메뉴 건너뛰기




Volumn 21, Issue 7, 2009, Pages 762-770

Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: A randomized and controlled double blind study

Author keywords

Ammonia; Branched chain amino acids; Cirrhosis; Hepatic coma; L acetylcarnitine

Indexed keywords

AMMONIA; BRANCHED CHAIN AMINO ACID; LEVACECARNINE;

EID: 67651053228     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e328309c791     Document Type: Article
Times cited : (29)

References (67)
  • 1
    • 0036191173 scopus 로고    scopus 로고
    • Hepatic encephalopathy - Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998
    • DOI 10.1053/jhep.2002.31250
    • Ferenci P, Lockwood A, Mullen K, Tarter R,Weissenborn K, Blei AT. Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: Final Report Of The Working Party At The 11th World Congresses Of Gastroenterology, Vienna, 1998. J Hepatol 2002; 35:716-721. (Pubitemid 34183979)
    • (2002) Hepatology , vol.35 , Issue.3 , pp. 716-721
    • Ferenci, P.1    Lockwood, A.2    Mullen, K.3    Tarter, R.4    Weissenborn, K.5    Blei, A.T.6
  • 6
    • 0036556409 scopus 로고    scopus 로고
    • Communication between astrocytes and neurons: A complex language
    • DOI 10.1016/S0928-4257(02)00007-4, PII S0928425702000074
    • Perea G, Araque A. Communication between astrocytes and neurons: a complex language. J Physiol Paris 2002; 96:199-207. (Pubitemid 36090356)
    • (2002) Journal of Physiology Paris , vol.96 , Issue.3-4 , pp. 199-207
    • Perea, G.1    Araque, A.2
  • 7
    • 0033220224 scopus 로고    scopus 로고
    • Encephalopathy with idiopathic hyperammonaemia and Alzheimer type II astrocytes in Equidae
    • Hasel KM, Summers BA, De Lahunta A. Encephalopathy with idiopathic hyperammonaemia and Alzheimer type II astrocytes in equidae. Equine Vet J 1999; 31:478-482. (Pubitemid 129650655)
    • (1999) Equine Veterinary Journal , vol.31 , Issue.6 , pp. 478-482
    • Hasel, K.M.1    Summers, B.A.2    De Lahunta, A.3
  • 8
    • 0037347231 scopus 로고    scopus 로고
    • Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
    • DOI 10.1097/00004850-200303000-00001
    • Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003; 18:61-71. (Pubitemid 36343974)
    • (2003) International Clinical Psychopharmacology , vol.18 , Issue.2 , pp. 61-71
    • Montgomery, S.A.1    Thal, L.J.2    Amrein, R.3
  • 11
    • 0022370573 scopus 로고
    • Treatment of acute hepatic encephalopathy in cirrhotics with a branched-chain amino acids enriched versus a conventional amino acids mixture. a controlled study of 70 patients
    • Michel H, Bories P, Aubin JP, Pomier-Layrargues G, Bauret P, Bellet-Herman H. Treatment of acute hepatic encephalopathy in cirrhotics with a branchedchain amino acids enriched versus a conventional amino acids mixture. A controlled study of 70 patients. Liver 1985; 5:282-289. (Pubitemid 16203415)
    • (1985) Liver , vol.5 , Issue.5 , pp. 282-289
    • Michel, H.1    Bories, P.2    Aubin, J.P.3
  • 12
    • 0024459322 scopus 로고
    • Meta-analysis of branched-chain amino acids in hepatic encephalopathy
    • Berlin JA, Chalmers TC. Meta-analysis of branched-chain amino acids in hepatic encephalopathy. Gastroenterology 1989; 97:1043-1045. (Pubitemid 19239050)
    • (1989) Gastroenterology , vol.97 , Issue.4 , pp. 1043-1045
    • Berlin, J.A.1    Chalmers, T.C.2
  • 13
    • 0036227771 scopus 로고    scopus 로고
    • Branched chain amino acids in heptatic encephalopathy
    • DOI 10.1016/S0002-9610(02)00808-5, PII S0002961002008085
    • Howard J. Branched chain amino acid in hepatic encephalopathy. Am J Surg 2002; 183:424-429. (Pubitemid 34442508)
    • (2002) American Journal of Surgery , vol.183 , Issue.4 , pp. 424-429
    • James, J.H.1
  • 19
    • 0342314620 scopus 로고    scopus 로고
    • Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle
    • Desjardins P, Rao KV, Michalak A, Rose C, Butterworth RF. Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle. Metab Brain Dis 1999; 14:273-280. (Pubitemid 30337701)
    • (1999) Metabolic Brain Disease , vol.14 , Issue.4 , pp. 273-280
    • Desjardins, P.1    Rama Rao, K.V.2    Michalak, A.3    Rose, C.4    Butterworth, R.F.5
  • 20
    • 0019988832 scopus 로고
    • Branched-chain amino acids in the treatment of chronic hepatic encephalopathy
    • Eriksson LS, Persson A, Wahren J. Branched-chain amino acids in the treatment of chronic hepatic encephalopathy. Gut 1982; 23:801-806. (Pubitemid 12018505)
    • (1982) Gut , vol.23 , Issue.10 , pp. 801-806
    • Eriksson, L.S.1    Persson, A.2    Wahren, J.3
  • 22
    • 0038047688 scopus 로고    scopus 로고
    • Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: A double-blind, randomized trial
    • Italian BCAA Study Group
    • Marchesini G, Bianchi G, Merli M, Amodio P, Panella C, Loguercio C, et al.; Italian BCAA Study Group. Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial. Gastroenterology 2003; 124:1792-1801.
    • (2003) Gastroenterology , vol.124 , pp. 1792-1801
    • Marchesini, G.1    Bianchi, G.2    Merli, M.3    Amodio, P.4    Panella, C.5    Loguercio, C.6
  • 23
    • 0027312242 scopus 로고
    • Long-term treatment of latent portosystemic encephalopathy with branched-chain amino acids. a double-blind placebo-controlled crossover study
    • Plauth M, Egberts EH, HamsterW, Torok M, Muller PH, Brand O, et al. Longterm treatment of latent portosystemic encephalopathy with branched-chain amino acids. A double-blind placebo-controlled crossover study. J Hepatol 1993; 17:308-314. (Pubitemid 23134926)
    • (1993) Journal of Hepatology , vol.17 , Issue.3 , pp. 308-314
    • Plauth, M.1    Egberts, E.-H.2    Hamster, W.3    Torok, M.4    Muller, P.H.5    Brand, O.6    Furst, P.7    Dolle, W.8
  • 24
    • 2342487336 scopus 로고    scopus 로고
    • Non-absorbable disaccharides for hepatic encephalopathy: Systematic review of randomised trials
    • Als-Nielsen B, Gluud LL, Gluud C. Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials. Br Med J 2004; 328:1046. (Pubitemid 38580827)
    • (2004) British Medical Journal , vol.328 , Issue.7447 , pp. 1046-1050
    • Als-Nielsen, B.1    Gluud, L.L.2    Gluud, C.3
  • 25
    • 0022475988 scopus 로고
    • Entry of L-acetylcarnitine into biosynthetic pathways
    • Farrel L, Vogel J, Bierber LL. Entry of L-acetylcarnitine into biosynthetic pathways. Biochim Biophys Acta 1986; 876:175-177.
    • (1986) Biochim Biophys Acta , vol.876 , pp. 175-177
    • Farrel, L.1    Vogel, J.2    Bierber, L.L.3
  • 26
    • 0019366250 scopus 로고
    • Effect of carnitine on liver fat and nitrogen balance in intravenously fed growing rats
    • Tao RC, Peck GK, Yoshimura NN. Effect of carnitine on liver fat and nitrogen balance in intravenously fed growing rats. J Nutr 1981; 111:171-177.
    • (1981) J Nutr , vol.111 , pp. 171-177
    • Tao, R.C.1    Peck, G.K.2    Yoshimura, N.N.3
  • 27
    • 0020712885 scopus 로고
    • TIEREXPERIMENTELLE UNTERSUCHUNGEN UBER VERANDERUNGEN des LIPID- Und PROTEINSTOFFWECHSELS BEI L-CARNITIN-SUPPLEMENTIERTER TOTALER PARENTERALER ERNAHRUNG
    • Bohles H, Segerer H, Fekl W, Stehr K. Animal experiment studies on the changes in lipid and protein metabolism in L-carnitine-supplemented total parenteral nutrition. Infusionsther Klin Ernahr 1983; 10:24-31. (Pubitemid 13154382)
    • (1983) Infusionstherapie und Klinische Ernahrung - Forschung und Praxis , vol.10 , Issue.1 , pp. 24-31
    • Bohles, H.1    Segerer, H.2    Fekl, W.3    Stehr, K.4
  • 28
    • 0037379314 scopus 로고    scopus 로고
    • Bioenergetic approaches for neuroprotection in Parkinson's disease
    • Beal MF. Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann Neurol 2003; 53:S39-S47.
    • (2003) Ann Neurol , vol.53
    • Beal, M.F.1
  • 29
    • 0028300338 scopus 로고
    • Pharmacological treatment of diabetic peripheral neuropathy: Challenges and possibilities
    • Schoemaker JH. Pharmacological treatment of diabetic peripheral neuropathy: challenges and possibilities. Br J Clin Pract 1994; 48:91-96. (Pubitemid 24099699)
    • (1994) British Journal of Clinical Practice , vol.48 , Issue.2 , pp. 91-96
    • Schoemaker, J.H.1
  • 31
    • 33645099306 scopus 로고    scopus 로고
    • L-carnitine reduces severity of physical and mental fatigue and improves daily activities in the elderly
    • Malaguarnera M, Di Mauro A, Gargante PM, Rampello L. L-carnitine reduces severity of physical and mental fatigue and improves daily activities in the elderly. South Med J 2006; 99:315-316.
    • (2006) South Med J , vol.99 , pp. 315-316
    • Malaguarnera, M.1    Di Mauro, A.2    Gargante, P.M.3    Rampello, L.4
  • 32
    • 0026460074 scopus 로고
    • Double-blind parallel design pilot study of acetyl-L-carnitine in patients with Alzheimer's disease
    • Sano M, Bell K, Cote L, Dooneief G, Lawton A, Legler L, et al. Double-blind parallel design pilot study of acetyl-L-carnitine in patients with Alzheimer's disease. Arch Neurol 1992; 49:1137-1141.
    • (1992) Arch Neurol , vol.49 , pp. 1137-1141
    • Sano, M.1    Bell, K.2    Cote, L.3    Dooneief, G.4    Lawton, A.5    Legler, L.6
  • 34
  • 35
    • 0020853336 scopus 로고
    • Liver Dis 1983; 3:298-307.
    • (1983) Liver Dis , vol.3 , pp. 298-307
  • 36
    • 0009804862 scopus 로고
    • Pathogenesis of portal-systemic encephalopathy
    • Conn HO, Lieberthal MM, editors. Baltimore: Williams And Wilkims
    • Conn HO. Pathogenesis of portal-systemic encephalopathy. In: Conn HO, Lieberthal MM, editors. The hepatic coma syndromes and lactulose. Baltimore: Williams And Wilkims; 1979:46-84.
    • (1979) The Hepatic Coma Syndromes and Lactulose , pp. 46-84
    • Conn, H.O.1
  • 37
    • 0020853336 scopus 로고
    • Methods for assessing hepatic encephalopathy
    • Pappas SC, Jones EA. Methods for assessing hepatic encephalopathy. Semin Liver Dis 1983; 3:298-307.
    • (1983) Semin Liver Dis , vol.3 , pp. 298-307
    • Pappas, S.C.1    Jones, E.A.2
  • 38
    • 0033103666 scopus 로고    scopus 로고
    • Nutritional support in hepatic encephalopathy
    • Barry A. Mizock "nutritional support in hepatic encephalopathy" . Nutrition 1999; 3:220-228.
    • (1999) Nutrition , vol.3 , pp. 220-228
    • Mizock, B.A.1
  • 39
    • 0027715183 scopus 로고
    • Effects of ornithine aspartate on plasma ammonia and plasma and amino acids in patients with cirrhosis. a double-blind, randomized study using a four-fold crossover design
    • Staedt U, Leweling H, Gladisch R, Kortsik C, Hagmuller E, Holm E. Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J Hepatol 1993; 19:424-430. (Pubitemid 24029921)
    • (1993) Journal of Hepatology , vol.19 , Issue.3 , pp. 424-430
    • Staedt, U.1    Leweling, H.2    Gladisch, R.3    Kortsik, C.4    Hagmuller, E.5    Holm, E.6
  • 40
    • 17844398237 scopus 로고    scopus 로고
    • Treatment of hepatic encephalopathy
    • Blei AT. Treatment of hepatic encephalopathy. Lancet 2005; 365:1383-1384.
    • (2005) Lancet , vol.365 , pp. 1383-1384
    • Blei, A.T.1
  • 41
    • 0016391336 scopus 로고
    • Assessment of coma and impaired consciousness
    • Tesdale G, Jennet B. Assessment of coma and impaired consciousness. Lancet 1974; 2:81-83.
    • (1974) Lancet , vol.2 , pp. 81-83
    • Tesdale, G.1    Jennet, B.2
  • 42
    • 0034026244 scopus 로고    scopus 로고
    • Revisiting the Glasgow Coma Scale and Coma Score
    • Teasdale GM, Murray L. Revisiting the Glasgow Coma Scale and Coma Score. Intensive Care Med 2000; 26:153-154. (Pubitemid 30186586)
    • (2000) Intensive Care Medicine , vol.26 , Issue.2 , pp. 153-154
    • Teasdale, G.M.1    Murray, L.2
  • 44
    • 0001051028 scopus 로고
    • Direkte plasmaammoniakbestimmung ohne enteiweissung
    • De Fonseca-Wollheim F. Direkte plasmaammoniakbestimmung ohne enteiweissung. Clin Chem Clin Biochem 1973; 11:421-431.
    • (1973) Clin Chem Clin Biochem , vol.11 , pp. 421-431
    • De Fonseca-Wollheim, F.1
  • 46
    • 0020011165 scopus 로고
    • Potential neural mechanisms in the pathogenesis of hepatic encephalopathy
    • Schafer DF, Jones EA. Potential neural mechanisms in the pathogenesis of hepatic encephalopathy. Prog Liver Dis 1982; 7:615-627.
    • (1982) Prog Liver Dis , vol.7 , pp. 615-627
    • Schafer, D.F.1    Jones, E.A.2
  • 47
    • 0025119184 scopus 로고
    • Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure
    • Yurdaydin C, Hortnagl H, Steindl P, Zimmermann C, Pifl C, Singer EA, et al. Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure. J Hepatol 1990; 12:695-700. (Pubitemid 20349253)
    • (1990) Hepatology , vol.12 , Issue.4 I , pp. 695-700
    • Yurdaydin, C.1    Hortnagl, H.2    Steindl, P.3    Zimmermann, C.4    Pifl, C.5    Singer, E.A.6    Roth, E.7    Ferenci, P.8
  • 49
    • 0343238857 scopus 로고    scopus 로고
    • Hepatic encephalopathy in chronic liver disease: A clinical manifestation of astrocyte swelling and low-grade cerebral edema?
    • Haussinger D, Kircheis G, Fischer R, Schliess F, Vom Dahl S. Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema? J Hepatol 2000;32:1035-1038.
    • (2000) J Hepatol , vol.32 , pp. 1035-1038
    • Haussinger, D.1    Kircheis, G.2    Fischer, R.3    Schliess, F.4    Vom Dahl, S.5
  • 50
    • 0015978511 scopus 로고
    • Synergism between mercaptans and ammonia or fatty acids in the production of coma: A possible role for mercaptans in the pathogenesis of hepatic coma
    • Zieve L, Doizaki WM, Zieve J. Synergism between mercaptans and ammonia or fatty acids in the production of coma: a possible role for mercaptans in the pathogenesis of hepatic coma. J Lab Clin Med 1974; 83:16-28.
    • (1974) J Lab Clin Med , vol.83 , pp. 16-28
    • Zieve, L.1    Doizaki, W.M.2    Zieve, J.3
  • 51
    • 0018091132 scopus 로고
    • Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis
    • James JH, Escourrou J, Fischer JE. Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis. Science 1978; 200:1395-1397. (Pubitemid 8373560)
    • (1978) Science , vol.200 , Issue.4348 , pp. 1395-1397
    • James, J.H.1    Escourrou, J.2    Fischer, J.E.3
  • 54
    • 0036256827 scopus 로고    scopus 로고
    • Hyperammonemic encephalopathy
    • Brusilow SW. Hyperammonemic encephalopathy. Medicine (Baltimore) 2002; 81:240-249.
    • (2002) Medicine (Baltimore) , vol.81 , pp. 240-249
    • Brusilow, S.W.1
  • 55
    • 0036984785 scopus 로고    scopus 로고
    • Prevention of ammonia and glutamate neurotoxicity by carnitine: Molecular mechanisms
    • DOI 10.1023/A:1021922305036
    • Llansola M, Erceg S, Hernandez-Viadel M, Felipo V. Prevention of ammonia and glutamate neurotoxicity by carnitine: molecular mechanisms. Metab Brain Dis 2002; 17:389-397. (Pubitemid 36204768)
    • (2002) Metabolic Brain Disease , vol.17 , Issue.4 , pp. 389-397
    • Llansola, M.1    Erceg, S.2    Hernandez-Viadel, M.3    Felipo, V.4
  • 56
  • 57
    • 0028009993 scopus 로고
    • L-carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity
    • Felipo V, Minana MD, Cabedo H, Grisolia S. L-carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity. Neurochem Res 1994; 19:373-377. (Pubitemid 24054810)
    • (1994) Neurochemical Research , vol.19 , Issue.3 , pp. 373-377
    • Felipo, V.1    Minana, M.-D.2    Cabedo, H.3    Grisolia, S.4
  • 58
    • 0029902428 scopus 로고    scopus 로고
    • Mammalian mitochondrial beta-oxidation
    • Eaton S, Bartlett K, Pourfarzam M. Mammalian mitochondrial beta-oxidation. Biochem J 1996; 320:345-357.
    • (1996) Biochem J , vol.320 , pp. 345-357
    • Eaton, S.1    Bartlett, K.2    Pourfarzam, M.3
  • 59
    • 0842287450 scopus 로고    scopus 로고
    • Mitochondrial beta-oxidation
    • Bartlett K, Eaton S. Mitochondrial beta-oxidation. Eur J Biochem 2004; 271:462-469.
    • (2004) Eur J Biochem , vol.271 , pp. 462-469
    • Bartlett, K.1    Eaton, S.2
  • 62
    • 0036834752 scopus 로고    scopus 로고
    • Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults
    • Muller DM, Seim H, Kiess W, Loster H, Richter T. Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism 2002; 51:1389-1391.
    • (2002) Metabolism , vol.51 , pp. 1389-1391
    • Muller, D.M.1    Seim, H.2    Kiess, W.3    Loster, H.4    Richter, T.5
  • 63
    • 75549094121 scopus 로고
    • Carnitine and its role in fatty acid metabolism
    • Fritz IB. Carnitine and its role in fatty acid metabolism. ADV Lipid Res 1963; 64:285-334.
    • (1963) ADV Lipid Res , vol.64 , pp. 285-334
    • Fritz, I.B.1
  • 64
    • 0029367143 scopus 로고
    • Evaluation of oxidative stress in diabetics
    • Singh RB, Naiz MA. Evaluation of oxidative stress in diabetics. J Assoc Physicians India 1995; 43:654.
    • (1995) J Assoc Physicians India , vol.43 , pp. 654
    • Singh, R.B.1    Naiz, M.A.2
  • 65
    • 0026332787 scopus 로고
    • Suppression of neurotoxicity of ammonia by L-carnitine
    • Matsuoka M, Igisu H, Kohriyama K, Inoue N. Suppression of neurotoxicity of ammonia by L-carnitine. Brain Res 1991; 567:328-331.
    • (1991) Brain Res , vol.567 , pp. 328-331
    • Matsuoka, M.1    Igisu, H.2    Kohriyama, K.3    Inoue, N.4
  • 67
    • 33846989018 scopus 로고    scopus 로고
    • Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: Randomized double-blind, placebo-controlled trial
    • Malaguarnera M, Pistone G, Astuto M, Vecchio I, Raffaele R, Lo Giudice E, Rampello L. Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. Dig Dis Sci 2006; 51:2242-2247.
    • (2006) Dig Dis Sci , vol.51 , pp. 2242-2247
    • Malaguarnera, M.1    Pistone, G.2    Astuto, M.3    Vecchio, I.4    Raffaele, R.5    Lo Giudice, E.6    Rampello, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.