In vitro and in vivo evaluation of a novel capsule for colon-specific drug delivery

Journal of Pharmaceutical Sciences

Volumn 98, Issue 8, 2009, Pages 2626-2635

  Han, Min ^a   Fang, Qiu Li ^a   Zhan, Hong Wei ^b   Luo, Tao ^a   Liang, Wen Quan ^a   Gao, Jian Qing ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Colon specific capsule; Colon specific drug delivery; Gamma scintigraphy; In vitro release; Pharmacokinetics

Indexed keywords

BUFFER; EUDRAGIT; EUDRAGIT RS; TECHNETIUM 99M; THEOPHYLLINE;

ADULT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; ASCENDING COLON; BIOAVAILABILITY; COLON; COLON SPECIFIC CAPSULE; CONTROLLED STUDY; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; GAMMA SCINTIGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO CULTURE; MALE; MEAN RESIDENCE TIME; NONHUMAN; NORMAL HUMAN; RAT; SMALL INTESTINE; STOMACH; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 68249116984     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21627     Document Type: Article

References (30)

1. Van den Mooter G. 2006. Colon drug delivery. Expert Opin Drug Deliv 3:111-125.
2. Yang L, Chu JS, Fix JA. 2002. Colon specific drug delivery: New approaches and in vitro/in vivo evaluation. Int J Pharm 235:1-15. (Pubitemid 34185432)
3. Chourasia MK, Jain SK. 2003. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharm Sci 6:33-66.
4. Vandamme TF, Lenourry A, Charrueau C, Chaumeil JC. 2002. The use of polysaccharides to target drugs to the colon. Carbohydr Polym 48:219-231. (Pubitemid 34141159)
5. Jones BE. 2004. The history of the medicinal capsule. In: Podczeck F, Jones BE, editors. Pharmaceutical capsules. 2nd edition. London: Pharmaceutical Press. pp. 1-22.
6. Ogura T, Furuya Y, Matsuura S. 1998. HPMC capsules-an alternative to gelatin. Pharm Techn Eur 11:32-42.
7. Cole ET, Scott RA, Cade D, Connor AL, Wilding IR. 2004. In vitro and in vivo pharmacoscintigraphic evaluation of ibuprofen hypromellose and gelatin capsules. Pharm Res 21:793-798.
8. Cole ET, Scott RA, Connor AL, Wilding IR, Petereit HU, Schminke C, Beckert T, Cadé D. 2002. Enteric coated HPMC capsules designed to achieve intestinal targeting. Int J Pharm 231:83-95. (Pubitemid 33086822)
9. Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamoto A, Muranishi S. 1997. Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption form the rat colon. J Pharm Sci 86:1016-1021. (Pubitemid 27382903)
10. Xu C, Zhang JS, Mo Y, Tan RX. 2005. Calcium pectinate capsules for colon-specific drug delivery. Drug Dev Ind Pharm 31:127-134. (Pubitemid 40315708)
11. Tozaki H, Odoriba T, Okada N, Fujita T, Terabe A, Suzuki T, Okabe S, Muranishi S, Yamamoto A. 2002. Chitosan capsules for colon-specific drug delivery: Enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. J Control Release 82:51-61. (Pubitemid 34775047)
12. Fetih G, Lindberg S, Itoh K, Okada N, Fujita T, Habib F, Artersson P, Attia M, Yamamoto A. 2005. Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan capsules. Int J Pharm 293:127-135. (Pubitemid 40381086)
13. Fetih G, Fausia H, Okada N, Fujita T, Attia M, Yamamoto A. 2006. Colon-specific delivery and enhanced colonic absorption of [Asu(1,7)]-eel calcitonin using chitosan capsules containing various additives in rats. J Drug Target 14:165-172. (Pubitemid 43878825)
14. Yamamoto A. 2007. Study on the colon specific delivery of prednisolone using chitosan capsules. Yakugaku Zasshi 127:621-630. (Pubitemid 46536535)
15. Skloot GS. 2002. Nocturnal asthma: Mechanisms and management. Mt Sinai J Med 69:140-147.
16. Staib AH, Loew D, Harder S, Graul EH, Pfab R. 1986. Measurement of theophylline absorption from different regions of the gastro-intestinal tract using a remote controlled drug delivery device. Eur J Clin Pharmacol 30:691-697. (Pubitemid 16018948)
17. McConnell EL, Short MD, Basit AW. 2008. An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man. J Control Release 130:154-160.
18. Wilding IR, Coupe AJ, Davis SS. 2001. The role of gamma scintigraphy in oral drug delivery. Adv Drug Del Rev 46:103-124.
19. Yamaoka K, Nakagava J, Uno T. 1978. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 6:547-558.
20. Haeberlin B, Friend DR. 1992. Anatomy and physiology of the GI tract: Implications for colonic drug delivery. In: Friend DR, editor. Oral colon-specific drug delivery. Boca Raton, FL: CRC Press. pp. 1-44.
21. Pye G, Evans DF, Ledingham S, Hardcastle JD. 1990. Gastrointestinal intraluminal pH in normal subjects and those with colorectal adenoma or carcinoma. Gut 31:1355-1357.
22. Davis SS, Hardy JG, Fara JW. 1986. Transit of pharmaceutical dosage forms through the small intestine. Gut 27:886-892.
23. Wong D, Larrabee S, Clifford K, Tremblay J, Friend DR. 1997. USP dissolution apparatus III (reciprocating cylinder) for screening of guar-based colonic delivery formulations. J Control Release 47:173-179. (Pubitemid 27212344)
24. Krishnaiah YS, Satyanarayana V, Dinesh Kumar B, Karthikeyan RS. 2002. In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil. Eur J Pharm Sci 16:185-192.
25. Chourasia MK, Jain SK. 2004. Potential of guar gum microspheres for target specific drug release to colon. J Drug Target 12:435-442.
26. Rubinstein A, Gliko-kabir I. 1995. Synthesis and swelling dependent enzymatic degradation of borax modified guar gum for colonic delivery purpose. STP Pharm Sci 5:41-46.
27. Gliko-Kabir I, Yagen B, Baluom M, Rubinstein A. 2000. Phosphated crosslinked guar for colon-specific drug delivery. II. In vitro and in vivo evaluation in the rat. J Control Release 63:129-134.
28. Tuǧcu-Demiröz F, Acartürk F, Takka S, Konuş-Boyunaǧa O. 2004. In-vitro and in-vivo evaluation of mesalazine-guar gum matrix tablets for colonic drug delivery. J Drug Target 12:105-112. (Pubitemid 38786919)
29. Sinha VR, Kumria R. 2003. Microbial triggered drug delivery to colon. Eur J Pharm Sci 18:3-18. (Pubitemid 36120550)
30. Krishnaiah YSR, Satyanarayana S, Rama Prasad YV, Narasimha Rao S. 1998. Evaluation of guar gum as a compression coat for drug targeting to colon. Int J Pharm 171:137-146. (Pubitemid 29023106)