Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 1, 1996, Pages 194-199

  Miñana, María Dolores ^a   Hermenegildo, Carlos ^a   Llansola, Marta ^a   Montoliu, Carmina ^a   Grisolía, Santiago ^a   Felipo, Vicente ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 PHOSPHONOPROPIONIC ACID; ACETYLCARNITINE; ACETYLCHOLINE; AMMONIUM ACETATE; ATROPINE; BETAINE; CARBACHOL; CARNITINE DERIVATIVE; CHOLINE; CHOLINE DERIVATIVE; GLUTAMIC ACID; TRIMETHYLAMINE OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMMONIA; ANIMALS; CARNITINE; CELLS, CULTURED; CHOLINE; CYCLOLEUCINE; GLUTAMIC ACID; MALE; METHYLAMINES; MICE; NEURONS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0030434484     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. CHALLIS, R. A. J., MISTRY, R., GRAY, D. W. AND NAHORSKI, S. R.: Modulation of muscarinic cholinoreceptor-stimulated inositol 1,4,5-triphosphate accumulation by N-methyl-D-aspartate in neonatal rat cerebral cortex. Neuropharmacology 33: 15-25, 1994.
2. CHOI, D. W.: Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7: 369-379, 1987.
3. COURTNEY, M. J. AND NICHOLLS, D. G.: Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: Protein kinase C mediated inhibition of N-methyl-D-aspartate responses. J. Neurochem. 59: 983-992, 1992.
4. DICHIARA, G., MORELLI, M. AND CONSOLO, S.: Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions. Trends Neurol. Sci. 17: 228-233, 1994.
5. FELIPO, V., MIÑANA, M. D., CABEDO, H. AND GRISOLÍA, S.: L-Carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity. Neurochem. Res. 19: 373-377, 1994.
6. FELIPO, V., MIÑANA, M. D. AND GRISOLÍA, S.: Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures. Brain Res. 604: 192-196, 1993.
7. GIOVANNINI, M. G., CAMILLI, F., MUNDULA, A. AND PEPEU, G.: Glutamatergic regulation of acetylcholine output in different brain regions: A microdialysis study in the rat. Neurochem. Int. 25: 23-26, 1994.
8. 3H]norepinephrine release from rat cortical slices. J. Pharmacol. Exp. Ther. 264: 282-288, 1993.
9. KLOIBER, O., BANJAC, B. AND DREWES, L. R.: Protection against acute hyperammonemia: The role of quaternary amines. Toxiciology 49: 83-90, 1988.
10. KOH, J. Y., PALMER, E. AND COTMAN, C. W.: Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88: 9431-935, 1991.
11. MARCAIDA, G., FELIPO, V., HERMENEGILDO, C., MIÑANA, M. D. AND GRISOLÍA, S.: Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors. FEBS Lett. 296: 67-68, 1992.
12. NOVELLI, A., REILLY, J. A., LYSKO, P. G. AND HENNEBERRY, R. C.: Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. 451: 205-212, 1988.
13. O'CONNOR, J. E., COSTELL, M. AND GRISOLÍA, S.: Protective effect of L-carnitine on hyperammonemia. FEBS Lett. 166: 331-334, 1984.
14. PESSOTTO, P., LIBERATI, R., PETRELLA, O. AND HÜSMANN, W. C.: Quaternary nitrogen compounds affect carnitine distribution in rats. Particular emphasis on endrophonium. Biochim. Biophys. Acta 1299: 245-251, 1996.
15. SILIPRANDI, R., LIPARTITI, M., FADDA, E., SAUTTER, J. AND MANEV, H.: Activation of metabotropic receptor protects retina against N-methyl-D-aspartate toxicity. Eur. J. Pharmacol. 219: 173-174, 1992.