Synthesis of benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines as DNA-binding and potential anticancer agents

Medicinal Chemistry

Volumn 9, Issue 2, 2013, Pages 177-192

  Kamal, Ahmed ^a   Rajender, ^a   Reddy, Methuku Kashi ^a   Reddy, Vangala Santhosh ^a   Kumar, Gajjela Bharath ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

2,2 dimethyl benzopyran; Cytotoxicity; DNA binding affinity; Pyrrolo 2 1 c 1 4 benzodiazepines and piperazine

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 2,2,8,8 TETRAMETHYL 2H,8H PYRANO[3,2 G]CHROMEN 5 OL; 5 HYDROXY 2,2,8,8 TETRAMETHYL 3,4,7,8 TETRAHYDRO 2H,6H PYRANO[3,2 G]CHROMENE 4,6 DIONE; 6 (3 BROMOPROPOXY) 7 METHOXY 2,2 DIMETHYL 2H CHROMENE; 6 (3 BROMOPROPOXY) 7 METHOXY 2,2 DIMETHYL 4 CHROMANONE; 6 (4 BROMOBUTOXY) 7 METHOXY 2,2 DIMETHYL 2H CHROMENE; 6 (4 BROMOBUTOXY) 7 METHOXY 2,2 DIMETHYL 4 CHROMANONE; 7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]BUTYLPIPERAZINE; 7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PENTYLPIPERAZINE; 7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PROPYLPIPERAZINE; 7 METHOXY 8 [3 [7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PROPYLOXY] (11AS) 1,2,3, 11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [4 [7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PROPYLOXY] (11AS) 1,2,3, 11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [5 [7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PROPYLOXY] (11AS) 1,2,3, 11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTINEOPLASTIC AGENT; BENZOPYRAN DERIVATIVE; N (4 HYDROXY) 5 METHOXY 2 NITROBENZOYL)PYRROLIDINE 2 CARBOXALDEHYDEDIET HYLTHIOACETAL; N [4 (3 BROMOPROPYL)OXY 5 METHOXY 2 NITROBENZOYL]PYRROLIDINE 2 CARBOXALDEHYDE DIETHYLTHIOACETAL; N [4 (4 BROMOBUTYL)OXY 5 METHOXY 2 NITROBENZOYL]PYRROLIDINE 2 CARBOXALDEHYDE DIETHYLTHIOACETAL; N [4 (5 BROMOPENTYL)OXY 5 METHOXY 2 NITROBENZOYL]PYRROLIDINE 2 CARBOXALDEHYDE DIETHYLTHIOACETAL; N [4 [4 (2,2,8,8 TETRAMETHYL 2H,8H PYRANO[3,2 G]CHROMEN 5 YL)OXY]BUTYLOXY 5 METHOXY 2 NITROBENZOYL]PYRROLIDINE 2 CARBOXALDEHYDEDIETHYLTHIOACETAL; N [4 [5 (2,2,8,8 TETRAMETHYL 2H,8H PYRANO[3,2 G]CHROMEN 5 YL)OXY]BUTYLOXY 5 METHOXY 2 NITROBENZOYL]PYRROLIDINE 2 CARBOXALDEHYDEDIETHYLTHIOACETAL; PHLOROGLUCINOL; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; TERT BUTYL 4 [3 (2,2,8,8 TETRAMETHYL 2H,8H PYRANO[3,2 G]CHROMEN 5 YL)OXY]PROPYL 1 PIPERAZINECARBOXYLATE; TERT BUTYL 4 [3 (7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PROPYL 1 PIPERAZINE CARBOXYLATE; TERT BUTYL 4 [4 (2,2,8,8 TETRAMETHYL 2H,8H PYRANO[3,2 G]CHROMEN 5 YL)OXY]BUTYL 1 PIPERAZINECARBOXYLATE; TERT BUTYL 4 [4 (7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PROPYL 1 PIPERAZINE CARBOXYLATE; TERT BUTYL 4 [5 (2,2,8,8 TETRAMETHYL 2H,8H PYRANO[3,2 G]CHROMEN 5 YL)OXY]PENTYL 1 PIPERAZINECARBOXYLATE; TERT BUTYL 4 [5 (7 METHOXY 2,2 DIMETHYL 2H 6 CHROMENYL)OXY]PROPYL 1 PIPERAZINE CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; BENZOPYRANS; BIOLOGICAL AVAILABILITY; CATTLE; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA; DNA RESTRICTION ENZYMES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; NUCLEIC ACID DENATURATION; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 84877974476     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/1573406411309020003     Document Type: Article

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