Immunosuppression withdrawal after liver transplantation: What are the next steps?

Transplantation

Volumn 91, Issue 7, 2011, Pages 697-699

  Mazariegos, George V ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Immunosuppression withdrawal; Liver transplantation; Operational tolerance

Indexed keywords

BIOLOGICAL MARKER; HLA G ANTIGEN; INTERLEUKIN 17F;

CLINICAL TRIAL (TOPIC); DENDRITIC CELL; DISEASE MARKER; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; LYMPHOCYTE FUNCTION; MULTICENTER STUDY (TOPIC); PATIENT MONITORING; PATIENT SAFETY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REGULATORY T LYMPHOCYTE; REVIEW; RISK BENEFIT ANALYSIS; TREATMENT WITHDRAWAL;

HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; TRANSPLANTATION TOLERANCE;

EID: 79954778147     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31820c85a3     Document Type: Review

References (14)

1. Auchincloss H Jr. In search of the elusive Holy Grail: The mechanisms and prospects for achieving clinical transplantation tolerance. Am J Transplant 2001; 1: 6.
2. Orlando G, Soker S, Wood K. Operational tolerance after liver transplantation. J Hepatol 2009; 50: 1247.
3. Feng S. Immunosuppression withdrawal in pediatric recipients of parental living donor liver transplants: Preliminary results of a pilot study. Am J Transplant 2009; 9: 244.
4. Turka LA, Wood K, Bluestone JA. Bringing transplantation tolerance into the clinic: Lessons from the ITN and RISET for the establishment of tolerance consortia. Curr Opin Organ Transplant 2010; 15: 441.
5. Castellaneta A, Thomson A, Nayyar N, et al. Monitoring the operationally tolerant liver allograft recipient. Curr Opin Organ Transplant 2010; 15: 28.
6. Sanchez-Fueyo A. Identification of operationally tolerant liver transplant recipients. Liver Transpl 2010; 16: S82.
7. Martinez-Llordella M, Lozano JJ, Puig-Pey I, et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008; 118: 2845.
8. Girnita A, Mazariegos GV, Castellaneta A, et al. Liver transplant recipients weaned off immunosuppression lack circulating donor-specific antibodies. Hum Immunol 2010; 71: 274.
9. Pons JA, Revilla-Nuin B, Baroja-Mazo A, et al. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal. Transplantation 2008; 86: 1370.
10. Jiang S, Lechler RI. Regulatory T cells in the control of transplantation tolerance and autoimmunity. Am J Transplant 2003; 3: 516.
11. Natarajan S, Thomson AW. Tolerogenic dendritic cells and myeloidderived suppressor cells: Potential for regulation and therapy of liver auto- and alloimmunity. Immunobiology 2010; 215: 698.
12. Demetris AJ, Lunz JG III, Randhawa P, et al. Monitoring of human liver and kidney allograft tolerance: A tissue/histopathology perspective. Transpl Int 2009; 22: 120.
13. Yoshitomi M, Koshiba T, Haga H, et al. Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation. Transplantation 2009; 87: 606.
14. Kirk A.D. Meteorology and tolerance. Am J Transplant 2006; 6: 645.