Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of "chemoattractant receptor homologous molecule expressed on Th2 cells" (CRTH2)

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 3, 2013, Pages 434-440

  Tasaki, Mamoru ^a   Kobayashi, Miki ^a   Tenda, Yoshiyuki ^a   Tsujimoto, Susumu ^a   Nakazato, Shoko ^a   Numazaki, Mako ^a   Hirano, Yasuno ^a   Matsuda, Hiroshi ^a   Terasaka, Tadashi ^a   Miyao, Yasuhiro ^a   Shimizu, Yasuaki ^a   Hirayama, Yoshitaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Airway hyper responsiveness; ASP5642; Chemoattractant receptor homologous molecule expressed on T helper type 2 cells; Guinea pig; Prostaglandin D2

Indexed keywords

ANTIINFLAMMATORY AGENT; ASP 5642; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON T HELPER TYPE 2 CELL; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RAMATROBAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG EFFECT; EOSINOPHILIA; EXPERIMENTAL GUINEA PIG; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY FUNCTION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIGENS; BENZHYDRYL COMPOUNDS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CARBAZOLES; CELL COUNT; EOSINOPHILIA; GUINEA PIGS; HEK293 CELLS; HUMANS; K562 CELLS; MALE; OVALBUMIN; PNEUMONIA; PROSTAGLANDIN D2; PYRIDAZINES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SULFONAMIDES;

EID: 84878005145     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.04.017     Document Type: Article

References (27)

1. H. Abe, T. Takeshita, K. Nagata, T. Arita, Y. Endo, T. Fujita, H. Takayama, M. Kubo, and K. Sugamura Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family Gene 227 1999 71 77
2. F.G. Gervais, R.P. Cruz, A. Chateauneuf, S. Gale, N. Sawyer, F. Nantel, K.M. Metters, and G.P. O'Neill Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP J. Allergy Clin. Immunol. 108 2001 982 988
3. F.G. Gervais, N. Sawyer, R. Stocco, M. Hamel, C. Krawczyk, S. Sillaots, D. Denis, E. Wong, Z. Wang, M. Gallant, W.M. Abraham, D. Slipetz, M.A. Crackower, and G.P. O'Neill Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist Mol. Pharmacol. 79 2011 69 76
4. G.J. Gleich Mechanisms of eosinophil-associated inflammation J. Allergy Clin. Immunol. 105 2000 651 663
5. P. Gosset, F. Bureau, V. Angeli, M. Pichavant, C. Faveeuw, A.B. Tonnel, and F. Trottein Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells J. Immunol. 170 2003 4943 4952
6. H. Hirai, K. Tanaka, O. Yoshie, K. Ogawa, K. Kenmotsu, Y. Takamori, M. Ichimasa, K. Sugamura, M. Nakamura, S. Takano, and K. Nagata Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193 2001 255 261
7. S. Kagawa, K. Fukunaga, T. Oguma, Y. Suzuki, T. Shiomi, K. Sayama, T. Kimura, H. Hirai, K. Nagata, M. Nakamura, and K. Asano Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma Int. Arch. Allergy Immunol. 155 Suppl. 1 2011 6 11
8. P. Kallos, and L. Kallos Experimental asthma in guinea pigs revisited Int. Arch. Allergy Appl. Immunol. 73 1984 77 85
9. J.G. Kirby, F.E. Hargreave, G.J. Gleich, and P.M. O'Byrne Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects Am. Rev. Respir. Dis. 136 1987 379 383
10. M. Larche, D.S. Robinson, and A.B. Kay The role of T lymphocytes in the pathogenesis of asthma J. Allergy Clin. Immunol. 111 2003 450 463 quiz 464
11. H.Q. Lou, Y.F. Ying, and Y. Hu CRTH2 antagonist ameliorates airway inflammation in rats with asthma Zhejiang Da Xue Xue Bao Yi Xue Ban 39 2010 64 70
12. N.W. Lukacs, A.A. Berlin, K. Franz-Bacon, R. Sasik, L.J. Sprague, T.W. Ly, G. Hardiman, S.A. Boehme, and K.B. Bacon CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation Am. J. Physiol. Lung Cell. Mol. Physiol. 295 2008 L767 779
13. A. Miadonna, A. Tedeschi, C. Brasca, G. Folco, A. Sala, and R.C. Murphy Mediator release after endobronchial antigen challenge in patients with respiratory allergy J. Allergy Clin. Immunol. 85 1990 906 913
14. G. Monneret, S. Gravel, M. Diamond, J. Rokach, and W.S. Powell Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood 98 2001 1942 1948
15. R.M. Muccitelli, S.S. Tucker, D.W. Hay, T.J. Torphy, and M.A. Wasserman Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractions J. Pharmacol. Exp. Ther. 243 1987 467 473
16. R. Pettipher The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses Br. J. Pharmacol. 153 Suppl. 1 2008 S191 199
17. R. Pettipher, S.L. Vinall, L. Xue, G. Speight, E.R. Townsend, L. Gazi, C.J. Whelan, R.E. Armer, M.A. Payton, and M.G. Hunter Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils J. Pharmacol. Exp. Ther. 340 2012 473 482
18. J.F. Royer, P. Schratl, S. Lorenz, E. Kostenis, T. Ulven, R. Schuligoi, B.A. Peskar, and A. Heinemann A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst Allergy 62 2007 1401 1409
19. P. Schratl, J.F. Royer, E. Kostenis, T. Ulven, E.M. Sturm, M. Waldhoer, G. Hoefler, R. Schuligoi, I.T. Lippe, B.A. Peskar, and A. Heinemann The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking J. Immunol. 179 2007 4792 4799
20. M. Shichijo, H. Sugimoto, K. Nagao, H. Inbe, J.A. Encinas, K. Takeshita, K.B. Bacon, and F. Gantner Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats J. Pharmacol. Exp. Ther. 307 2003 518 525
21. C.S. Stevenson, and M.G. Belvisi Preclinical animal models of asthma and chronic obstructive pulmonary disease Exp. Rev. Respir. Med. 2 2008 631 643
22. H. Sugimoto, M. Shichijo, T. Iino, Y. Manabe, A. Watanabe, M. Shimazaki, F. Gantner, and K.B. Bacon An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro J. Pharmacol. Exp. Ther. 305 2003 347 352
23. L. Uller, J.M. Mathiesen, L. Alenmyr, M. Korsgren, T. Ulven, T. Hogberg, G. Andersson, C.G. Persson, and E. Kostenis Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation Respir. Res. 8 2007 16
24. L. Walch, C. Labat, J.P. Gascard, V. de Montpreville, C. Brink, and X. Norel Prostanoid receptors involved in the relaxation of human pulmonary vessels Br. J. Pharmacol. 126 1999 859 866
25. C.J. Whelan Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5 Inflam. Res. 58 2009 103 108
26. L. Xue, S.L. Gyles, F.R. Wettey, L. Gazi, E. Townsend, M.G. Hunter, and R. Pettipher Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells J. Immunol. 175 2005 6531 6536
27. C. Yoshimura-Uchiyama, M. Iikura, M. Yamaguchi, H. Nagase, A. Ishii, K. Matsushima, K. Yamamoto, M. Shichijo, K.B. Bacon, and K. Hirai Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2 Clin. Exp. Allergy 34 2004 1283 1290