Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats

Behavioural Brain Research

Volumn 221, Issue 1, 2011, Pages 19-24

  Wang, Chao ^a   Ning, Li Ping ^a   Wang, Yong Hui ^a   Zhang, Yang ^a   Ding, Xin Li ^c   Ge, Hong You ^b   Arendt Nielsen, Lars ^b   Yue, Shou Wei ^a  

^a SHANDONG UNIVERSITY   (China)

^b AALBORG UNIVERSITY   (Denmark)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Nitric oxide (NO); Nuclear factor kappa B (NF B); Thermal hyperalgesia; TRPV4

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4ALPHA PHORBOL DIDECANOATE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; PYRROLIDINE DITHIOCARBAMATE; VANILLOID RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; NERVE COMPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RISK FACTOR; SPINAL GANGLION; THERMAL HYPERALGESIA;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HYPERALGESIA; I-KAPPA B PROTEINS; MALE; NERVE COMPRESSION SYNDROMES; NEURALGIA; NF-KAPPA B; NITRIC OXIDE; NITRILES; PHORBOLS; PYRROLIDINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SULFONES; THIOCARBAMATES; TRPV CATION CHANNELS;

EID: 79952708673     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.02.028     Document Type: Article

References (47)

1. Alessandri-Haber N., Dina O.A., Chen X., Levine J.D. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci 2009, 29:6217-6228.
2. Alessandri-Haber N., Dina O.A., Yeh J.J., Parada C.A., Reichling D.B., Levine J.D. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci 2004, 24:4444-4452.
3. Alessandri-Haber N., Joseph E., Dina O.A., Liedtke W., Levine J.D. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 2005, 118:70-79.
4. Arruda J.L., Sweitzer S., Rutkowski M.D., DeLeo J.A. Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res 2000, 879:216-225.
5. Bonnefous C., Payne J.E., Roppe J., Zhuang H., Chen X., Symons K.T., et al. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, Part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J Med Chem 2009, 52:3047-3062.
6. Brisby H., Byrod G., Olmarker K., Miller V.M., Aoki Y., Rydevik B. Nitric oxide as a mediator of nucleus pulposus-induced effects on spinal nerve roots. J Orthop Res 2000, 18:815-820.
7. Chu S.C., Marks-Konczalik J., Wu H.P., Banks T.C., Moss J. Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters. Biochem Biophys Res Commun 1998, 248:871-878.
8. Cruz M.T., Duarte C.B., Goncalo M., Carvalho A.P., Lopes M.C. LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42. Nitric Oxide 2001, 5:53-61.
9. Cuzzocrea S., Chatterjee P.K., Mazzon E., Dugo L., Serraino I., Britti D., et al. Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br J Pharmacol 2002, 135:496-510.
10. Ding X.L., Wang Y.H., Ning L.P., Zhang Y., Ge H.Y., Jiang H., et al. Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. Behav Brain Res 2010, 208:194-201.
11. Ebersberger A., Buchmann M., Ritzeler O., Michaelis M., Schaible H.G. The role of spinal nuclear factor-kappa B in spinal hyperexcitability. Neuroreport 2006, 17:1615-1618.
12. Fu E.S., Zhang Y.P., Sagen J., Candiotti K.A., Morton P.D., Liebl D.J., et al. Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury. Pain 2010, 148:509-518.
13. Grant A.D., Cottrell G.S., Amadesi S., Trevisani M., Nicoletti P., Materazzi S., et al. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol 2007, 578:715-733.
14. Hamanaka K., Jian M.Y., Townsley M.I., King J.A., Liedtke W., Weber D.S., et al. TRPV4 channels augment macrophage activation and ventilator-induced lung injury. Am J Physiol 2010, 299:L353-L362.
15. Heinzen E.L., Pollack G.M. Pharmacodynamics of morphine-induced neuronal nitric oxide production and antinociceptive tolerance development. Brain Res 2004, 1023:175-184.
16. Hu S.J., Xing J.L. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain 1998, 77:15-23.
17. Jin X.G., He S.Q., Yan X.T., Zhang G., Wan L., Wang J., et al. Variants of neural nitric oxide synthase in the spinal cord of neuropathic rats and their effects on nuclear factor-kappaB (NF-kappaB) activity in PC12 cells. J Pain 2009, 10:80-89.
18. Kohler R., Heyken W.T., Heinau P., Schubert R., Si H., Kacik M., et al. Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation. Arterioscler Thromb Vasc Biol 2006, 26:1495-1502.
19. Laughlin T.M., Bethea J.R., Yezierski R.P., Wilcox G.L. Cytokine involvement in dynorphin-induced allodynia. Pain 2000, 84:159-167.
20. Ledeboer A., Gamanos M., Lai W., Martin D., Maier S.F., Watkins L.R., et al. Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci 2005, 22:1977-1986.
21. Lee K.M., Jeon S.M., Cho H.J. Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model. Eur J Pain 2009, 13:794-806.
22. Lee K.M., Kang B.S., Lee H.L., Son S.J., Hwang S.H., Kim D.S., et al. NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity. Eur J Neurosci 2004, 19:3375-3381.
23. Levine J.D., Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochim Biophys Acta 2007, 1772:989-1003.
24. Liedtke W., Friedman J.M. Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci USA 2003, 100:13698-13703.
25. Lima-Cabello E., Cuevas M.J., Garatachea N., Baldini M., Almar M., Gonzalez-Gallego J. Eccentric exercise induces nitric oxide synthase expression through nuclear factor-kappaB modulation in rat skeletal muscle. J Appl Physiol 2010, 108:575-583.
26. Ma W., Bisby M.A. Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries. Brain Res 1998, 797:243-254.
27. Ma X.L., Li Y.H., Gao J.X., Li J., Guo L., Wu C.Z. Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A-induced hepatitis. J Gastroenterol Hepatol 2008, 23:e231-e235.
28. Ma Z.L., Zhang W., Gu X.P., Yang W.S., Zeng Y.M. Effects of intrathecal injection of prednisolone acetate on expression of NR2B subunit and nNOS in spinal cord of rats after chronic compression of dorsal root ganglia. Ann Clin Lab Sci 2007, 37:349-355.
29. Meunier A., Latremoliere A., Dominguez E., Mauborgne A., Philippe S., Hamon M., et al. Lentiviral-mediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat. Mol Ther 2007, 15:687-697.
30. Muthuraman A., Ramesh M., Sood S. Development of animal model for vasculatic neuropathy: induction by ischemic-reperfusion in the rat femoral artery. J Neurosci Methods 2010, 186:215-221.
31. Nakata S., Tsutsui M., Shimokawa H., Yamashita T., Tanimoto A., Tasaki H., et al. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. Arterioscler Thromb Vasc Biol 2007, 27:92-98.
32. Park H.J., Lee H.S., Lee H.J., Yoo Y.M., Lee H.J., Kim S.A., et al. Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-kappa B1 knockout mice. Neurosci Lett 2002, 319:141-144.
33. Podichetty V.K. The aging spine: the role of inflammatory mediators in intervertebral disc degeneration. Cell Mol Biol (Noisy-le-grand) 2007, 53:4-18.
34. Rahman S.H., Ammori B.J., Larvin M., McMahon M.J. Increased nitric oxide excretion in patients with severe acute pancreatitis: evidence of an endotoxin mediated inflammatory response?. Gut 2003, 52:270-274.
35. Sakaue G., Shimaoka M., Fukuoka T., Hiroi T., Inoue T., Hashimoto N., et al. B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport 2001, 12:2079-2084.
36. Song X.J., Hu S.J., Greenquist K.W., Zhang J.M., LaMotte R.H. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol 1999, 82:3347-3358.
37. Sun T., Song W.G., Fu Z.J., Liu Z.H., Liu Y.M., Yao S.L. Alleviation of neuropathic pain by intrathecal injection of antisense oligonucleotides to p65 subunit of NF-kappaB. Br J Anaesth 2006, 97:553-558.
38. Suzuki M., Mizuno A., Kodaira K., Imai M. Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 2003, 278:22664-22668.
39. Takeda-Nakazawa H., Harada N., Shen J., Kubo N., Zenner H.P., Yamashita T. Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea. Hear Res 2007, 230:93-104.
40. Tan Z.Y., Donnelly D.F., LaMotte R.H. Effects of a chronic compression of the dorsal root ganglion on voltage-gated Na+ and K+ currents in cutaneous afferent neurons. J Neurophysiol 2006, 95:1115-1123.
41. Tarpey M.M., Wink D.A., Grisham M.B. Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am J Physiol 2004, 286:R431-R444.
42. Villetti G., Bergamaschi M., Bassani F., Bolzoni P.T., Maiorino M., Pietra C., et al. Antinociceptive activity of the N-methyl-d-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. J Pharmacol Exp Ther 2003, 306:804-814.
43. Wallace J.L. Nitric oxide, aspirin-triggered lipoxins and NO-aspirin in gastric protection. Inflamm Allergy Drug Targets 2006, 5:133-137.
44. Wan Y. Involvement of hyperpolarization-activated, cyclic nucleotide-gated cation channels in dorsal root ganglion in neuropathic pain. Sheng Li Xue Bao 2008, 60:579-580.
45. Wang C., Wang S., Qin J., Lv Y., Ma X., Liu C. Ethanol upregulates iNOS expression in colon through activation of nuclear factor-kappa B in rats. Alcohol Clin Exp Res 2010, 34:57-63.
46. Xiao H.S., Huang Q.H., Zhang F.X., Bao L., Lu Y.J., Guo C., et al. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci USA 2002, 99:8360-8365.
47. Zhang Y., Wang Y.H., Ge H.Y., Arendt-Nielsen L., Wang R., Yue S.W. A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats. Neurosci Lett 2008, 432:222-227.