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Volumn 11, Issue 5, 2013, Pages 494-505

Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURBITACIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE 2; JSI 124; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

EID: 84877906130     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0528     Document Type: Article
Times cited : (59)

References (50)
  • 1
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008; 359:492-507.
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 3
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9:157-73.
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3    Forrest, W.F.4    Soriano, R.H.5    Wu, T.D.6
  • 4
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Network CGAR
    • Network CGAR. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455: 1061-8.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 5
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 6
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumours
    • Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 2010;463:318-25.
    • (2010) Nature , vol.463 , pp. 318-325
    • Carro, M.S.1    Lim, W.K.2    Alvarez, M.J.3    Bollo, R.J.4    Zhao, X.5    Snyder, E.Y.6
  • 8
    • 84856641109 scopus 로고    scopus 로고
    • NF-kappaB, the first quarter-century: Remarkable progress and outstanding questions
    • Hayden MS, Ghosh S. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 2012; 26:203-34.
    • (2012) Genes Dev , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 9
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 10
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 2009;1:a000141.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Karin, M.1
  • 11
    • 84859972127 scopus 로고    scopus 로고
    • JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
    • O'Shea JJ, Plenge R. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 2012;36:542-50.
    • (2012) Immunity , vol.36 , pp. 542-550
    • O'Shea, J.J.1    Plenge, R.2
  • 12
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship?
    • Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann N Y Acad Sci 2009;1171:59-76.
    • (2009) Ann N y Acad Sci , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3    Gupta, S.R.4    Tharakan, S.T.5    Koca, C.6
  • 13
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 14
    • 34249660614 scopus 로고    scopus 로고
    • SOCS proteins, cytokine signalling and immune regulation
    • Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 2007;7:454-65.
    • (2007) Nat Rev Immunol , vol.7 , pp. 454-465
    • Yoshimura, A.1    Naka, T.2    Kubo, M.3
  • 15
    • 77953633109 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 signaling in glioma: Targets for future therapies
    • Atkinson GP, Nozell SE, Benveniste ET. NF-kappaB and STAT3 signaling in glioma: targets for future therapies. Expert Rev Neurother 2010;10:575-86.
    • (2010) Expert Rev Neurother , vol.10 , pp. 575-586
    • Atkinson, G.P.1    Nozell, S.E.2    Benveniste, E.T.3
  • 16
    • 58649100056 scopus 로고    scopus 로고
    • Inflammation and cancer: IL-6 and STAT3 complete the link
    • Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 2009;15:79-80.
    • (2009) Cancer Cell , vol.15 , pp. 79-80
    • Bromberg, J.1    Wang, T.C.2
  • 17
    • 51049089073 scopus 로고    scopus 로고
    • Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: Implications for STAT-3 activation and gene expression
    • Brantley EC, Nabors LB, Gillespie GY, Choi YH, Palmer CA, Harrison K, et al. Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression. Clin Cancer Res 2008;14:4694-704.
    • (2008) Clin Cancer Res , vol.14 , pp. 4694-4704
    • Brantley, E.C.1    Nabors, L.B.2    Gillespie, G.Y.3    Choi, Y.H.4    Palmer, C.A.5    Harrison, K.6
  • 18
    • 33845370278 scopus 로고    scopus 로고
    • Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: Correlation with EGFR status, tumor grade, and survival
    • Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL. Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. J Neuropathol Exp Neurol 2006;65:1181-8.
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 1181-1188
    • Mizoguchi, M.1    Betensky, R.A.2    Batchelor, T.T.3    Bernay, D.C.4    Louis, D.N.5    Nutt, C.L.6
  • 19
    • 55449102824 scopus 로고    scopus 로고
    • The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes
    • Nozell S, Laver T, Moseley D, Nowoslawski L, De Vos M, Atkinson GP, et al. The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. Mol Cell Biol 2008;28:6632-45.
    • (2008) Mol Cell Biol , vol.28 , pp. 6632-6645
    • Nozell, S.1    Laver, T.2    Moseley, D.3    Nowoslawski, L.4    De Vos, M.5    Atkinson, G.P.6
  • 20
    • 58149144782 scopus 로고    scopus 로고
    • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in highgrade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators
    • Lo HW, Cao X, Zhu H, Ali-Osman F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in highgrade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin Cancer Res 2008;14:6042-54.
    • (2008) Clin Cancer Res , vol.14 , pp. 6042-6054
    • Lo, H.W.1    Cao, X.2    Zhu, H.3    Ali-Osman, F.4
  • 22
    • 84856213846 scopus 로고    scopus 로고
    • The diverse and complex roles of NF-kappaB subunits in cancer
    • Perkins ND. The diverse and complex roles of NF-kappaB subunits in cancer. Nat Rev Cancer 2012;12:121-32.
    • (2012) Nat Rev Cancer , vol.12 , pp. 121-132
    • Perkins, N.D.1
  • 23
    • 84860630975 scopus 로고    scopus 로고
    • Targeting the interleukin-6/Jak/stat pathway in human malignancies
    • Sansone P, Bromberg J. Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol 2012;30:1005-14.
    • (2012) J Clin Oncol , vol.30 , pp. 1005-1014
    • Sansone, P.1    Bromberg, J.2
  • 24
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003;63:1270-9.
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 25
    • 49749129612 scopus 로고    scopus 로고
    • JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment
    • Su Y, Li G, Zhang X, Gu J, Zhang C, Tian Z, et al. JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment. Cancer Biol Ther 2008;7:1243-9.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1243-1249
    • Su, Y.1    Li, G.2    Zhang, X.3    Gu, J.4    Zhang, C.5    Tian, Z.6
  • 26
    • 78650488834 scopus 로고    scopus 로고
    • Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis
    • Ishdorj G, Johnston JB, Gibson SB. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Mol Cancer Ther 2010;9:3302-14.
    • (2010) Mol Cancer Ther , vol.9 , pp. 3302-3314
    • Ishdorj, G.1    Johnston, J.B.2    Gibson, S.B.3
  • 27
    • 77956561531 scopus 로고    scopus 로고
    • Dasatinib synergizes with JSI-124 to inhibit growth and migration and induce apoptosis of malignant human glioma cells
    • Premkumar DR, Jane EP, Agostino NR, Scialabba JL, Pollack IF. Dasatinib synergizes with JSI-124 to inhibit growth and migration and induce apoptosis of malignant human glioma cells. J Carcinog 2010; 9:1-14.
    • (2010) J Carcinog , vol.9 , pp. 1-14
    • Premkumar, D.R.1    Jane, E.P.2    Agostino, N.R.3    Scialabba, J.L.4    Pollack, I.F.5
  • 29
    • 79958189859 scopus 로고    scopus 로고
    • An NF-kappaB p65-cIAP2 link is necessary for mediating resistance to TNF-alpha induced cell death in gliomas
    • Zhao X, Laver T, Hong SW, Twitty GB Jr, Devos A, Devos M, et al. An NF-kappaB p65-cIAP2 link is necessary for mediating resistance to TNF-alpha induced cell death in gliomas. J Neurooncol 2011;102: 367-81.
    • (2011) J Neurooncol , vol.102 , pp. 367-381
    • Zhao, X.1    Laver, T.2    Hong, S.W.3    Twitty Jr., G.B.4    Devos, A.5    Devos, M.6
  • 30
    • 34447119530 scopus 로고    scopus 로고
    • Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: Functional effects in apoptosis
    • Meares GP, Jope RS. Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis. J Biol Chem 2007;282:16989-7001.
    • (2007) J Biol Chem , vol.282 , pp. 16989-17001
    • Meares, G.P.1    Jope, R.S.2
  • 32
    • 33745806566 scopus 로고    scopus 로고
    • Mechanism of IFN-betamediated inhibition of IL-8 gene expression in astroglioma cells
    • Nozell S, Laver T, Patel K, Benveniste EN. Mechanism of IFN-betamediated inhibition of IL-8 gene expression in astroglioma cells. J Immunol 2006;177:822-30.
    • (2006) J Immunol , vol.177 , pp. 822-830
    • Nozell, S.1    Laver, T.2    Patel, K.3    Benveniste, E.N.4
  • 33
    • 79959424651 scopus 로고    scopus 로고
    • Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells
    • Ishdorj G, Johnson JB, Gibson SB. Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells. BMC Cancer 2011;11:1-12.
    • (2011) BMC Cancer , vol.11 , pp. 1-12
    • Ishdorj, G.1    Johnson, J.B.2    Gibson, S.B.3
  • 34
    • 33751090746 scopus 로고    scopus 로고
    • Phosphorylation and functions of the RNA polymerase II CTD
    • Phatnani HP, Greenleaf AL. Phosphorylation and functions of the RNA polymerase II CTD. Genes Dev 2006;20:2922-36.
    • (2006) Genes Dev , vol.20 , pp. 2922-2936
    • Phatnani, H.P.1    Greenleaf, A.L.2
  • 35
    • 0030772376 scopus 로고    scopus 로고
    • Novel inhibitors of cytokine-induced Ikappa Balpha phosphorylation and endothelial cell adhesion molecule expression show antiinflammatory effects in vivo
    • Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, et al. Novel inhibitors of cytokine-induced Ikappa Balpha phosphorylation and endothelial cell adhesion molecule expression show antiinflammatory effects in vivo. J Biol Chem 1997;272:21096-103.
    • (1997) J Biol Chem , vol.272 , pp. 21096-21103
    • Pierce, J.W.1    Schoenleber, R.2    Jesmok, G.3    Best, J.4    Moore, S.A.5    Collins, T.6
  • 36
    • 70949094349 scopus 로고    scopus 로고
    • The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
    • Hedvat M, Huszar D, Herrmann A, Gozgit JM, Schroeder A, Sheehy A, et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 2009;16:487-97.
    • (2009) Cancer Cell , vol.16 , pp. 487-497
    • Hedvat, M.1    Huszar, D.2    Herrmann, A.3    Gozgit, J.M.4    Schroeder, A.5    Sheehy, A.6
  • 38
    • 0242298578 scopus 로고    scopus 로고
    • CK2 is a C-terminal IkappaB kinase responsible for NF-kappaB activation during the UV response
    • Kato T Jr, Delhase M, Hoffmann A, Karin M. CK2 is a C-terminal IkappaB kinase responsible for NF-kappaB activation during the UV response. Mol Cell 2003;12:829-39.
    • (2003) Mol Cell , vol.12 , pp. 829-839
    • Kato Jr., T.1    Delhase, M.2    Hoffmann, A.3    Karin, M.4
  • 39
    • 0037112514 scopus 로고    scopus 로고
    • Protein kinase CK2 promotes aberrant activation of nuclear factorkappaB, transformed phenotype, and survival of breast cancer cells
    • Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Sonenshein GE. Protein kinase CK2 promotes aberrant activation of nuclear factorkappaB, transformed phenotype, and survival of breast cancer cells. Cancer Res 2002;62:6770-8.
    • (2002) Cancer Res , vol.62 , pp. 6770-6778
    • Romieu-Mourez, R.1    Landesman-Bollag, E.2    Seldin, D.C.3    Sonenshein, G.E.4
  • 40
    • 0037591401 scopus 로고    scopus 로고
    • Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of i kappa B alpha and serine phosphorylation of p65: Evidence for the involvement of i kappa B alpha kinase and Syk protein-tyrosine kinase
    • Takada Y, Mukhopadhyay A, Kundu GC, Mahabeleshwar GH, Singh S, Aggarwal BB. Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J Biol Chem 2003;278:24233-41.
    • (2003) J Biol Chem , vol.278 , pp. 24233-24241
    • Takada, Y.1    Mukhopadhyay, A.2    Kundu, G.C.3    Mahabeleshwar, G.H.4    Singh, S.5    Aggarwal, B.B.6
  • 41
    • 0032491410 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha
    • Abu-Amer Y, Ross FP, McHugh KP, Livolsi A, Peyron JF, Teitelbaum SL. Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha. J Biol Chem 1998;273:29417-23.
    • (1998) J Biol Chem , vol.273 , pp. 29417-29423
    • Abu-Amer, Y.1    Ross, F.P.2    McHugh, K.P.3    Livolsi, A.4    Peyron, J.F.5    Teitelbaum, S.L.6
  • 42
    • 2942716907 scopus 로고    scopus 로고
    • P53 induces NFkappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    • Bohuslav J, Chen LF, Kwon H, Mu Y, Greene WC. p53 induces NFkappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J Biol Chem 2004;279:26115-25.
    • (2004) J Biol Chem , vol.279 , pp. 26115-26125
    • Bohuslav, J.1    Chen, L.F.2    Kwon, H.3    Mu, Y.4    Greene, W.C.5
  • 44
    • 77955911497 scopus 로고    scopus 로고
    • Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
    • Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 2010;24: 1731-45.
    • (2010) Genes Dev , vol.24 , pp. 1731-1745
    • Inda, M.M.1    Bonavia, R.2    Mukasa, A.3    Narita, Y.4    Sah, D.W.5    Vandenberg, S.6
  • 45
    • 17844397949 scopus 로고    scopus 로고
    • The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
    • Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 2005;7:122-33.
    • (2005) Neuro Oncol , vol.7 , pp. 122-133
    • Brat, D.J.1    Bellail, A.C.2    Van Meir, E.G.3
  • 47
    • 77956944087 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 inhibits antiviral IFNbeta signaling to enhance HIV-1 replication in macrophages
    • Akhtar LN, Qin H, Muldowney MT, Yanagisawa LL, Kutsch O, Clements JE, et al. Suppressor of cytokine signaling 3 inhibits antiviral IFNbeta signaling to enhance HIV-1 replication in macrophages. J Immunol 2010;185:2393-404.
    • (2010) J Immunol , vol.185 , pp. 2393-2404
    • Akhtar, L.N.1    Qin, H.2    Muldowney, M.T.3    Yanagisawa, L.L.4    Kutsch, O.5    Clements, J.E.6
  • 48
    • 57149092384 scopus 로고    scopus 로고
    • Influenza A virus inhibits type i IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression
    • Pauli EK, Schmolke M, Wolff T, Viemann D, Roth J, Bode JG, et al. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog 2008;4: e1000196.
    • (2008) PLoS Pathog , vol.4
    • Pauli, E.K.1    Schmolke, M.2    Wolff, T.3    Viemann, D.4    Roth, J.5    Bode, J.G.6
  • 49
    • 0037159513 scopus 로고    scopus 로고
    • IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa Bmediated inflammatory response program
    • Li X, Massa PE, Hanidu A, Peet GW, Aro P, Savitt A, et al. IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa Bmediated inflammatory response program. J Biol Chem 2002;277: 45129-40.
    • (2002) J Biol Chem , vol.277 , pp. 45129-45140
    • Li, X.1    Massa, P.E.2    Hanidu, A.3    Peet, G.W.4    Aro, P.5    Savitt, A.6
  • 50
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • Nakanishi C, Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 2005;5:297-309.
    • (2005) Nat Rev Cancer , vol.5 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2


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