Acetyl-L-carnitine treatment in minimal hepatic encephalopathy

Digestive Diseases and Sciences

Volumn 53, Issue 11, 2008, Pages 3018-3025

  Malaguarnera, Mariano ^a   Gargante, Maria Pia ^a   Cristaldi, Erika ^a   Vacante, Marco ^a   Risino, Corrado ^a   Cammalleri, Lisa ^a   Pennisi, Giovanni ^a   Rampello, Liborio ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Acetyl L carnitine; Ammonia levels; Cirrhosis; Cognitive activity; Hepatitis; Minimal hepatic encephalopathy; Neuropsychological function

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; AMMONIA; ASPARTATE AMINOTRANSFERASE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BILIRUBIN; DIURETIC AGENT; LEVACECARNINE; PLACEBO;

ABDOMINAL PAIN; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; AMMONIA BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; ELECTROENCEPHALOGRAM; FEMALE; HEADACHE; HEPATIC ENCEPHALOPATHY; HEPATITIS B; HEPATITIS C; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NAUSEA; PRIORITY JOURNAL; PROTHROMBIN TIME; PSYCHOLOGIC TEST; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ACETYLCARNITINE; ADULT; AMMONIA; BILIRUBIN; COGNITION; DOUBLE-BLIND METHOD; FEMALE; HEPATIC ENCEPHALOPATHY; HUMANS; INTELLIGENCE TESTS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NOOTROPIC AGENTS; PROTHROMBIN TIME; SERUM ALBUMIN; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 53849128200     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0238-6     Document Type: Article

References (31)

1. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT (2002) Hepatic encephalopathy: definition, nomenclature, diagnosis, and quantification: final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna,1998. Hepatology 35:716-721. doi: 10.1053/jhep.2002. 31250
2. Blei AT (2000) Diagnosis and treatment of hepatic encephalopathy. Baillieres Best Pract Res Clin Gastroenterol 14:959-974. doi: 10.1053/bega.2000.0141
3. Quero JC, Hartmann IJ, Meulstee J, Hop WC, Schalm SW (1996) The diagnosis of subclinical hepatic encephalopathy in patients with cirrhosis using neuropsychological tests and automated electroencephalogram analysis. Hepatology 24:556-560. doi: 10.1002/hep.510240316
4. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA (2007) Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 52:3259-3265. doi: 10.1007/s10620-006-9687-y
5. N Siliprandi D Siliprandi M Ciman 1965 Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine Biochem J 96 777 780
6. Dolezal V, Tucek S (1981) Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 36:1323-1330. doi: 10.1111/j.1471-4159.1981.tb00569.x
7. A Spagnoli U Lucca G Menasce L Bandera G Cizza G Forloni M Tettamanti L Frattura P Tiraboschi M Pomelli 1991 Long term acetyl-l-carnitine treatment in Alzheimer's disease Neurology 41 1726 1732
8. Virmani A, Gaetani F, Binienda Z, Xu A, Duhart H, Ali SF (2004) Role of mitochondrial dysfunction in neurotoxicity of MPP+: partial protection of PC12 cells by acetyl-L-carnitine. Ann N Y Acad Sci 1025:267-273. doi: 10.1196/annals.1316.033
9. Cheng AY, Leiter LA (2006) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Curr Opin Cardiol 21:400-404. doi: 10.1097/01.hco.0000231412.15049.fb
10. M McCrea J Cordoba J Vessey AT Blei C Randolph 1996 Neuropsychological characterization and detection of subclinical hepatic encephalopathy Arch Neurol 53 758 763
11. Reitan RM, Wolfson D (1993) The Halstead-Reitan: neuropsychological test battery: theory and clinical interpretation. Neuropsychology Press, Tucson, AZ
12. Wechsler D (1981) Wechsler Adult Intelligence Scale-Revised. Psychological Corp, New York
13. PS Kharbanda VA Saraswat RK Dhiman 2003 Minimal hepatic encephalopathy: diagnosis by neuropsychological and neurophysiologic methods Indian J Gastroenterol 22 S37 S41
14. Smith A (1982) Symbol Digit Modalities Test (SDMT): manual (revised). Western Psychological Services, Los Angeles, CA
15. Folstein MF, Folstein SE, McHugh PR (1975) "Mini Mental State". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198. doi: 10.1016/0022-3956(75)90026-6
16. Schmidt M (1996) Rey Auditory and Verbal Learning Test. Instruction manual. Western Psychological Services, Los Angeles, CA
17. M Malaguarnera G Pistone BA Trovato M Scuderi M Vinci M Romano F Marletta 1996 Electrophysiological alterations in hepatic encephalopathy detected by brain mapping Panminerva Med 38 84 88
18. Pugh RN, Murray-Lyon IM, Dawson JL, Petroni MC, Williams R (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60:646-649. doi: 10.1002/bjs.1800600817
19. F Da Fonseca-Wollheim 1973 Direkte plasmaammoniakbestimmung ohne Enteiweissung Z Klin Chem Biochem 11 426 431
20. World Medical Association Declaration of Helsinki (1997) Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 35:2-3. doi: 10.1016/S0008-6363(97)00109-0
21. Montgomery SA, Thal LJ, Amrein R (2003) Meta-analysis of double blind randomized controlled clinical trials of acetyl-l-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 18:61-71. doi: 10.1097/00004850-200303000-00001
22. Malaguarnera M, Pistone G, Astuto M, Dell'Arte S, Finocchiaro G, Lo Giudice E, Pennisi G (2003) L-Carnitine in the treatment of mild or moderate hepatic encephalopathy. Dig Dis 21:271-275. doi: 10.1159/000073347
23. KD Mullen R Gacad 1994 Pathogenetic mechanism of acute hepatic encephalopathy New Horiz 2 505 511
24. H Casas B Murtra M Casas J Ibanez JL Ventura A Ricart F Rodriguez G Viscor L Palacios T Pages R Rama 2001 Increased blood ammonia in hypoxia during exercise in humans J Physiol Biochem 57 303 312
25. Therrien G, Rose C, Butterworth J, Butterworth RF (1997) Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat. Hepatology 25:551-556. doi: 10.1002/hep.510250310
26. WJ Davanzo ME Ullian 2002 L-Carnitine administration reverses acute mental status changes in a chronic haemodialysis patient with hepatitis C infection Clin Nephrol 57 402 405
27. Pettegrew JW, Levine J, McClure RJ (2000) Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Mol Psychiatry 5:616-632. doi: 10.1038/sj.mp.4000805
28. M Malaguarnera G Pistone E Rampello C Leotta L Scarpello L Rampello 2005 Effects of L-carnitine in patients with hepatic encephalopathy World J Gastroenterol 11 7197 7202
29. Malaguarnera M, Pistone G, Astuto M, Vecchio I, Raffaele R, Lo Giudice E, Rampello L (2006) Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. Dig Dis Sci 51:2242-2247. doi: 10.1007/s10620-006-9187-0
30. Ortiz M, Cordoba J, Jacas C, Montserrat F, Esteban R, Guardia J (2006) Neuropsychological abnormalities in include learning impairment. J Hepatol 44:104-110. doi: 10.1016/j.jhep.2005.06.013
31. Virmani A, Binienda Z (2004) Role of carnitine esters in brain 351 neuropathology. Mol Aspects Med 25:533-549. doi: 10.1016/j.mam.2004.06.003