Promoted interaction of nuclear factor-κB with demethylated cystathionine-β-synthetase gene contributes to gastric hypersensitivity in diabetic rats

Journal of Neuroscience

Volumn 33, Issue 21, 2013, Pages 9028-9038

  Zhang, Hong Hong ^a   Hu, Ji ^a   Zhou, You Lang ^a,b   Hu, Shufen ^a   Wang, Yong Meng ^a   Chen, Wei ^b   Xiao, Ying ^a   Huang, Li Yen Mae ^c   Jiang, Xinghong ^a   Xu, Guang Yin ^a  

^a SOOCHOW UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DIABETES MELLITUS; DOWN REGULATION; FEMALE; GASTRIC HYPERSENSITIVITY; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPINAL GANGLION; STOMACH DISEASE; UPREGULATION; WESTERN BLOTTING;

AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; CASE-CONTROL STUDIES; CHROMATIN IMMUNOPRECIPITATION; CPG ISLANDS; CYSTATHIONINE BETA-SYNTHASE; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROMYOGRAPHY; ENZYME INHIBITORS; FEMALE; GANGLIA, SPINAL; HYPERSENSITIVITY; MEMBRANE POTENTIALS; METHYLATION; NEOPLASM PROTEINS; NF-KAPPA B; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; OXAMIC ACID; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SENSORY RECEPTOR CELLS; STOMACH DISEASES; SULFITES; UP-REGULATION;

EID: 84877943573     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1068-13.2013     Document Type: Article

References (36)

1. Anitha M, Gondha C, Sutliff R, Parsadanian A, Mwangi S, Sitaraman SV, Srinivasan S (2006) GDNF rescues hyperglycemia-induced diabetic en-teric neuropathy through activation of the PI3K/Akt pathway. J Clin In-vest 116:344-356.
2. Beyak MJ, Bulmer DC, Sellers D, Grundy D (2009) Impairment of rectal afferent mechanosensitivity in experimental diabetes in the rat. Neuro-gastroenterol Motil 21:678-681.
3. Bytzer P, Talley NJ, Leemon M, Young LJ, Jones MP, Horowitz M (2001) Prevalence of gastrointestinal symptoms associated with diabetes melli-tus: a population-based survey of 15, 000 adults. Arch Intern Med 161: 1989-1996.
4. Chandrasekharan B, Srinivasan S (2007) Diabetes and the enteric nervous system. Neurogastroenterol Motil 19:951-960.
5. Frøkjaer JB, Andersen SD, Ejskaer N, Funch-Jensen P, Arendt-Nielsen L, Gregersen H, Drewes AM (2007) Gut sensations in diabetic autonomic neuropathy. Pain 131:320-329.
6. Frøkjaer JB, Søfteland E, Graversen C, Dimcevski G, Egsgaard LL, Arendt-Nielsen L, Drewes AM (2009) Central processing of gut pain in diabetic patients with gastrointestinal symptoms. Diabetes Care 32:1274-1277.
7. Frøkjaer JB, Egsgaard LL, Graversen C, Søfteland E, Dimcevski G, Blauenfeldt RA, Drewes AM (2011) Gastrointestinal symptoms in type-1 diabetes: is it all about brain plasticity? Eur J Pain 15:249-257.
8. Frommer M, McDonald LE, Millar DS, Collis CM, Watt F, Grigg GW, Molloy PL, Paul CL (1992) A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 89:1827-1831.
9. Grabauskas G, Heldsinger A, Wu X, Xu D, Zhou S, Owyang C (2011) Dia- betic visceral hypersensitivity is associated with activation of mitogen- activated kinase in rat dorsal root ganglia. Diabetes 60:1743-1751.
10. He CL, Soffer EE, Ferris CD, Walsh RM, Szurszewski JH, Farrugia G (2001) Loss of interstitial cells of cajal and inhibitory innervation in insulin- dependent diabetes. Gastroenterology 121:427-434.
11. Herman JG, Graff JR, Myöhänen S, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 93:9821-9826.
12. Hoogerwerf WA, Pasricha PJ, Kalloo AN, Schuster MM (1999) Pain: the overlookedsymptomingastroparesis. AmJGastroenterol94:1029-1033.
13. Hunt SP, Mantyh PW (2001) The molecular dynamics of pain control. Nat Rev Neurosci 2:83-91.
14. Kashyap P, Farrugia G (2010) Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years. Gut 59:1716-1726.
15. Kordi-Tamandani DM, Moazeni-Roodi AK, Rigi-Ladiz MA, Hashemi M, Birjandian E, Torkamanzehi A (2010) Promoter hypermethylation and expression profile of MGMT and CDH1 genes in oral cavity cancer. Arch Oral Biol 55:809-814.
16. Lee A, Kuo B (2010) Metoclopramide in the treatment of diabetic gastropa- resis. Expert Rev Endocrinol Metab 5:653-662.
17. Li L, Xie R, Hu S, Wang Y, Yu T, Xiao Y, Jiang X, Gu J, Hu CY, Xu GY (2012) Upregulation of cystathionine beta-synthetase expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult ratswithneonatalmaternaldeprivation. MolPain 8:89.
18. Liao D, Zhao J, Gregersen H (2006) Three-dimensional geometry analysis ofthestomachintypeIIdiabeticGKrats. DiabetesResClinPract 71:1-13.
19. Liu LS, Shenoy M, Pasricha PJ (2011) The analgesic effects of the GABAB receptor agonist, baclofen, in a rodent model of functional dyspepsia. Neurogastroenterol Motil 23:356-361, e160-e351.
20. Owyang C (2011) Phenotypic switching in diabetic gastroparesis: mecha- nism directs therapy. Gastroenterology 141:1134-1137.
21. Qi F, Zhou Y, Xiao Y, Tao J, Gu J, Jiang X, Xu GY (2013) Promoter demeth- ylation of cystathionine-beta-synthetase gene contributes to inflamma- tory pain in rats. Pain 154:34-45.
22. Samsom M, Akkermans LM, Jebbink RJ, vanIsselt H, van Berge-Henegouwen GP, Smout AJ (1997) Gastrointestinal motor mechanisms in hypergly- caemia induced delayed gastric emptying in type I diabetes mellitus. Gut 40:641-646.
23. Schemann M, Grundy D (2009) Role of hydrogen sulfide in visceral nocice- ption. Gut 58:744-747.
24. Shi L, Zhang H, Xiao Y, Hu J, Xu GY (2013) Electroacupuncture suppresses mechanical allodynia and nuclear factor kappa B signaling in streptozotocin-induced diabetic rats. CNS Neurosci Ther 19:83-90.
25. Srinivasan S, Wiley JW (2000) New insights into neural injury, repair, and adaptationinvisceralafferentsandtheentericnervoussystem. CurrOpin Gastroenterol 16:78-82.
26. Turek-Plewa J, Jagodziński PP (2005) The role of mammalian DNA meth- yltransferases in the regulation of gene expression. Cell Mol Biol Lett 10:631-647.
27. Vinik AI, Maser RE, Mitchell BD, Freeman R (2003) Diabetic autonomic neuropathy. Diabetes Care 26:1553-1579.
28. Wang C, Ning LP, Wang YH, Zhang Y, Ding XL, Ge HY, Arendt-Nielsen L, Yue SW (2011) Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. Behav Brain Res 221:19-24.
29. Wang Y, Qu R, Hu S, Xiao Y, Jiang X, Xu GY (2012) Upregulation of Cys- tathionine beta-Synthetase Expression Contributes to Visceral Hyperal- gesia Induced by Heterotypic Intermittent Stress in Rats. PLoS One 7:e53165.
30. Watkins CC, Sawa A, Jaffrey S, Blackshaw S, Barrow RK, Snyder SH, Ferris CD (2000) Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. J Clin Invest 106:373-384.
31. Xu GY, Huang LY (2002) Peripheral inflammation sensitizes P2X receptor- mediatedresponsesinratdorsalrootganglionneurons. JNeurosci 22:93-102.
32. Xu GY, Shenoy M, Winston JH, Mittal S, Pasricha PJ (2008) P2X receptor- mediated visceral hyperalgesia in a rat model of chronic visceral hyper- sensitivity. Gut 57:1230-1237.
33. Xu GY, Winston JH, Shenoy M, Zhou S, Chen JD, Pasricha PJ (2009) The endogenous hydrogen sulfide producing enzyme cystathionine-beta syn- thase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome. Mol Pain 5:44.
34. Xu GY, Li G, Liu N, Huang LY (2011) Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats. Mol Pain 7:60.
35. Yang G, Yang W, Wu L, Wang R (2007) H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells. J Biol Chem 282: 16567-16576.
36. Zhang Z, Cai YQ, Zou F, Bie B, Pan ZZ (2011) Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med 17:1448-1455.