A highly conserved sequence associated with the HIV gp41 loop region is an immunomodulator of antigen-specific T cells in mice

Blood

Volumn 121, Issue 12, 2013, Pages 2244-2252

  Ashkenazi, Avraham ^a   Faingold, Omri ^a   Kaushansky, Nathali ^a   Ben Nun, Avraham ^a   Shai, Yechiel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE LOOP ASSOCIATED DETERMINANT; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; IMMUNOLOGIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; CONSERVED SEQUENCE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN; HUMAN CELL; IC50; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE MEMBRANE; LYMPHOCYTE PROLIFERATION; MITOSIS INHIBITION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SIMIAN IMMUNODEFICIENCY VIRUS;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CONSERVED SEQUENCE; HIV ENVELOPE PROTEIN GP41; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC FACTORS; JURKAT CELLS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; SIMIAN IMMUNODEFICIENCY VIRUS; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTES;

MLCS; MLOWN;

EID: 84877928488     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-11-468900     Document Type: Article

References (49)

1. Douek DC, Picker LJ, Koup RA. T cell dynamics in HIV-1 infection. Annu Rev Immunol. 2003;21(21): 265-304.
2. Grossman Z, Meier-Schellersheim M, Sousa AE, et al. CD41 T-cell depletion in HIV infection: Are we closer to understanding the cause?. Nat Med. 2002;8(4):319-323.
3. Stevenson M. HIV-1 pathogenesis. Nat Med. 2003;9(7):853-860.
4. Baur AS, Sawai ET, Dazin P, et al. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity. 1994;1(5): 373-384.
5. Weiss A, Imboden J, Hardy K, et al. The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol. 1986;4:593-619.
6. Cosson P, Lankford SP, Bonifacino JS, et al. Membrane protein association by potential intramembrane charge pairs. Nature. 1991; 351(6325):414-416.
7. Call ME, Pyrdol J, Wiedmann M, et al. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell. 2002;111(7): 967-979.
8. Manolios N, Collier S, Taylor J, et al. T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease. Nat Med. 1997;3(1):84-88.
9. Chirmule N, McCloskey TW, Hu R, et al. HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). J Immunol. 1995;155(2): 917-924.
10. Masci AM, Galgani M, Cassano S, et al. HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-Amediated signaling. J Leukoc Biol. 2003;74(6): 1117-1124.
11. Fernando K, Hu H, Ni H, et al. Vaccine-delivered HIV envelope inhibits CD4(1) T-cell activation, a mechanism for poor HIV vaccine responses. Blood. 2007;109(6):2538-2544.
12. Zhang R, Lifson JD, Chougnet C. Failure of HIVexposed CD41 T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions. Blood. 2006;107(5):1989-1995.
13. Ruegg CL, Strand M. A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. Cell Immunol. 1991;137(1):1-13.
14. Denner J, Norley S, Kurth R. The immunosuppressive peptide of HIV-1: Functional domains and immune response in AIDS patients. AIDS. 1994;8(8):1063-1072.
15. Donaghy H, Stebbing J, Patterson S. Antigen presentation and the role of dendritic cells in HIV. Curr Opin Infect Dis. 2004;17(1):1-6.
16. Eckert DM, Kim PS. Mechanisms of viral membrane fusion and its inhibition. Annu Rev Biochem. 2001;70:777-810.
17. Harrison SC. Viral membrane fusion. Nat Struct Mol Biol. 2008;15(7):690-698.
18. Finzi A, Xiang SH, Pacheco B, et al. Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions. Mol Cell. 2010;37(5): 656-667.
19. Gallaher WR, Ball JM, Garry RF, et al. A general model for the transmembrane proteins of HIV and other retroviruses. AIDS Res Hum Retroviruses. 1989;5(4):431-440.
20. Freed EO, Myers DJ, Risser R. Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41. Proc Natl Acad Sci USA. 1990; 87(12):4650-4654.
21. Shang L, Yue L, Hunter E. Role of the membranespanning domain of human immunodeficiency virus type 1 envelope glycoprotein in cell-cell fusion and virus infection. J Virol. 2008;82(11): 5417-5428.
22. McDonald D, Wu L, Bohks SM, et al. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science. 2003;300(5623):1295-1297.
23. Cohen T, Cohen SJ, Antonovsky N, et al. HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation. PLoS Pathog. 2010; 6(9):e1001085.
24. Quintana FJ, Gerber D, Kent SC, et al. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Clin Invest. 2005;115(8):2149-2158.
25. Caffrey M, Cai M, Kaufman J, et al. Threedimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 1998;17(16): 4572-4584.
26. Schulz TF, Jameson BA, Lopalco L, et al. Conserved structural features in the interaction between retroviral surface and transmembrane glycoproteins?. AIDS Res Hum Retroviruses. 1992;8(9):1571-1580.
27. Bär S, Alizon M. Role of the ectodomain of the gp41 transmembrane envelope protein of human immunodeficiency virus type 1 in late steps of the membrane fusion process. J Virol. 2004;78(2): 811-820.
28. Ashkenazi A, Viard M, Wexler-Cohen Y, et al. Viral envelope protein folding and membrane hemifusion are enhanced by the conserved loop region of HIV-1 gp41. FASEB J. 2011;25(7): 2156-2166.
29. Ben-Nun A, Lando Z. Detection of autoimmune cells proliferating to myelin basic protein and selection of T cell lines that mediate experimental autoimmune encephalomyelitis (EAE) in mice. J Immunol. 1983;130(3):1205-1209.
30. Weiss A, Wiskocil RL, Stobo JD. The role of T3 surface molecules in the activation of human T cells: A two-stimulus requirement for IL 2 production reflects events occurring at a pretranslational level. J Immunol. 1984;133(1): 123-128.
31. Zhong MC, Cohen L, Meshorer A, et al. T-cells specific for soluble recombinant oligodendrocytespecific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2(b) and H-2(s) mice. J Neuroimmunol. 2000; 105(1):39-45.
32. Ben-Nun A, Kerlero de Rosbo N, Kaushansky N, et al. Anatomy of T cell autoimmunity to myelin oligodendrocyte glycoprotein (MOG): Prime role of MOG44F in selection and control of MOGreactive T cells in H-2b mice. Eur J Immunol. 2006;36(2):478-493.
33. Kaushansky N, Zilkha-Falb R, Hemo R, et al. Pathogenic T cells in MOBP-induced murine EAE are predominantly focused to recognition of MOBP21F and MOBP27P epitopic residues. Eur J Immunol. 2007;37(11):3281-3292.
34. Papo N, Shai Y. A molecular mechanism for lipopolysaccharide protection of Gram-negative bacteria from antimicrobial peptides. J Biol Chem. 2005;280(11):10378-10387.
35. Rapaport D, Ovadia M, Shai Y. A synthetic peptide corresponding to a conserved heptad repeat domain is a potent inhibitor of Sendai viruscell fusion: An emerging similarity with functional domains of other viruses. EMBO J. 1995;14(22): 5524-5531.
36. Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol. 2005;23(23): 683-747.
37. Schroder K, Hertzog PJ, Ravasi T, et al. Interferon-gamma: An overview of signals, mechanisms and functions. J Leukoc Biol. 2004; 75(2):163-189.
38. Kubin M, Chow JM, Trinchieri G. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood. 1994;83(7):1847-1855.
39. White SH, Wimley WC. Hydrophobic interactions of peptides with membrane interfaces. Biochim Biophys Acta. 1998;1376(3):339-352.
40. Gruters RA, Neefjes JJ, Tersmette M, et al. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature. 1987;330(6143):74-77.
41. Fischer PB, Collin M, Karlsson GB, et al. The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post- CD4 binding. J Virol. 1995;69(9):5791-5797.
42. Hovanessian AG, Briand JP, Said EA, et al. The caveolin-1 binding domain of HIV-1 glycoprotein gp41 is an efficient B cell epitope vaccine candidate against virus infection. Immunity. 2004;21(5):617-627.
43. Chan DC, Fass D, Berger JM, et al. Core structure of gp41 from the HIV envelope glycoprotein. Cell. 1997;89(2):263-273.
44. Bloch I, Quintana FJ, Gerber D, et al. T-cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif. FASEB J. 2007;21(2):393-401.
45. Kawamura T, Gatanaga H, Borris DL, et al. Decreased stimulation of CD41 T cell proliferation and IL-2 production by highly enriched populations of HIV-infected dendritic cells. J Immunol. 2003;170(8):4260-4266.
46. Garg H, Blumenthal R. Role of HIV Gp41 mediated fusion/hemifusion in bystander apoptosis. Cell Mol Life Sci. 2008;65(20):3134-3144.
47. Clerici M, Stocks NI, Zajac RA, et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virusseropositive patients. Independence of CD41 cell numbers and clinical staging. J Clin Invest. 1989; 84(6):1892-1899.
48. Wu Y, Marsh JW. Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science. 2001; 293(5534):1503-1506.
49. Woods TC, Roberts BD, Butera ST, et al. Loss of inducible virus in CD45RA naive cells after human immunodeficiency virus-1 entry accounts for preferential viral replication in CD45RO memory cells. Blood. 1997;89(5):1635-1641.