Expression of α1-adrenergic receptors in rat prefrontal cortex: Cellular co-localization with 5-HT2A receptors

International Journal of Neuropsychopharmacology

Volumn 16, Issue 5, 2013, Pages 1139-1151

  Santana, Noemí ^a,b   Mengod, Guadalupe ^a,c   Artigas, Francesc ^a,b  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

1 adrenergic receptors; 5 HT2A receptors; GABA interneurons; prefrontal cortex; pyramidal neurons

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; MESSENGER RNA; SEROTONIN 2A RECEPTOR; VESICULAR GLUTAMATE TRANSPORTER 1;

ANTERIOR CINGULATE; ARTICLE; BINDING AFFINITY; CLAUSTRUM; IN SITU HYBRIDIZATION; IN VITRO STUDY; INSULA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORBITAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; PYRIFORM CORTEX; QUANTITATIVE STUDY; RAT; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; GENE EXPRESSION; GLUCOSE TRANSPORTER TYPE 1; GLUTAMATE DECARBOXYLASE; MALE; NEURONS; NOREPINEPHRINE; PREFRONTAL CORTEX; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, ADRENERGIC, ALPHA-1; RNA, MESSENGER;

EID: 84877993051     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145712001083     Document Type: Article

References (74)

1. Acosta-Martinez M, Fiber JM, Brown RD, Etgen AM (1999). Localization of alpha(1B)-adrenergic receptor in female rat brain regions involved in stress and neuroendocrine function. Neurochemistry International 35, 383-391.
2. Aghajanian GK, Marek GJ (1997). Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology 36, 589-599.
3. Aghajanian GK, Marek GJ (1999). Serotonin and hallucinogens. Neuropsychopharmacology 21, 16S-23S.
4. Amargós-Bosch M, Adell A, Bortolozzi A, Artigas F (2003). Stimulation of alpha(1) adrenoceptors in the rat medial prefrontal cortex increases the local in vivo 5-hydroxytryptamine release: reversal by antipsychotic drugs. Journal of Neurochemistry 87, 831-842.
5. Amargós-Bosch M, Bortolozzi A, Puig MV, Serrats J, et al. (2004). Co-expression and in vivo interaction of serotonin(1A) and serotonin(2A) receptors in pyramidal neurons of prefrontal cortex. Cerebral Cortex 14, 281-299.
6. 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 40, 399-412.
7. Arnt J, Skarsfeldt T (1998). Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 18, 63-101.
8. Artigas F (1995). Selective serotonin noradrenaline reuptake inhibitors (SNRI)-pharmacology and therapeutic potential in the treatment of depressive-disorders. CNS Drugs 4, 79-89.
9. Artigas F (2010). The prefrontal cortex: a target for antipsychotic drugs. Acta Psychiatrica Scandinavica 121, 11-21.
10. Ashby CR, Edwards E, Harkins K, Wang RY (1989). Characterization of 5-hydroxytryptamine3 receptors in the medial prefrontal cortex: a microiontophoretic study. European Journal of Pharmacology 173, 193-196.
11. Aston-Jones G, Chiang C, Alexinsky T (1991). Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Progress in Brain Research 88, 501-520.
12. Auclair A, Blanc G, Glowinski J, Tassin JP (2004). Role of serotonin(2A) receptors in the D-amphetamine-induced release of dopamine: comparison with previous data on alpha 1b-adrenergic receptors. Journal of Neurochemistry 91, 318-326.
13. 2A/2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. European Journal of Neuroscience 11, 2917-2934.
14. 2A receptor-mediated outward current in C6 glioma cells is mimicked by intracellular IP3 release. Neuroreport 5, 1245-1248.
15. Beique JC, Imad M, Mladenovic L, Gingrich JA, et al. (2007). Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex. Proceedings of the National Academy of Sciences USA 104, 9870-9875.
16. Berg KA, Maayani S, Goldfarb J, Scaramellini C, et al. (1998). Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Molecular Pharmacology 54, 94-104.
17. 2A receptors: effect of antipsychotic drugs. European Journal of Neuroscience 18, 1235-1246.
18. Bymaster FP, Hemrick-Luecke SK, Perry KW, Fuller RW (1996). Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, alpha(1)-adrenergic and muscarinic receptors in vivo in rats. Psychopharmacology 124, 87-94.
19. 2A receptors in the medial prefrontal cortex to different aspects of executive control such as impulsivity and compulsive perseveration in rats. Neuropsychopharmacology 31, 757-767.
20. Clarke HF, Dalley JW, Crofts HS, Robbins TW, et al. (2004). Cognitive inflexibility after prefrontal serotonin depletion. Science 304, 878-880.
21. Claro E, Fain JN, Picatoste F (1993). Noradrenaline stimulation unbalances the phosphoinositide cycle in rat cerebral cortical slices. Journal of Neurochemistry 60, 2078-2086.
22. 2A receptor in the central nervous system of adult rat. Journal of Comparative Neurology 409, 187-209.
23. Dalley JW, Theobald DE, Bouger P, Chudasama Y, et al. (2004). Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex. Cerebral Cortex 14, 922-932.
24. Day HE, Campeau S, Watson Jr. SJ, Akil H (1997). Distribution of alpha 1a-, alpha 1b-and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. Journal of Chemical Neuroanatomy 13, 115-139.
25. 2A receptors are active under physiological conditions. Psychopharmacology 128, 198-205.
26. 3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. Journal of Neuroscience 22, 7389-7397.
27. Ferré S, Baler R, Bouvier M, Caron MG, et al. (2009). Building a new conceptual framework for receptor heteromers. Nature Chemical Biology 5, 131-134.
28. Fuster JM (1997). The Prefrontal Cortex. Anatomy, Physiology, and Neuropsychology of the Frontal Lobe. Philadelphia, PA: Lipincott-Raven.
29. 3 receptors in 6-hydroxydopamine-induced Parkinsonian rats. Neuroscience 169, 1315-1325.
30. 2A receptors. British Journal of Psychiatry 174, 12-22.
31. Jacobs BL, Azmitia EC (1992). Structure and function of the brain serotonin system. Physiological Reviews 72, 165-229.
32. Jakab RL, Goldman-Rakic PS (1998). 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proceedings of the National Academy of Sciences USA 95, 735-740.
33. 3 receptors in inhibitory circuits of the primate cerebral cortex. Journal of Comparative Neurology 417, 337-348.
34. Kawaguchi Y, Shindou T (1998). Noradrenergic excitation and inhibition of GABAergic cell types in rat frontal cortex. Journal of Neuroscience 18, 6963-6976.
35. Landry M, Holmberg K, Zhang X, Hokfelt T (2000). Effect of axotomy on expression of NPY, galanin, and NPY Y1 and Y2 receptors in dorsal root ganglia and the superior cervical ganglion studied with double-labeling in situ hybridization and immunohistochemistry. Experimental Neurology 162, 361-384.
36. Lewis DA, Lieberman JA (2000). Catching up on schizophrenia: natural history and neurobiology. Neuron 28, 325-334.
37. Lewis SJ, Zammit S, Gunnell D, Smith GD (2005). A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135, 2-4.
38. 2A receptor or alpha1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex. European Journal of Pharmacology 367, 197-206.
39. Martín-Ruiz R, Puig MV, Celada P, Shapiro DA, et al. (2001). Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. Journal of Neuroscience 21, 9856-9866.
40. McCormick DA, Wang Z, Huguenard J (1993). Neurotransmitter control of neocortical neuronal activity and excitability. Cerebral Cortex 3, 387-398.
41. Meltzer HY (1999). Treatment of schizophrenia and spectrum disorders: pharmacotherapy, psychosocial treatments, and neurotransmitter interactions. Biological Psychiatry 46, 1321-1327.
42. Michel MC, Erdbrugger W, Bischoff A, Brodde OE (1993). Differential phospholipase-A(2) and phospholipase-C coupling for rat renal angiotensin-II, neuropeptide-y and alpha(1)-adrenergic receptors. FASEB Journal 7, A467.
43. Miller EK, Cohen JD (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience 24, 167-202.
44. Miner LAH, Backstrom JR, Sanders-Bush E, Sesack SR (2003). Ultrastructural localization of serotonin(2A) receptors in the middle layers of the rat prelimbic prefrontal cortex. Neuroscience 116, 107-117.
45. Mitrano DA, Schroeder JP, Smith Y, Cortright JJ, et al. (2012). Alpha-1 adrenergic receptors are localized on presynaptic elements in the nucleus accumbens and regulate mesolimbic dopamine transmission. Neuropsychopharmacology 37, 2161-2172.
46. Molinoff PB (1984). Alpha-and beta-adrenergic receptor subtypes properties, distribution and regulation. Drugs 28 (Suppl. 2), 1-15.
47. Morales M, Battenberg E, de Lecea L, Bloom FE (1996). The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus. Brain Research 731, 199-202.
48. Palacios JM, Hoyer D, Cortes R (1987). alpha 1-Adrenoceptors in the mammalian brain: similar pharmacology but different distribution in rodents and primates. Brain Research 419, 65-75.
49. Paxinos G, Watson C (2005). The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Elsevier Academic Press.
50. Pieribone VA, Nicholas AP, Dagerlind A, Hokfelt T (1994). Distribution of alpha 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes. Journal of Neuroscience 14, 4252-4268.
51. Puig MV, Artigas F, Celada P (2005). Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA. Cerebral Cortex 15, 1-14.
52. 2A receptors: relationship to thalamocortical afferents. Cerebral Cortex 13, 870-882.
53. Puig MV, Santana N, Celada P, Mengod G, et al. (2004). In vivo excitation of GABA interneurons in the medial prefrontal cortex through 5-HT3 receptors. Cerebral Cortex 14, 1365-1375.
54. 2A receptors. Journal of Neuroscience 30, 2211-2222.
55. Ramos BP, Arnsten AF (2007). Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacology and Therapeutics 113, 523-536.
56. Robbins TW (2000). From arousal to cognition: the integrative position of the prefrontal cortex. Progress in Brain Research 126, 469-483.
57. Roberts AC, De Salvia MA, Wilkinson LS, Collins P, et al. (1994). 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine. Journal of Neuroscience 14, 2531-2544.
58. Santana N, Bortolozzi A, Serrats J, Mengod G, et al. (2004). Expression of serotonin1A and serotonin2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex. Cerebral Cortex 14, 1100-1109.
59. Santana N, Mengod G, Artigas F (2009). Quantitative analysis of the expression of dopamine D1 and D2 receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex. Cerebral Cortex 19, 849-860.
60. 1A agonists. Journal of Pharmacology and Experimental Therapeutics 273, 101-112.
61. Selemon LD, Goldman-Rakic PS (1999). The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biological Psychiatry 45, 17-25.
62. B receptor mRNA in the raphe nuclei: co-expression with serotonin transporter and glutamic acid decarboxylase. Journal of Neurochemistry 84, 743-752.
63. Swanson LW (2005). Brain Maps: Structure of the Rat Brain. Amsterdam: Elsevier.
64. Tanaka E, North RA (1993). Actions of 5 hydroxytryptamine on neurons of the rat cingulate cortex. Journal of Neurophysiology 69, 1749-1757.
65. Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, et al. (2007). Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 10, 376-384.
66. Wadenberg ML, Hertel P, Fernholm R, Hygge BK, et al. (2000). Enhancement of antipsychotic-like effects by combined treatment with the alpha1-adrenoceptor antagonist prazosin and the dopamine D2 receptor antagonist raclopride in rats. Journal of Neural Transmission 107, 1229-1238.
67. Weber ET, Andrade R (2010). Htr2a gene and 5-HT(2A) receptor expression in the cerebral cortex studied using genetically modified mice. Frontiers in Neuroscience 4, 1-12.
68. Weinberger DR, Egan MF, Bertolino A, Callicott JH, et al. (2001). Prefrontal neurons and the genetics of schizophrenia. Biological Psychiatry 50, 825-844.
69. Williams GV, Goldman-Rakic PS (1995). Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 376, 572-575.
70. 2A receptors in working memory. Journal of Neuroscience 22, 2843-2854.
71. Winstanley CA, Chudasama Y, Dalley JW, Theobald DE, et al. (2003). Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. Psychopharmacology 167, 304-314.
72. Zhang ZW, Arsenault D (2005). Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex. Journal of Physiology 566, 379-94.
73. Zhong P, Yan Z (2011). Differential regulation of the excitability of prefrontal cortical fast-spiking interneurons and pyramidal neurons by serotonin and fluoxetine. PLoS One 6, e16970.
74. Zhou FM, Hablitz JJ (1999). Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. Journal of Neurophysiology 82, 2989-2999.