Enhanced cell-volume regulation in cyclosporin A cardioprotection

Cardiovascular Research

Volumn 98, Issue 3, 2013, Pages 411-419

  Diaz, Roberto J ^a,b   Fernandes, Kelly ^a,c   Lytvyn, Yuliya ^b   Hawrylyshyn, Krista ^b   Harvey, Kordan ^a,c   Hossain, Taneya ^a   Hinek, Alina ^a   Wilson, Gregory J ^a,b,c  

^a MCMASTER UNIVERSITY   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cardiomyocytes; Cell volume regulation; Chloride channels; Cyclosporine A; Mitochondrial permeability transition pore

Indexed keywords

(2 CYCLOPENTYL 6,7 DICHLORO 2 METHYL 1 OXO 5 INDANYLOXY)ACETIC ACID; 5,5',6,6' TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE; 6 METHOXY N (3 SULFOPROPYL)QUINOLINIUM; BENZIMIDAZOLE DERIVATIVE; CHLORIDE CHANNEL; CYCLOSPORIN A; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VALINOMYCIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL SWELLING; CELL VIABILITY; CELL VOLUME; CHLORIDE TRANSPORT; CONTROLLED STUDY; EXPERIMENTAL RABBIT; HEART MUSCLE CELL; HEART PROTECTION; HYPOOSMOTIC STRESS; ISCHEMIA; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

CARDIOMYOCYTES; CELL VOLUME REGULATION; CHLORIDE CHANNELS; CYCLOSPORINE A; MITOCHONDRIAL PERMEABILITY TRANSITION PORE;

ANIMALS; CELL SIZE; CELLS, CULTURED; CHLORIDE CHANNELS; CHLORIDES; CYCLOSPORINE; CYTOPROTECTION; ION TRANSPORT; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NECROSIS; OSMOTIC PRESSURE; PROTECTIVE AGENTS; RABBITS; TIME FACTORS;

EID: 84877992121     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt056     Document Type: Article

References (29)

1. Baines CP. The mitochondrial permeability transition pore and the cardiac necrotic program. Pediatr Cardiol 2011;32:258-262.
2. Hausenloy DJ, Ong SB, Yellon DM. The mitochondrial permeability transition pore as a target for preconditioning and postconditioning. Basic Res Cardiol 2009;104: 189-202.
3. Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res 2004;61:372-385.
4. Baines CP. The molecular composition of the mitochondrial permeability transition pore. J Mol Cell Cardiol 2009;46:850-857.
5. Hausenloy DJ, Lim SY, Ong SG, Davidson SM, Yellon DM. Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning. Cardiovasc Res 2010;88:67-74.
6. Wu MS, Yang CW, Bens M, Peng KC, Yu HM, Vandewalle A. Cyclosporine stimulates Na+-K+-Clcotransport activity in cultured mouse medullary thick ascending limb cells. Kidney Int 2000;58:1652-1663.
7. Kim JA, Kang YS, Lee YS. Role of Ca2+-activated Clchannels in the mechanism of apoptosis induced by cyclosporin A in a human hepatoma cell line. Biochem Biophys Res Commun 2003;309:291-297.
8. Diaz RJ, Hinek A, Wilson GJ. Direct evidence of chloride ion efflux in ischaemic and pharmacological preconditioning of cultured cardiomyocytes. Cardiovasc Res 2010;87: 545-551.
9. Diaz RJ, Armstrong SC, Batthish M, Backx PH, Ganote CE, Wilson GJ. Enhanced cell volume regulation: a key protective mechanism of ischaemic preconditioning in rabbit ventricular myocytes. J Mol Cell Cardiol 2003;35:45-58.
10. Diaz RJ, Losito VA, Mao GD, Ford MK, Backx PH, Wilson GJ. Chloride channel inhibition blocks the protection of ischaemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium. Circ Res 1999;84:763-775.
11. Diaz RJ, Zobel C, Cho HC, Batthish M, Hinek A, Backx PH et al. Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischaemic preconditioning in rabbit ventricular cardiomyocytes. Circ Res 2004;95:325-332.
12. Illsley NP, Verkman AS. Membrane chloride transport measured using a chloridesensitive fluorescent probe. Biochemistry 1987;26:1215-1219.
13. Chen PY, Illsley NP, Verkman AS. Renal brush-border chloride transport mechanisms characterized using a fluorescent indicator. Am J Physiol 1988;254:F114-F120.
14. Rakhit RD, Mojet MH, Marber MS, Duchen MR. Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes. Circulation 2001;103:2617-2623.
15. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW et al. Intracel-lular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 1991;88:3671-3675.
16. Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ. Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovasc Res 2002; 55:660-671.
17. Bozeat N. The role of ClC-3 chloride channels in early and late ischaemic preconditioning in mouse heart. In: Coronary Heart Disease. Reno: University of Nevada, Reno, 2006, p. 22-45.
18. Xiong D, Heyman NS, Airey J, Zhang M, Singer CA, Rawat S et al. Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice. J Mol Cell Cardiol 2010;48: 211-219.
19. Li J, Wu X, Cui T. Functional characteristics and molecular identification of swelling-activated chloride conductance in adult rabbit heart ventricles. J Huazhong Univ Sci Technolog Med Sci 2008;28:37-41.
20. Britton FC, Hatton WJ, Rossow CF, Duan D, Hume JR, Horowitz B. Molecular distribution of volume-regulated chloride channels (ClC-2 and ClC-3) in cardiac tissues. Am J Physiol Heart Circ Physiol 2000;279:H2225-H2233.
21. Chen H, Liu LL, Ye LL, McGuckin C, Tamowski S, Scowen P et al. Targeted inactiva-tion of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischaemic preconditioning in isolated mouse heart. Circulation 2004;110: 700-704.
22. Jennings RB, Reimer KA, Steenbergen C. Myocardial ischemia revisited. The osmolar load, membrane damage, and reperfusion. J Mol Cell Cardiol 1986;18:769-780.
23. Diaz RJ, Wilson GJ. Studying ischaemic preconditioning in isolated cardiomyocyte models. Cardiovasc Res 2006;70:286-296.
24. Kaasik A, Safiulina D, Zharkovsky A, Veksler V. Regulation of mitochondrial matrix volume. Am J Physiol Cell Physiol 2007;292:C157-C163.
25. Nogueira V, Devin A, Walter L, Rigoulet M, Leverve X, Fontaine E. Effects of decreasing mitochondrial volume on the regulation of the permeability transition pore. J Bioenerg Biomembr 2005;37:25-33.
26. Di Lisa F, Carpi A, Giorgio V, Bernardi P. The mitochondrial permeability transition pore and cyclophilin D in cardioprotection. Biochim Biophys Acta 2011;1813: 1316-1322.
27. Hausenloy DJ, Duchen MR, Yellon DM. Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardi-ovasc Res 2003;60:617-625.
28. Crompton M, McGuinness O, Nazareth W. The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction. Biochim Biophys Acta 1992;1101:214-217.
29. Petronilli V, Miotto G, Canton M, Colonna R, Bernardi P, Di Lisa F. Imaging the mitochondrial permeability transition pore in intact cells. Biofactors 1998;8: 263-272.