-
1
-
-
47049112231
-
Combinations of 2'-Cmethylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system
-
Bassit, L., Grier, J., Bennett, M., Schinazi, R.F., 2008. Combinations of 20-Cmethylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system. Antivir. Chem. Chemother. 19, 25-31.
-
(2008)
Antivir. Chem. Chemother.
, vol.19
, pp. 25-31
-
-
Bassit, L.1
Grier, J.2
Bennett, M.3
Schinazi, R.F.4
-
3
-
-
77649247824
-
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
-
Chockalingam, K., Simeon, R.L., Rice, C.M., Chen, Z., 2010. A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle. Proc. Natl. Acad. Sci. USA 107, 3764-3769.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 3764-3769
-
-
Chockalingam, K.1
Simeon, R.L.2
Rice, C.M.3
Chen, Z.4
-
4
-
-
76249126162
-
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection
-
Gastaminza, P., Whitten-Bauer, C., Chisari, F.V., 2010. Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection. Proc. Natl. Acad. Sci. USA 107, 291-296.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 291-296
-
-
Gastaminza, P.1
Whitten-Bauer, C.2
Chisari, F.V.3
-
5
-
-
78751634447
-
Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity
-
Gentzsch, J., Hinkelmann, B., Kaderali, L., Irschik, H., Jansen, R., Sasse, F., Frank, R., Pietschmann, T., 2011. Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res. 89, 136-148.
-
(2011)
Antiviral Res.
, vol.89
, pp. 136-148
-
-
Gentzsch, J.1
Hinkelmann, B.2
Kaderali, L.3
Irschik, H.4
Jansen, R.5
Sasse, F.6
Frank, R.7
Pietschmann, T.8
-
6
-
-
80053339008
-
An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases
-
American Association for Study of Liver, D
-
Ghany, M.G., Nelson, D.R., Strader, D.B., Thomas, D.L., Seeff, L.B., American Association for Study of Liver, D., 2011. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 54, 1433-1444.
-
(2011)
Hepatology
, vol.54
, pp. 1433-1444
-
-
Ghany, M.G.1
Nelson, D.R.2
Strader, D.B.3
Thomas, D.L.4
Seeff, L.B.5
-
7
-
-
33644547392
-
Antiviral therapy for chronic hepatitis C: past, present, and future
-
Hayashi, N., Takehara, T., 2006. Antiviral therapy for chronic hepatitis C: past, present, and future. J. Gastroenterol. 41, 17-27.
-
(2006)
J. Gastroenterol.
, vol.41
, pp. 17-27
-
-
Hayashi, N.1
Takehara, T.2
-
8
-
-
76349104162
-
Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system
-
Jones, C.T., Catanese, M.T., Law, L.M., Khetani, S.R., Syder, A.J., Ploss, A., Oh, T.S., Schoggins, J.W., MacDonald, M.R., Bhatia, S.N., Rice, C.M., 2010. Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat. Biotechnol. 28, 167-171.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 167-171
-
-
Jones, C.T.1
Catanese, M.T.2
Law, L.M.3
Khetani, S.R.4
Syder, A.J.5
Ploss, A.6
Oh, T.S.7
Schoggins, J.W.8
MacDonald, M.R.9
Bhatia, S.N.10
Rice, C.M.11
-
9
-
-
72849113547
-
Identification of hepatitis C virus NS5A inhibitors
-
Lemm, J.A., O'Boyle 2nd, D., Liu, M., Nower, P.T., Colonno, R., Deshpande, M.S., Snyder, L.B., Martin, S.W., St Laurent, D.R., Serrano-Wu, M.H., Romine, J.L., Meanwell, N.A., Gao, M., 2010. Identification of hepatitis C virus NS5A inhibitors. J. Virol. 84, 482-491.
-
(2010)
J. Virol.
, vol.84
, pp. 482-491
-
-
Lemm, J.A.1
O'Boyle, D.2
Liu, M.3
Nower, P.T.4
Colonno, R.5
Deshpande, M.S.6
Snyder, L.B.7
Martin, S.W.8
St Laurent, D.R.9
Serrano-Wu, M.H.10
Romine, J.L.11
Meanwell, N.A.12
Gao, M.13
-
10
-
-
84870372937
-
Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
-
Li, Y.P., Ramirez, S., Jensen, S.B., Purcell, R.H., Gottwein, J.M., Bukh, J., 2012. Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system. Proc. Natl. Acad. Sci. USA 109, 19757-19762.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 19757-19762
-
-
Li, Y.P.1
Ramirez, S.2
Jensen, S.B.3
Purcell, R.H.4
Gottwein, J.M.5
Bukh, J.6
-
11
-
-
33646446894
-
VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells
-
Lin, K., Perni, R.B., Kwong, A.D., Lin, C., 2006. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells. Antimicrob. Agents Chemother. 50, 1813-1822.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 1813-1822
-
-
Lin, K.1
Perni, R.B.2
Kwong, A.D.3
Lin, C.4
-
12
-
-
23044437222
-
Complete replication of hepatitis C virus in cell culture
-
Lindenbach, B.D., Evans, M.J., Syder, A.J., Wolk, B., Tellinghuisen, T.L., Liu, C.C., Maruyama, T., Hynes, R.O., Burton, D.R., McKeating, J.A., Rice, C.M., 2005. Complete replication of hepatitis C virus in cell culture. Science 309, 623-626.
-
(2005)
Science
, vol.309
, pp. 623-626
-
-
Lindenbach, B.D.1
Evans, M.J.2
Syder, A.J.3
Wolk, B.4
Tellinghuisen, T.L.5
Liu, C.C.6
Maruyama, T.7
Hynes, R.O.8
Burton, D.R.9
McKeating, J.A.10
Rice, C.M.11
-
13
-
-
33644862356
-
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
-
Lindenbach, B.D., Meuleman, P., Ploss, A., Vanwolleghem, T., Syder, A.J., McKeating, J.A., Lanford, R.E., Feinstone, S.M., Major, M.E., Leroux-Roels, G., Rice, C.M., 2006. Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro. Proc. Nat. Acad. Sci. USA 103, 3805-3809.
-
(2006)
Proc. Nat. Acad. Sci. USA
, vol.103
, pp. 3805-3809
-
-
Lindenbach, B.D.1
Meuleman, P.2
Ploss, A.3
Vanwolleghem, T.4
Syder, A.J.5
McKeating, J.A.6
Lanford, R.E.7
Feinstone, S.M.8
Major, M.E.9
Leroux-Roels, G.10
Rice, C.M.11
-
14
-
-
0345188811
-
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
-
Lohmann, V., Korner, F., Koch, J., Herian, U., Theilmann, L., Bartenschlager, R., 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285, 110-113.
-
(1999)
Science
, vol.285
, pp. 110-113
-
-
Lohmann, V.1
Korner, F.2
Koch, J.3
Herian, U.4
Theilmann, L.5
Bartenschlager, R.6
-
15
-
-
33645805870
-
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection
-
Loo, Y.M., Owen, D.M., Li, K., Erickson, A.K., Johnson, C.L., Fish, P.M., Carney, D.S., Wang, T., Ishida, H., Yoneyama, M., Fujita, T., Saito, T., Lee, W.M., Hagedorn, C.H., Lau, D.T., Weinman, S.A., Lemon, S.M., Gale Jr., M., 2006. Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc. Nat. Acad. Sci. USA 103, 6001-6006.
-
(2006)
Proc. Nat. Acad. Sci. USA
, vol.103
, pp. 6001-6006
-
-
Loo, Y.M.1
Owen, D.M.2
Li, K.3
Erickson, A.K.4
Johnson, C.L.5
Fish, P.M.6
Carney, D.S.7
Wang, T.8
Ishida, H.9
Yoneyama, M.10
Fujita, T.11
Saito, T.12
Lee, W.M.13
Hagedorn, C.H.14
Lau, D.T.15
Weinman, S.A.16
Lemon, S.M.17
Gale, M.18
-
16
-
-
34547428987
-
Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro
-
Lu, L., Dekhtyar, T., Masse, S., Pithawalla, R., Krishnan, P., He, W., Ng, T., Koev, G., Stewart, K., Larson, D., Bosse, T., Wagner, R., Pilot-Matias, T., Mo, H., Molla, A., 2007. Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro. Antiviral Res. 76, 93-97.
-
(2007)
Antiviral Res.
, vol.76
, pp. 93-97
-
-
Lu, L.1
Dekhtyar, T.2
Masse, S.3
Pithawalla, R.4
Krishnan, P.5
He, W.6
Ng, T.7
Koev, G.8
Stewart, K.9
Larson, D.10
Bosse, T.11
Wagner, R.12
Pilot-Matias, T.13
Mo, H.14
Molla, A.15
-
17
-
-
33747797031
-
Treating viral hepatitis C: efficacy, side effects, and complications
-
Manns, M.P., Wedemeyer, H., Cornberg, M., 2006. Treating viral hepatitis C: efficacy, side effects, and complications. Gut 55, 1350-1359.
-
(2006)
Gut
, vol.55
, pp. 1350-1359
-
-
Manns, M.P.1
Wedemeyer, H.2
Cornberg, M.3
-
18
-
-
62049083697
-
Development of a cell-based assay for high-throughput screening of inhibitors against HCV genotypes 1a and 1b in a single well
-
Mondal, R., Koev, G., Pilot-Matias, T., He, Y., Ng, T., Kati, W., Molla, A., 2009. Development of a cell-based assay for high-throughput screening of inhibitors against HCV genotypes 1a and 1b in a single well. Antiviral Res. 82, 82-88.
-
(2009)
Antiviral Res.
, vol.82
, pp. 82-88
-
-
Mondal, R.1
Koev, G.2
Pilot-Matias, T.3
He, Y.4
Ng, T.5
Kati, W.6
Molla, A.7
-
19
-
-
3142764760
-
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes
-
Moradpour, D., Evans, M.J., Gosert, R., Yuan, Z., Blum, H.E., Goff, S.P., Lindenbach, B.D., Rice, C.M., 2004. Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J. Virol. 78, 7400-7409.
-
(2004)
J. Virol.
, vol.78
, pp. 7400-7409
-
-
Moradpour, D.1
Evans, M.J.2
Gosert, R.3
Yuan, Z.4
Blum, H.E.5
Goff, S.P.6
Lindenbach, B.D.7
Rice, C.M.8
-
20
-
-
78049375232
-
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977
-
Murakami, E., Tolstykh, T., Bao, H., Niu, C., Steuer, H.M., Bao, D., Chang, W., Espiritu, C., Bansal, S., Lam, A.M., Otto, M.J., Sofia, M.J., Furman, P.A., 2010. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J. Biol. Chem 285, 34337-34347.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 34337-34347
-
-
Murakami, E.1
Tolstykh, T.2
Bao, H.3
Niu, C.4
Steuer, H.M.5
Bao, D.6
Chang, W.7
Espiritu, C.8
Bansal, S.9
Lam, A.M.10
Otto, M.J.11
Sofia, M.J.12
Furman, P.A.13
-
21
-
-
33646556662
-
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras
-
Pietschmann, T., Kaul, A., Koutsoudakis, G., Shavinskaya, A., Kallis, S., Steinmann, E., Abid, K., Negro, F., Dreux, M., Cosset, F.L., Bartenschlager, R., 2006. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc. Nat. Acad. Sci. USA 103, 7408-7413.
-
(2006)
Proc. Nat. Acad. Sci. USA
, vol.103
, pp. 7408-7413
-
-
Pietschmann, T.1
Kaul, A.2
Koutsoudakis, G.3
Shavinskaya, A.4
Kallis, S.5
Steinmann, E.6
Abid, K.7
Negro, F.8
Dreux, M.9
Cosset, F.L.10
Bartenschlager, R.11
-
22
-
-
34547697754
-
Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation
-
Shepherd, J., Jones, J., Hartwell, D., Davidson, P., Price, A., Waugh, N., 2007. Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation. Health Technol. Assess. 11, 1-205, iii.
-
(2007)
Health Technol. Assess.
, vol.11
, pp. 1-205
-
-
Shepherd, J.1
Jones, J.2
Hartwell, D.3
Davidson, P.4
Price, A.5
Waugh, N.6
-
23
-
-
25844523297
-
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
-
Simmonds, P., Bukh, J., Combet, C., Deleage, G., Enomoto, N., Feinstone, S., Halfon, P., Inchauspe, G., Kuiken, C., Maertens, G., Mizokami, M., Murphy, D.G., Okamoto, H., Pawlotsky, J.M., Penin, F., Sablon, E., Shin, I.T., Stuyver, L.J., Thiel, H.J., Viazov, S., Weiner, A.J., Widell, A., 2005. Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 42, 962-973.
-
(2005)
Hepatology
, vol.42
, pp. 962-973
-
-
Simmonds, P.1
Bukh, J.2
Combet, C.3
Deleage, G.4
Enomoto, N.5
Feinstone, S.6
Halfon, P.7
Inchauspe, G.8
Kuiken, C.9
Maertens, G.10
Mizokami, M.11
Murphy, D.G.12
Okamoto, H.13
Pawlotsky, J.M.14
Penin, F.15
Sablon, E.16
Shin, I.T.17
Stuyver, L.J.18
Thiel, H.J.19
Viazov, S.20
Weiner, A.J.21
Widell, A.22
more..
-
24
-
-
77957913871
-
Discovery of a beta-d-20- deoxy-20-alpha-fluoro-20-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus
-
Sofia, M.J., Bao, D., Chang, W., Du, J., Nagarathnam, D., Rachakonda, S., Reddy, P.G., Ross, B.S., Wang, P., Zhang, H.R., Bansal, S., Espiritu, C., Keilman, M., Lam, A.M., Steuer, H.M., Niu, C., Otto, M.J., Furman, P.A., 2010. Discovery of a beta-d-20- deoxy-20-alpha-fluoro-20-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J. Med. Chem. 53, 7202-7218.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7202-7218
-
-
Sofia, M.J.1
Bao, D.2
Chang, W.3
Du, J.4
Nagarathnam, D.5
Rachakonda, S.6
Reddy, P.G.7
Ross, B.S.8
Wang, P.9
Zhang, H.R.10
Bansal, S.11
Espiritu, C.12
Keilman, M.13
Lam, A.M.14
Steuer, H.M.15
Niu, C.16
Otto, M.J.17
Furman, P.A.18
-
25
-
-
22544470874
-
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
-
Wakita, T., Pietschmann, T., Kato, T., Date, T., Miyamoto, M., Zhao, Z., Murthy, K., Habermann, A., Krausslich, H.G., Mizokami, M., Bartenschlager, R., Liang, T.J., 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 11, 791-796.
-
(2005)
Nat. Med.
, vol.11
, pp. 791-796
-
-
Wakita, T.1
Pietschmann, T.2
Kato, T.3
Date, T.4
Miyamoto, M.5
Zhao, Z.6
Murthy, K.7
Habermann, A.8
Krausslich, H.G.9
Mizokami, M.10
Bartenschlager, R.11
Liang, T.J.12
-
26
-
-
85030415632
-
-
WHO, 2012. http://www.who.int/csr/disease/hepatitis/whocdscsrlyo2003/en/ index4.html.
-
(2012)
WHO
-
-
-
27
-
-
84864717950
-
High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus
-
Wichroski, M.J., Fang, J., Eggers, B.J., Rose, R.E., Mazzucco, C.E., Pokornowski, K.A., Baldick, C.J., Anthony, M.N., Dowling, C.J., Barber, L.E., Leet, J.E., Beno, B.R., Gerritz, S.W., Agler, M.L., Cockett, M.I., Tenney, D.J., 2012. High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus. PLoS ONE 7, e42609.
-
(2012)
PLoS ONE
, vol.7
-
-
Wichroski, M.J.1
Fang, J.2
Eggers, B.J.3
Rose, R.E.4
Mazzucco, C.E.5
Pokornowski, K.A.6
Baldick, C.J.7
Anthony, M.N.8
Dowling, C.J.9
Barber, L.E.10
Leet, J.E.11
Beno, B.R.12
Gerritz, S.W.13
Agler, M.L.14
Cockett, M.I.15
Tenney, D.J.16
-
28
-
-
33144471074
-
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells
-
Yi, M., Villanueva, R.A., Thomas, D.L., Wakita, T., Lemon, S.M., 2006. Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc. Natl. Acad. Sci. USA 103, 2310-2315.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2310-2315
-
-
Yi, M.1
Villanueva, R.A.2
Thomas, D.L.3
Wakita, T.4
Lemon, S.M.5
-
29
-
-
21544440397
-
Robust hepatitis C virus infection in vitro
-
Zhong, J., Gastaminza, P., Cheng, G., Kapadia, S., Kato, T., Burton, D.R., Wieland, S.F., Uprichard, S.L., Wakita, T., Chisari, F.V., 2005. Robust hepatitis C virus infection in vitro. Proc. Natl. Acad. Sci. USA 102, 9294-9299.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9294-9299
-
-
Zhong, J.1
Gastaminza, P.2
Cheng, G.3
Kapadia, S.4
Kato, T.5
Burton, D.R.6
Wieland, S.F.7
Uprichard, S.L.8
Wakita, T.9
Chisari, F.V.10
|