SUMO under stress

Biochemical Society Transactions

Volumn 36, Issue 5, 2008, Pages 874-878

  Tempé, Denis ^a   Piechaczyk, Marc ^a   Bossis, Guillaume ^a  

^a CNRS   (France)

Author keywords

Conjugation; Phospho dependent SUMO motif (PDSM); Phosphorylation; Post translational modification; Small ubiquitin related modifier (SUMO); Stress

Indexed keywords

CAMPTOTHECIN; CISPLATIN; DOUBLE STRANDED DNA; DOXORUBICIN; ETOPOSIDE; SUMO PROTEIN;

CELL HYPOXIA; CELL STRESS; CONFERENCE PAPER; CYTOTOXICITY; DNA STRAND BREAKAGE; GENOTOXICITY; HEAT SHOCK; HUMAN; HYPOXIA; NONHUMAN; OSMOTIC STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SUMOYLATION; TRANSCRIPTION INITIATION;

ANIMALS; HUMANS; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS;

EID: 53849114331     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360874     Document Type: Conference Paper

References (44)

1. Geiss-Friedlander, R. and Melchior, F. (2007) Concepts in sumoylation: a decade on. Nat. Rev. Mol. Cell Biol. 8, 947-956
2. Kerscher, 0. (2007) SUMO junction - what's your function? New insights through SUMO-interacting motifs. EMBO Rep. 8, 550-555
3. Hietakangas, V., Anckar, J., Blomster, H.A., Fujimoto, M., Palvinno, J.J., Nakai, A. and Sistonen, L. (2006) PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl. Acad. Sci. U.S.A. 103, 45-50
4. Bossis, G. and Melchior, F. (2006) SUMO: regulating the regulator. Cell Div. 1, 13
5. Saitoh, H. and Hinchey, J. (2000) Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J. Biol. Chem. 275, 62S2-6258
6. Zhou, W., Ryan, J.J. and Zhou, H. (2004) Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J. Biol. Chem. 279, 32262-32268
7. 727 phosphorylation promotes SUMOylation of STAT1. Biochem. J. 409, 179-185
8. Sramko M., Markus, J., Kabat, J., Wolff, L. and Bies, J. (2006) Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins. J. Biol. Chem. 281, 40065-40075
9. Hong, Y., Rogers, R., Matunis, M.J., Mayhew, C.N., Goodson, M.L., Park-Sarge, O.K. and Sarge, K.D. (2001) Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J. Biol. Chem. 276, 40263-40267
10. Hietakangas, V., Ahlskog, J.K., Jakobsson, A.M., Hellesuo, M., Sahlberg, N.M., Holmberg, C.I., Mikhailov, A., Palvimo, J.J., Pirkkala, L. and Sistonen, L. (2003) Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol. Cell. Biol. 23, 2953-2968
11. Bossis, G., Malnou, C.E., Farras, R., Andermarcher, E., Hipskind, R., Rodriguez, M., Schmidt, D., Muller, S., Jariel-Encontre, I. and Piechaczyk, M. (2005) Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol. Cell. Biol. 25, 6964-6979
12. Deng, T. and Karin, M. (1994) c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature 371, 171-175
13. Mo, Y.Y., Yu, Y., Shen, Z. and Beck, W.T. (2002) Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein. J. Biol. Chem. 277, 2958-2964
14. 2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 and 25 differently. J. Cell Sci. 116, 513-524
15. Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G.K., Holsboer, F. and Arzt, E. (2007) RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1α during hypoxia. Cell 131, 309-323
16. Bossis, G. and Melchior, F. (2006) Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes. Mol. Cell 21, 349-357
17. Xu, Z., Lam, L.S., Lam, L.H., Chau, S.F., Ng, T.B. and Au, S.W. (2008) Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation. FASEB J. 22, 127-137
18. Degerny, C., Monte, D., Beaudoin, C., Jaffray, E., Portois, L., Hay, R.T., de Launoit, Y. and Baert, J.L. (2005) SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. J. Biol. Chem. 280, 24330-24338
19. Mabb, A.M., Wuerzberger-Davis, S.M. and Miyamoto, S. (2006) PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress. Nat. Cell Biol. 8, 986-993
20. Wuerzberger-Davis, S.M., Nakamura, Y., Seufzer, B.J. and Miyamoto, S. (2007) NF-κB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene 26, 641-651
21. Li, T., Santockyte, R., Shen, R.F., Tekle, E., Wang, G., Yang, D.C. and Chock, P.B. (2006) Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J. Biol. Chem. 281, 36221-36227
22. Qu, J., Liu, G.H., Wu, K., Han, P., Wang, P., Li, J., Zhang, X. and Chen, C. (2007) Nitric oxide destabilizes Pias3 and regulates sumoylation. PLoS ONE 2, e1085
23. Comerford, K.M., Leonard, M.O., Karhausen, J., Carey, R., Colgan, S.P. and Taylor, C.T. (2003) Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc. Natl. Acad. Sci. U.S.A. 100, 986-991
24. Shao, R., Zhang, F.P., Tian, F., Anders Friberg, P., Wang, X., Sjoland, H. and Billig, H. (2004) increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1α in adult mouse brain and heart in vivo. FEBS Lett. 569, 293-300
25. Ulrich, H. D. (2007) SUMO teams up with ubiquitin to manage hypoxia. Cell 131, 446-447
26. Bae, S.H., Jeong, J.W., Park, J.A., Kim, S.H., Bae, M.K., Choi, S.J. and Kim, K.W. (2004) Sumoylation increases HIF-1α stability and its transcriptional activity. Biochem. Biophys. Res. Commun. 324, 394-400
27. Cheng, J., Kang, X., Zhang, S. and Yeh, E.T. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia. Cell 131, 584-595
28. Sacher, M., Pfander, B., Hoege, C. and Jentsch, S. (2006) Control of Rad52 recombination activity by double-strand break-induced SUMO modification. Nat. Cell Biol. 8, 1284-1290
29. Shinbo, Y., Niki, T., Taira, T., Ooe, H., Takahashi-Niki, K., Maita, C., Seino, C., Iguchi-Ariga, S.M. and Ariga, H. (2006) Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death Differ. 13, 96-108
30. Wang, Q.E., Zhu, Q., Wani, G., El-Mahdy, M.A., Li, J. and Wani, A.A. (2005) DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation, Nucleic Acids Res. 33, 4023-4034
31. Cheng, Z., Ke, Y., Ding, X., Wang, F., Wang, H., Ahmed, K., Liu, Z., Xu, Y., Aikhionbare, F., Yan, H. et al. (2008) Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. Oncogene 27, 931-941
32. Park, J., Seo, T., Kim, H. and Choe, J. (2005) Sumoylation of the novel protein hRIP β is involved in replication protein A deposition in PML nuclear bodies. Mol. Cell. Biol. 25, 8202-8214
33. Mao, Y., Sun, M., Desai, S.D. and Liu, L.F. (2000) SUMO-1 conjugation to topoisomerase I: a possible repair response to topoisomerase-mediated DNA damage. Proc. Natl. Acad. Sci. U.S.A. 97, 4046-4051
34. Lee, Y.K., Thomas, S.N., Yang, A.J. and Ann, D.K. (2007) Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J. Biol. Chem. 282, 1595-1606
35. Li, X., Lee, Y.K., Jeng, J.C., Yen, Y., Schultz, D.C., Shih, H.M. and Ann, D.K. (2007) Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. J. Biol. Chem. 282, 36177-36189
36. Ivanov, A.V., Peng, H., Yurchenko, V., Yap, K-L., Negorev, D.G., Schultz, D.C., Psulkowski, E., Fredericks, W.J., White, D.E., Maul, G.G. et al. (2007) PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol. Cell 28, 823-837
37. Lin, J.Y., Ohshima, T. and Shimotohno, K. (2004) Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53. FEES Lett. 573, 15-18
38. Huang, T.T., Wuerzberger-Davis, S.M., Wu, Z.H. and Miyamoto, S. (2003) Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress. Cell 115, 565-576
39. Janssens, S., Tinel, A., Lippens, S. and Tschopp, J. (2005) PIDD mediates NF-κB activation in response to DNA damage. Cell 123, 1079-1092
40. Yang, S.H., Galanis, A., Witty, J. and Shafrocks, A.D. (2006) An extended consensus motif enhances the specificity of substrate modification by SUMO. EMBO J. 25, 5083-5093
41. Yang, S.H. and Sharrocks, A.D. (2006) PIASxα differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways. Mol. Cell 22, 477-487
42. Jacquiau, H.R., van Waardenburg, R.C., Reid, R.J., Woo, M.H., Guo, H., Johnson, E.S. and Bjornsti, M.A. (2005) Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage. J. Biol. Chem. 280, 23566-23575
43. Mo, Y.Y., Yu, Y., Ee, P.L. and Beck, W.T. (2004) Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs. Cancer Res. 64, 2793-2798
44. Wu, F., Ciocca, S., Beck, W.T. and Mo, Y.Y. (2007) Gam-1 associated alteration of drug responsiveness through activation of apoptosis. Mol. Cancer Ther. 6, 1823-1830