Development of 2′-substituted (2S,1′ R,2′S)-2- (carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists

Journal of Medicinal Chemistry

Volumn 56, Issue 10, 2013, Pages 4071-4081

  Risgaard, Rune ^a   Nielsen, Simon D ^a   Hansen, Kasper B ^a,b   Jensen, Christina M ^a   Nielsen, Birgitte ^a   Traynelis, Stephen F ^b   Clausen, Rasmus P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2,2) 2 (CARBOXYCYCLOPROPYL)GLYCINE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; (ALPHA CARBOXYCYCLOPROPYL)GLYCINE; (ALPHA-CARBOXYCYCLOPROPYL)GLYCINE; AMINO ACID RECEPTOR STIMULATING AGENT; CYCLOPROPANE; CYCLOPROPANE DERIVATIVE; DICARBOXYLIC AMINO ACID; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; SOLVENT;

ARTICLE; CENTRAL NERVOUS SYSTEM; CHEMICAL BOND; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; MOLECULAR DOCKING; ANIMAL; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; DRUG POTENTIATION; IN VITRO STUDY; METABOLISM; OOCYTE; PATCH CLAMP; RAT; SYNAPTOSOME; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY; XENOPUS;

AMINO ACIDS, DICARBOXYLIC; ANIMALS; CHROMATOGRAPHY, THIN LAYER; CYCLOPROPANES; DRUG DESIGN; EXCITATORY AMINO ACID AGONISTS; INDICATORS AND REAGENTS; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SYNAPTOSOMES; XENOPUS;

MLCS; MLOWN;

EID: 84878024701     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400346a     Document Type: Article

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