cells; Helicobacter pylori; Inflammation; Mucosa; Regulatory T cells; Stomach

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 23;

CELL ACTIVATION; CELL FUNCTION; CELL LINEAGE; DENDRITIC CELL; DOWN REGULATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOMEOSTASIS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; STOMACH MUCOSA; TH1 CELL; TH17 CELL;

EID: 84878131488     PISSN: None     EISSN: 2049632X     Source Type: Journal    
DOI: 10.1111/2049-632X.12014     Document Type: Short Survey

References (54)

1. Algood HM, Gallo-Romero J, Wilson KT, Peek RM Jr & Cover TL (2007) Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol Med Microbiol 51: 577-586.
2. Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, Taube C & Muller A (2011) Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest 121: 3088-3093.
3. Bimczok D, Clements RH, Waites KB, Novak L, Eckhoff DE, Mannon PJ, Smith PD & Smythies LE (2010) Human primary gastric dendritic cells induce a Th1 response to H. pylori. Mucosal Immunol 3: 260-269.
4. Bimczok D, Grams JM, Stahl RD, Waites KB, Smythies LE & Smith PD (2011) Stromal regulation of human gastric dendritic cells restricts the Th1 response to Helicobacter pylori. Gastroenterology 141: 929-938.
5. Cao W & Liu YJ (2007) Innate immune functions of plasmacytoid dendritic cells. Curr Opin Immunol 19: 24-30.
6. Chen Y & Blaser MJ (2008) Helicobacter pylori colonization is inversely associated with childhood asthma. J Infect Dis 198: 553-560.
7. Coombes JL & Powrie F (2008) Dendritic cells in intestinal immune regulation. Nat Rev Immunol 8: 435-446.
8. Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y & Powrie F (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204: 1757-1764.
9. Denning TL, Norris BA, Medina-Contreras O, Manicassamy S, Geem D, Madan R, Karp CL & Pulendran B (2011) Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization. J Immunol 187: 733-747.
10. Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI & Blaser MJ (1989) Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 321: 1562-1566.
11. Hafsi N, Voland P, Schwendy S, Rad R, Reindl W, Gerhard M & Prinz C (2004) Human dendritic cells respond to Helicobacter pylori, promoting NK cell and Th1-effector responses in vitro. J Immunol 173: 1249-1257.
12. Heath WR & Carbone FR (2009) Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat Immunol 10: 1237-1244.
13. Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M & Hatakeyama M (2002) SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295: 683-686.
14. Hitzler I, Oertli M, Becher B, Agger EM & Muller A (2011) Dendritic cells prevent rather than promote immunity conferred by a helicobacter vaccine using a mycobacterial adjuvant. Gastroenterology 141: 186-196 196 e181.
15. Hitzler I, Sayi A, Kohler E, Engler DB, Koch KN, Hardt WD & Muller A (2012) Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1beta and IL-18. J Immunol 188: 3594-3602.
16. Joffre OP, Segura E, Savina A & Amigorena S (2012) Cross-presentation by dendritic cells. Nat Rev Immunol 12: 557-569.
17. Kao JY, Rathinavelu S, Eaton KA, Bai L, Zavros Y, Takami M, Pierzchala A & Merchant JL (2006) Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense. Am J Physiol Gastrointest Liver Physiol 291: G73-G81.
18. Kao JY, Zhang M, Miller MJ, et al. (2010) Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology 138: 1046-1054.
19. Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, Bamford KB, Lechler RI & Lombardi G (2010) Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes. Infect Immun 78: 845-853.
20. Kido M, Tanaka J, Aoki N, Iwamoto S, Nishiura H, Chiba T & Watanabe N (2010) Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses. Infect Immun 78: 108-114.
21. Kiriya K, Watanabe N, Nishio A, et al. (2007) Essential role of Peyer's patches in the development of Helicobacter-induced gastritis. Int Immunol 19: 435-446.
22. Kobayashi K, Yokota K, Yoshino T, Kawahara Y, Dey A, Hirai Y, Oguma K & Akagi T (1998) Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT). J Clin Pathol 51: 396-3.
23. Kranzer K, Sollner L, Aigner M, Lehn N, Deml L, Rehli M & Schneider-Brachert W (2005) Impact of Helicobacter pylori virulence factors and compounds on activation and maturation of human dendritic cells. Infect Immun 73: 4180-4189.
24. Kranzer K, Eckhardt A, Aigner M, Knoll G, Deml L, Speth C, Lehn N, Rehli M & Schneider-Brachert W (2004) Induction of maturation and cytokine release of human dendritic cells by Helicobacter pylori. Infect Immun 72: 4416-4423.
25. Mueller A, O'Rourke J, Chu P, Chu A, Dixon MF, Bouley DM, Lee A & Falkow S (2005) The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Am J Pathol 167: 797-812.
26. Nagai S, Mimuro H, Yamada T, Baba Y, Moro K, Nochi T, Kiyono H, Suzuki T, Sasakawa C & Koyasu S (2007) Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. P Natl Acad Sci USA 104: 8971-8976.
27. Necchi V, Manca R, Ricci V & Solcia E (2009) Evidence for transepithelial dendritic cells in human H. pylori active gastritis. Helicobacter 14: 208-222.
28. Niess JH, Brand S, Gu X, et al. (2005) CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307: 254-258.
29. Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W & Haas R (2000) Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287: 1497-1500.
30. Oertli M, Sundquist M, Hitzler I, et al. (2012) DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J Clin Invest 122: 1082-1096.
31. Otani K, Tanigawa T, Watanabe T, et al. (2012) Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis. Biochem Biophys Res Commun 426: 342-349.
32. Otsu S, Gotoh K, Yamashiro T, Yamagata J, Shin K, Fujioka T & Nishizono A (2006) Transfer of antigen-pulsed dendritic cells induces specific T-Cell proliferation and a therapeutic effect against long-term Helicobacter pylori infection in mice. Infect Immun 74: 984-993.
33. Pulendran B, Tang H & Manicassamy S (2010) Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol 11: 647-655.
34. Rad R, Brenner L, Krug A, et al. (2007) Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133(150-163): e153.
35. Rad R, Ballhorn W, Voland P, et al. (2009) Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136: 2247-2257.
36. Rathinavelu S, Kao JY, Zavros Y & Merchant JL (2005) Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function. Helicobacter 10: 424-432.
37. Sansonetti PJ, Phalipon A, Arondel J, Thirumalai K, Banerjee S, Akira S, Takeda K & Zychlinsky A (2000) Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity 12: 581-590.
38. Savina A, Peres A, Cebrian I, Carmo N, Moita C, Hacohen N, Moita LF & Amigorena S (2009) The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells. Immunity 30: 544-555.
39. Sayi A, Kohler E, Toller IM, Flavell RA, Muller W, Roers A & Muller A (2011) TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. J Immunol 186: 878-890.
40. Schulz O, Jaensson E, Persson EK, Liu X, Worbs T, Agace WW & Pabst O (2009) Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206: 3101-3114.
41. Serbina NV, Salazar-Mather TP, Biron CA, Kuziel WA & Pamer EG (2003) TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19: 59-70.
42. Shortman K & Naik SH (2007) Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 7: 19-30.
43. Shortman K & Heath WR (2010) The CD8+ dendritic cell subset. Immunol Rev 234: 18-31.
44. Stein M, Rappuoli R & Covacci A (2000) Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. P Natl Acad Sci USA 97: 1263-1268.
45. Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ & Covacci A (2002) c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 43: 971-980.
46. Steinman RM (2012) Decisions about dendritic cells: past, present, and future. Annu Rev Immunol 30: 1-22.
47. Steinman RM & Cohn ZA (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 137: 1142-1162.
48. Steinman RM & Witmer MD (1978) Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. P Natl Acad Sci USA 75: 5132-5136.
49. Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR & Belkaid Y (2007) Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204: 1775-1785.
50. Tanaka H, Yoshida M, Nishiumi S, Ohnishi N, Kobayashi K, Yamamoto K, Fujita T, Hatakeyama M & Azuma T (2010) The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice. Arch Biochem Biophys 498: 35-42.
51. Uematsu S, Fujimoto K, Jang MH, et al. (2008) Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 9: 769-776.
52. Wang YH, Gorvel JP, Chu YT, Wu JJ & Lei HY (2010) Helicobacter pylori impairs murine dendritic cell responses to infection. PLoS ONE 5: e10844.
53. Zhang M, Berndt BE, Eaton KA, Rathinavelu S, Pierzchala A & Kao JY (2008) Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in mice. Helicobacter 13: 200-208.
54. Zhang M, Liu M, Luther J & Kao JY (2010) Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes 1: 325-329.