-
1
-
-
80755128213
-
Clinicaldiagnosis and management of amyotrophic lateral sclerosis
-
Hardiman O, Van den Berg LH, Kiernan MC. Clinicaldiagnosis and management of amyotrophic lateral sclerosis. NatRev Neurol 2011;7(11):639-49.
-
(2011)
NatRev Neurol
, vol.7
, Issue.11
, pp. 639-649
-
-
Den Van, H.O.1
Berg, L.H.2
Kiernan, M.C.3
-
2
-
-
33745924415
-
SUMO-1 modification increaseshuman SOD1 stability and aggregation
-
Fei E, Jia N, Yan M, et al. SUMO-1 modification increaseshuman SOD1 stability and aggregation. Biochem Biophys ResCommun 2006;347(2):406-12.
-
(2006)
Biochem Biophys ResCommun
, vol.347
, Issue.2
, pp. 406-412
-
-
Fei, E.1
Jia, N.2
Yan, M.3
-
3
-
-
77950658888
-
Multiplex SILA Canalysis of a cellular TDP-43 proteinopathy model reveals proteininclusions associated with SUMOylation and diversepolyubiquitin chains
-
Seyfried NT, Gozal YM, Dammer EB, et al. Multiplex SILACanalysis of a cellular TDP-43 proteinopathy model reveals proteininclusions associated with SUMOylation and diversepolyubiquitin chains. Mol Cell Proteomics 2010;9(4):705-18.
-
(2010)
Mol Cell Proteomics
, vol.9
, Issue.4
, pp. 705-718
-
-
Seyfried, N.T.1
Gozal, Y.M.2
Dammer, E.B.3
-
4
-
-
77149134314
-
Ebp1 sumoylation, regulated byTLS/FUS E3 ligase, is required for its anti-proliferative activity
-
Oh S-M, Liu Z,Okada M, et al. Ebp1 sumoylation, regulated byTLS/FUS E3 ligase, is required for its anti-proliferative activity.Oncogene 2010;29(7):1017-30.
-
(2010)
Oncogene
, vol.29
, Issue.7
, pp. 1017-1030
-
-
Oh, S.-M.1
Liu Zokada, M.2
-
5
-
-
61349156118
-
Mutationsin the FUS/TLS gene on chromosome 16 cause familial amyotrophiclateral sclerosis
-
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, et al. Mutationsin the FUS/TLS gene on chromosome 16 cause familial amyotrophiclateral sclerosis. Science 2009;323(5918):1205-8.
-
(2009)
Science
, vol.323
, Issue.5918
, pp. 1205-1208
-
-
Kwiatkowski Jr., T.J.1
Bosco, D.A.2
Leclerc, A.L.3
-
6
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosistype 6
-
Vance C, Rogelj B, Hortob́agyi T, et al. Mutations in FUS, anRNA processing protein, cause familial amyotrophic lateral sclerosistype 6. Science 2009;323(5918):1208-11.
-
(2009)
Science
, vol.323
, Issue.5918
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortob́agyi, T.3
-
7
-
-
84863067477
-
SOD1 ANG TARDBPand FUS mutations in amyotrophic lateral sclerosis: A UnitedStates clinical testing lab experience
-
Brown JA, Min J, Staropoli JF, et al. SOD1, ANG, TARDBPand FUS mutations in amyotrophic lateral sclerosis: a UnitedStates clinical testing lab experience. Amyotroph Lateral Scler2012;13(2):217-22.
-
(2012)
Amyotroph Lateral Scler
, vol.13
, Issue.2
, pp. 217-222
-
-
Brown, J.A.1
Min, J.2
Staropoli, J.F.3
-
8
-
-
79151482596
-
Linking hypoxic and oxidativeinsults to cell death mechanisms in models of ALS
-
Xu R, Wu C, Zhang X, et al. Linking hypoxic and oxidativeinsults to cell death mechanisms in models of ALS. Brain Res2011;1372:133-44.
-
(2011)
Brain Res
, vol.1372
, pp. 133-144
-
-
Xu, R.1
Wu, C.2
Zhang, X.3
-
9
-
-
3042644131
-
A M55V polymorphismin a novel SUMO gene (SUMO-4) differentiallyactivates heat shock transcription factors and is associatedwith susceptibility to type i diabetes mellitus
-
Bohren KM, Nadkarni V, Song JH, et al. A M55V polymorphismin a novel SUMO gene (SUMO-4) differentiallyactivates heat shock transcription factors and is associatedwith susceptibility to type I diabetes mellitus. J Biol Chem2004;279(26):27233-8.
-
J Biol Chem2004
, vol.279
, Issue.26
, pp. 27233-27238
-
-
Bohren, K.M.1
Nadkarni, V.2
Song, J.H.3
-
10
-
-
0031104910
-
SMT3A ahuman homologue of the S. cerevisiae SMT3 gene maps tochromosome 21qter and defines a novel gene family
-
Lapenta V, Chiurazzi P, Van der Spek P, et al. SMT3A, ahuman homologue of the S. cerevisiae SMT3 gene, maps tochromosome 21qter and defines a novel gene family. Genomics1997;40(2):362-6.
-
(1997)
Genomics
, vol.40
, Issue.2
, pp. 362-366
-
-
Lapenta, V.1
Chiurazzi, P.2
Van Der Spek, P.3
-
11
-
-
70349191359
-
Differential SUMOylationof LXRalpha and LXRbeta mediates transrepression of STAT1inflammatory signaling in IFN-gamma-stimulated brain astrocytes
-
Lee JH, Park SM, Kim OS, et al. Differential SUMOylationof LXRalpha and LXRbeta mediates transrepression of STAT1inflammatory signaling in IFN-gamma-stimulated brain astrocytes.Mol Cell 2009;35(6):806-17.
-
(2009)
Mol Cell
, vol.35
, Issue.6
, pp. 806-817
-
-
Lee, J.H.1
Park, S.M.2
Kim, O.S.3
-
12
-
-
84863435384
-
Protein SUMOylation in spine structureand function
-
Craig TJ, Henley JM. Protein SUMOylation in spine structureand function. Curr Opin Neurobiol 2012;22(3):480-7.
-
Curr Opin Neurobiol 2012
, vol.22
, Issue.3
, pp. 480-487
-
-
Craig, T.J.1
Henley, J.M.2
-
13
-
-
0035929557
-
Polymeric chains ofSUMO-2 and SUMO-3 are conjugated to protein substrates bySAE1/SAE2 and Ubc9
-
Tatham MH, Jaffray E, Vaughan OA, et al. Polymeric chains ofSUMO-2 and SUMO-3 are conjugated to protein substrates bySAE1/SAE2 and Ubc9. J Biol Chem 2001;276(38):35368-74.
-
(2001)
J Biol Chem
, vol.276
, Issue.38
, pp. 35368-35374
-
-
Tatham, M.H.1
Jaffray, E.2
Vaughan, O.A.3
-
14
-
-
39049093685
-
In vivo identificationof human small ubiquitin-like modifier polymerization sites byhigh accuracy mass spectrometry and an in vitro to in vivo strategy
-
Matic I, Van Hagen M, Schimmel J, et al. In vivo identificationof human small ubiquitin-like modifier polymerization sites byhigh accuracy mass spectrometry and an in vitro to in vivo strategy.Mol Cell Proteomics 2008;7(1):132-44.
-
(2008)
Mol Cell Proteomics
, vol.7
, Issue.1
, pp. 132-144
-
-
Matic, I.1
Van Hagen, M.2
Schimmel, J.3
-
15
-
-
0033060826
-
Molecular cloningand characterization of human AOS1 and UBA2 componentsof the sentrin-activating enzyme complex
-
Gong L, Li B, Millas S, Yeh ET. Molecular cloningand characterization of human AOS1 and UBA2, componentsof the sentrin-activating enzyme complex. FEBS Lett1999;448(1):185-9.
-
(1999)
FEBS Lett
, vol.448
, Issue.1
, pp. 185-189
-
-
Gong, L.1
Li, B.2
Millas, S.3
Yeh, E.T.4
-
16
-
-
0030826334
-
Ubc9p is the conjugating enzymefor the ubiquitin-like protein Smt3p
-
Johnson ES, Blobel G. Ubc9p is the conjugating enzymefor the ubiquitin-like protein Smt3p. J Biol Chem1997;272(43):26799-802.
-
(1997)
J Biol Chem
, vol.272
, Issue.43
, pp. 26799-26802
-
-
Johnson, E.S.1
Blobel, G.2
-
17
-
-
67449091213
-
What was theset of ubiquitin and ubiquitin-like conjugating enzymes in theeukaryote common ancestor?
-
Michelle C, Vourc'h P, Mignon L, Andres CR. What was theset of ubiquitin and ubiquitin-like conjugating enzymes in theeukaryote common ancestor? J Mol Evol 2009;68(6):616-28.
-
(2009)
J Mol Evol
, vol.68
, Issue.6
, pp. 616-628
-
-
Michelle, C.1
Vourc'H, P.2
Mignon, L.3
Andres, C.R.4
-
18
-
-
0033571214
-
SUMO-1 modificationactivates the transcriptional response of p53
-
Rodriguez MS, Desterro JM, Lain S, et al. SUMO-1 modificationactivates the transcriptional response of p53. EMBO J1999;18(22):6455-61.
-
(1999)
EMBO J
, vol.18
, Issue.22
, pp. 6455-6461
-
-
Rodriguez, M.S.1
Desterro, J.M.2
Lain, S.3
-
19
-
-
0035877693
-
The small ubiquitinlikemodifier-1 (SUMO-1) consensus sequence mediates Ubc9binding and is essential for SUMO-1 modification
-
Sampson DA, Wang M, Matunis MJ. The small ubiquitinlikemodifier-1 (SUMO-1) consensus sequence mediates Ubc9binding and is essential for SUMO-1 modification. J Biol Chem2001;276(24):21664-9.
-
(2001)
J Biol Chem
, vol.276
, Issue.24
, pp. 21664-21669
-
-
Sampson, D.A.1
Wang, M.2
Matunis, M.J.3
-
20
-
-
30444440554
-
PDSM, a motiffor phosphorylation-dependent SUMO modification
-
Hietakangas V, Anckar J, Blomster HA, et al. PDSM, a motiffor phosphorylation-dependent SUMO modification. Proc NatlAcad Sci USA 2006;103(1):45-50.
-
(2006)
Proc NatlAcad Sci USA
, vol.103
, Issue.1
, pp. 45-50
-
-
Hietakangas, V.1
Anckar, J.2
Blomster, H.A.3
-
21
-
-
33645213038
-
SUMO-3 enhances androgenreceptor transcriptional activity through a sumoylationindependentmechanism in prostate cancer cells
-
Zheng Z, Cai C, Omwancha J, et al. SUMO-3 enhances androgenreceptor transcriptional activity through a sumoylationindependentmechanism in prostate cancer cells. J Biol Chem2006;281(7):4002-12.
-
(2006)
J Biol Chem
, vol.281
, Issue.7
, pp. 4002-4012
-
-
Zheng, Z.1
Cai, C.2
Omwancha, J.3
-
22
-
-
0032135131
-
SUMO-1 modificationof IkappaBalpha inhibits NF-kappaB activation
-
Desterro JM, Rodriguez MS, Hay RT. SUMO-1 modificationof IkappaBalpha inhibits NF-kappaB activation. Mol Cell1998;2(2):233-9.
-
(1998)
Mol Cell
, vol.2
, Issue.2
, pp. 233-239
-
-
Desterro, J.M.1
Rodriguez, M.S.2
Hay, R.T.3
-
23
-
-
0035873076
-
Neuronspecificexpression of mutant superoxide dismutase 1 in transgenicmice does not lead to motor impairment
-
Pramatarova A, Laganìere J, Roussel J, et al. Neuronspecificexpression of mutant superoxide dismutase 1 in transgenicmice does not lead to motor impairment. J Neurosci2001;21(10):3369-74.
-
(2001)
J Neurosci
, vol.21
, Issue.10
, pp. 3369-3374
-
-
Pramatarova, A.1
Laganìere, J.2
Roussel, J.3
-
24
-
-
84864018984
-
Identification of estrogenreceptor ? as a SUMO-1 target reveals a novel phosphorylatedsumoylation motif and regulation by glycogen synthase kinase3?
-
Picard N, Caron V, Bilodeau S, et al. Identification of estrogenreceptor ? as a SUMO-1 target reveals a novel phosphorylatedsumoylation motif and regulation by glycogen synthase kinase3?. Mol Cell Biol 2012;32(14):2709-21.
-
(2012)
Mol Cell Biol
, vol.32
, Issue.14
, pp. 2709-2721
-
-
Picard, N.1
Caron, V.2
Bilodeau, S.3
-
25
-
-
78951474065
-
Estrogen receptor agonistsand estrogen attenuate TNF-?-induced apoptosis in VSC4.1motoneurons
-
Das A, Smith JA, Gibson C, et al. Estrogen receptor agonistsand estrogen attenuate TNF-?-induced apoptosis in VSC4.1motoneurons. J Endocrinol 2011;208(2):171-82.
-
(2011)
J Endocrinol
, vol.208
, Issue.2
, pp. 171-182
-
-
Das, A.1
Smith, J.A.2
Gibson, C.3
-
26
-
-
44449109533
-
Mechanism andconsequences for paralog-specific sumoylation of ubiquitinspecificprotease 25
-
Meulmeester E, Kunze M, Hsiao HH, et al. Mechanism andconsequences for paralog-specific sumoylation of ubiquitinspecificprotease 25. Mol Cell 2008;30(5):610-9.
-
(2008)
Mol Cell
, vol.30
, Issue.5
, pp. 610-619
-
-
Meulmeester, E.1
Kunze, M.2
Hsiao, H.H.3
-
27
-
-
48349117947
-
Ubc9 sumoylationregulates SUMO target discrimination
-
Knipscheer P, Flotho A, Klug H, et al. Ubc9 sumoylationregulates SUMO target discrimination. Mol Cell2008;31(3):371-82.
-
(2008)
Mol Cell
, vol.31
, Issue.3
, pp. 371-382
-
-
Knipscheer, P.1
Flotho, A.2
Klug, H.3
-
28
-
-
77952544821
-
Mutant superoxide dismutase1 overexpression in NSC-34 cells: Effect of trehalose on aggregation,TDP-43 localization and levels of co-expressed glycoproteins
-
Gomes C, Escrevente C, Costa J. Mutant superoxide dismutase1 overexpression in NSC-34 cells: effect of trehalose on aggregation,TDP-43 localization and levels of co-expressed glycoproteins.Neurosci Lett 2010;475(3):145-9.
-
(2010)
Neurosci Lett
, vol.475
, Issue.3
, pp. 145-149
-
-
Gomes, C.1
Escrevente, C.2
Costa, J.3
-
29
-
-
3543018486
-
Global analyses of sumoylated proteinsin Saccharomyces cerevisiae. Induction of protein sumoylationby cellular stresses
-
Zhou W, Ryan JJ, Zhou H. Global analyses of sumoylated proteinsin Saccharomyces cerevisiae. Induction of protein sumoylationby cellular stresses. J Biol Chem 2004;279(31):32262-8.
-
(2004)
J Biol Chem
, vol.279
, Issue.31
, pp. 32262-32268
-
-
Zhou, W.1
Ryan, J.J.2
Zhou, H.3
-
30
-
-
0037108967
-
Higher order arrangementof the eukaryotic nuclear bodies
-
Wang I-F, Reddy NM, Shen C-KJ. Higher order arrangementof the eukaryotic nuclear bodies. Proc Natl Acad Sci USA2002;99(21):13583-8.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.21
, pp. 13583-13588
-
-
Wang, I.-F.1
Reddy, N.M.2
Shen, C.-K.J.3
-
31
-
-
33748990136
-
SUSP1 antagonizesformation of highly SUMO2/3-conjugated species
-
Mukhopadhyay D, Ayaydin F, Kolli N, et al. SUSP1 antagonizesformation of highly SUMO2/3-conjugated species. J CellBiol 2006;174(7):939-49.
-
(2006)
J CellBiol
, vol.174
, Issue.7
, pp. 939-949
-
-
Mukhopadhyay, D.1
Ayaydin, F.2
Kolli, N.3
-
32
-
-
4043051557
-
A proteomic study ofSUMO-2 target proteins
-
Vertegaal ACO, Ogg SC, Jaffray E, et al. A proteomic study ofSUMO-2 target proteins. J Biol Chem 2004;279(32):33791-8.
-
(2004)
J Biol Chem
, vol.279
, Issue.32
, pp. 33791-33798
-
-
Aco, V.1
Ogg, S.C.2
Jaffray, E.3
-
33
-
-
67649173012
-
System-widechanges to SUMO modifications in response to heat shock
-
Golebiowski F, Matic I, Tatham MH, et al. System-widechanges to SUMO modifications in response to heat shock. SciSignal 2009;2(72):ra24.
-
(2009)
Sci Signal
, vol.2
, Issue.72
-
-
Golebiowski, F.1
Matic, I.2
Tatham, M.H.3
-
34
-
-
67650720512
-
Systematic study of protein sumoylation:development of a site-specific predictor of SUMOsp 2.0
-
Ren J, Gao X, Jin C, et al. Systematic study of protein sumoylation:development of a site-specific predictor of SUMOsp 2.0.Proteomics 2009;9(12):3409-12.
-
(2009)
Proteomics
, vol.9
, Issue.12
, pp. 3409-3412
-
-
Ren, J.1
Gao, X.2
Jin, C.3
-
35
-
-
80755163102
-
Molecular pathways ofmotor neuron injury in amyotrophic lateral sclerosis
-
Ferraiuolo L, Kirby J, Grierson AJ, et al.Molecular pathways ofmotor neuron injury in amyotrophic lateral sclerosis. Nat RevNeurol 2011;7(11):616-30.
-
(2011)
Nat RevNeurol
, vol.7
, Issue.11
, pp. 616-630
-
-
Ferraiuolo, L.1
Kirby, J.2
Grierson, A.J.3
-
36
-
-
46749152929
-
SUMO-1 transientlylocalizes to Cajal bodies in mammalian neurons
-
Navascues J, Bengoechea R, Tapia O, et al. SUMO-1 transientlylocalizes to Cajal bodies in mammalian neurons. J Struct Biol2008;163(2):137-46.
-
(2008)
J Struct Biol
, vol.163
, Issue.2
, pp. 137-146
-
-
Navascues, J.1
Bengoechea, R.2
Tapia, O.3
-
37
-
-
84860428058
-
P53 and cell cycle proteins participatein spinal motor neuron cell death in ALS
-
Ranganathan S, Bowser R. p53 and cell cycle proteins participatein spinal motor neuron cell death in ALS. Open Pathol J2010;4:11-22.
-
(2010)
Open Pathol J
, vol.4
, pp. 11-22
-
-
Ranganathan, S.1
Bowser, R.2
-
38
-
-
36349022018
-
Emergingextranuclear roles of protein SUMOylation in neuronal functionand dysfunction
-
Martin S, Wilkinson KA, Nishimune A, Henley JM. Emergingextranuclear roles of protein SUMOylation in neuronal functionand dysfunction. Nat Rev Neurosci 2007;8(12):948-59.
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.12
, pp. 948-959
-
-
Martin, S.1
Wilkinson, K.A.2
Nishimune, A.3
Henley, J.M.4
-
40
-
-
33645422711
-
ANG mutationssegregate with familial and sporadic amyotrophic lateralsclerosis
-
Greenway MJ, Andersen PM, Russ C, et al. ANG mutationssegregate with familial and sporadic amyotrophic lateralsclerosis. Nat Genet 2006;38(4):411-3.
-
(2006)
Nat Genet
, vol.38
, Issue.4
, pp. 411-413
-
-
Greenway, M.J.1
Andersen, P.M.2
Russ, C.3
-
41
-
-
54049119245
-
Mutations of the ANG genein French patients with sporadic amyotrophic lateral sclerosis
-
Paubel A, Violette J, Amy M, et al. Mutations of the ANG genein French patients with sporadic amyotrophic lateral sclerosis.Arch Neurol 2008;65(10):1333-6.
-
(2008)
Arch Neurol
, vol.65
, Issue.10
, pp. 1333-1336
-
-
Paubel, A.1
Violette, J.2
Amy, M.3
-
42
-
-
35348904953
-
RSUMEa small RWD-containing protein enhances SUMO conjugationand stabilizes HIF-1alpha during hypoxia
-
Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. RSUME,a small RWD-containing protein, enhances SUMO conjugationand stabilizes HIF-1alpha during hypoxia. Cell2007;131(2):309-23.
-
(2007)
Cell
, vol.131
, Issue.2
, pp. 309-323
-
-
Carbia-Nagashima, A.1
Gerez, J.2
Perez-Castro, C.3
-
43
-
-
79551524400
-
SUMO-1 interacts with mutant ataxin-1 andcolocalizes to its aggregates in Purkinje cells of SCA1 transgenicmice
-
Kang S, Hong S. SUMO-1 interacts with mutant ataxin-1 andcolocalizes to its aggregates in Purkinje cells of SCA1 transgenicmice. Arch Ital Biol 2010;148(4):351-63.
-
(2010)
Arch Ital Biol
, vol.148
, Issue.4
, pp. 351-363
-
-
Kang, S.1
Hong, S.2
-
44
-
-
35548935098
-
SUMO-specific protease1 is essential for stabilization of HIF1alpha during hypoxia
-
Cheng J, Kang X, Zhang S, Yeh ETH. SUMO-specific protease1 is essential for stabilization of HIF1alpha during hypoxia. Cell2007;131(3):584-95.
-
(2007)
Cell
, vol.131
, Issue.3
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.H.4
-
45
-
-
79953002264
-
Small ubiquitinrelatedmodifier (SUMO)-1 promotes glycolysis in hypoxia
-
Agbor TA, Cheong A, Comerford KM, et al. Small ubiquitinrelatedmodifier (SUMO)-1 promotes glycolysis in hypoxia.J Biol Chem 2011;286(6):4718-26.
-
J Biol Chem 2011
, vol.286
, Issue.6
, pp. 4718-4726
-
-
Agbor, T.A.1
Cheong, A.2
Comerford, K.M.3
-
46
-
-
0033967220
-
The sentrinconjugatingenzyme mUbc9 interacts with GLUT4 andGLUT1 glucose transporters and regulates transporter levelsin skeletal muscle cells
-
Giorgino F, De Robertis O, Laviola L, et al. The sentrinconjugatingenzyme mUbc9 interacts with GLUT4 andGLUT1 glucose transporters and regulates transporter levelsin skeletal muscle cells. Proc Natl Acad Sci USA2000;97(3):1125-30.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.3
, pp. 1125-1130
-
-
Giorgino, F.1
De Robertis, O.2
Laviola, L.3
-
47
-
-
84865501729
-
Impaired response ofhypoxic sensor protein HIF-1? and its downstream proteinsin the spinal motor neurons of ALS model mice
-
Sato K, Morimoto N, Kurata T, et al. Impaired response ofhypoxic sensor protein HIF-1? and its downstream proteinsin the spinal motor neurons of ALS model mice. Brain Res2012;1473:55-62.
-
(2012)
Brain Res
, vol.1473
, pp. 55-62
-
-
Sato, K.1
Morimoto, N.2
Kurata, T.3
-
48
-
-
77957562993
-
The role of oxidativestress in amyotrophic lateral sclerosis and Parkinson's disease
-
Baillet A, Chanteperdrix V, Trocḿe C, et al. The role of oxidativestress in amyotrophic lateral sclerosis and Parkinson's disease.Neurochem Res 2010;35(10):1530-7.
-
(2010)
Neurochem Res
, vol.35
, Issue.10
, pp. 1530-1537
-
-
Baillet, A.1
Chanteperdrix, V.2
Trocḿe, C.3
-
50
-
-
55849125016
-
Arf-inducedturnover of the nucleolar nucleophosmin-associated SUMO-2/3protease Senp3
-
KuoM-L, Den BestenW, ThomasMC, Sherr CJ. Arf-inducedturnover of the nucleolar nucleophosmin-associated SUMO-2/3protease Senp3. Cell Cycle 2008;7(21):3378-87.
-
(2008)
Cell Cycle
, vol.7
, Issue.21
, pp. 3378-3387
-
-
Kuo, M.-L.1
Den Besten, W.2
Thomas, M.C.3
Sherr, C.J.4
-
51
-
-
0037961625
-
P300transcriptional repression is mediated by SUMO modification
-
Girdwood D, Bumpass D, Vaughan OA, Thain A, et al. P300transcriptional repression is mediated by SUMO modification.Mol Cell 2003;11(4):1043-54.
-
(2003)
Mol Cell
, vol.11
, Issue.4
, pp. 1043-1054
-
-
Girdwood, D.1
Bumpass, D.2
Vaughan, O.A.3
Thain, A.4
-
52
-
-
70349168446
-
Hypoxia-induciblemir-210 regulates normoxic gene expression involved in tumorinitiation
-
Huang X, Ding L, Bennewith KL, et al. Hypoxia-induciblemir-210 regulates normoxic gene expression involved in tumorinitiation. Mol Cell 2009;35(6):856-67.
-
(2009)
Mol Cell
, vol.35
, Issue.6
, pp. 856-867
-
-
Huang, X.1
Ding, L.2
Bennewith, K.L.3
-
53
-
-
31544432283
-
Regulation of SUMOylation by reversibleoxidation of SUMO conjugating enzymes
-
Bossis G, Melchior F. Regulation of SUMOylation by reversibleoxidation of SUMO conjugating enzymes. Mol Cell2006;21(3):349-57.
-
(2006)
Mol Cell
, vol.21
, Issue.3
, pp. 349-357
-
-
Bossis, G.1
Melchior, F.2
-
54
-
-
23244436178
-
Role of GSK-3beta activityin motor neuronal cell death induced by G93A or A4V mutanthSOD1 gene
-
Koh S-H, Lee Y-B, Kim KS, et al. Role of GSK-3beta activityin motor neuronal cell death induced by G93A or A4V mutanthSOD1 gene. Eur J Neurosci 2005;22(2):301-9.
-
(2005)
Eur J Neurosci
, vol.22
, Issue.2
, pp. 301-309
-
-
Koh, S.-H.1
Lee, Y.-B.2
Kim, K.S.3
-
55
-
-
84864610364
-
The neuroprotective effect ofthe GSK-3? inhibitor and influence on the extrinsic apoptosisin the ALS transgenic mice
-
Ahn S-W, Kim J-E, Park KS, et al. The neuroprotective effect ofthe GSK-3? inhibitor and influence on the extrinsic apoptosisin the ALS transgenic mice. J Neurol Sci 2012;320(1-2):1-5.
-
(2012)
J Neurol Sci
, vol.320
, Issue.1-2
, pp. 1-5
-
-
Ahn, S.-W.1
Kim, J.-E.2
Park, K.S.3
-
56
-
-
77955365630
-
The small heat shock proteinB8 (HspB8) promotes autophagic removal of misfoldedproteins involved in amyotrophic lateral sclerosis (ALS)
-
Crippa V, Sau D, Rusmini P, et al. The small heat shock proteinB8 (HspB8) promotes autophagic removal of misfoldedproteins involved in amyotrophic lateral sclerosis (ALS). HumMol Genet 2010;19(17):3440-56.
-
(2010)
Hum Mol Genet
, vol.19
, Issue.17
, pp. 3440-3456
-
-
Crippa, V.1
Sau, D.2
Rusmini, P.3
-
57
-
-
78449275359
-
Redox regulation of the stabilityof the SUMO protease SENP3 via interactions with CHIP andHsp90
-
Yan S, Sun X, Xiang B, et al. Redox regulation of the stabilityof the SUMO protease SENP3 via interactions with CHIP andHsp90. EMBO J 2010;29(22):3773-86.
-
(2010)
EMBO J
, vol.29
, Issue.22
, pp. 3773-3786
-
-
Yan, S.1
Sun, X.2
Xiang, B.3
-
58
-
-
33846930615
-
The causes and mechanism of selective motorneuron death in amyotrophic lateral sclerosis
-
Van den Bosch L. [The causes and mechanism of selective motorneuron death in amyotrophic lateral sclerosis]. Verh K AcadGeneeskd Belg 2006;68(4):249-69.
-
(2006)
Verh K AcadGeneeskd Belg
, vol.68
, Issue.4
, pp. 249-269
-
-
Van Den Bosch, L.1
-
59
-
-
80052809771
-
Motor neuron impairmentmediated by a sumoylated fragment of the glial glutamatetransporter EAAT2
-
Foran E, Bogush A, Goffredo M, et al. Motor neuron impairmentmediated by a sumoylated fragment of the glial glutamatetransporter EAAT2. Glia 2011;59(11):1719-31.
-
(2011)
Glia
, vol.59
, Issue.11
, pp. 1719-1731
-
-
Foran, E.1
Bogush, A.2
Goffredo, M.3
-
60
-
-
77952419246
-
Mutations of optineurinin amyotrophic lateral sclerosis
-
Maruyama H, Morino H, Ito H, et al. Mutations of optineurinin amyotrophic lateral sclerosis. Nature 2010;465(7295):223-6.
-
(2010)
Nature
, vol.465
, Issue.7295
, pp. 223-226
-
-
Maruyama, H.1
Morino, H.2
Ito, H.3
-
61
-
-
33744909882
-
Caspase-3cleaves and inactivates the glutamate transporter EAAT2
-
Boston-Howes W, Gibb SL, Williams EO, et al. Caspase-3cleaves and inactivates the glutamate transporter EAAT2. J BiolChem 2006;281(20):14076-84.
-
(2006)
J BiolChem
, vol.281
, Issue.20
, pp. 14076-14084
-
-
Boston-Howes, W.1
Gibb, S.L.2
Williams, E.O.3
-
62
-
-
36148957860
-
A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 issumoylated and targeted to promyelocytic leukemia nuclearbodies in mutant SOD1-linked amyotrophic lateral sclerosis
-
Gibb SL, Boston-Howes W, Lavina ZS, et al. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 issumoylated and targeted to promyelocytic leukemia nuclearbodies in mutant SOD1-linked amyotrophic lateral sclerosis.J Biol Chem 2007;282(44):32480-90.
-
(2007)
J Biol Chem
, vol.282
, Issue.44
, pp. 32480-32490
-
-
Gibb, S.L.1
Boston-Howes, W.2
Lavina, Z.S.3
-
63
-
-
0036944699
-
Smad3-dependent inductionof plasminogen activator inhibitor-1 in astrocytes mediatesneuroprotective activity of transforming growth factorbeta1 against NMDA-induced necrosis
-
Docagne F, Nicole O, Gabriel C, et al. Smad3-dependent inductionof plasminogen activator inhibitor-1 in astrocytes mediatesneuroprotective activity of transforming growth factorbeta1 against NMDA-induced necrosis. Mol Cell Neurosci2002;21(4):634-44.
-
(2002)
Mol Cell Neurosci
, vol.21
, Issue.4
, pp. 634-644
-
-
Docagne, F.1
Nicole, O.2
Gabriel, C.3
-
64
-
-
39749124883
-
Phosphorylated Smad2/3immunoreactivity in sporadic and familial amyotrophic lateralsclerosis and its mouse model
-
Nakamura M, Ito H, Wate R, et al. Phosphorylated Smad2/3immunoreactivity in sporadic and familial amyotrophic lateralsclerosis and its mouse model. Acta Neuropathol2008;115(3):327-34.
-
(2008)
Acta Neuropathol
, vol.115
, Issue.3
, pp. 327-334
-
-
Nakamura, M.1
Ito, H.2
Wate, R.3
-
65
-
-
42249101377
-
Sumoylation of Smad3stimulates its nuclear export during PIASy-mediated suppressionof TGF-beta signaling
-
Imoto S, Ohbayashi N, Ikeda O, et al. Sumoylation of Smad3stimulates its nuclear export during PIASy-mediated suppressionof TGF-beta signaling. Biochem Biophys Res Commun2008;370(2):359-65.
-
(2008)
Biochem Biophys Res Commun
, vol.370
, Issue.2
, pp. 359-365
-
-
Imoto, S.1
Ohbayashi, N.2
Ikeda, O.3
-
66
-
-
84876416652
-
Activation of transforminggrowth factor-?/Smad signaling reduces aggregate formation ofmislocalized TAR DNA-binding protein-43
-
[Epub before print] DOI 10.1159/000338151
-
Nakamura M, Kaneko S, Ito H, et al. Activation of transforminggrowth factor-?/Smad signaling reduces aggregate formation ofmislocalized TAR DNA-binding protein-43. Neurodegener Dis2012. [Epub before print] DOI 10.1159/000338151.
-
(2012)
Neurodegener Dis
-
-
Nakamura, M.1
Kaneko, S.2
Ito, H.3
-
67
-
-
80755189921
-
How can we improve clinicaltrials in amyotrophic lateral sclerosis?
-
Gordon PH, Meininger V. How can we improve clinicaltrials in amyotrophic lateral sclerosis? Nat Rev Neurol2011;7(11):650-4.
-
Nat Rev Neurol2011
, vol.7
, Issue.11
, pp. 650-654
-
-
Gordon, P.H.1
Meininger, V.2
-
68
-
-
33645822300
-
Chronic activation inpresymptomatic amyotrophic lateral sclerosis (ALS) mice of afeedback loop involving Fas
-
Raoul C, Buhler E, Sadeghi C, et al. Chronic activation inpresymptomatic amyotrophic lateral sclerosis (ALS) mice of afeedback loop involving Fas, Daxx, and FasL. Proc Natl AcadSci USA 2006;103(15):6007-12.
-
(2006)
Daxx, and FasL. Proc Natl AcadSci USA
, vol.103
, Issue.15
, pp. 6007-6012
-
-
Raoul, C.1
Buhler, E.2
Sadeghi, C.3
-
69
-
-
33750491062
-
Role of SUMO-interactingmotif in Daxx SUMO modification subnuclear localizationand repression of sumoylated transcription factors
-
Lin D-Y, Huang Y-S, Jeng J-C, et al. Role of SUMO-interactingmotif in Daxx SUMO modification, subnuclear localization,and repression of sumoylated transcription factors. Mol Cell2006;24(3):341-54.
-
(2006)
Mol Cell
, vol.24
, Issue.3
, pp. 341-354
-
-
Lin, D.-Y.1
Huang, Y.-S.2
Jeng, J.-C.3
-
70
-
-
84862798314
-
DeSUMOylating isopeptidase: A second class of SUMO protease
-
Shin EJ, Shin HM, Nam E, et al. DeSUMOylating isopeptidase:a second class of SUMO protease. EMBO Rep2012;13(4):339-46.
-
(2012)
EMBO Rep
, vol.13
, Issue.4
, pp. 339-346
-
-
Shin, E.J.1
Shin, H.M.2
Nam, E.3
-
71
-
-
0027401203
-
Mutations in Cu/Znsuperoxide dismutase gene are associated with familial amyotrophiclateral sclerosis
-
Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Znsuperoxide dismutase gene are associated with familial amyotrophiclateral sclerosis. Nature 1993;362:59-62.
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
-
72
-
-
33645422711
-
ANG mutationssegregate with familial and sporadic amyotrophic lateral sclerosis
-
Greenway MJ, Andersen PM, Russ C, et al. ANG mutationssegregate with familial and "sporadic" amyotrophic lateral sclerosis.Nat Genet 2006;38:411-3.
-
(2006)
Nat Genet
, vol.38
, pp. 411-413
-
-
Greenway, M.J.1
Andersen, P.M.2
Russ, C.3
-
73
-
-
84908016489
-
TDP-43 mutationsin familial and sporadic amyotrophic lateral sclerosis
-
Sreedharan J, Blair IP, Tripathi VB, et al. TDP-43 mutationsin familial and sporadic amyotrophic lateral sclerosis. Science2008;3191668-72.
-
Science2008
, pp. 3191668-3191672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
-
74
-
-
77952419246
-
Mutations of optineurinin amyotrophic lateral sclerosis
-
Maruyama H, Morino H, Ito H, et al. Mutations of optineurinin amyotrophic lateral sclerosis. Nature 2010;465:223-6.
-
(2010)
Nature
, vol.465
, pp. 223-226
-
-
Maruyama, H.1
Morino, H.2
Ito, H.3
-
75
-
-
80052580969
-
Mutations in UBQLN2cause dominant X-linked juvenile and adult-onset ALS andALS/dementia
-
Deng H-X, Chen W, Hong S-T, et al. Mutations in UBQLN2cause dominant X-linked juvenile and adult-onset ALS andALS/dementia. Nature 2011;477:211-5.
-
(2011)
Nature
, vol.477
, pp. 211-215
-
-
Deng, H.-X.1
Chen, W.2
Hong, S.-T.3
-
76
-
-
0034785509
-
The gene encoding alsin aprotein with three guanine-nucleotide exchange factor domains,is mutated in a form of recessive amyotrophic lateral sclerosis
-
Yang Y, Hentati A, Deng HX, et al. The gene encoding alsin, aprotein with three guanine-nucleotide exchange factor domains,is mutated in a form of recessive amyotrophic lateral sclerosis.Nat Genet 2001;29:160-5.
-
(2001)
Nat Genet
, vol.29
, pp. 160-165
-
-
Yang, Y.1
Hentati, A.2
Deng, H.X.3
-
77
-
-
2442658908
-
DNA/RNA helicasegene mutations in a form of juvenile amyotrophic lateral sclerosis(ALS4
-
Chen Y-Z, Bennett CL, Huynh HM, et al. DNA/RNA helicasegene mutations in a form of juvenile amyotrophic lateral sclerosis(ALS4). Am J Hum Genet 2004;74:1128-35.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 1128-1135
-
-
Chen, Y.-Z.1
Bennett, C.L.2
Huynh, H.M.3
-
78
-
-
77249126425
-
SPATACSIN mutationscause autosomal recessive juvenile amyotrophic lateralsclerosis
-
Orlacchio A, Babalini C, Borreca A, et al. SPATACSIN mutationscause autosomal recessive juvenile amyotrophic lateralsclerosis. Brain 2010;133:591-8.
-
(2010)
Brain
, vol.133
, pp. 591-598
-
-
Orlacchio, A.1
Babalini, C.2
Borreca, A.3
-
79
-
-
6344257200
-
A mutationin the vesicle-trafficking protein VAPB causes late-onset spinalmuscular atrophy and amyotrophic lateral sclerosis
-
Nishimura AL, Mitne-Neto M, Silva HCA et al. A mutationin the vesicle-trafficking protein VAPB causes late-onset spinalmuscular atrophy and amyotrophic lateral sclerosis. Am J HumGenet 2004;75:822-31.
-
(2004)
Am J HumGenet
, vol.75
, pp. 822-831
-
-
Nishimura, A.L.1
Mitne-Neto, M.2
Hca, S.3
-
80
-
-
58049192812
-
Deleterious variantsof FIG4, a phosphoinositide phosphatase in patients with ALS
-
Chow CY, Landers JE, Bergren SK, et al. Deleterious variantsof FIG4, a phosphoinositide phosphatase, in patients with ALS.Am J Hum Genet 2009;84:85-8.
-
(2009)
Am J Hum Genet
, vol.84
, pp. 85-88
-
-
Chow, C.Y.1
Landers, J.E.2
Bergren, S.K.3
-
81
-
-
78249273602
-
Sigma nonopioidintracellular receptor 1 mutations cause frontotemporallobar degeneration-motor neuron disease
-
Luty AA, Kwok JBJ, Dobson-Stone C, et al. Sigma nonopioidintracellular receptor 1 mutations cause frontotemporallobar degeneration-motor neuron disease. Ann Neurol2010;68:639-49.
-
(2010)
Ann Neurol
, vol.68
, pp. 639-649
-
-
Luty, A.A.1
Kwok, J.B.J.2
Dobson-Stone, C.3
-
82
-
-
84155163741
-
A mutation in sigma-1 receptorcauses juvenile amyotrophic lateral sclerosis
-
Al-Saif A, Al-Mohanna F, Bohlega S. A mutation in sigma-1 receptorcauses juvenile amyotrophic lateral sclerosis. Ann Neurol2011;70:913-9.
-
(2011)
Ann Neurol
, vol.70
, pp. 913-919
-
-
Al-Saif, A.1
Al-Mohanna, F.2
Bohlega, S.3
-
83
-
-
80054837386
-
A hex nucleotide repeatexpansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
-
Renton AE, Majounie E, Waite A, et al. A hex nucleotide repeatexpansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 2011;72:257-68.
-
(2011)
Neuron
, vol.72
, pp. 257-268
-
-
Renton, A.E.1
Majounie, E.2
Waite, A.3
-
84
-
-
80054832080
-
Expanded GGGGCC hex nucleotide repeat in noncoding regionof C9ORF72 causes chromosome 9p-linked FTD and ALS
-
DeJesus-Hernandez M, Mackenzie IR, Boeve BF, et al. ExpandedGGGGCC hex nucleotide repeat in noncoding regionof C9ORF72 causes chromosome 9p-linked FTD and ALS.Neuron 2011;72:245-56.
-
(2011)
Neuron
, vol.72
, pp. 245-256
-
-
Dejesus-Hernandez, M.1
MacKenzie, I.R.2
Boeve, B.F.3
-
85
-
-
0032543684
-
Association of missenseand 5'-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M, Lendon CL, Rizzu P, et al. Association of missenseand 5'-splice-site mutations in tau with the inherited dementiaFTDP-17. Nature 1998;393:702-5.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
-
86
-
-
78649941297
-
Exome sequencingreveals VCP mutations as a cause of familial ALS
-
Johnson JO, Mandrioli J, Benatar M, et al. Exome sequencingreveals VCP mutations as a cause of familial ALS. Neuron2010;68:857-64.
-
(2010)
Neuron
, vol.68
, pp. 857-864
-
-
Johnson, J.O.1
Mandrioli, J.2
Benatar, M.3
-
87
-
-
0041104778
-
ApolipoproteinE in Guamanian amyotrophic lateral sclerosis/ parkinsonismdementiacomplex: Genotype analysis and relationships toneuropathological changes
-
Búee L, Ṕerez-Tur J, Leveugle B, et al. ApolipoproteinE in Guamanian amyotrophic lateral sclerosis/parkinsonismdementiacomplex: genotype analysis and relationships toneuropathological changes. Acta Neuropathol 1996;91:247-53.
-
(1996)
Acta Neuropathol
, vol.91
, pp. 247-253
-
-
Búee, L.1
Ṕerez-Tur, J.2
Leveugle, B.3
-
88
-
-
77956155218
-
Ataxin-2 intermediatelengthpolyglutamine expansions are associated with increasedrisk for ALS
-
Elden AC, Kim H-J, Hart MP, et al. Ataxin-2 intermediatelengthpolyglutamine expansions are associated with increasedrisk for ALS. Nature 2010;466:1069-75.
-
(2010)
Nature
, vol.466
, pp. 1069-1075
-
-
Elden, A.C.1
Kim, H.-J.2
Hart, M.P.3
-
89
-
-
76049085112
-
ChromograninB P413L variant as risk factor and modifier of disease onsetfor amyotrophic lateral sclerosis
-
Gros-Louis F, Andersen PM, Dupre N, et al. ChromograninB P413L variant as risk factor and modifier of disease onsetfor amyotrophic lateral sclerosis. Proc Natl Acad Sci USA2009;106:21777-82.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 21777-21782
-
-
Gros-Louis, F.1
Andersen, P.M.2
Dupre, N.3
-
90
-
-
33749006845
-
ALS phenotypes withmutations in CHMP2B (charged multivesicular body protein2B
-
Parkinson N, Ince PG, Smith MO, et al. ALS phenotypes withmutations in CHMP2B (charged multivesicular body protein2B). Neurology 2006;67:1074-7.
-
(2006)
Neurology
, vol.67
, pp. 1074-1077
-
-
Parkinson, N.1
Ince, P.G.2
Smith, M.O.3
-
91
-
-
33748707208
-
Paraoxonase clusterpolymorphisms are associated with sporadic ALS
-
Saeed M, Siddique N, Hung WY, et al. Paraoxonase clusterpolymorphisms are associated with sporadic ALS. Neurology2006;67:771-6.
-
(2006)
Neurology
, vol.67
, pp. 771-776
-
-
Saeed, M.1
Siddique, N.2
Hung, W.Y.3
-
92
-
-
79952815816
-
Association between divalentmetal transport 1 encoding gene (SLC11A2) and diseaseduration in amyotrophic lateral sclerosis
-
Blasco H, Vourc'h P, Nadjar Y, et al. Association between divalentmetal transport 1 encoding gene (SLC11A2) and diseaseduration in amyotrophic lateral sclerosis. J Neurol Sci2011;303:124-7.
-
(2011)
J Neurol Sci
, vol.303
, pp. 124-127
-
-
Blasco, H.1
Vourc'H, P.2
Nadjar, Y.3
-
93
-
-
0036156999
-
Abnormal SMN1gene copy number is a susceptibility factor for amyotrophic lateralsclerosis
-
Corcia P, Mayeux-Portas V, Khoris J, et al. Abnormal SMN1gene copy number is a susceptibility factor for amyotrophic lateralsclerosis. Ann Neurol 2002;51:243-6.
-
(2002)
Ann Neurol
, vol.51
, pp. 243-246
-
-
Corcia, P.1
Mayeux-Portas, V.2
Khoris, J.3
-
94
-
-
0035957312
-
Homozygousdeletion of the survival motor neuron 2 gene isa prognostic factor in sporadic ALS
-
Veldink JH, van den Berg LH, Cobben JM, et al. Homozygousdeletion of the survival motor neuron 2 gene isa prognostic factor in sporadic ALS. Neurology 2001;56:749-52.
-
(2001)
Neurology
, vol.56
, pp. 749-752
-
-
Veldink, J.H.1
Van Den Berg, L.H.2
Cobben, J.M.3
-
95
-
-
70349592269
-
Genome-wide associationstudy identifies 19p13.3 (UNC13A) and 9p21.2 assusceptibility loci for sporadic amyotrophic lateral sclerosis
-
van Es MA, Veldink JH, Saris CGJ, et al. Genome-wide associationstudy identifies 19p13.3 (UNC13A) and 9p21.2 assusceptibility loci for sporadic amyotrophic lateral sclerosis. NatGenet 2009;41:1083-7.
-
(2009)
NatGenet
, vol.41
, pp. 1083-1087
-
-
Van Es, M.A.1
Veldink, J.H.2
Saris, C.G.J.3
|