Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas

Genes Chromosomes and Cancer

Volumn 52, Issue 7, 2013, Pages 644-655

  Wu, Hui ^a   Zhang, Haihong ^a   Wang, Peng ^a   Mao, Zhuo ^b   Feng, Li ^b   Wang, Yuqian ^a   Liu, Chenlu ^a   Xia, Qiu ^a   Li, Bo ^a   Zhao, Heya ^a   Chen, Yan ^a   Wu, Jiaxin ^a   Kong, Wei ^a   Yu, Xianghui ^a  

^a JILIN UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE G9A; MULTIPROTEIN COMPLEX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; CARCINOMA, HEPATOCELLULAR; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HISTOCOMPATIBILITY ANTIGENS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; LIVER NEOPLASMS; PROTEIN ISOFORMS; PROTEINS;

EID: 84877921744     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.22060     Document Type: Article

References (30)

1. Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410:120-124.
2. Caron C, Pivot-Pajot C, van Grunsven LA, Col E, Lestrat C, Rousseaux S, Khochbin S. 2003. Cdyl: A new transcriptional co-repressor. EMBO Rep 4:877-882.
3. Caron C, Lestrat C, Marsal S, Escoffier E, Curtet S, Virolle V, Barbry P, Debernardi A, Brambilla C, Brambilla E, Rousseaux S, Khochbin S. 2010. Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers. Oncogene 29:5171-5181.
4. Dialynas GK, Vitalini MW, Wallrath LL. 2008. Linking heterochromatin protein 1 (HP1) to cancer progression. Mutat Res 647:13-20.
5. Dorus S, Gilbert SL, Forster ML, Barndt RJ, Lahn BT. 2003. The CDY-related gene family: Coordinated evolution in copy number, expression profile and protein sequence. Hum Mol Genet 12:1643-1650.
6. Eisen A, Utley RT, Nourani A, Allard S, Schmidt P, Lane WS, Lucchesi JC, Cote J. 2001. The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J Biol Chem 276:3484-3491.
7. Fischle W, Franz H, Jacobs SA, Allis CD, Khorasanizadeh S. 2008. Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs. J Biol Chem 283:19626-19635.
8. Franz H, Mosch K, Soeroes S, Urlaub H, Fischle W. 2009. Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association. J Biol Chem 284:35049-35059.
9. Grunstein M. 1997. Histone acetylation in chromatin structure and transcription. Nature 389:349-352.
10. Huang J, Dorsey J, Chuikov S, Pérez-Burgos L, Zhang X, Jenuwein T, Reinberg D, Berger SL. 2010. G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem 285:9636-9641.
11. Herceg Z, Paliwal A. 2011. Epigenetic mechanisms in hepatocellular carcinoma: How environmental factors influence the epigenome. Mutat Res 727:55-61.
12. Ikeguchi M, Hirooka Y, Kaibara N. 2002. Quantitative analysis of apoptosis-related gene expression in hepatocellular carcinoma. Cancer 95:1938-1945.
13. Joshi AA, Struhl K. 2005. Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol Cell 20:971-978.
14. Kondo Y, Shen L, Issa JP. 2003. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol 23:206-215.
15. Kondo Y, Shen L, Suzuki S, Kurokawa T, Masuko K, Tanaka Y, Kato H, Mizuno Y, Yokoe M, Sugauchi F, Hirashima N, Orito E, Osada H, Ueda R, Guo Y, Chen X, Issa JP, Sekido Y. 2007. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res 37:974-983.
16. Kouzarides T. 2007. Chromatin modifications and their function. Cell 128:693-705.
17. Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. 2001. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410:116-120.
18. Li X, Liang J, Yu H, Su B, Xiao C, Shang Y, Wang W. 2007. Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends Genet 23:427-431.
19. Margueron R, Trojer P, Reinberg D. 2005. The key to development: Interpreting the histone code? Curr Opin Genet Dev 15:163-176.
20. Martin C, Zhang Y. 2005. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 6:838-849.
21. Meng CF, Zhu XJ, Peng G, Dai DQ. 2009. Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells. Oncol Rep 22:1221-1227.
22. Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y. 2008. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell 32:718-726.
23. Nguyen CT, Weisenberger DJ, Velicescu M, Gonzales FA, Lin JC, Liang G, Jones PA. 2002. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Res 62:6456-6461.
24. Peter AJ, Stephen BB. 2007. The epigenomics of cancer. Cell 128:683-692.
25. Sampath SC, Marazzi I, Yap KL, Sampath SC, Krutchinsky AN, Mecklenbräuker I, Viale A, Rudensky E, Zhou MM, Chait BT, Tarakhovsky A. 2007. Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell 27:596-608.
26. Scholzen T, Gerdes J. 2000. The Ki-67 protein: From the known and the unknown. J Cell Physiol 182:311-322.
27. Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM. 2007. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell 128:1003-1012.
28. Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y. 2002. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev 16:1779-1791.
29. Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y. 2005. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev 19:815-826.
30. Yuan W, Xie J, Long C, Erdjument-Bromage H, Ding X, Zheng Y, Tempst P, Chen S, Zhu B, Reinberg D. 2009. Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem 284:15701-15707.