Impacts of TCF7L2 gene polymorphisms on the susceptibility of hepatogenous diabetes and hepatocellular carcinoma in cirrhotic patients

Gene

Volumn 522, Issue 2, 2013, Pages 214-218

  Ling, Qi ^a   Dong, Fengqin ^b   Geng, Lei ^a   Liu, Zhikun ^a   Xie, Haiyang ^a   Xu, Xiao ^a   Zheng, Shusen ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Diabetes mellitus; Hepatocellular carcinoma; Liver cirrhosis; Single nucleotide polymorphism

Indexed keywords

TRANSCRIPTION FACTOR 7 LIKE 2;

ADULT; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CHINESE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEPATOGENOUS DIABETES MELLITUS; HOMOZYGOTE; HUMAN; INSULIN RESISTANCE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, HEPATOCELLULAR; CHINA; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INSULIN RESISTANCE; LIVER CIRRHOSIS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84878114600     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.03.089     Document Type: Article

References (32)

1. Bhalla K., et al. Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis. Cancer Prev. Res. (Phila) 2012, 5:544-552.
2. Cervin C., et al. Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes. Diabetes 2008, 57:1433-1437.
3. Chang Y.C., et al. Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes 2007, 56:2631-2637.
4. Chang Y.C., et al. TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance. J. Mol. Med. (Berl) 2010, 88:183-192.
5. Connor A.E., et al. Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic White women: the Breast Cancer Health Disparities Study. Breast Cancer Res. Treat. 2012, 136:593-602.
6. Doria A., Patti M.E., Kahn C.R. The emerging genetic architecture of type 2 diabetes. Cell Metab. 2008, 8:186-200.
7. Dragani T.A. Risk of HCC: genetic heterogeneity and complex genetics. J. Hepatol. 2010, 52:252-257.
8. Duval A., Rolland S., Tubacher E., Bui H., Thomas G., Hamelin R. The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res. 2000, 60:3872-3879.
9. Fang M., Li J., Blauwkamp T., Bhambhani C., Campbell N., Cadigan K.M. C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila. EMBO J. 2006, 25:2735-2745.
10. Garcia-Compean D., Jaquez-Quintana J.O., Maldonado-Garza H. Hepatogenous diabetes. Current views of an ancient problem. Ann. Hepatol. 2009, 8:13-20.
11. Hines I.N., et al. Insulin resistance and metabolic hepatocarcinogenesis with parent-of-origin effects in A×B mice. Am. J. Pathol. 2011, 179:2855-2865.
12. Holstein A., Hinze S., Thiessen E., Plaschke A., Egberts E.H. Clinical implications of hepatogenous diabetes in liver cirrhosis. J. Gastroenterol. Hepatol. 2002, 17:677-681.
13. Kurzawski M., Dziewanowski K., Kedzierska K., Wajda A., Lapczuk J., Drozdzik M. Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus. Pharmacol. Rep. 2011, 63:826-833.
14. Kwon S.Y., et al. Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus. Diabet. Med. 2005, 22:1530-1535.
15. Ling Q., et al. Impact of preexisting diabetes mellitus on outcome after liver transplantation in patients with hepatitis B virus-related liver disease. Dig. Dis. Sci. 2011, 56:889-893.
16. Ling Q., et al. Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population. J. Hepatol. 2013, 58:271-277.
17. Liu P.H., et al. Genetic variants of TCF7L2 are associated with insulin resistance and related metabolic phenotypes in Taiwanese adolescents and Caucasian young adults. J. Clin. Endocrinol. Metab. 2009, 94:3575-3582.
18. Lukacs K., Hosszufalusi N., Dinya E., Bakacs M., Madacsy L., Panczel P. The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study. Diabetologia 2012, 55:689-693.
19. Luo Y., et al. Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population. Diabetes Res. Clin. Pract. 2009, 85:139-146.
20. Machiela M.J., et al. Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the breast and prostate cancer cohort consortium. Am. J. Epidemiol. 2012, 176:1121-1129.
21. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
22. Ng M.C., Tam C.H., Lam V.K., So W.Y., Ma R.C., Chan J.C. Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese. J. Clin. Endocrinol. Metab. 2007, 92:3733-3737.
23. Nishida T., et al. Oral glucose tolerance test predicts prognosis of patients with liver cirrhosis. Am. J. Gastroenterol. 2006, 101:70-75.
24. Norton L., et al. Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism. Diabetologia 2011, 54:3132-3142.
25. Oh K.J., Park J., Kim S.S., Oh H., Choi C.S., Koo S.H. TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver. PLoS Genet. 2012, 8:e1002986.
26. Polakis P. Drugging Wnt signalling in cancer. EMBO J. 2012, 31:2737-2746.
27. Qiao H., et al. Genetic variants of TCF7L2 are associated with type 2 diabetes in a northeastern Chinese population. Gene 2012, 495:115-119.
28. Ren Q., et al. Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. Diabetologia 2008, 51:1146-1152.
29. Weise A., et al. Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res. 2010, 38:1964-1981.
30. Wen J., et al. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One 2010, 5:e9153.
31. Yang W.S., et al. The role of pre-existing diabetes mellitus on hepatocellular carcinoma occurrence and prognosis: a meta-analysis of prospective cohort studies. PLoS One 2011, 6:e27326.
32. Yoo H.Y., Thuluvath P.J. The effect of insulin-dependent diabetes mellitus on outcome of liver transplantation. Transplantation 2002, 74:1007-1012.