메뉴 건너뛰기




Volumn 26, Issue 6, 2013, Pages 576-589

Achieving operational tolerance in transplantation: How can lessons from the clinic inform research directions?

Author keywords

cellular therapy; clinical trials; immune regulation; regulatory T cell; tolerance; transplantation

Indexed keywords

ABATACEPT; ALEMTUZUMAB; ATACICEPT; BASILIXIMAB; BELATACEPT; BELIMUMAB; BORTEZOMIB; CYCLOSPORIN; DACLIZUMAB; ECULIZUMAB; EFALIZUMAB; INDUCIBLE NITRIC OXIDE SYNTHASE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; PROSTAGLANDIN E2; RAPAMYCIN; RECOMBINANT INTERLEUKIN 2; SUPPRESSOR OF CYTOKINE SIGNALING 1; TACROLIMUS; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA;

EID: 84878014212     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12081     Document Type: Review
Times cited : (39)

References (120)
  • 1
    • 0038148286 scopus 로고    scopus 로고
    • Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation
    • Karam V, Castaing D, Danet C, et al,. Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation. Liver Transpl 2003; 9: 703.
    • (2003) Liver Transpl , vol.9 , pp. 703
    • Karam, V.1    Castaing, D.2    Danet, C.3
  • 2
    • 1642327515 scopus 로고    scopus 로고
    • Frequency and impact of nonadherence to immunosuppressants after renal transplantation: A systematic review
    • Butler JA, Roderick P, Mullee M, Mason JC, Peveler RC,. Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review. Transplantation 2004; 77: 769.
    • (2004) Transplantation , vol.77 , pp. 769
    • Butler, J.A.1    Roderick, P.2    Mullee, M.3    Mason, J.C.4    Peveler, R.C.5
  • 3
    • 79951965811 scopus 로고    scopus 로고
    • US Organ Procurement and Transplantation Network Accessed 10 January 2013. Available from:
    • US Organ Procurement and Transplantation Network. Scientific Registry of Transplant Recipients: Annual Data Report 2011. Accessed 10 January 2013. Available from: http://srtr.transplant.hrsa.gov/annual-reports/2011/Default.aspx
    • Scientific Registry of Transplant Recipients: Annual Data Report 2011
  • 4
    • 84878012038 scopus 로고    scopus 로고
    • NHS Blood and Transplant Accessed 10 January 2013. Available from
    • NHS Blood and Transplant. Organ Donation-Centre-specific Reports 2011. Accessed 10 January 2013. Available from: http://www.organdonation.nhs.uk/ statistics/centre-specific-reports/.
    • Organ Donation - Centre-specific Reports 2011
  • 5
    • 74949094555 scopus 로고    scopus 로고
    • KDIGO clinical practice guideline for the care of kidney transplant recipients
    • Kidney Disease: Improving Global Outcomes Transplant Work G
    • Kidney Disease: Improving Global Outcomes Transplant Work G. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant. 2009; 9 (Suppl. 3): S1.
    • (2009) Am J Transplant , vol.9 , Issue.SUPPL. 3
  • 7
    • 79955529736 scopus 로고    scopus 로고
    • Reduced-dose tacrolimus with mycophenolate mofetil vs. standard-dose tacrolimus in liver transplantation: A randomized study
    • Boudjema K, Camus C, Saliba F, et al,. Reduced-dose tacrolimus with mycophenolate mofetil vs. standard-dose tacrolimus in liver transplantation: a randomized study. Am J Transplant 2011; 11: 965.
    • (2011) Am J Transplant , vol.11 , pp. 965
    • Boudjema, K.1    Camus, C.2    Saliba, F.3
  • 8
    • 79955548854 scopus 로고    scopus 로고
    • Guidance for liver transplant immunosuppression
    • Knechtle SJ,. Guidance for liver transplant immunosuppression. Am J Transplant 2011; 11: 886.
    • (2011) Am J Transplant , vol.11 , pp. 886
    • Knechtle, S.J.1
  • 9
    • 78650017786 scopus 로고    scopus 로고
    • Identification of tolerant recipients following liver transplantation
    • Sanchez-Fueyo A,. Identification of tolerant recipients following liver transplantation. Int Immunopharmacol 2010; 10: 1501.
    • (2010) Int Immunopharmacol , vol.10 , pp. 1501
    • Sanchez-Fueyo, A.1
  • 10
    • 0005984244 scopus 로고
    • 'Actively acquired tolerance' of foreign cells
    • Billingham R, Brent L, Medawar P,. 'Actively acquired tolerance' of foreign cells. Nature 1953; 172: 603.
    • (1953) Nature , vol.172 , pp. 603
    • Billingham, R.1    Brent, L.2    Medawar, P.3
  • 11
    • 0011283331 scopus 로고
    • Immunological effects of experimental embryonal parabiosis
    • Hasek M, Hraba T,. Immunological effects of experimental embryonal parabiosis. Nature 1955; 175: 764.
    • (1955) Nature , vol.175 , pp. 764
    • Hasek, M.1    Hraba, T.2
  • 12
    • 0000658958 scopus 로고
    • Immunogenetic consequences of vascular anastomoses between bovine twins
    • Owen R,. Immunogenetic consequences of vascular anastomoses between bovine twins. Science 1945; 102: 400.
    • (1945) Science , vol.102 , pp. 400
    • Owen, R.1
  • 14
    • 84655170198 scopus 로고    scopus 로고
    • Mechanisms of rejection: Current perspectives
    • Wood KJ, Goto R,. Mechanisms of rejection: current perspectives. Transplantation 2012; 93: 1.
    • (2012) Transplantation , vol.93 , pp. 1
    • Wood, K.J.1    Goto, R.2
  • 15
    • 3042722261 scopus 로고    scopus 로고
    • Exploiting tolerance processes in transplantation
    • Waldmann H, Cobbold S,. Exploiting tolerance processes in transplantation. Science 2004; 305: 209.
    • (2004) Science , vol.305 , pp. 209
    • Waldmann, H.1    Cobbold, S.2
  • 17
    • 77953178765 scopus 로고    scopus 로고
    • Identification of a B cell signature associated with renal transplant tolerance in humans
    • Newell KA, Asare A, Kirk AD, et al,. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010; 120: 1836.
    • (2010) J Clin Invest , vol.120 , pp. 1836
    • Newell, K.A.1    Asare, A.2    Kirk, A.D.3
  • 18
    • 77953209236 scopus 로고    scopus 로고
    • Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
    • Sagoo P, Perucha E, Sawitzki B, et al,. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120: 1848.
    • (2010) J Clin Invest , vol.120 , pp. 1848
    • Sagoo, P.1    Perucha, E.2    Sawitzki, B.3
  • 19
    • 38449100017 scopus 로고    scopus 로고
    • Spontaneous operational tolerance after immunosuppressive drug withdrawal in clinical renal allotransplantation
    • Ashton-Chess J, Giral M, Brouard S, Soulillou JP,. Spontaneous operational tolerance after immunosuppressive drug withdrawal in clinical renal allotransplantation. Transplantation 2007; 84: 1215.
    • (2007) Transplantation , vol.84 , pp. 1215
    • Ashton-Chess, J.1    Giral, M.2    Brouard, S.3    Soulillou, J.P.4
  • 20
    • 67349182474 scopus 로고    scopus 로고
    • Operational tolerance after liver transplantation
    • Orlando G, Soker S, Wood K,. Operational tolerance after liver transplantation. J Hepatol 2009; 50: 1247.
    • (2009) J Hepatol , vol.50 , pp. 1247
    • Orlando, G.1    Soker, S.2    Wood, K.3
  • 21
    • 78650179150 scopus 로고    scopus 로고
    • Clinical operational tolerance after renal transplantation: Current status and future challenges
    • Orlando G, Hematti P, Stratta RJ, et al,. Clinical operational tolerance after renal transplantation: current status and future challenges. Ann Surg 2010; 252: 915.
    • (2010) Ann Surg , vol.252 , pp. 915
    • Orlando, G.1    Hematti, P.2    Stratta, R.J.3
  • 22
    • 79954778147 scopus 로고    scopus 로고
    • Immunosuppression withdrawal after liver transplantation: What are the next steps?
    • Mazariegos GV,. Immunosuppression withdrawal after liver transplantation: what are the next steps? Transplantation 2011; 91: 697.
    • (2011) Transplantation , vol.91 , pp. 697
    • Mazariegos, G.V.1
  • 23
    • 0035941959 scopus 로고    scopus 로고
    • Repopulation of liver endothelium by bone-marrow-derived cells
    • Gao Z, McAlister VC, Williams GM,. Repopulation of liver endothelium by bone-marrow-derived cells. Lancet 2001; 357: 932.
    • (2001) Lancet , vol.357 , pp. 932
    • Gao, Z.1    McAlister, V.C.2    Williams, G.M.3
  • 24
    • 0028816806 scopus 로고
    • Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow
    • Svendsen UG, Aggestrup S, Heilmann C, et al,. Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow. Eur Respir J 1995; 8: 334.
    • (1995) Eur Respir J , vol.8 , pp. 334
    • Svendsen, U.G.1    Aggestrup, S.2    Heilmann, C.3
  • 25
    • 67649111125 scopus 로고    scopus 로고
    • Immune tolerance after total lymphoid irradiation for heart transplantation: Immunosuppressant-free survival for 8 years
    • Comerci GD Jr, Williams TM, Kellie S,. Immune tolerance after total lymphoid irradiation for heart transplantation: immunosuppressant-free survival for 8 years. J Heart Lung Transplant 2009; 28: 743.
    • (2009) J Heart Lung Transplant , vol.28 , pp. 743
    • Comerci, Jr.G.D.1    Williams, T.M.2    Kellie, S.3
  • 26
    • 0035487527 scopus 로고    scopus 로고
    • The "privileged" liver and hepatic tolerogenicity
    • Starzl TE,. The "privileged" liver and hepatic tolerogenicity. Liver Transpl 2001; 7: 918.
    • (2001) Liver Transpl , vol.7 , pp. 918
    • Starzl, T.E.1
  • 27
    • 84879797355 scopus 로고    scopus 로고
    • Frequent hepatocyte chimerism in long-term human liver allografts independent of graft outcome
    • doi: 10.1016/j.trim.2012.12.002
    • Aini W, Miyagawa-Hayashino A, Ozeki M, et al,. Frequent hepatocyte chimerism in long-term human liver allografts independent of graft outcome. Transpl Immunol 2012; doi: 10.1016/j.trim.2012.12.002.
    • (2012) Transpl Immunol
    • Aini, W.1    Miyagawa-Hayashino, A.2    Ozeki, M.3
  • 28
    • 79952411376 scopus 로고    scopus 로고
    • Operational tolerance: Past lessons and future prospects
    • Levitsky J,. Operational tolerance: past lessons and future prospects. Liver Transpl 2011; 17: 222.
    • (2011) Liver Transpl , vol.17 , pp. 222
    • Levitsky, J.1
  • 29
    • 84855993116 scopus 로고    scopus 로고
    • Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants
    • Feng S, Ekong UD, Lobritto SJ, et al,. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA 2012; 307: 283.
    • (2012) JAMA , vol.307 , pp. 283
    • Feng, S.1    Ekong, U.D.2    Lobritto, S.J.3
  • 30
    • 33745804056 scopus 로고    scopus 로고
    • An appraisal of tolerance in liver transplantation
    • Lerut J, Sanchez-Fueyo A,. An appraisal of tolerance in liver transplantation. Am J Transplant 2006; 6: 1774.
    • (2006) Am J Transplant , vol.6 , pp. 1774
    • Lerut, J.1    Sanchez-Fueyo, A.2
  • 31
    • 83955163645 scopus 로고    scopus 로고
    • Factors affecting operational tolerance after pediatric living-donor liver transplantation: Impact of early post-transplant events and HLA match
    • Ohe H, Waki K, Yoshitomi M, et al,. Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match. Transpl Int 2012; 25: 97.
    • (2012) Transpl Int , vol.25 , pp. 97
    • Ohe, H.1    Waki, K.2    Yoshitomi, M.3
  • 32
    • 84872078847 scopus 로고    scopus 로고
    • Predicting operational tolerance in pediatric living-donor liver transplantation by absence of HLA antibodies
    • Waki K, Sugawara Y, Mizuta K, et al,. Predicting operational tolerance in pediatric living-donor liver transplantation by absence of HLA antibodies. Transplantation 2013; 95: 177.
    • (2013) Transplantation , vol.95 , pp. 177
    • Waki, K.1    Sugawara, Y.2    Mizuta, K.3
  • 33
    • 0038298787 scopus 로고    scopus 로고
    • Tolerogenic immunosuppression for organ transplantation
    • Starzl TE, Murase N, Abu-Elmagd K, et al,. Tolerogenic immunosuppression for organ transplantation. Lancet 2003; 361: 1502.
    • (2003) Lancet , vol.361 , pp. 1502
    • Starzl, T.E.1    Murase, N.2    Abu-Elmagd, K.3
  • 34
    • 20044380331 scopus 로고    scopus 로고
    • Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion
    • Pearl JP, Parris J, Hale DA, et al,. Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion. Am J Transplant 2005; 5: 465.
    • (2005) Am J Transplant , vol.5 , pp. 465
    • Pearl, J.P.1    Parris, J.2    Hale, D.A.3
  • 36
    • 0035875792 scopus 로고    scopus 로고
    • Tolerance in renal transplantation after allogeneic bone marrow transplantation-6-year follow-up
    • Sellers MT, Deierhoi MH, Curtis JJ, et al,. Tolerance in renal transplantation after allogeneic bone marrow transplantation-6-year follow-up. Transplantation 2001; 71: 1681.
    • (2001) Transplantation , vol.71 , pp. 1681
    • Sellers, M.T.1    Deierhoi, M.H.2    Curtis, J.J.3
  • 37
    • 0036785208 scopus 로고    scopus 로고
    • Bone marrow transfusions in cadaver renal allografts: Pilot trials with concurrent controls
    • Light J, Salomon DR, Diethelm AG, et al,. Bone marrow transfusions in cadaver renal allografts: pilot trials with concurrent controls. Clin Transplant 2002; 16: 317.
    • (2002) Clin Transplant , vol.16 , pp. 317
    • Light, J.1    Salomon, D.R.2    Diethelm, A.G.3
  • 38
    • 0036853026 scopus 로고    scopus 로고
    • Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease
    • Buhler LH, Spitzer TR, Sykes M, et al,. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation 2002; 74: 1405.
    • (2002) Transplantation , vol.74 , pp. 1405
    • Buhler, L.H.1    Spitzer, T.R.2    Sykes, M.3
  • 39
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al,. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358: 353.
    • (2008) N Engl J Med , vol.358 , pp. 353
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 40
    • 38549134052 scopus 로고    scopus 로고
    • Tolerance and chimerism after renal and hematopoietic-cell transplantation
    • Scandling JD, Busque S, Dejbakhsh-Jones S, et al,. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008; 358: 362.
    • (2008) N Engl J Med , vol.358 , pp. 362
    • Scandling, J.D.1    Busque, S.2    Dejbakhsh-Jones, S.3
  • 41
    • 79958863773 scopus 로고    scopus 로고
    • Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation
    • Andreola G, Chittenden M, Shaffer J, et al,. Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation. Am J Transplant 2011; 11: 1236.
    • (2011) Am J Transplant , vol.11 , pp. 1236
    • Andreola, G.1    Chittenden, M.2    Shaffer, J.3
  • 42
    • 11144355749 scopus 로고    scopus 로고
    • Homeostatic proliferation is a barrier to transplantation tolerance
    • Wu Z, Bensinger SJ, Zhang J, et al,. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med 2004; 10: 87.
    • (2004) Nat Med , vol.10 , pp. 87
    • Wu, Z.1    Bensinger, S.J.2    Zhang, J.3
  • 43
    • 0042532322 scopus 로고    scopus 로고
    • Heterologous immunity provides a potent barrier to transplantation tolerance
    • Adams AB, Williams MA, Jones TR, et al,. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003; 111: 1887.
    • (2003) J Clin Invest , vol.111 , pp. 1887
    • Adams, A.B.1    Williams, M.A.2    Jones, T.R.3
  • 45
    • 84863229939 scopus 로고    scopus 로고
    • Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation
    • Leventhal J, Abecassis M, Miller J, et al,. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med 2012; 4: 124ra28.
    • (2012) Sci Transl Med , vol.4
    • Leventhal, J.1    Abecassis, M.2    Miller, J.3
  • 47
    • 84872069226 scopus 로고    scopus 로고
    • Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: Durable chimerism predicts outcome
    • Leventhal J, Abecassis M, Miller J, et al,. Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: durable chimerism predicts outcome. Transplantation 2013; 95: 169.
    • (2013) Transplantation , vol.95 , pp. 169
    • Leventhal, J.1    Abecassis, M.2    Miller, J.3
  • 48
    • 84870566641 scopus 로고    scopus 로고
    • The natural history of clinical operational tolerance after kidney transplantation through twenty-seven cases
    • Brouard S, Pallier A, Renaudin K, et al,. The natural history of clinical operational tolerance after kidney transplantation through twenty-seven cases. Am J Transplant 2012; 12: 3296.
    • (2012) Am J Transplant , vol.12 , pp. 3296
    • Brouard, S.1    Pallier, A.2    Renaudin, K.3
  • 50
    • 53549133080 scopus 로고    scopus 로고
    • Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation
    • Hutchinson JA, Riquelme P, Brem-Exner BG, et al,. Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. Transpl Int 2008; 21: 728.
    • (2008) Transpl Int , vol.21 , pp. 728
    • Hutchinson, J.A.1    Riquelme, P.2    Brem-Exner, B.G.3
  • 51
    • 53549101269 scopus 로고    scopus 로고
    • A cell-based approach to the minimization of immunosuppression in renal transplantation
    • Hutchinson JA, Brem-Exner BG, Riquelme P, et al,. A cell-based approach to the minimization of immunosuppression in renal transplantation. Transpl Int 2008; 21: 742.
    • (2008) Transpl Int , vol.21 , pp. 742
    • Hutchinson, J.A.1    Brem-Exner, B.G.2    Riquelme, P.3
  • 52
    • 80052650727 scopus 로고    scopus 로고
    • Cutting edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients
    • Hutchinson JA, Riquelme P, Sawitzki B, et al,. Cutting edge: immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J Immunol 2011; 187: 2072.
    • (2011) J Immunol , vol.187 , pp. 2072
    • Hutchinson, J.A.1    Riquelme, P.2    Sawitzki, B.3
  • 53
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working G
    • Biomarkers Definitions Working G. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69: 89.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89
  • 57
    • 84870242123 scopus 로고    scopus 로고
    • The pits and pearls in translating operational tolerance biomarkers into clinical practice
    • Roedder S, Gao X, Sarwal MM,. The pits and pearls in translating operational tolerance biomarkers into clinical practice. Curr Opin Organ Transplant 2012; 17: 655.
    • (2012) Curr Opin Organ Transplant , vol.17 , pp. 655
    • Roedder, S.1    Gao, X.2    Sarwal, M.M.3
  • 58
    • 34848857054 scopus 로고    scopus 로고
    • Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance
    • Brouard S, Mansfield E, Braud C, et al,. Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci USA 2007; 104: 15448.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15448
    • Brouard, S.1    Mansfield, E.2    Braud, C.3
  • 59
    • 84862783161 scopus 로고    scopus 로고
    • A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation
    • Li L, Wozniak LJ, Rodder S, et al,. A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation. Am J Transplant 2012; 12: 1218.
    • (2012) Am J Transplant , vol.12 , pp. 1218
    • Li, L.1    Wozniak, L.J.2    Rodder, S.3
  • 60
    • 84856536708 scopus 로고    scopus 로고
    • GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation
    • Moraes-Vieira PM, Takenaka MC, Silva HM, et al,. GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation. Clin Immunol 2012; 142: 117.
    • (2012) Clin Immunol , vol.142 , pp. 117
    • Moraes-Vieira, P.M.1    Takenaka, M.C.2    Silva, H.M.3
  • 61
    • 80052265345 scopus 로고    scopus 로고
    • Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients
    • Lozano JJ, Pallier A, Martinez-Llordella M, et al,. Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients. Am J Transplant 2011; 11: 1916.
    • (2011) Am J Transplant , vol.11 , pp. 1916
    • Lozano, J.J.1    Pallier, A.2    Martinez-Llordella, M.3
  • 62
    • 58149330244 scopus 로고    scopus 로고
    • FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal
    • Pons JA, Revilla-Nuin B, Baroja-Mazo A, et al,. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal. Transplantation 2008; 86: 1370.
    • (2008) Transplantation , vol.86 , pp. 1370
    • Pons, J.A.1    Revilla-Nuin, B.2    Baroja-Mazo, A.3
  • 63
    • 33846910502 scopus 로고    scopus 로고
    • Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
    • Koshiba T, Li Y, Takemura M, et al,. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transpl Immunol 2007; 17: 94.
    • (2007) Transpl Immunol , vol.17 , pp. 94
    • Koshiba, T.1    Li, Y.2    Takemura, M.3
  • 64
    • 10044262162 scopus 로고    scopus 로고
    • Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation
    • Li Y, Koshiba T, Yoshizawa A, et al,. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant 2004; 4: 2118.
    • (2004) Am J Transplant , vol.4 , pp. 2118
    • Li, Y.1    Koshiba, T.2    Yoshizawa, A.3
  • 65
    • 78650267436 scopus 로고    scopus 로고
    • The significance of non-T-cell pathways in graft rejection: Implications for transplant tolerance
    • Li XC,. The significance of non-T-cell pathways in graft rejection: implications for transplant tolerance. Transplantation 2010; 90: 1043.
    • (2010) Transplantation , vol.90 , pp. 1043
    • Li, X.C.1
  • 66
    • 49849103955 scopus 로고    scopus 로고
    • Contrasted blood and intragraft toll-like receptor 4 mRNA profiles in operational tolerance versus chronic rejection in kidney transplant recipients
    • Braudeau C, Ashton-Chess J, Giral M, et al,. Contrasted blood and intragraft toll-like receptor 4 mRNA profiles in operational tolerance versus chronic rejection in kidney transplant recipients. Transplantation 2008; 86: 130.
    • (2008) Transplantation , vol.86 , pp. 130
    • Braudeau, C.1    Ashton-Chess, J.2    Giral, M.3
  • 67
    • 79959667859 scopus 로고    scopus 로고
    • Peripheral blood sampling for the detection of allograft rejection: Biomarker identification and validation
    • Heidt S, San Segundo D, Shankar S, et al,. Peripheral blood sampling for the detection of allograft rejection: biomarker identification and validation. Transplantation 2011; 92: 1.
    • (2011) Transplantation , vol.92 , pp. 1
    • Heidt, S.1    San Segundo, D.2    Shankar, S.3
  • 68
    • 82455200651 scopus 로고    scopus 로고
    • Biomarkers of transplantation tolerance: More hopeful than helpful?
    • Cobbold SP, Adams E, Waldmann H,. Biomarkers of transplantation tolerance: more hopeful than helpful? Front Immunol 2011; 2: 9.
    • (2011) Front Immunol , vol.2 , pp. 9
    • Cobbold, S.P.1    Adams, E.2    Waldmann, H.3
  • 69
    • 84862769981 scopus 로고    scopus 로고
    • Gene expression signature in transplantation tolerance
    • Braza F, Soulillou JP, Brouard S,. Gene expression signature in transplantation tolerance. Clin Chim Acta 2012; 413: 1414.
    • (2012) Clin Chim Acta , vol.413 , pp. 1414
    • Braza, F.1    Soulillou, J.P.2    Brouard, S.3
  • 70
    • 84867263974 scopus 로고    scopus 로고
    • Cellular infiltrates and NFkappaB subunit c-Rel signaling in kidney allografts of patients with clinical operational tolerance
    • Becker LE, De Oliveira Biazotto F, Conrad H, et al,. Cellular infiltrates and NFkappaB subunit c-Rel signaling in kidney allografts of patients with clinical operational tolerance. Transplantation 2012; 94: 729.
    • (2012) Transplantation , vol.94 , pp. 729
    • Becker, L.E.1    De Oliveira Biazotto, F.2    Conrad, H.3
  • 71
    • 84867520227 scopus 로고    scopus 로고
    • Importance of liver biopsy findings in immunosuppression management: Biopsy monitoring and working criteria for patients with operational tolerance
    • Banff Working Group on Liver Allograft P
    • Banff Working Group on Liver Allograft P. Importance of liver biopsy findings in immunosuppression management: biopsy monitoring and working criteria for patients with operational tolerance. Liver Transpl 2012; 18: 1154.
    • (2012) Liver Transpl , vol.18 , pp. 1154
  • 72
    • 84861568296 scopus 로고    scopus 로고
    • Regulatory immune cells in transplantation
    • Wood KJ, Bushell A, Hester J,. Regulatory immune cells in transplantation. Nat Rev Immunol 2012; 12: 417.
    • (2012) Nat Rev Immunol , vol.12 , pp. 417
    • Wood, K.J.1    Bushell, A.2    Hester, J.3
  • 73
    • 78349233811 scopus 로고    scopus 로고
    • Non-human primate regulatory T cells: Current biology and implications for transplantation
    • Dons EM, Raimondi G, Cooper DK, Thomson AW,. Non-human primate regulatory T cells: current biology and implications for transplantation. Transplantation 2010; 90: 811.
    • (2010) Transplantation , vol.90 , pp. 811
    • Dons, E.M.1    Raimondi, G.2    Cooper, D.K.3    Thomson, A.W.4
  • 74
    • 84859005710 scopus 로고    scopus 로고
    • Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant
    • Danger R, Pallier A, Giral M, et al,. Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant. J Am Soc Nephrol 2012; 23: 597.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 597
    • Danger, R.1    Pallier, A.2    Giral, M.3
  • 75
    • 84855467970 scopus 로고    scopus 로고
    • Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation
    • Bohne F, Martinez-Llordella M, Lozano JJ, et al,. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest 2012; 122: 368.
    • (2012) J Clin Invest , vol.122 , pp. 368
    • Bohne, F.1    Martinez-Llordella, M.2    Lozano, J.J.3
  • 76
    • 70349208518 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury
    • Gandolfo MT, Jang HR, Bagnasco SM, et al,. Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int 2009; 76: 717.
    • (2009) Kidney Int , vol.76 , pp. 717
    • Gandolfo, M.T.1    Jang, H.R.2    Bagnasco, S.M.3
  • 78
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov YP, Rasmussen JP, Chi EY, et al,. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008; 28: 546.
    • (2008) Immunity , vol.28 , pp. 546
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3
  • 79
    • 51049101255 scopus 로고    scopus 로고
    • CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner
    • Andersson J, Tran DQ, Pesu M, et al,. CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med 2008; 205: 1975.
    • (2008) J Exp Med , vol.205 , pp. 1975
    • Andersson, J.1    Tran, D.Q.2    Pesu, M.3
  • 80
    • 67749091321 scopus 로고    scopus 로고
    • Infectious tolerance via the consumption of essential amino acids and mTOR signaling
    • Cobbold SP, Adams E, Farquhar CA, et al,. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci USA 2009; 106: 12055.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12055
    • Cobbold, S.P.1    Adams, E.2    Farquhar, C.A.3
  • 81
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
    • Groux H, Bigler M, de Vries JE, Roncarolo MG,. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 1996; 184: 19.
    • (1996) J Exp Med , vol.184 , pp. 19
    • Groux, H.1    Bigler, M.2    De Vries, J.E.3    Roncarolo, M.G.4
  • 82
    • 0032797704 scopus 로고    scopus 로고
    • Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells
    • Liu Z, Tugulea S, Cortesini R, Lederman S, Suciu-Foca N,. Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells. Hum Immunol 1999; 60: 568.
    • (1999) Hum Immunol , vol.60 , pp. 568
    • Liu, Z.1    Tugulea, S.2    Cortesini, R.3    Lederman, S.4    Suciu-Foca, N.5
  • 83
    • 0033929005 scopus 로고    scopus 로고
    • Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    • Zhang ZX, Yang L, Young KJ, DuTemple B, Zhang L,. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 2000; 6: 782.
    • (2000) Nat Med , vol.6 , pp. 782
    • Zhang, Z.X.1    Yang, L.2    Young, K.J.3    Dutemple, B.4    Zhang, L.5
  • 84
    • 1842732223 scopus 로고    scopus 로고
    • Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance
    • Cai J, Lee J, Jankowska-Gan E, et al,. Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance. J Exp Med 2004; 199: 1017.
    • (2004) J Exp Med , vol.199 , pp. 1017
    • Cai, J.1    Lee, J.2    Jankowska-Gan, E.3
  • 85
    • 50949120674 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion
    • Dugast AS, Haudebourg T, Coulon F, et al,. Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion. J Immunol 2008; 180: 7898.
    • (2008) J Immunol , vol.180 , pp. 7898
    • Dugast, A.S.1    Haudebourg, T.2    Coulon, F.3
  • 86
    • 77957338676 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Facilitators of successful transplantation?
    • English K, French A, Wood KJ,. Mesenchymal stromal cells: facilitators of successful transplantation? Cell Stem Cell 2010; 7: 431.
    • (2010) Cell Stem Cell , vol.7 , pp. 431
    • English, K.1    French, A.2    Wood, K.J.3
  • 87
    • 80052180187 scopus 로고    scopus 로고
    • Regulatory macrophages: Setting the threshold for therapy
    • Fleming BD, Mosser DM,. Regulatory macrophages: setting the threshold for therapy. Eur J Immunol 2011; 41: 2498.
    • (2011) Eur J Immunol , vol.41 , pp. 2498
    • Fleming, B.D.1    Mosser, D.M.2
  • 89
    • 79952756877 scopus 로고    scopus 로고
    • Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease
    • Spitzer TR, Sykes M, Tolkoff-Rubin N, et al,. Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation 2011; 91: 672.
    • (2011) Transplantation , vol.91 , pp. 672
    • Spitzer, T.R.1    Sykes, M.2    Tolkoff-Rubin, N.3
  • 90
    • 61849157420 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation for tolerance induction: Animal models to clinical trials
    • Sykes M,. Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials. Transplantation 2009; 87: 309.
    • (2009) Transplantation , vol.87 , pp. 309
    • Sykes, M.1
  • 91
    • 0030956404 scopus 로고    scopus 로고
    • Chimerism and tolerance: From freemartin cattle and neonatal mice to humans
    • Jankowski RA, Ildstad ST,. Chimerism and tolerance: from freemartin cattle and neonatal mice to humans. Hum Immunol 1997; 52: 155.
    • (1997) Hum Immunol , vol.52 , pp. 155
    • Jankowski, R.A.1    Ildstad, S.T.2
  • 92
    • 80052874431 scopus 로고    scopus 로고
    • Immuno-intervention for the induction of transplantation tolerance through mixed chimerism
    • Sachs DH, Sykes M, Kawai T, Cosimi AB,. Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol 2011; 23: 165.
    • (2011) Semin Immunol , vol.23 , pp. 165
    • Sachs, D.H.1    Sykes, M.2    Kawai, T.3    Cosimi, A.B.4
  • 93
    • 84860433872 scopus 로고    scopus 로고
    • Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants
    • Scandling JD, Busque S, Dejbakhsh-Jones S, et al,. Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant 2012; 12: 1133.
    • (2012) Am J Transplant , vol.12 , pp. 1133
    • Scandling, J.D.1    Busque, S.2    Dejbakhsh-Jones, S.3
  • 94
    • 78650835204 scopus 로고    scopus 로고
    • Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    • Issa F, Hester J, Goto R, Nadig SN, Goodacre TE, Wood K,. Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 2010; 90: 1321.
    • (2010) Transplantation , vol.90 , pp. 1321
    • Issa, F.1    Hester, J.2    Goto, R.3    Nadig, S.N.4    Goodacre, T.E.5    Wood, K.6
  • 95
    • 80053612507 scopus 로고    scopus 로고
    • Regulatory T cells as modulators of chronic allograft dysfunction
    • Issa F, Chandrasekharan D, Wood KJ,. Regulatory T cells as modulators of chronic allograft dysfunction. Curr Opin Immunol 2011; 23: 648.
    • (2011) Curr Opin Immunol , vol.23 , pp. 648
    • Issa, F.1    Chandrasekharan, D.2    Wood, K.J.3
  • 96
    • 78049267160 scopus 로고    scopus 로고
    • T regulatory cells and the control of alloimmunity: From characterisation to clinical application
    • Wieckiewicz J, Goto R, Wood KJ,. T regulatory cells and the control of alloimmunity: from characterisation to clinical application. Curr Opin Immunol 2010; 22: 662.
    • (2010) Curr Opin Immunol , vol.22 , pp. 662
    • Wieckiewicz, J.1    Goto, R.2    Wood, K.J.3
  • 97
    • 77954539326 scopus 로고    scopus 로고
    • In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    • Nadig SN, Wieckiewicz J, Wu DC, et al,. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med 2010; 16: 809.
    • (2010) Nat Med , vol.16 , pp. 809
    • Nadig, S.N.1    Wieckiewicz, J.2    Wu, D.C.3
  • 98
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: New therapeutics for graft-versus-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL,. CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med 2002; 196: 401.
    • (2002) J Exp Med , vol.196 , pp. 401
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 99
    • 23844455192 scopus 로고    scopus 로고
    • Expansion of functional endogenous antigen-specific CD4+ CD25+ regulatory T cells from nonobese diabetic mice
    • Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA,. Expansion of functional endogenous antigen-specific CD4+ CD25+ regulatory T cells from nonobese diabetic mice. J Immunol 2005; 175: 3053.
    • (2005) J Immunol , vol.175 , pp. 3053
    • Masteller, E.L.1    Warner, M.R.2    Tang, Q.3    Tarbell, K.V.4    McDevitt, H.5    Bluestone, J.A.6
  • 100
    • 33846214275 scopus 로고    scopus 로고
    • In vitro-expanded donor alloantigen-specific CD4+ CD25+ regulatory T cells promote experimental transplantation tolerance
    • Golshayan D, Jiang S, Tsang J, Garin MI, Mottet C, Lechler RI,. In vitro-expanded donor alloantigen-specific CD4+ CD25+ regulatory T cells promote experimental transplantation tolerance. Blood 2007; 109: 827.
    • (2007) Blood , vol.109 , pp. 827
    • Golshayan, D.1    Jiang, S.2    Tsang, J.3    Garin, M.I.4    Mottet, C.5    Lechler, R.I.6
  • 101
    • 77955380678 scopus 로고    scopus 로고
    • Human antigen-specific regulatory T cells generated by T cell receptor gene transfer
    • Brusko TM, Koya RC, Zhu S, et al,. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PLoS One 2010; 5: e11726.
    • (2010) PLoS One , vol.5
    • Brusko, T.M.1    Koya, R.C.2    Zhu, S.3
  • 102
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, et al,. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011; 117: 1061.
    • (2011) Blood , vol.117 , pp. 1061
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 103
    • 80053597291 scopus 로고    scopus 로고
    • Regulatory T cells in stem cell transplantation: Strategies and first clinical experiences
    • Edinger M, Hoffmann P,. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr Opin Immunol 2011; 23: 679.
    • (2011) Curr Opin Immunol , vol.23 , pp. 679
    • Edinger, M.1    Hoffmann, P.2
  • 104
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M, Falzetti F, Carotti A, et al,. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011; 117: 3921.
    • (2011) Blood , vol.117 , pp. 3921
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 105
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW,. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007; 178: 7018.
    • (2007) J Immunol , vol.178 , pp. 7018
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 106
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF,. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105: 1815.
    • (2005) Blood , vol.105 , pp. 1815
    • Aggarwal, S.1    Pittenger, M.F.2
  • 107
    • 45249100402 scopus 로고    scopus 로고
    • Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in rats
    • Aksu AE, Horibe E, Sacks J, et al,. Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in rats. Clin Immunol 2008; 127: 348.
    • (2008) Clin Immunol , vol.127 , pp. 348
    • Aksu, A.E.1    Horibe, E.2    Sacks, J.3
  • 108
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study
    • Le Blanc K, Frassoni F, Ball L, et al,. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008; 371: 1579.
    • (2008) Lancet , vol.371 , pp. 1579
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3
  • 109
    • 77952319188 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy: Two steps forward, one step back
    • Ankrum J, Karp JM,. Mesenchymal stem cell therapy: two steps forward, one step back. Trends Mol Med 2010; 16: 203.
    • (2010) Trends Mol Med , vol.16 , pp. 203
    • Ankrum, J.1    Karp, J.M.2
  • 110
    • 79957602397 scopus 로고    scopus 로고
    • Regulatory T cells get their chance to shine
    • Leslie M. Immunology,. Regulatory T cells get their chance to shine. Science 2011; 332: 1020.
    • (2011) Science , vol.332 , pp. 1020
    • Leslie, M.I.1
  • 111
    • 84874206502 scopus 로고    scopus 로고
    • Translating tolerogenic therapies to the clinic - Where do we stand?
    • Issa F, Wood KJ,. Translating tolerogenic therapies to the clinic-where do we stand? Front Immunol 2012; 3: 254.
    • (2012) Front Immunol , vol.3 , pp. 254
    • Issa, F.1    Wood, K.J.2
  • 112
  • 113
    • 41849131031 scopus 로고    scopus 로고
    • Immunosuppressive drug-free operational immune tolerance in human kidney transplant recipients: Part I. Blood gene expression statistical analysis
    • Braud C, Baeten D, Giral M, et al,. Immunosuppressive drug-free operational immune tolerance in human kidney transplant recipients: part I. Blood gene expression statistical analysis. J Cell Biochem 2008; 103: 1681.
    • (2008) J Cell Biochem , vol.103 , pp. 1681
    • Braud, C.1    Baeten, D.2    Giral, M.3
  • 114
    • 41849100385 scopus 로고    scopus 로고
    • Immunosuppressive drug-free operational immune tolerance in human kidney transplants recipients. Part II. Non-statistical gene microarray analysis
    • Sivozhelezov V, Braud C, Giacomelli L, et al,. Immunosuppressive drug-free operational immune tolerance in human kidney transplants recipients. Part II. Non-statistical gene microarray analysis. J Cell Biochem 2008; 103: 1693.
    • (2008) J Cell Biochem , vol.103 , pp. 1693
    • Sivozhelezov, V.1    Braud, C.2    Giacomelli, L.3
  • 115
    • 79955563324 scopus 로고    scopus 로고
    • Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients
    • Brouard S, Le Bars A, Dufay A, et al,. Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients. Transpl Int 2011; 24: 536.
    • (2011) Transpl Int , vol.24 , pp. 536
    • Brouard, S.1    Le Bars, A.2    Dufay, A.3
  • 117
    • 84869016099 scopus 로고    scopus 로고
    • PARVG gene polymorphism and operational renal allograft tolerance
    • Danger R, Thervet E, Grisoni ML, et al,. PARVG gene polymorphism and operational renal allograft tolerance. Transplant Proc 2012; 44: 2845.
    • (2012) Transplant Proc , vol.44 , pp. 2845
    • Danger, R.1    Thervet, E.2    Grisoni, M.L.3
  • 118
    • 33846252277 scopus 로고    scopus 로고
    • Multiparameter immune profiling of operational tolerance in liver transplantation
    • Martinez-Llordella M, Puig-Pey I, Orlando G, et al,. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007; 7: 309.
    • (2007) Am J Transplant , vol.7 , pp. 309
    • Martinez-Llordella, M.1    Puig-Pey, I.2    Orlando, G.3
  • 119
    • 48749084927 scopus 로고    scopus 로고
    • Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients
    • Martinez-Llordella M, Lozano JJ, Puig-Pey I, et al,. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008; 118: 2845.
    • (2008) J Clin Invest , vol.118 , pp. 2845
    • Martinez-Llordella, M.1    Lozano, J.J.2    Puig-Pey, I.3
  • 120
    • 79955623447 scopus 로고    scopus 로고
    • HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance
    • Castellaneta A, Mazariegos GV, Nayyar N, Zeevi A, Thomson AW,. HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance. Transplantation 2011; 91: 1132.
    • (2011) Transplantation , vol.91 , pp. 1132
    • Castellaneta, A.1    Mazariegos, G.V.2    Nayyar, N.3    Zeevi, A.4    Thomson, A.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.