A systematic, integrated study on the neuroprotective effects of hydroxysafflor yellow a revealed by 1H NMR-based metabonomics and the NF-κB pathway

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Liu, Yuanyan ^a,b   Lian, Zeqin ^a   Zhu, Haibo ^a   Wang, Yinghong ^a   Yu, Shishan ^a   Chen, Tingting ^a   Qu, Jing ^a   Li, Jianbei ^a   Ma, Shuanggang ^a   Chen, Xianhong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYSAFFLOR YELLOW A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; NEUROPROTECTIVE AGENT; PLANT MEDICINAL PRODUCT; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING KINETICS; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; ENERGY METABOLISM; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SAFFLOWER; UPREGULATION;

EID: 84877994420     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/147362     Document Type: Article

References (73)

1. Hachinski V., Iadecola C., Petersen R. C., Breteler M. M., Nyenhuis D. L., Black S. E., Powers W. J., DeCarli C., Merino J. G., Kalaria R. N., Vinters H. V., Holtzman D. M., Rosenberg G. A., Wallin A., Dichgans M., Marler J. R., Leblanc G. G., National institute of neurological disorders and stroke-Canadian stroke network vascular cognitive impairment harmonization standards. Stroke 2007 37 9 2220 2241
2. Kazuma K., Takahashi T., Sato K., Takeuchi H., Matsumoto T., Okuno T., Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L. Bioscience, Biotechnology and Biochemistry 2000 64 8 1588 1599 2-s2.0-0034251947
3. Zang B. X., Jin M., Si N., Zhang Y., Wu W., Piao Y. Z., Antagonistic effect of hydroxysafflor yellow a on the platelet activating factor receptor. Yao Xue Xue Bao 2002 37 9 696 699 2-s2.0-0041915884
4. Tian J., Jang W., Wang Z., Wang C., Fu F., Effects of safflower flavone on local cerebral ischemia and thrombosis formation in rats. Chinese Traditional and Herbal Drugs 2003 34 741 743
5. Zhu H., Wang Z., Ma C., Tian J., Fu F., Li C., Guo D., Roeder E., Liu K., Neuroprotective effects of hydroxysafflor yellow a: in vivo and in vitro studies. Planta Medica 2003 69 5 429 433 2-s2.0-0038095439 10.1055/s-2003-39714 (Pubitemid 36774183)
6. Wei X., Liu H., Sun X., Fu F., Zhang X., Wang J., An J., Ding H., Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action. Neuroscience Letters 2005 386 1 58 62 2-s2.0-22544451583 10.1016/j.neulet.2005.05.069 (Pubitemid 41019643)
7. Liu Z., Li C., Li M., Li D., Liu K., The subchronic toxicity of hydroxysafflor yellow A of 90 days repeatedly intraperitoneal injections in rats. Toxicology 2004 203 1-3 139 143 2-s2.0-4444331450 10.1016/j.tox.2004.06. 007 (Pubitemid 39200944)
8. Nurmi A., Lindsberg P. J., Koistinaho M., Zhang W., Juettler E., Karjalainen-Lindsberg M. L., Weih F., Frank N., Schwaninger M., Koistinaho J., Nuclear factor- B contributes to infarction after permanent focal ischemia. Stroke 2004 35 4 987 991 2-s2.0-12144287458 10.1161/01.STR.0000120732.45951.26 (Pubitemid 38419815)
9. Lindon J. C., Holmes E., Nicholson J. K., Metabonomics techniques and applications to pharmaceutical research & development. Pharmaceutical Research 2006 23 6 1075 1088 2-s2.0-33745361258 10.1007/s11095-006-0025-z (Pubitemid 43946133)
10. Mattson M. P., NF- B in the survival and plasticity of neurons. Neurochemical Research 2005 30 6-7 883 893 2-s2.0-26244445240 10.1007/s11064-005-6961-x (Pubitemid 41413945)
11. Collart M. A., Baeuerle P., Vassalli P., Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four B-like motifs and of constitutive and inducible forms of NF- B. Molecular and Cellular Biology 1990 10 4 1498 1506 2-s2.0-0025260779
12. Yu Z., Zhou D., Bruce-Keller A. J., Kindy M. S., Mattson M. P., Lack of the p50 subunit of nuclear factor- b increases the vulnerability of hippocampal neurons to excitotoxic injury. Journal of Neuroscience 1999 19 20 8856 8865 2-s2.0-0033570299 (Pubitemid 30226707)
13. Lindon J. C., Nicholson J. K., Analytical technologies for metabonomics and metabolomics, and multi-omic information recovery. TrAC-Trends in Analytical Chemistry 2008 27 3 194 204 2-s2.0-41149120469 10.1016/j.trac.2007.08.009 (Pubitemid 351436617)
14. Holmes E., Loo R. L., Stamler J., Bictash M., Yap I. K. S., Chan Q., Ebbels T., de Iorio M., Brown I. J., Veselkov K. A., Daviglus M. L., Kesteloot H., Ueshima H., Zhao L., Nicholson J. K., Elliott P., Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008 453 7193 396 400 2-s2.0-43749087841 10.1038/nature06882 (Pubitemid 351693125)
15. Nicholson J. K., Lindon J. C., Holmes E., 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999 29 11 1181 1189 2-s2.0-0032694577
16. Longa E. Z., Weinstein P. R., Carlson S., Cummins R., Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989 20 1 84 91 2-s2.0-0024494427 (Pubitemid 19040218)
17. Ziegler-Heitbrock H. W. L., Sternsdorf T., Liese J., Belohradsky B., Weber C., Wedel A., Schreck R., Bauerle P., Strobel M., Pyrrolidine dithiocarbamate inhibits NF- B mobilization and TNF production in human monocytes. Journal of Immunology 1993 151 12 6986 6993 2-s2.0-0027146488 (Pubitemid 24001073)
18. Gavaghan C. L., Wilson I. D., Nicholson J. K., Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA. FEBS Letters 2002 530 1-3 191 196 2-s2.0-0037163864 10.1016/S0014-5793(02)03476-2 (Pubitemid 35248210)
19. Kong S. Z., Xian Y. F., Ip S. P., Lai X. P., Shi X. G., Lin Z. X., Su Z. R., Protective effects of hydroxysafflor yellow A on β -amyloid-induced neurotoxicity in PC12 cells. Neurochemical Research 2013 10.1007/s11064-013- 1002-7
20. Seegers H., Grillon E., Trioullier Y., Väth A., Verna J. M., Blum D., Nuclear factor- B activation in permanent intraluminal focal cerebral ischemia in the rat. Neuroscience Letters 2000 288 3 241 245 2-s2.0-0034698509 10.1016/S0304-3940(00)01245-3 (Pubitemid 30411924)
21. Li Y., Zhang Z. Y., Zhang J. I., Determination of hydroxysafflor yellow A in rat plasma and tissues by high-performance liquid chromatography after oral administration of safflower extract or safflor yellow. Biomedical Chromatography 2007 21 3 326 334 2-s2.0-33947610012 10.1002/bmc.769 (Pubitemid 46477476)
22. Yu Z., Gao X., Zhao Y., Bi K., HPLC determination of safflor yellow A and three active isoflavones from TCM Naodesheng in rat plasma and tissues and its application to pharmacokinetic studies. Biomedical Chromatography 2007 21 6 577 584 2-s2.0-34250613118 10.1002/bmc.764 (Pubitemid 46929720)
23. Broughton B. R. S., Reutens D. C., Sobey C. G., Apoptotic mechanisms after cerebral ischemia. Stroke 2009 40 5 e331 e339 2-s2.0-65549098614 10.1161/STROKEAHA.108.531632
24. Gladden L. B., Lactate metabolism: a new paradigm for the third millennium. The Journal of Physiology 2004 558 1 5 30 2-s2.0-4043110513 10.1113/jphysiol.2003.058701 (Pubitemid 39077388)
25. Zhang B., Halouska S., Schiaffo C. E., Sadykov M. R., Somerville G. A., Powers R., NMR analysis of a stress response metabolic signaling network. Journal of Proteome Research 2011 10 8 3743 3754 2-s2.0-79961235661 10.1021/pr200360w
26. Griffin J. L., Kauppinen R. A., A metabolomics perspective of human brain tumours. FEBS Journal 2007 274 5 1132 1139 2-s2.0-33846981150 10.1111/j.1742-4658.2007.05676.x
27. Ohta K., Graf R., Rosner G., Heiss W. D., Calcium ion transients in peri-infarct depolarizations may deteriorate ion homeostasis and expand infarction in focal cerebral ischemia in cats. Stroke 2001 32 2 535 543 2-s2.0-0035135596 (Pubitemid 32155248)
28. Mies G., Iijima T., Hossmann K. A., Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat. NeuroReport 1993 4 6 709 711 2-s2.0-0027246395 (Pubitemid 23190898)
29. Budd S. L., Mechanisms of neuronal damage in brain hypoxia/ischemia: focus on the role of mitochondrial calcium accumulation. Pharmacology and Therapeutics 1998 80 2 203 229 2-s2.0-0031770414 10.1016/S0163-7258(98)00029-1 (Pubitemid 28498228)
30. Giffard R. G., Swanson R. A., Ischemia-induced programmed cell death in astrocytes. Glia 2005 50 4 299 306 2-s2.0-20344403989 10.1002/glia.20167 (Pubitemid 40780836)
31. Mori T., Tateishi N., Kagamiishi Y., Shimoda T., Satoh S., Ono S., Katsube N., Asano T., Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506. Neurochemistry International 2004 45 2-3 381 387 2-s2.0-2442629711 10.1016/j.neuint.2003.06.001 (Pubitemid 38625628)
32. Bliss T. M., Ip M., Cheng E., Minami M., Pellerin L., Magistretti P., Sapolsky R. M., Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics. Journal of Neuroscience 2004 24 27 6202 6208 2-s2.0-3042798646 10.1523/JNEUROSCI.0805-04.2004 (Pubitemid 38891111)
33. McIntosh T. K., Juhler M., Wieloch T., Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998. Journal of Neurotrauma 1998 15 10 731 769 2-s2.0-0031766138 (Pubitemid 28487990)
34. Mehta S. L., Manhas N., Raghubir R., Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Research Reviews 2007 54 1 34 66 2-s2.0-33947628060 10.1016/j.brainresrev.2006.11.003 (Pubitemid 46498164)
35. Yang Z. J., Xie Y., Bosco G. M., Chen C., Camporesi E. M., Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release. European Journal of Applied Physiology 2010 108 3 513 522 2-s2.0-76449088088 10.1007/s00421-009-1229-9
36. Ye H., Jalini S., Zhang L., Charlton M., Carlen P. L., Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons. Journal of Cerebral Blood Flow and Metabolism 2010 30 3 555 565 2-s2.0-77649274986 10.1038/jcbfm.2009.227
37. Zhou J., Li Y., Yan G., Bu Q., Lv L., Yang Y., Zhao J., Shao X., Deng Y., Zhu R., Zhao Y., Cen X., Protective role of taurine against morphine-induced neurotoxicity in C6 cells via inhibition of oxidative stress. Neurotoxicity Research 2011 20 4 334 342 10.1007/s12640-011-9247-x
38. Lang F., Madlung J., Siemen D., Ellory C., Lepple-Wienhues A., Gulbins E., The involvement of caspases in the CD95(Fas/Apo-1)-but not swelling-induced cellular taurine release from Jurkat T-lymphocytes. Pflugers Archiv European The Journal of Physiology 2000 440 1 93 99 2-s2.0-0034061029 10.1007/s004240051026 (Pubitemid 30265915)
39. Friis M. B., Friborg C. R., Schneider L., Nielsen M. B., Lambert I. H., Christensen S. T., Hoffman E. K., Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts. The Journal of Physiology 2005 567 2 427 443 2-s2.0-24944582139 10.1113/jphysiol.2005.087130 (Pubitemid 41301043)
40. Gómez-Angelats M., Cidlowski J. A., Invited review: cell volume control and signal transduction in apoptosis. Toxicologic Pathology 2002 30 5 541 551 2-s2.0-0036743714 10.1080/01926230290105820
41. Sá Santos S., Sonnewald U., Carrondo M. J. T., Alves P. M., The role of glia in neuronal recovery following anoxia: in vitro evidence of neuronal adaptation. Neurochemistry International 2011 58 6 665 675 2-s2.0-79953723123 10.1016/j.neuint.2011.02.005
42. Sternau L. L., Lust W. D., Ricci A. J., Ratcheson R., Role for γ -aminobutyric acid in selective vulnerability in gerbils. Stroke 1989 20 2 281 287 2-s2.0-0024562496 (Pubitemid 19057990)
43. Pitkanen A., Riekkinen P. J., Halonen T., Ylinen A., Ruutiainen T., Lehtinen M., Amino acid levels in human CSF after generalized seizure. Journal of Neural Transmission 1987 70 3-4 313 319 2-s2.0-0023613278 (Pubitemid 18022479)
44. Nita D. A. I., Nita V., Spulber S., Moldovan M., Popa D. P., Zagrean A. M., Zagrean L., Oxidative damage following cerebral ischemia depends on reperfusion-a biochemical study in rat. Journal of Cellular and Molecular Medicine 2001 5 2 163 170 2-s2.0-0035312208
45. Chan P. H., Reactive oxygen radicals in signaling and damage in the ischemic brain. Journal of Cerebral Blood Flow and Metabolism 2001 21 1 2 14 2-s2.0-0035149749 (Pubitemid 32036708)
46. Guidi C., Potenza L., Sestili P., Martinelli C., Guescini M., Stocchi L., Zeppa S., Polidori E., Annibalini G., Stocchi V., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochimica et Biophysica Acta 2008 1780 1 16 26 2-s2.0-36749030624 10.1016/j.bbagen.2007.09. 018 (Pubitemid 350216949)
47. Zhang X., Liu H., Wu J., Zhang X., Liu M., Wang Y., Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats. Neurochemistry International 2009 54 8 481 487 2-s2.0-64049103209 10.1016/j.neuint.2009.02.004
48. Lan M. J., McLoughlin G. A., Griffin J. L., Tsang T. M., Huang J. T. J., Yuan P., Manji H., Holmes E., Bahn S., Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder. Molecular Psychiatry 2009 14 3 269 279 2-s2.0-60549109881 10.1038/sj.mp.4002130
49. +-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. Journal of Pharmacology and Experimental Therapeutics 2000 295 1 392 403 2-s2.0-0033798624
50. Jalil M. A., Begumi L., Contreras L., Pardo B., Iijima M., Li M. X., Ramos M., Marmol P., Horiuchi M., Shimotsu K., Nakagawa S., Okubo A., Sameshima M., Isashiki Y., Del Arco A., Kobayashi K., Satrústegui J., Saheki T., Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. The Journal of Biological Chemistry 2005 280 35 31333 31339 2-s2.0-24744452808 10.1074/jbc.M505286200 (Pubitemid 41294508)
51. Demougeot C., Marie C., Giroud M., Beley A., N-acetylaspartate: a literature review of animal research on brain ischaemia. Journal of Neurochemistry 2004 90 4 776 783 2-s2.0-4143101328 10.1111/j.1471-4159.2004. 02583.x (Pubitemid 39099958)
52. Moffett J. R., Ross B., Arun P., Madhavarao C. N., Namboodiri A. M. A., N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Progress in Neurobiology 2007 81 2 89 131 2-s2.0-33847141978 10.1016/j.pneurobio.2006.12. 003 (Pubitemid 46282272)
53. 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of batten disease. The Journal of Biological Chemistry 2005 280 52 42508 42514 2-s2.0-30044447943 10.1074/jbc.M507380200 (Pubitemid 43049207)
54. Wardlaw J. M., Marshall I., Wild J., Dennis M. S., Cannon J., Lewis S. C., Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: relation between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome. Stroke 1998 29 8 1618 1624 2-s2.0-0031880193 (Pubitemid 28365584)
55. Senaratne R., Milne A. M., MacQueen G. M., Hall G. B. C., Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study. Psychiatry Research-Neuroimaging 2009 172 3 205 209 2-s2.0-67349210197 10.1016/j.pscychresns.2008.07.007
56. Schneider A., Martin-Villalba A., Weih F., Vogel J., Wirth T., Schwaninger M., NF- B is activated and promotes cell death in focal, cerebral ischemia. Nature Medicine 1999 5 5 554 559 2-s2.0-0032587072 10.1038/8432 (Pubitemid 29220215)
57. Mulcahy N. J., Ross J., Rothwell N. J., Loddick S. A., Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. The British Journal of Pharmacology 2003 140 3 471 476 2-s2.0-0142153881 10.1038/sj.bjp.0705462 (Pubitemid 37330491)
58. Lee J. M., Grabb M. C., Zipfel G. J., Choi D. W., Brain tissue responses to ischemia. Journal of Clinical Investigation 2000 106 6 723 731 2-s2.0-0033805182
59. Dirnagl U., Iadecola C., Moskowitz M. A., Pathobiology of ischaemic stroke: an integrated view. Trends in Neurosciences 1999 22 9 391 397 2-s2.0-0033199996 10.1016/S0166-2236(99)01401-0 (Pubitemid 29453643)
60. Ridder D. A., Schwaninger M., NF- B signaling in cerebral ischemia. Neuroscience 2009 158 3 995 1006 2-s2.0-59349107204 10.1016/j.neuroscience.2008. 07.007
61. Candelario-Jalil E., Yang Y., Rosenberg G. A., Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience 2009 158 3 983 994 2-s2.0-59349113948 10.1016/j.neuroscience.2008.06.025
62. Ueno T., Sawa Y., Kitagawa-Sakakida S., Nishimura M., Morishita R., Kaneda Y., Kohmura E., Yoshimine T., Matsuda H., Nuclear factor- B decoy attenuates neuronal damage after global brain ischemia: a future strategy for brain protection during circulatory arrest. Journal of Thoracic and Cardiovascular Surgery 2001 122 4 720 727 2-s2.0-0035497348 10.1067/mtc.2001. 115917 (Pubitemid 35470116)
63. Zhai Q. H., Futrell N., Chen F. J., Gene expression of IL-10 in relationship to TNF- α IL-1 β and IL-2 in the rat brain following middle cerebral artery occlusion. Journal of the Neurological Sciences 1997 152 2 119 124 2-s2.0-0030703663 10.1016/S0022-510X(97)00154-8 (Pubitemid 27509177)
64. Uno H., Matsuyama T., Akita H., Nishimura H., Sugita M., Induction of tumor necrosis factor- α in the mouse hippocampus following transient forebrain ischemia. Journal of Cerebral Blood Flow and Metabolism 1997 17 5 491 499 2-s2.0-0030965046 (Pubitemid 27250975)
65. Lavine S. D., Hofman F. M., Zlokovic B. V., Circulating antibody against tumor necrosis factor- α protects rat brain from reperfusion injury. Journal of Cerebral Blood Flow and Metabolism 1998 18 1 52 58 2-s2.0-0031963924 (Pubitemid 28019011)
66. Barone F. C., Arvin B., White R. F., Miller A., Webb C. L., Willette R. N., Lysko P. G., Feuerstein G. Z., Tumor necrosis factor- α: a mediator of focal ischemic brain injury. Stroke 1997 28 6 1233 1244 2-s2.0-0030976856 (Pubitemid 27248902)
67. Ooboshi H., Ibayashi S., Shichita T., Kumai Y., Takada J., Ago T., Arakawa S., Sugimori H., Kamouchi M., Kitazono T., Iida M., Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia. Circulation 2005 111 7 913 919 2-s2.0-20044368016 10.1161/01.CIR. 0000155622.68580.DC (Pubitemid 40279894)
68. Chang Y. C., Huang C. C., Perinatal brain injury and regulation of transcription. Current Opinion in Neurology 2006 19 2 141 147 2-s2.0-33645070308 10.1097/01.wco.0000218229.73678.a8
69. Carroll J. E., Hess D. C., Howard E. F., Hill W. D., Is nuclear factor- B a good treatment target in brain ischemia/reperfusion injury? NeuroReport 2000 11 9 R1 R4 2-s2.0-0034717368 (Pubitemid 30429113)
70. de Vries H. E., Kuiper J., de Boer A. G., van Berkel T. J. C., Breimer D. D., The blood-brain barrier in neuroinflammatory diseases. Pharmacological Reviews 1997 49 2 143 156 2-s2.0-0030791228
71. Cao J., Viholainen J. I., Dart C., Warwick H. K., Leyland M. L., Courtney M. J., The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. Journal of Cell Biology 2005 168 1 117 126 2-s2.0-12144271690 10.1083/jcb.200407024 (Pubitemid 40111062)
72. Nichols T. C., NF- B and reperfusion injury. Drug News and Perspectives 2004 17 2 99 104 2-s2.0-2342519916 10.1358/dnp.2004.17.2.829042 (Pubitemid 38568406)
73. Hayden M. S., Ghosh S., Signaling to NF- B. Genes and Development 2004 18 18 2195 2224 2-s2.0-4444376712 10.1101/gad.1228704 (Pubitemid 39209568)