12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash

Chemical Research in Toxicology

Volumn 26, Issue 5, 2013, Pages 817-827

  Sharma, Amy M ^a   Novalen, Maria ^a   Tanino, Tadatoshi ^b   Uetrecht, Jack P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYL 1 HEXANOL; 12 HYDROXY NEVIRAPINE SULFATE; ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; DERMATOLOGICAL AGENT; DRUG METABOLITE; HEXANOL; NEVIRAPINE; PRASTERONE; SALICYLAMIDE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; 12-HYDROXYNEVIRAPINE SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CYTOSOL; DERMIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ERUPTION; ENZYME INHIBITION; EPIDERMIS; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NONHUMAN; RAT; SULFATION; ANALOGS AND DERIVATIVES; ANIMAL; BROWN NORWAY RAT; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; METABOLISM; PATHOLOGY; RASH; TIME;

ANIMALS; EXANTHEMA; FEMALE; HUMANS; MOLECULAR STRUCTURE; NEVIRAPINE; RATS; RATS, INBRED BN; TIME FACTORS;

EID: 84877970771     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400098z     Document Type: Article

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