Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: A mechanism of ineffective host defense

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 1, 2006, Pages

  Kao, John Y ^a   Rathinavelu, Sivaprakash ^a   Eaton, Kathryn A ^a   Bai, Longchuan ^a   Zavros, Yana ^a   Takami, Mimi ^a   Pierzchala, Anna ^a   Merchant, Juanita L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Acinetobacter lwoffi; Antigen presenting cells; Inflammation; Interferon ; Interleukin 10

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 1BETA ANTIBODY; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ACINETOBACTER LWOFFII; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BONE MARROW CELL; CELL PROLIFERATION; CELL SECRETION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GASTRITIS; HELICOBACTER PYLORI; HOST RESISTANCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPLEEN CELL; STOMACH MUCOSA; SUPERNATANT; THERMOSTABILITY;

ACINETOBACTER; ANIMALS; BACTERIAL PROTEINS; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; GASTRIC MUCOSA; HELICOBACTER PYLORI; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; INTERLEUKIN-12; MICE; MICE, INBRED C57BL;

EID: 33745804730     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00139.2005     Document Type: Article

References (38)

1. Akhiani AA, Pappo J, Kabok Z, Schon K, Gao W, Franzen LE, and Lycke N. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169: 6977-6984, 2002.
2. Appelmelk BJ, van Die I, van Vliet SJ, Vandenbroucke-Grauls CM, Geijtenbeek TB, and van Kooyk Y. Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol 170: 1635-1639, 2003.
3. Bergman MP, Engering A, Smits HH, van Vliet SJ, van Bodegraven AA, Wirth HP, Kapsenberg ml, Vandenbroucke-Grauls CM, van Kooyk Y, and Appelmelk BJ. Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN. J Exp Med 200: 979-990, 2004.
4. Bilsborough J and Viney JL. Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology 127: 300-309, 2004.
5. Crabtree JE, Shallcross TM, Heatley RV, and Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 32: 1473-1477, 1991.
6. Dixon MF. Histological responses to Helicobacter pylori infection: gastritis, atrophy and preneoplasia. Baillieres Clin Gastroenterol 9: 467-486, 1995.
7. Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI, and Blaser MJ. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 321: 1562-1566, 1989.
8. Eaton KA and Mefford ME. Cure of Helicobacter pylori infection and resolution of gastritis by adoptive transfer of splenocytes in mice. Infect Immun 69: 1025-1031, 2001.
9. Eaton KA, Mefford M, and Thevenot T. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166: 7456-7461, 2001.
10. Eaton KA, Gilbert JV, Joyce EA, Wanken AE, Thevenot T, Baker P, Plaut A, and Wright A. In vivo complementation of ureB restores the ability of Helicobacter pylori to colonize. Infect Immun 70: 771-778, 2002.
11. Fan X, Gunasena H, Cheng Z, Espejo R, Crowe SE, Ernst PB, and Reyes VE. Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosis. J Immunol 165: 1918-1924, 2000.
12. Fox JG, Beck P, Dangler CA, Whary MT, Wang TC, Shi HN, and Nagler-Anderson C.. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces Helicobacter-induced gastric atrophy. Nat Med 6: 536-542, 2000.
13. Garhart CA, Heinzel FP, Czinn SJ, and Nedrud JG. Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent. Infect Immun 71: 910-921, 2003.
14. Goodwin CS, Armstrong JA, and Marshall BJ. Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol 39: 353-365, 1986.
15. Guiney DG, Hasegawa P, and Cole SP. Helicobacter pylori preferentially induces interleukin 12 (IL-12) rather than IL-6 or IL-10 in human dendritic cells. Infect Immun 71: 4163-4166, 2003.
16. Hafsi N, Voland P, Schwendy S, Rad R, Reindl W, Gerhard M, and Prinz C. Human dendritic cells respond to Helicobacter pylori, promoting NK cell and Th1-effector responses in vitro. J Immunol 173: 1249-1257, 2004.
17. Kao JY, Gong Y, Chen CM, Zheng QD, and Chen JJ. Tumor-derived TGF-β reduces the efficacy of dendritic cell/tumor fusion vaccine. J Immunol 170: 3806-3811, 2003.
18. Kelsall BL, Biron CA, Sharma O, and Kaye PM. Dendritic cells at the host-pathogen interface. Nat Immun 3: 699-702, 2002.
19. Kranzer K, Eckhardt A, Aigner M, Knoll G, Deml L, Speth C, Lehn N, Rehli M, and Schneider-Brachert W. Induction of maturation and cytokine release of human dendritic cells by Helicobacter pylori. Infect Immun 72: 4416-4423, 2004.
20. Liu T, Nishimura H, Matsuguchi T, and Yoshikai Y. Differences in interleukin-12 and -15 production by dendritic cells at the early stage of Listeria monocytogenes infection between BALB/c and C57 BL/6 mice. Cell Immunol 202: 31-40, 2000.
21. Liu T, Matsuguchi T, Tsuboi N, Yajima T, and Yoshikai Y. Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB/c and C57BL/6 mice. Infect Immun 70: 6638-6645, 2002.
22. Lundgren A, Suri-Payer E, Enarsson K, Svennerholm AM, and Lundin BS. Helicobacter pylori-specific CD4(+) CD25(high) regulatory T cells suppress memory T cell responses to H. pylori in infected individuals. Infect Immun 71: 1755-1762, 2003.
23. Molinari M, Salio M, Galli C, Norais N, Rappuoli R, Lanzavecchia A, and Montecucco C. Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J Exp Med 187: 135-140, 1998.
24. Nishi T, Okazaki K, Kawasaki K, Fukui T, Tamaki H, Matsuura M, Asada M, Watanabe T, Uchida K, Watanabe N, Nakase H, Ohana M, Hiai H, and Chiba T. Involvement of myeloid dendritic cells in the development of gastric secondary lymphoid follicles in Helicobacter pylori-infected neonatally thymectomized BALB/c mice. Infect Immun 71: 2153-2162, 2003.
25. Osterholzer JJ, Ames T, Polak T, Sonstein J, Moore BB, Chensue SW, Toews GB, and Curtis JL. CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. J Immunol 175: 874-883, 2005.
26. Perez-Perez GI, Dworkin BM, Chodos JE, and Blaser MJ. Campylobacter pylori antibodies in humans. Ann Intern Med 109: 11-17, 1988.
27. Rathinavelu S, Zavros Y, and Merchant JL. Acinetobacter lwoffii infection and gastritis. Microbes Infect 5: 651-657, 2003.
28. Rescigno M, Granucci F, Citterio S, Foti M, and Ricciardi-Castagnoli P. Coordinated events during bacteria-induced DC maturation. Immunol Today 20: 200-203, 1999.
29. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, Granucci F, Kraehenbuhl JP, and Ricciardi-Castagnoli P. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immun 2: 361-367, 2001.
30. Sarsfield P, Jones DB, Wotherspoon AC, Harvard T, and Wright DH. A study of accessory cells in the acquired lymphoid tissue of Helicobacter gastritis. J Pathol 180: 18-25, 1996.
31. Suerbaum S and Michetti P. Helicobacter pylori infection. N Engl J Med 347: 1175-1186, 2002.
32. Wang J, Brooks EG, Bamford KB, Denning TL, Pappo J, and Ernst PB. Negative selection of T cells by Helicobacter pylori as a model for bacterial strain selection by immune evasion. J Immunol 167: 926-934, 2001.
33. Westphal O and Jann K. Bacterial lipopolysaccharides. Extraction with phenol-water and further application of the procedure. Methods Carbohydrate Chem 1: 83-91, 1965.
34. Yamaoka Y, Kita M, Kodama T, Sawai N, and Imanishi J. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology 110: 1744-1752, 1996.
35. Yamaoka Y, Kita M, Kodama T, Sawai N, Kashima K, and Imanishi J. Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut 41: 442-451, 1997.
36. Zavros Y, Rieder G, Ferguson A, and Merchant JL. Gastritis and hypergastrinemia due to Acinetobacter lwoffii in mice. Infect Immun 70: 2630-2639, 2002.
37. Zavros Y, Ranthinavelu S, Kao JY, Todisco, and ADV, J, Weinstock JV, Low MJ, Merchant JL. Treatment of Helicobacter gastritis by IL-4 requires somatostatin. Proc Natl Acad Sci USA 100: 12944-12949, 2001.
38. Zhu K, Shen Q, Ulrich M, and Zheng M. Human monocyte-derived dendritic cells expressing both chemotactic cytokines IL-8, MCP-1, RANTES and their receptors, and their selective migration to these chemokines. Chin Med J (Engl) 113: 1124-1128, 2000.