Parkinson's disease cybrids, differentiated or undifferentiated, maintain morphological and biochemical phenotypes different from those of control cybrids

Journal of Neuroscience Research

Volumn 91, Issue 7, 2013, Pages 963-970

  Appukuttan, T A ^a   Ali, N ^a   Varghese, M ^a,c   Singh, A ^a   Tripathy, D ^a   Padmakumar, M ^a   Gangopadhyay, P K ^b   Mohanakumar, K P ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b CALCUTTA NATIONAL MEDICAL COLLEGE   (India)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

C RET; Dopamine release; Dopamine transporter; Neuritogenesis; Neuronal differentiation; Retinoic acid

Indexed keywords

DAT PROTEIN; DOPAMINE; MESSENGER RNA; PENTRAXIN 3; PROTEIN; PROTEIN RET; RETINOIC ACID; TH PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DENSITY; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYBRID; DOPAMINE RELEASE; DOPAMINERGIC ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; INDIAN; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEURITE; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; NEURITES; NEUROBLASTOMA; PARKINSON DISEASE; RNA, MESSENGER; TRETINOIN; TYROSINE 3-MONOOXYGENASE; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 84877920993     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23241     Document Type: Article

References (33)

1. Alladi PA, Mahadevan A, Shankar SK, Raju TR, Muthane U. 2010. Expression of GDNF receptors GFRα1 and RET is preserved in substantia nigra pars compacta of aging Asian Indians. J Chem Neuroanat 40:43-52.
2. Appukuttan TA, Varghese M, Gangopadhyay PK, Mohanakumar KP. 2011. Creation of cybrids for investigating mitochondrial electron transport chain functions in Parkinson's disease. J Cell Tissue Res 11:2445-2450.
3. Borland MK, Trimmer PA, Rubinstein JD, Keeney PM, Mohanakumar K, Liu L, Bennett JP Jr. 2008. Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells. Mol Neurodegen 3:21.
4. Borland MK, Mohanakumar KP, Rubinstein JD, Keeney PM, Xie J, Capaldi R, Dunham LD, Trimmer PA, Bennett JP Jr. 2009. Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues. Biochim Biophys Acta 1792:68-74.
5. Cazorla P, Smidt MP, O'Malley KL, Burbach JP. 2000. A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter. J Neurochem 74:1829-1837.
6. Chao J, Lau WK, Huie MJ, Ho YS, Yu MS, Lai CS, Wang M, Yuen WH, Lam WH, Chan TH, Chang RC. 2010. A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine. Neurosci Lett 469:360-364.
7. Cheung YT, Lau WK, Yu MS, Lai CS, Yeung SC, So KF, Chang RC. 2009. Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research. Neurotoxicology 30:127-135.
8. da Frota ML Jr, Pires AS, Zeidán-Chuliá F, Bristot IJ, Lopes FM, de Bittencourt Pasquali MA, Zanotto-Filho A, Behr GA, Klamt F, Gelain DP, Moreira JC. 2011. In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox. Mol Cell Biochem 358:325-234.
9. Esteves AR, Domingues AF, Ferreira IL, Januário C, Swerdlow RH, Oliveira CR, Cardoso SM. 2008. Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion 8:219-228.
10. Kowsky S, Pöppelmeyer C, Kramer ER, Falkenburger BH, Kruse A, Klein R, Schulz JB. 2007. RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals. Proc Natl Acad Sci U S A 104:20049-20054.
11. Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. 2006. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet 38:518-520.
12. Lopes FM, Schröder R, da Frota ML Jr, Zanotto-Filho A, Müller CB, Pires AS, Meurer RT, Colpo GD, Gelain DP, Kapczinski F, Moreira JC, Fernandes MdC, Klamt F. 2010. Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies. Brain Res 1337:85-94.
13. Lopes FM, Londero GF, de Medeiros LM, da Motta LL, Behr GA, de Oliveira VA, Ibrahim M, Moreira JC, de Oliveira Porciúncula L, da Rocha JB, Klamt F. 2012. Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamine. Neurotox Res 22:138-149.
14. LoPresti P, Poluha W, Poluha DK, Drinkwater E, Ross AH. 1992. Neuronal differentiation triggered by blocking cell proliferation. Cell Growth Differ 3:627-635.
15. Mastroeni D, Grover A, Leonard B, Joyce JN, Coleman PD, Kozik B, Bellinger DL, Rogers J. 2009. Microglial responses to dopamine in a cell culture model of Parkinson's disease. Neurobiol Aging 30:1805-1817.
16. Muralikrishnan D, Mohanakumar KP. 1998. Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced neurotoxicity in mice. FASEB J 12:905-912.
17. Nakano Y, Hirko AC, Smith AD, Oka M, Dawson R, Peris J, Terada N, Meyer EM. 2004. Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells. Neurochem Int 45:1067-1073.
18. Påhlman S, Odelstad L, Larsson E, Grotte G, Nilsson K. 1981. Phenotypic changes of human neuroblastoma cells in culture induced by 12-O-tetradecanoyl-phorbol-13-acetate. Int J Cancer 28:583-589.
19. Påhlman S, Ruusala AI, Abrahamsson L, Mattsson ME, Esscher T. 1984. Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation. Cell Differ 14:135-144.
20. Paratcha G, Ledda F, Baars L, Coulpier M, Besset V, Anders J, Scott R, Ibáñez CF. 2001. Released GFR-alpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. Neuron 29:171-184.
21. Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL. 1997. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci U S A 94:6238-6243.
22. Schneider L, Giordano S, Zelickson BR, Johnson M, Benavides G, Ouyang X, Fineberg N, Darley-Usmar VM, Zhang J. 2011. Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress. Free Rad Biol Med 51:2007-2017.
23. Sheehan JP, Palmer PE, Helm GA, Tuttle JB. 1997. MPP+ induced apoptotic cell death in SH-SY5Y neuroblastoma cells: an electron microscope study. J Neurosci Res 48:226-237.
24. Sherer TB, Trimmer PA, Borland K, Parks JK, Bennett JP Jr, Tuttle JB. 2001. Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells. Brain Res 891:94-105.
25. Smith AD, Antion M, Zigmond MJ, Austin MC. 2003. Effect of 6-hydroxydopamine on striatal GDNF and nigral GFRalpha1 and RET mRNAs in the adult rat. Brain Res Mol Brain Res 117:129-138.
26. Trimmer PA, Swerdlow RH, Parks JK, Keeney P, Bennett JP Jr, Miller SW, Davis RE, Parker WD Jr. 2000. Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines. Exp Neurol 162:37-50.
27. Trupp M, Belluardo N, Funakoshi H, Ibáñez CF. 1997. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-a indicates multiple mechanisms of trophic actions in the adult rat CNS. J Neurosci 17:3554-3567.
28. Varghese M, Pandey M, Samanta A, Gangopadhyay PK, Mohanakumar KP. 2009. Reduced NADH coenzyme Q dehydrogenase activity in platelets of Parkinson's disease, but not Parkinson plus patients, from an Indian population. J Neurol Sci 279:39-42.
29. Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. 2008. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet 40:392-394.
30. Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, Bellen HJ. 2005. Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 47:365-378.
31. Xiang B, Fei X, Zhuang W, Fang Y, Qin Z, Liang Z. 2011. Cathepsin L is involved in 6-hydroxydopamine-induced apoptosis of SH-SY5Y neuroblastoma cells. Brain Res 1387:29-38.
32. Xie HR, Hu LS, Li GY. 2010. SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. Chin Med J 123:1086-1092.
33. Xiong N, Jia M, Chen C, Xiong J, Zhang Z, Huang J, Hou L, Yang H, Cao X, Liang Z, Sun S, Lin Z, Wang T. 2011. Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y. Neuroscience 199:292-302.