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Volumn 37, Issue 11, 2007, Pages 3281-3292

Pathogenic T cells in MOBP-induced murine EAE are predominantly focused to recognition of MOBP21F and MOBP27P epitopic residues

Author keywords

Autoimmunity; B cells; Neuroimmunology; T cells

Indexed keywords

CYTOPLASM PROTEIN; MYELIN ASSOCIATED OLIGODENDROCYTE BASIC PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 36349018864     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737438     Document Type: Article
Times cited : (11)

References (50)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra, M. and Martin, R., Immunology of multiple sclerosis. Annu. Rev. Immunol. 2005. 23: 683-747.
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 2
    • 0005966256 scopus 로고    scopus 로고
    • T cell response to myelin antigens in multiple sclerosis: Relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein
    • Kerlero de Rosbo, N., Ben-Nun, A., T cell response to myelin antigens in multiple sclerosis: Relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein. J. Autoimmun. 1998. 11: 287-299.
    • (1998) J. Autoimmun , vol.11 , pp. 287-299
    • Kerlero de Rosbo, N.1    Ben-Nun, A.2
  • 3
    • 0030851699 scopus 로고    scopus 로고
    • Developmental expression of the myelin gene MOBP in the rat nervous system
    • Holz, A., Schwab, M. E., Developmental expression of the myelin gene MOBP in the rat nervous system. J. Neurocytol. 1997. 26: 467-477.
    • (1997) J. Neurocytol , vol.26 , pp. 467-477
    • Holz, A.1    Schwab, M.E.2
  • 4
    • 0028020575 scopus 로고
    • Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin
    • Yamamoto, Y., Mizuno, R., Nishimura, T., Ogawa, Y., Yoshikawa, H., Fujimura, H.,Adachi, E. et al., Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. J. Biol. Chem. 1994. 269: 31725-31730.
    • (1994) J. Biol. Chem , vol.269 , pp. 31725-31730
    • Yamamoto, Y.1    Mizuno, R.2    Nishimura, T.3    Ogawa, Y.4    Yoshikawa, H.5    Fujimura, H.6    Adachi, E.7
  • 5
    • 0033006444 scopus 로고    scopus 로고
    • Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin
    • Yamamoto, Y., Yoshikawa, H., Nagano, S., Kondoh, G., Sadahiro, S., Gotow, T., Yanagihara, T. and Sakoda, S., Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Eur. J. Neurosci. 1999. 11: 847-855.
    • (1999) Eur. J. Neurosci , vol.11 , pp. 847-855
    • Yamamoto, Y.1    Yoshikawa, H.2    Nagano, S.3    Kondoh, G.4    Sadahiro, S.5    Gotow, T.6    Yanagihara, T.7    Sakoda, S.8
  • 6
    • 0030058663 scopus 로고    scopus 로고
    • Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein
    • Holz, A., Schaeren-Wiemers, N., Schaefer, C., Pott, U., Colello, R. J. and Schwab, M. E., Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. J. Neurosci. 1996. 16: 467-477.
    • (1996) J. Neurosci , vol.16 , pp. 467-477
    • Holz, A.1    Schaeren-Wiemers, N.2    Schaefer, C.3    Pott, U.4    Colello, R.J.5    Schwab, M.E.6
  • 7
    • 0034087145 scopus 로고    scopus 로고
    • Morphometric analysis of the myelin-associated oligodendrocytic basic protein-deficient mouse reveals a possible role for myelin-associated oligodendrocytic basic protein in regulating axonal diameter
    • Sadahiro, S., Yoshikawa, H., Yagi, N., Yamamoto, Y., Yanagihara, T., Kimura, M. and Sakoda, S., Morphometric analysis of the myelin-associated oligodendrocytic basic protein-deficient mouse reveals a possible role for myelin-associated oligodendrocytic basic protein in regulating axonal diameter. Neuroscience 2000. 98: 361-367.
    • (2000) Neuroscience , vol.98 , pp. 361-367
    • Sadahiro, S.1    Yoshikawa, H.2    Yagi, N.3    Yamamoto, Y.4    Yanagihara, T.5    Kimura, M.6    Sakoda, S.7
  • 8
    • 0033621626 scopus 로고    scopus 로고
    • The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS)
    • Kaye, J. F., Kerlero de Rosbo, N., Mendel, L, Flechter, S., Hoffman, M., Yust, I., Ben-Nun, A., The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS). J. Neuroimmunol. 2000. 102: 189-198.
    • (2000) J. Neuroimmunol , vol.102 , pp. 189-198
    • Kaye, J.F.1    Kerlero de Rosbo, N.2    Mendel, L.3    Flechter, S.4    Hoffman, M.5    Yust, I.6    Ben-Nun, A.7
  • 9
    • 3142781394 scopus 로고    scopus 로고
    • The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501
    • de Rosbo, N. K. Kaye, J. F., Eisenstein, M., Mendel, L, Hoeftberger, R., Lassmann, H., Milo, R. and Ben-Nun, A., The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501. J. Immunol. 2004. 173: 1426-1435.
    • (2004) J. Immunol , vol.173 , pp. 1426-1435
    • de Rosbo, N.K.1    Kaye, J.F.2    Eisenstein, M.3    Mendel, L.4    Hoeftberger, R.5    Lassmann, H.6    Milo, R.7    Ben-Nun, A.8
  • 10
    • 0034650603 scopus 로고    scopus 로고
    • Myelin-associated oligodendrocytic basic protein: Identification of an encephalitogenic epitope and association with multiple sclerosis
    • Holz, A., Bielekova, B., Martin, R. and Oldstone, M. B., Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis. J. Immunol. 2000. 164: 1103-1109.
    • (2000) J. Immunol , vol.164 , pp. 1103-1109
    • Holz, A.1    Bielekova, B.2    Martin, R.3    Oldstone, M.B.4
  • 11
    • 0031731797 scopus 로고    scopus 로고
    • Encephalitogenicity of myelin-associated oligodendrocytic basic protein and 2′,3′-cyclic nucleotide 3′-phosphodiesterase for BALB/c and SJL mice
    • Maatta, J. A., Kaldman, M. S., Sakoda, S., Salmi, A. A. and Hinkkanen, A. E., Encephalitogenicity of myelin-associated oligodendrocytic basic protein and 2′,3′-cyclic nucleotide 3′-phosphodiesterase for BALB/c and SJL mice. Immunology 1998. 95: 383-388.
    • (1998) Immunology , vol.95 , pp. 383-388
    • Maatta, J.A.1    Kaldman, M.S.2    Sakoda, S.3    Salmi, A.A.4    Hinkkanen, A.E.5
  • 12
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster, J. and Allen, P. M., Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 1996. 14: 1-27.
    • (1996) Annu. Rev. Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 13
    • 0025620007 scopus 로고
    • T cell recognition in experimental autoimmune encephalomyelitis: Prospects for immune intervention with synthetic peptides
    • Wraith, D. C., Smilek, D. E., Mitchell, D. J., Steinman, L. and McDevitt, H. O., T cell recognition in experimental autoimmune encephalomyelitis: prospects for immune intervention with synthetic peptides. Int. Rev. Immunol. 1990. 6: 37-47.
    • (1990) Int. Rev. Immunol , vol.6 , pp. 37-47
    • Wraith, D.C.1    Smilek, D.E.2    Mitchell, D.J.3    Steinman, L.4    McDevitt, H.O.5
  • 14
    • 0036467394 scopus 로고    scopus 로고
    • The specificity of TCR/pMHC interaction
    • Rudolph, M. G. and Wilson, I. A., The specificity of TCR/pMHC interaction. Curr. Opin. Immunol. 2002. 14: 52-65.
    • (2002) Curr. Opin. Immunol , vol.14 , pp. 52-65
    • Rudolph, M.G.1    Wilson, I.A.2
  • 15
    • 0032033445 scopus 로고    scopus 로고
    • Crystal structure of I-Aκ in complex with dominant epitope of Isozyme
    • Fremont, D. H., Donnaie, D., Nelson, C. A., Hendrickson, W. A., Unanue, E. R., Crystal structure of I-Aκ in complex with dominant epitope of Isozyme. Immunity 1998. 8: 305-317.
    • (1998) Immunity , vol.8 , pp. 305-317
    • Fremont, D.H.1    Donnaie, D.2    Nelson, C.A.3    Hendrickson, W.A.4    Unanue, E.R.5
  • 16
  • 17
    • 0033520962 scopus 로고    scopus 로고
    • The crystal structure of a T cell receptor in complex with peptide and MHC class II
    • Reinherz, E. L., Tan, K., Tang, L., Kern, P., Liu, J., Xiong, Y., Hussey, R. E. et al., The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science 1999. 286: 1913-1921.
    • (1999) Science , vol.286 , pp. 1913-1921
    • Reinherz, E.L.1    Tan, K.2    Tang, L.3    Kern, P.4    Liu, J.5    Xiong, Y.6    Hussey, R.E.7
  • 18
    • 5144235394 scopus 로고    scopus 로고
    • Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines
    • Hohlfeld, R. and Wekerle, H., Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc. Natl. Acad. Sci. USA 2004. 101 Suppl 2: 14599-14606.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.SUPPL. 2 , pp. 14599-14606
    • Hohlfeld, R.1    Wekerle, H.2
  • 19
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Nicholson, L. B., Greer, J. M., Sobel, R. A., Lees, M. B., Kuchroo, V. K., An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995. 3: 397-405.
    • (1995) Immunity , vol.3 , pp. 397-405
    • Nicholson, L.B.1    Greer, J.M.2    Sobel, R.A.3    Lees, M.B.4    Kuchroo, V.K.5
  • 20
    • 0030973661 scopus 로고    scopus 로고
    • Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms
    • Gaut, A., Boehme, S. A., Chalmers, D., Crowe, P. D., Pahuja, A., Ling, N., Brocke, S. et al., Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J. Neuroimmunol. 1997. 74: 149-158.
    • (1997) J. Neuroimmunol , vol.74 , pp. 149-158
    • Gaut, A.1    Boehme, S.A.2    Chalmers, D.3    Crowe, P.D.4    Pahuja, A.5    Ling, N.6    Brocke, S.7
  • 21
    • 0031228204 scopus 로고    scopus 로고
    • Changes in cytokine secretion induced by altered peptide ligand of myelin basic protein peptide 85-99
    • Ausubel, L. J., Krieger, J. I. and Hafler, D. A., Changes in cytokine secretion induced by altered peptide ligand of myelin basic protein peptide 85-99. J. Immunol. 1997. 59: 2502-2512
    • (1997) J. Immunol , vol.59 , pp. 2502-2512
    • Ausubel, L.J.1    Krieger, J.I.2    Hafler, D.A.3
  • 22
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The altered peptide ligand in relapsing MS study group
    • Kappos, L., Comi, G., Panitch, H., Oger, J., Antel, J., Conlon, P., Steinman, L., Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The altered peptide ligand in relapsing MS study group. Nat. Med. 2000. 6: 1176-1182.
    • (2000) Nat. Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6    Steinman, L.7
  • 24
    • 0029462088 scopus 로고
    • Signalling events in the anergy induction of T helper 1 cells
    • discussion 196-202
    • Sloan-Lancaster, J. and Allen, P. M., Signalling events in the anergy induction of T helper 1 cells. Ciba Found. Symp. 1995. 195: 189-196; discussion 196-202.
    • (1995) Ciba Found. Symp , vol.195 , pp. 189-196
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 26
    • 33745221626 scopus 로고    scopus 로고
    • A dual altered peptide ligand down regulates myasthenogenic T cell responses and reverses experimental autoimmune myasthenia gravis via up regulation of Fas-Fas L-mediated apoptosis
    • Aruna, B. V., Ben-David, H., Sela, M. and Mozes, E., A dual altered peptide ligand down regulates myasthenogenic T cell responses and reverses experimental autoimmune myasthenia gravis via up regulation of Fas-Fas L-mediated apoptosis. Immunology 2006. 118: 413-424.
    • (2006) Immunology , vol.118 , pp. 413-424
    • Aruna, B.V.1    Ben-David, H.2    Sela, M.3    Mozes, E.4
  • 27
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D. and Allen, P. M., Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 1991. 252: 1308-1310.
    • (1991) Science , vol.252 , pp. 1308-1310
    • Evavold, B.D.1    Allen, P.M.2
  • 28
    • 0028956146 scopus 로고
    • Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand
    • Windhagen, A., Scholz, C., Hollsberg, P., Fukaura, H., Sette, A. and Hafler, D. A., Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 1995. 2: 373-380.
    • (1995) Immunity , vol.2 , pp. 373-380
    • Windhagen, A.1    Scholz, C.2    Hollsberg, P.3    Fukaura, H.4    Sette, A.5    Hafler, D.A.6
  • 30
    • 0026032553 scopus 로고
    • Functional diversity of T lymphocytes due to secretion of different cytokine patterns
    • Street, N. E. and Mosmann, T. R., Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 1991. 5: 171-177.
    • (1991) FASEB J , vol.5 , pp. 171-177
    • Street, N.E.1    Mosmann, T.R.2
  • 32
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
    • Alleva, D. G., Gaur, A., Jin, L., Wegmann, D., Gottlieb, P. A., Pahuja, A., Johnson, E. B., Motheral, T. et al., Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 2002. 51: 2126-2134
    • (2002) Diabetes , vol.51 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3    Wegmann, D.4    Gottlieb, P.A.5    Pahuja, A.6    Johnson, E.B.7    Motheral, T.8
  • 33
    • 22244462396 scopus 로고    scopus 로고
    • Regulatory T cells in immunologic self-tolerance and autoimmune disease
    • Sakaguchi, S. and Sakaguchi, N., Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int. Rev. Immunol. 2005. 24: 211-226.
    • (2005) Int. Rev. Immunol , vol.24 , pp. 211-226
    • Sakaguchi, S.1    Sakaguchi, N.2
  • 34
    • 0034084162 scopus 로고    scopus 로고
    • Shevach, E. M., Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 2000. 18: 423-449.
    • Shevach, E. M., Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 2000. 18: 423-449.
  • 36
    • 0024325672 scopus 로고
    • Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy
    • Wraith, D. C., Smilek, D. E., Mitchell, D. J., Steinman, L. and McDevitt, H. C., Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 1989. 59: 247-255.
    • (1989) Cell , vol.59 , pp. 247-255
    • Wraith, D.C.1    Smilek, D.E.2    Mitchell, D.J.3    Steinman, L.4    McDevitt, H.C.5
  • 37
    • 0024592929 scopus 로고
    • Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein
    • Clayton, J. P., Gammon, G. M., Ando, D. G., Kono, D. H., Hood, L. and Sercarz, E. E., Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein. J. Exp. Med. 1989. 169: 1681-1691.
    • (1989) J. Exp. Med , vol.169 , pp. 1681-1691
    • Clayton, J.P.1    Gammon, G.M.2    Ando, D.G.3    Kono, D.H.4    Hood, L.5    Sercarz, E.E.6
  • 38
    • 0027056539 scopus 로고
    • Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy
    • Gaut, A., Wiers, B., Liu, A., Rothbard, J. and Fathman, C. G., Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 1992. 258: 1491-1494.
    • (1992) Science , vol.258 , pp. 1491-1494
    • Gaut, A.1    Wiers, B.2    Liu, A.3    Rothbard, J.4    Fathman, C.G.5
  • 39
    • 0025174370 scopus 로고
    • Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides
    • Kennedy, M. K., Tan, L. J., Dal Canto, M. C., Tuohy, V. K., Lu, Z. J., Trotter, J. L. and Miller, S. D., Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides. J. Immunol. 1990. 144: 909-915.
    • (1990) J. Immunol , vol.144 , pp. 909-915
    • Kennedy, M.K.1    Tan, L.J.2    Dal Canto, M.C.3    Tuohy, V.K.4    Lu, Z.J.5    Trotter, J.L.6    Miller, S.D.7
  • 40
    • 0030893962 scopus 로고    scopus 로고
    • Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide
    • Devaux, B., Enderlin, F., Wallner, B. and Smilek, D. E., Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide. J. Neuroimmunol. 1997. 75: 169-173.
    • (1997) J. Neuroimmunol , vol.75 , pp. 169-173
    • Devaux, B.1    Enderlin, F.2    Wallner, B.3    Smilek, D.E.4
  • 41
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova, B., Goodwin, B., Richert, N., Cortese, L, Kondo, T., Afshar, G., Gran, B. et al., Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat. Med. 2000. 6: 1167-1175.
    • (2000) Nat. Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, L.4    Kondo, T.5    Afshar, G.6    Gran, B.7
  • 42
    • 32944455545 scopus 로고    scopus 로고
    • Anatomy of T cell autoimmunity to myelin oligodendrocyte glycoprotein (MOG): Prime role of MOG44F in selection and control of MOG-reactive T cells in H-2b mice
    • Ben-Nun, A., Kerlero de Rosbo, N., Kaushansky, N., Eisenstein, M., Cohen, L., Kaye, J. F., Mendel, I., Anatomy of T cell autoimmunity to myelin oligodendrocyte glycoprotein (MOG): prime role of MOG44F in selection and control of MOG-reactive T cells in H-2b mice. Eur. J. Immunol. 2006. 36: 478-493.
    • (2006) Eur. J. Immunol , vol.36 , pp. 478-493
    • Ben-Nun, A.1    Kerlero de Rosbo, N.2    Kaushansky, N.3    Eisenstein, M.4    Cohen, L.5    Kaye, J.F.6    Mendel, I.7
  • 43
    • 34447512764 scopus 로고    scopus 로고
    • Oligodendrocyte-specific protein (OSP) (claudin -11)-induced EAE in C57B1 mice is mediated by pathogenic T cells primarily governed by a single epitopic residue (OSP192Y) of the major encephalitogenic region OSP179-207
    • Kaushansky, N., Hemo, R., Eisenstein, M. and Ben-Nun, A., Oligodendrocyte-specific protein (OSP) (claudin -11)-induced EAE in C57B1 mice is mediated by pathogenic T cells primarily governed by a single epitopic residue (OSP192Y) of the major encephalitogenic region OSP179-207. Eur. J. Immunol. 2002. 37:2018-2031
    • (2002) Eur. J. Immunol , vol.37 , pp. 2018-2031
    • Kaushansky, N.1    Hemo, R.2    Eisenstein, M.3    Ben-Nun, A.4
  • 44
    • 0023753713 scopus 로고
    • Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
    • Acha-Orbea, H., Mitchell, D. J., Timmermann, L., Wraith, D. C., Tausch, G. S., Waldor, M. K., Zamvil, S. S. et al., Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988. 54: 263-273.
    • (1988) Cell , vol.54 , pp. 263-273
    • Acha-Orbea, H.1    Mitchell, D.J.2    Timmermann, L.3    Wraith, D.C.4    Tausch, G.S.5    Waldor, M.K.6    Zamvil, S.S.7
  • 45
    • 0034212928 scopus 로고    scopus 로고
    • T cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2(b) and H-2(s) mice
    • Zhong, M. C., Cohen, L., Meshorer, A., Kerlero de Rosbo, N. and Ben-Nun, A., T cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2(b) and H-2(s) mice. J. Neuroimmunol. 2000. 105: 39-45.
    • (2000) J. Neuroimmunol , vol.105 , pp. 39-45
    • Zhong, M.C.1    Cohen, L.2    Meshorer, A.3    Kerlero de Rosbo, N.4    Ben-Nun, A.5
  • 47
    • 85047692323 scopus 로고    scopus 로고
    • Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice
    • Delarasse, C., Daubas, P., Mars, L. T., Vizler, C., Litzenburger, T., Iglesias, A., Bauer, J. et al., Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J. Clin. Invest. 2003. 112: 544-553.
    • (2003) J. Clin. Invest , vol.112 , pp. 544-553
    • Delarasse, C.1    Daubas, P.2    Mars, L.T.3    Vizler, C.4    Litzenburger, T.5    Iglesias, A.6    Bauer, J.7
  • 48
    • 33750836408 scopus 로고    scopus 로고
    • Epitope specificity of autoreactive T and B cells associated with experimental autoimmune encephalomyelitis and optic neuritis induced by oligodendrocyte-specific protein in SJL/J mice
    • Kaushansky, N., Zhong, M. C., Kerlero de Rosbo, N., Hoeftberger, R., Lassmarm, H. and Ben-Nun, A., Epitope specificity of autoreactive T and B cells associated with experimental autoimmune encephalomyelitis and optic neuritis induced by oligodendrocyte-specific protein in SJL/J mice. J. Immunol. 2006. 177: 7364-7376.
    • (2006) J. Immunol , vol.177 , pp. 7364-7376
    • Kaushansky, N.1    Zhong, M.C.2    Kerlero de Rosbo, N.3    Hoeftberger, R.4    Lassmarm, H.5    Ben-Nun, A.6
  • 49
    • 0026777041 scopus 로고
    • Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice
    • Greer, J. M., Kuchroo, V. K., Sobel, R. A. and Lees, M. B., Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J. Immunol. 1992. 149: 783-788.
    • (1992) J. Immunol , vol.149 , pp. 783-788
    • Greer, J.M.1    Kuchroo, V.K.2    Sobel, R.A.3    Lees, M.B.4
  • 50
    • 0020658978 scopus 로고
    • Detection of autoimmune cells proliferating to myelin basic protein and selection of T cell lines that mediate experimental autoimmune encephalomyelitis (EAE) in mice
    • Ben-Nun, A. and Lando, Z., Detection of autoimmune cells proliferating to myelin basic protein and selection of T cell lines that mediate experimental autoimmune encephalomyelitis (EAE) in mice. J. Immunol. 1983. 130: 1205-1209.
    • (1983) J. Immunol , vol.130 , pp. 1205-1209
    • Ben-Nun, A.1    Lando, Z.2


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