N-hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

Journal of Medicinal Chemistry

Volumn 51, Issue 14, 2008, Pages 4179-4187

  Clausen, Rasmus P ^a   Christensen, Caspar ^a   Hansen, Kasper B ^a,b,c   Greenwood, Jeremy R ^a   Jørgensen, Lars ^a   Micale, Nicola ^a   Madsen, Jens Christian ^c   Nielsen, Birgitte ^a   Egebjerg, Jan ^c   Bräuner Osborne, Hans ^a   Traynelis, Stephen F ^b   Kristensen, Jesper L ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO (1 HYDROXY 4 CHLORO PYRAZOL 3 YL)ACETIC ACID; AMINO (1 HYDROXY 4 ETHYL PYRAZOL 3 YL)ACETIC ACID; AMINO (1 HYDROXY 4 ISOPROPYL PYRAZOL 3 YL)ACETIC ACID; AMINO (1 HYDROXY 4 METHYL PYRAZOL 3 YL)ACETIC ACID; AMINO (1 HYDROXY 4 PROPYL PYRAZOL 3 YL)ACETIC ACID; ASPARTIC ACID; CARBOXYLIC ACID; GLYCINE DERIVATIVE; LIGAND; N HYDROXYPYRAZOLYLGLYCINE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; IC 50; MOLECULAR DOCKING; NONHUMAN; RAT; RECEPTOR AFFINITY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; GLYCINE; LIGANDS; MODELS, MOLECULAR; PATCH-CLAMP TECHNIQUES; RECEPTORS, N-METHYL-D-ASPARTATE; XENOPUS;

EID: 47849098514     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800025e     Document Type: Article

References (39)

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