Novel pH-sensitive lipid-polymer composite microspheres of 10-hydroxycamptothecin exhibiting colon-specific biodistribution and reduced systemic absorption

Journal of Pharmaceutical Sciences

Volumn 102, Issue 6, 2013, Pages 1752-1759

  Gan, Li ^a   Gao, Yi Ping ^a,b   Zhu, Chun Liu ^a   Zhang, Xin Xin ^a   Gan, Yong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Xuhui District Central Hospital   (China)

Author keywords

10 hydroxycamptothecin; Bioavailability; Biodistribution; Colonic drug delivery; Lipids; Microspheres; PH sensitive; Polymers

Indexed keywords

10 HYDROXYCAMPTOTHECIN; COUMARIN; LIPID; MICROSPHERE;

AREA UNDER THE CURVE; ARTICLE; COLON ABSORPTION; CONTROLLED DRUG RELEASE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PARTICLE SIZE; PH; RAT;

EID: 84877923099     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23499     Document Type: Article

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