메뉴 건너뛰기




Volumn 28, Issue 2, 2013, Pages 193-199

Acetyl-L-carnitine in hepatic encephalopathy

Author keywords

Acetyl L carnitine; Ammonia; Cirrhosis; Hepatic encephalopathy; L carnitine

Indexed keywords

AMMONIA; FREE RADICAL; GLUTAMATE RECEPTOR; LEVACECARNINE; ACETYLCARNITINE;

EID: 84878016950     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-013-9376-4     Document Type: Conference Paper
Times cited : (51)

References (28)
  • 1
    • 0032527045 scopus 로고    scopus 로고
    • Acetyl-Lcarnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain
    • 10.1016/S0006-8993(98)00319-9 9689456 10.1016/S0006-8993(98)00319-9 1:CAS:528:DyaK1cXktFGntb0%3D
    • Aureli T, Di Cocco ME, Puccetti C, Ricciolini R, Scalibastri M, Miccheli A, Manetti C, Conti F (1998) Acetyl-Lcarnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain. Brain Res 796(1-2):75-81. doi: 10.1016/S0006-8993(98)00319-9
    • (1998) Brain Res , vol.796 , Issue.1-2 , pp. 75-81
    • Aureli, T.1    Di Cocco, M.E.2    Puccetti, C.3    Ricciolini, R.4    Scalibastri, M.5    Miccheli, A.6    Manetti, C.7    Conti, F.8
  • 2
    • 60449084556 scopus 로고    scopus 로고
    • Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy
    • 10.1007/s11011-008-9115-4 19085094 10.1007/s11011-008-9115-4 1:CAS:528:DC%2BD1MXhvVOjsrs%3D
    • Cauli O, Rodrigo R, Llansola M, Montoliu C, Monfort P, Piedrafita B, El Mlili N, Boix J, Agustí A, Felipo V (2009) Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. Metab Brain Dis 24(1):69-80. doi: 10.1007/s11011-008-9115-4
    • (2009) Metab Brain Dis , vol.24 , Issue.1 , pp. 69-80
    • Cauli, O.1    Rodrigo, R.2    Llansola, M.3    Montoliu, C.4    Monfort, P.5    Piedrafita, B.6    El Mlili, N.7    Boix, J.8    Agustí, A.9    Felipo, V.10
  • 3
    • 73749085197 scopus 로고    scopus 로고
    • The neuropathy-protective agent acetylL-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain
    • 10.1016/j.neuroscience.2009.11.021 19925851 10.1016/j.neuroscience.2009. 11.021
    • Di Cesare Mannelli L, Ghelardini C, Toscano A, Pacini A, Bartolini A (2010) The neuropathy-protective agent acetylL-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain. Neuroscience 165(4):1345-1352. doi: 10.1016/j.neuroscience.2009.11.021
    • (2010) Neuroscience , vol.165 , Issue.4 , pp. 1345-1352
    • Di Cesare Mannelli, L.1    Ghelardini, C.2    Toscano, A.3    Pacini, A.4    Bartolini, A.5
  • 4
    • 10244264754 scopus 로고    scopus 로고
    • Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress
    • 10.1023/B:JOBB.0000041766.71376.81 15377870 10.1023/B:JOBB.0000041766. 71376.81 1:CAS:528:DC%2BD2cXnsFyju7w%3D
    • Fiskum G, Rosenthal RE, Vereczki V, Martin E, Hoffman GE, Chinopoulos C, Kowaltowski A (2004) Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress. J Bioenerg Biomembr 36(4):347-352. doi: 10.1023/B:JOBB.0000041766.71376.81
    • (2004) J Bioenerg Biomembr , vol.36 , Issue.4 , pp. 347-352
    • Fiskum, G.1    Rosenthal, R.E.2    Vereczki, V.3    Martin, E.4    Hoffman, G.E.5    Chinopoulos, C.6    Kowaltowski, A.7
  • 6
    • 84856592689 scopus 로고    scopus 로고
    • Theories of the pathogenesis of hepatic encephalopathy
    • 10.1016/j.cld.2011.12.010 22321462 10.1016/j.cld.2011.12.010
    • Jones EA, Mullen KD (2012) Theories of the pathogenesis of hepatic encephalopathy. Clin Liver Dis 16(1):7-26. doi: 10.1016/j.cld.2011.12.010
    • (2012) Clin Liver Dis , vol.16 , Issue.1 , pp. 7-26
    • Jones, E.A.1    Mullen, K.D.2
  • 7
    • 39149101464 scopus 로고    scopus 로고
    • Hyperammonemic encephalopathy caused by carnitine deficiency
    • 10.1007/s11606-007-0473-0 18080167 10.1007/s11606-007-0473-0
    • Limketkai BN, Zucker SD (2008) Hyperammonemic encephalopathy caused by carnitine deficiency. J Gen Intern Med 23:210-213. doi: 10.1007/s11606-007-0473- 0
    • (2008) J Gen Intern Med , vol.23 , pp. 210-213
    • Limketkai, B.N.1    Zucker, S.D.2
  • 8
    • 0036984785 scopus 로고    scopus 로고
    • Prevention of ammonia and glutamate neurotoxicity by carnitine: Molecular mechanisms
    • 10.1023/A:1021922305036 12602515 10.1023/A:1021922305036 1:CAS:528:DC%2BD3sXislGruw%3D%3D
    • Llansola M, Erceg S, Hernández-Viadel M, Felipo V (2002) Prevention of ammonia and glutamate neurotoxicity by carnitine: molecular mechanisms. Metab Brain Dis 17(4):389-397. doi: 10.1023/A:1021922305036
    • (2002) Metab Brain Dis , vol.17 , Issue.4 , pp. 389-397
    • Llansola, M.1    Erceg, S.2    Hernández-Viadel, M.3    Felipo, V.4
  • 9
    • 33846989018 scopus 로고    scopus 로고
    • Effects of Lacetylcarnitine on cirrhotic patients with hepatic coma: Randomized double-blind, placebo-controlled trial
    • 10.1007/s10620-006-9187-0 17080254 10.1007/s10620-006-9187-0 1:CAS:528:DC%2BD2sXktFCksg%3D%3D
    • Malaguarnera M, Pistone G, Astuto M, Vecchio I, Raffaele R, Lo Giudice E, Rampello L (2006) Effects of Lacetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. Dig Dis Sci 51(12):2242-2247. doi: 10.1007/s10620-006-9187-0
    • (2006) Dig Dis Sci , vol.51 , Issue.12 , pp. 2242-2247
    • Malaguarnera, M.1    Pistone, G.2    Astuto, M.3    Vecchio, I.4    Raffaele, R.5    Lo Giudice, E.6    Rampello, L.7
  • 10
    • 53849128200 scopus 로고    scopus 로고
    • Acetyl-L-carnitine treatment in minimal hepatic encephalopathy
    • 10.1007/s10620-008-0238-6 18357530 10.1007/s10620-008-0238-6 1:CAS:528:DC%2BD1cXht1ChsbbO
    • Malaguarnera M, Gargante MP, Cristaldi E, Vacante M, Risino C, Cammalleri L, Pennisi G, Rampello L (2008) Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. Dig Dis Sci 53(11):3018-3025. doi: 10.1007/s10620-008-0238-6
    • (2008) Dig Dis Sci , vol.53 , Issue.11 , pp. 3018-3025
    • Malaguarnera, M.1    Gargante, M.P.2    Cristaldi, E.3    Vacante, M.4    Risino, C.5    Cammalleri, L.6    Pennisi, G.7    Rampello, L.8
  • 11
    • 67651053228 scopus 로고    scopus 로고
    • Branched chain amino acids supplemented with L-acetyl carniti ne versus BCAA treatment in hepatic coma: A randomized and controlled double blind study
    • 10.1097/MEG.0b013e328309c791 19357525 10.1097/MEG.0b013e328309c791 1:CAS:528:DC%2BD1MXnsVegs7o%3D
    • Malaguarnera M, Risino C, Cammalleri L, Malaguarnera L, Astuto M, Vecchio I, Rampello L (2009) Branched chain amino acids supplemented with L-acetyl carniti ne versus BCAA treatment in hepatic coma: a randomized and controlled double blind study. Eur J Gastroenterol Hepatol 21(7):762-770. doi: 10.1097/MEG.0b013e328309c791
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , Issue.7 , pp. 762-770
    • Malaguarnera, M.1    Risino, C.2    Cammalleri, L.3    Malaguarnera, L.4    Astuto, M.5    Vecchio, I.6    Rampello, L.7
  • 12
    • 79955949749 scopus 로고    scopus 로고
    • Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy
    • 10.3109/00365521.2011.565067 21443422 10.3109/00365521.2011.565067 1:CAS:528:DC%2BC3MXmtVWrtbk%3D
    • Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, Gargante MP, Motta M, Mistretta A, Rampello L, Pennisi G (2011a) Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Scand J Gastroenterol 46(6):750-759. doi: 10.3109/00365521. 2011.565067
    • (2011) Scand J Gastroenterol , vol.46 , Issue.6 , pp. 750-759
    • Malaguarnera, M.1    Bella, R.2    Vacante, M.3    Giordano, M.4    Malaguarnera, G.5    Gargante, M.P.6    Motta, M.7    Mistretta, A.8    Rampello, L.9    Pennisi, G.10
  • 13
    • 79953174586 scopus 로고    scopus 로고
    • Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: A randomized, double-blind, placebo-controlled study
    • 10.3945/ajcn.110.007393 21310833 10.3945/ajcn.110.007393 1:CAS:528:DC%2BC3MXjvFahu7Y%3D
    • Malaguarnera M, Vacante M, Giordano M, Pennisi G, Bella R, Rampello L, Malaguarnera M, Li Volti G, Galvano F (2011b) Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Am J Clin Nutr 93(4):799-808. doi: 10.3945/ajcn.110.007393
    • (2011) Am J Clin Nutr , vol.93 , Issue.4 , pp. 799-808
    • Malaguarnera, M.1    Vacante, M.2    Giordano, M.3    Pennisi, G.4    Bella, R.5    Rampello, L.6    Malaguarnera, M.7    Li Volti, G.8    Galvano, F.9
  • 14
    • 83655192001 scopus 로고    scopus 로고
    • Acetyl-L-carniti ne improves cognitive functions in severe hepatic encephal opathy: A randomized and controlled clinical trial
    • 10.1007/s11011-011-9260-z 21870121 10.1007/s11011-011-9260-z 1:CAS:528:DC%2BC3MXhsVeltb7I
    • Malaguarnera M, Vacante M, Motta M, Giordano M, Malaguarnera G, Bella R, Nunnari G, Rampello L, Pennisi G (2011c) Acetyl-L-carniti ne improves cognitive functions in severe hepatic encephal opathy: a randomized and controlled clinical trial. Metab Brain Dis 26(4):281-289. doi: 10.1007/s11011-011-9260-z
    • (2011) Metab Brain Dis , vol.26 , Issue.4 , pp. 281-289
    • Malaguarnera, M.1    Vacante, M.2    Motta, M.3    Giordano, M.4    Malaguarnera, G.5    Bella, R.6    Nunnari, G.7    Rampello, L.8    Pennisi, G.9
  • 15
    • 81755188299 scopus 로고    scopus 로고
    • L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-A 2b plus ribavirin
    • 10.3748/wjg.v17.i39.4414 22110268 10.3748/wjg.v17.i39.4414 1:CAS:528:DC%2BC3MXhs1WjtbzP
    • Malaguarnera M, Vacante M, Giordano M, Motta M, Bertino G, Pennisi M, Neri S, Malaguarnera M, Li Volti G, Galvano F (2011d) L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-a 2b plus ribavirin. World J Gastroenterol 17(39):4414-4420. doi: 10.3748/wjg.v17.i39.4414
    • (2011) World J Gastroenterol , vol.17 , Issue.39 , pp. 4414-4420
    • Malaguarnera, M.1    Vacante, M.2    Giordano, M.3    Motta, M.4    Bertino, G.5    Pennisi, M.6    Neri, S.7    Malaguarnera, M.8    Li Volti, G.9    Galvano, F.10
  • 16
    • 0022898515 scopus 로고
    • Carnitine status in Reye and Reye-like syndromes
    • 3508684 10.1016/0887-8994(86)90062-7 1:STN:280:DyaL1M3ks1Oqtg%3D%3D
    • Matsuda I, Ohtani Y (1986) Carnitine status in Reye and Reye-like syndromes. Pediatr Neurol 2(2):90-94
    • (1986) Pediatr Neurol , vol.2 , Issue.2 , pp. 90-94
    • Matsuda, I.1    Ohtani, Y.2
  • 18
    • 0030434484 scopus 로고    scopus 로고
    • Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons
    • 8858993
    • Miñana MD, Hermenegildo C, Llsansola M, Montoliu C, Grisolía S, Felipo V (1996) Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons. J Pharmacol Exp Ther 279(1):194-199
    • (1996) J Pharmacol Exp Ther , vol.279 , Issue.1 , pp. 194-199
    • Miñana, M.D.1    Hermenegildo, C.2    Llsansola, M.3    Montoliu, C.4    Grisolía, S.5    Felipo, V.6
  • 19
    • 5444262536 scopus 로고    scopus 로고
    • Oxidative stress in the pathogenesis of hepatic encephalopathy
    • 10.1023/B:MEBR.0000043978.91675.79 15554424 10.1023/B:MEBR.0000043978. 91675.79 1:CAS:528:DC%2BD2cXot1aiu7o%3D
    • Norenberg MD, Jayakumar AR, Rama Rao KV (2004) Oxidative stress in the pathogenesis of hepatic encephalopathy. Metab Brain Dis 19(3-4):313-329. doi: 10.1023/B:MEBR.0000043978.91675.79
    • (2004) Metab Brain Dis , vol.19 , Issue.3-4 , pp. 313-329
    • Norenberg, M.D.1    Jayakumar, A.R.2    Rama Rao, K.V.3
  • 20
    • 0033764847 scopus 로고    scopus 로고
    • Carnitine: An osmolyte that plays a metabolic role
    • 10.1002/1097-4644(20010101) 11029749 10.1002/1097-4644(20010101)80: 1<1: AID-JCB10>3.0.CO;2-W 1:CAS:528:DC%2BD3cXot1Gmu7k%3D
    • Peluso G, Barbarisi A, Savica V, Reda E, Nicolai R, Benatti P, Calvani M (2000) Carnitine: an osmolyte that plays a metabolic role. J Cell Biochem 80(1):1-10. doi: 10.1002/1097-4644(20010101)
    • (2000) J Cell Biochem , vol.80 , Issue.1 , pp. 1-10
    • Peluso, G.1    Barbarisi, A.2    Savica, V.3    Reda, E.4    Nicolai, R.5    Benatti, P.6    Calvani, M.7
  • 21
    • 84861599689 scopus 로고    scopus 로고
    • Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy
    • 10.1016/j.neuint.2011.09.007 21989389 10.1016/j.neuint.2011.09.007 1:CAS:528:DC%2BC38XnslSjt78%3D
    • Rama Rao KV, Norenberg MD (2012) Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy. Neurochem Int 60(7):697-706. doi: 10.1016/j.neuint.2011.09.007
    • (2012) Neurochem Int , vol.60 , Issue.7 , pp. 697-706
    • Rama Rao, K.V.1    Norenberg, M.D.2
  • 22
    • 84865797225 scopus 로고    scopus 로고
    • Glutamine in the pathogenesis of acute hepatic encephalopathy
    • doi: 10.1016/j.neuint.2012.01.012
    • Rama Rao KV, Jayakumar AR, Norenberg MD (2012) Glutamine in the pathogenesis of acute hepatic encephalopathy. Neurochem Int. doi: 10.1016/j.neuint.2012.01.012
    • (2012) Neurochem Int.
    • Rama Rao, K.V.1    Jayakumar, A.R.2    Norenberg, M.D.3
  • 23
    • 0027203913 scopus 로고
    • Effect of L-carnitine on cerebral and hepatic energy metabolites in congenitally hyperammonemic sparse-fur mice and its role during benzoate therapy
    • 10.1016/0026-0495(93)90020-O 8102193 10.1016/0026-0495(93)90020-O 1:CAS:528:DyaK3sXltFKit74%3D
    • Ratnakumari L, Qureshi IA, Butterworth RF (1993) Effect of L-carnitine on cerebral and hepatic energy metabolites in congenitally hyperammonemic sparse-fur mice and its role during benzoate therapy. Metabolism 42(8):1039-1046. doi: 10.1016/0026-0495(93)90020-O
    • (1993) Metabolism , vol.42 , Issue.8 , pp. 1039-1046
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 24
    • 0027049235 scopus 로고
    • Carnitine function and requirements during the life cycle
    • 1464372 1:CAS:528:DyaK3sXnvFyrsw%3D%3D
    • Rebouche CJ (1992) Carnitine function and requirements during the life cycle. FASEB J 6(15):3379-3386
    • (1992) FASEB J , vol.6 , Issue.15 , pp. 3379-3386
    • Rebouche, C.J.1
  • 25
    • 64949120484 scopus 로고    scopus 로고
    • Role of NMDA receptors in acute liver failure and ammonia toxicity: Therapeutical implications
    • 10.1016/j.neuint.2009.01.007 19428814 10.1016/j.neuint.2009.01.007 1:CAS:528:DC%2BD1MXltVKrs74%3D
    • Rodrigo R, Cauli O, Boix J, ElMlili N, Agusti A, Felipo V (2009) Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications. Neurochem Int 55(1-3):113-118. doi: 10.1016/j.neuint.2009.01.007
    • (2009) Neurochem Int , vol.55 , Issue.1-3 , pp. 113-118
    • Rodrigo, R.1    Cauli, O.2    Boix, J.3    Elmlili, N.4    Agusti, A.5    Felipo, V.6
  • 26
    • 29744437097 scopus 로고    scopus 로고
    • Limited capacity for ammonia removal by brain in chronic liver failure: Potential role of nitric oxide
    • 10.1007/s11011-005-7906-4 16382338 10.1007/s11011-005-7906-4 1:CAS:528:DC%2BD2MXhtlGhurfL
    • Rose C, Felipo V (2005) Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metab Brain Dis 20(4):275-283. doi: 10.1007/s11011-005-7906-4
    • (2005) Metab Brain Dis , vol.20 , Issue.4 , pp. 275-283
    • Rose, C.1    Felipo, V.2
  • 27
    • 77954321145 scopus 로고    scopus 로고
    • Metabolism of acetyl-Lcarnitine for energy and neurotransmitter synthesis in the immature rat brain
    • 10.1111/j.1471-4159.2010.06807.x 20477950 10.1111/j.1471-4159.2010.06807. x 1:CAS:528:DC%2BC3cXpslygur8%3D
    • Scafidi S, Fiskum G, Lindauer SL, Bamford P, Shi D, Hopkins I, McKenna MC (2010) Metabolism of acetyl-Lcarnitine for energy and neurotransmitter synthesis in the immature rat brain. J Neurochem 114(3):820-831. doi: 10.1111/j.1471-4159.2010.06807.x
    • (2010) J Neurochem , vol.114 , Issue.3 , pp. 820-831
    • Scafidi, S.1    Fiskum, G.2    Lindauer, S.L.3    Bamford, P.4    Shi, D.5    Hopkins, I.6    McKenna, M.C.7
  • 28
    • 0031050889 scopus 로고    scopus 로고
    • Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat
    • 10.1002/hep.510250310 9049197 10.1002/hep.510250310 1:CAS:528: DyaK2sXisVansLo%3D
    • Therrien G, Rose C, Butterworth J, Butterworth RF (1997) Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat. Hepatology 25(3):551-556. doi: 10.1002/hep.510250310
    • (1997) Hepatology , vol.25 , Issue.3 , pp. 551-556
    • Therrien, G.1    Rose, C.2    Butterworth, J.3    Butterworth, R.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.