메뉴 건너뛰기




Volumn 9, Issue , 2010, Pages

Dasatinib synergizes with JSI-124 to inhibit growth and migration and induce apoptosis of malignant human glioma cells

Author keywords

Apoptosis; dasatinib; glioma; JSI 124; migration

Indexed keywords

ANTINEOPLASTIC AGENT; DASATINIB; FOCAL ADHESION KINASE; JSI 124; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 77956561531     PISSN: 09746773     EISSN: 14773163     Source Type: Journal    
DOI: 10.4103/1477-3163.65448     Document Type: Article
Times cited : (18)

References (60)
  • 2
  • 3
    • 60149089005 scopus 로고    scopus 로고
    • Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
    • Du J, Bernasconi P, Clauser KR, Mani DR, Finn SP, Beroukhim R, et al. Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nat Biotechnol 2009;27:77-83.
    • (2009) Nat Biotechnol , vol.27 , pp. 77-83
    • Du, J.1    Bernasconi, P.2    Clauser, K.R.3    Mani, D.R.4    Finn, S.P.5    Beroukhim, R.6
  • 4
    • 33645072205 scopus 로고    scopus 로고
    • Treatment for advanced tumors: SRC reclaims center stage
    • Summy JM, Gallick GE. Treatment for advanced tumors: SRC reclaims center stage. Clin Cancer Res 2006;12:1398-401.
    • (2006) Clin Cancer Res , vol.12 , pp. 1398-1401
    • Summy, J.M.1    Gallick, G.E.2
  • 5
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman TJ. A renaissance for SRC. Nat Rev Cancer 2004;4:470-80.
    • (2004) Nat Rev Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 6
    • 70149112112 scopus 로고    scopus 로고
    • Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients
    • Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, et al. Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res 2009;69:6889-98.
    • (2009) Cancer Res , vol.69 , pp. 6889-6898
    • Lu, K.V.1    Zhu, S.2    Cvrljevic, A.3    Huang, T.T.4    Sarkaria, S.5    Ahkavan, D.6
  • 7
    • 0028989350 scopus 로고
    • EGF receptor deletions define a region specifically mediating STAT transcription factor activation
    • Coffer PJ, Kruijer W. EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Biochem Biophys Res Commun 1995;210:74-81.
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 74-81
    • Coffer, P.J.1    Kruijer, W.2
  • 8
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994;77:63-71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.6
  • 9
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JE Jr. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264:95-8.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 11
    • 0029916933 scopus 로고    scopus 로고
    • Activation and association of Stat3 with Src in v-Src-transformed cell lines
    • Cao X, Tay A, Guy GR, Tan YH. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol 1996;16:1595-603.
    • (1996) Mol Cell Biol , vol.16 , pp. 1595-1603
    • Cao, X.1    Tay, A.2    Guy, G.R.3    Tan, Y.H.4
  • 12
    • 0035799531 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
    • Garcia R, Bowman TL, Niu G, Yu H, Minton S, Muro-Cacho CA, et al. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 2001;20:2499-513.
    • (2001) Oncogene , vol.20 , pp. 2499-2513
    • Garcia, R.1    Bowman, T.L.2    Niu, G.3    Yu, H.4    Minton, S.5    Muro-Cacho, C.A.6
  • 13
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 1995;269:81-3.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6
  • 14
    • 0037160057 scopus 로고    scopus 로고
    • Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain
    • Schreiner SJ, Schiavone AP, Smithgall TE. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J Biol Chem 2002;277:45680-7.
    • (2002) J Biol Chem , vol.277 , pp. 45680-46587
    • Schreiner, S.J.1    Schiavone, A.P.2    Smithgall, T.E.3
  • 15
    • 0037153476 scopus 로고    scopus 로고
    • Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis
    • Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 2002;21:8075-88.
    • (2002) Oncogene , vol.21 , pp. 8075-8088
    • Wilson, M.B.1    Schreiner, S.J.2    Choi, H.J.3    Kamens, J.4    Smithgall, T.E.5
  • 18
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1- yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004;47:6658-61.
    • (2004) J Med Chem , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3    Norris, D.4    Barrish, J.C.5    Behnia, K.6
  • 19
    • 20144384004 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by fastatin, the fourth FAS1 domain of betaig-h3, via alphavbeta3 integrin
    • Nam JO, Jeong HW, Lee BH, Park RW, Kim IS. Regulation of tumor angiogenesis by fastatin, the fourth FAS1 domain of betaig-h3, via alphavbeta3 integrin. Cancer Res 2005;65:4153-61.
    • (2005) Cancer Res , vol.65 , pp. 4153-4161
    • Nam, J.O.1    Jeong, H.W.2    Lee, B.H.3    Park, R.W.4    Kim, I.S.5
  • 20
    • 26444468152 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells
    • Johnson FM, Saigal B, Talpaz M, Donato NJ. Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin Cancer Res 2005;11:6924-32.
    • (2005) Clin Cancer Res , vol.11 , pp. 6924-6932
    • Johnson, F.M.1    Saigal, B.2    Talpaz, M.3    Donato, N.J.4
  • 21
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 2006;66:5542-8.
    • (2006) Cancer Res , vol.66 , pp. 5542-6648
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 22
    • 62449283132 scopus 로고    scopus 로고
    • Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding
    • Sen B, Saigal B, Parikh N, Gallick G, Johnson FM. Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding. Cancer Res 2009;69:1958-65.
    • (2009) Cancer Res , vol.69 , pp. 1958-1965
    • Sen, B.1    Saigal, B.2    Parikh, N.3    Gallick, G.4    Johnson, F.M.5
  • 23
    • 34548701082 scopus 로고    scopus 로고
    • Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple- negative" breast cancer cell lines growing in vitro
    • Finn RS, Dering J, Ginther C, Wilson CA, Glaspy P, Tchekmedyian N, et al. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro. Breast Cancer Res Treat 2007;105:319-26.
    • (2007) Breast Cancer Res Treat , vol.105 , pp. 319-326
    • Finn, R.S.1    Dering, J.2    Ginther, C.3    Wilson, C.A.4    Glaspy, P.5    Tchekmedyian, N.6
  • 25
    • 27144547509 scopus 로고    scopus 로고
    • Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
    • Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R, et al. Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res 2005;65:9185-9.
    • (2005) Cancer Res , vol.65 , pp. 9185-9189
    • Nam, S.1    Kim, D.2    Cheng, J.Q.3    Zhang, S.4    Lee, J.H.5    Buettner, R.6
  • 26
    • 33846241683 scopus 로고    scopus 로고
    • Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib
    • Serrels A, Macpherson IR, Evans TR, Lee FY, Clark EA, Sansom OJ, et al. Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther 2006;5:3014-22.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3014-3022
    • Serrels, A.1    MacPherson, I.R.2    Evans, T.R.3    Lee, F.Y.4    Clark, E.A.5    Sansom, O.J.6
  • 27
    • 12944272024 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    • Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A 2000;97:4227-32.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4227-4232
    • Grandis, J.R.1    Drenning, S.D.2    Zeng, Q.3    Watkins, S.C.4    Melhem, M.F.5    Endo, S.6
  • 28
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in human prostate tumors and cell lines: Direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
    • Mora LB, Buettner R, Seigne J, Diaz J, Ahmad N, Garcia R, et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: Direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res 2002;62:6659-66.
    • (2002) Cancer Res , vol.62 , pp. 6659-6666
    • Mora, L.B.1    Buettner, R.2    Seigne, J.3    Diaz, J.4    Ahmad, N.5    Garcia, R.6
  • 29
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson J, Jove R. STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene 2000;19:6613-26.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 30
    • 34648835016 scopus 로고    scopus 로고
    • AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation
    • Jane EP, Premkumar DR, Pollack IF. AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation. Cancer Lett 2007;257:36-46.
    • (2007) Cancer Lett , vol.257 , pp. 36-46
    • Jane, E.P.1    Premkumar, D.R.2    Pollack, I.F.3
  • 31
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003;63:1270-9.
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 32
    • 33748341084 scopus 로고    scopus 로고
    • JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
    • Shi X, Franko B, Frantz C, Amin HM, Lai R. JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. Br J Haematol 2006;135:26-32.
    • (2006) Br J Haematol , vol.135 , pp. 26-32
    • Shi, X.1    Franko, B.2    Frantz, C.3    Amin, H.M.4    Lai, R.5
  • 33
    • 42149111675 scopus 로고    scopus 로고
    • Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
    • Fujita M, Zhu X, Sasaki K, Ueda R, Low KL, Pollack IF, et al. Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J Immunol 2008;180:2089-98.
    • (2008) J Immunol , vol.180 , pp. 2089-2098
    • Fujita, M.1    Zhu, X.2    Sasaki, K.3    Ueda, R.4    Low, K.L.5    Pollack, I.F.6
  • 34
    • 0000215699 scopus 로고
    • Comparison of MTT, XTT and a novel tetrazolium compound MTS for in vitro proliferation and chemosensitivity assays
    • Riss TL MR and Moravec RA. Comparison of MTT, XTT and a novel tetrazolium compound MTS for in vitro proliferation and chemosensitivity assays. Mol Biol Cell 1992;3:184.
    • (1992) Mol Biol Cell , vol.3 , pp. 184
    • Riss, T.L.M.R.1    Moravec, R.A.2
  • 35
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 36
    • 34247254388 scopus 로고    scopus 로고
    • SRC and STAT pathways
    • Haura EB. SRC and STAT pathways. J Thorac Oncol 2006;1:403-5.
    • (2006) J Thorac Oncol , vol.1 , pp. 403-405
    • Haura, E.B.1
  • 37
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006;6:184-92.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 38
    • 33749325184 scopus 로고    scopus 로고
    • Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations
    • Bradeen HA, Eide CA, O′Hare T, Johnson KJ, Willis SG, Lee FY, et al. Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations. Blood 2006;108:2332-8.
    • (2006) Blood , vol.108 , pp. 2332-2338
    • Bradeen Ha, E.1
  • 39
    • 66149192409 scopus 로고    scopus 로고
    • Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo
    • Hingorani P, Zhang W, Gorlick R, Kolb EA. Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo. Clin Cancer Res 2009;15:3416-22.
    • (2009) Clin Cancer Res , vol.15 , pp. 3416-3422
    • Hingorani, P.1    Zhang, W.2    Gorlick, R.3    Kolb, E.A.4
  • 40
    • 69849111159 scopus 로고    scopus 로고
    • Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling
    • Nautiyal J, Majumder P, Patel BB, Lee FY, Majumdar AP. Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling. Cancer Lett 2009;283:143-51.
    • (2009) Cancer Lett , vol.283 , pp. 143-151
    • Nautiyal, J.1    Majumder, P.2    Patel, B.B.3    Lee, F.Y.4    Majumdar, A.P.5
  • 41
    • 67649846431 scopus 로고    scopus 로고
    • Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells
    • Pichot CS, Hartig SM, Xia L, Arvanitis C, Monisvais D, Lee FY, et al. Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells. Br J Cancer 2009;101:38-47.
    • (2009) Br J Cancer , vol.101 , pp. 38-147
    • Pichot, C.S.1    Hartig, S.M.2    Xia, L.3    Arvanitis, C.4    Monisvais, D.5    Lee, F.Y.6
  • 42
    • 34547673056 scopus 로고    scopus 로고
    • Tumor cells from ultrasonic aspirations of glioblastomas migrate and form spheres with radial outgrowth
    • Beckner ME, Jane EP, Jankowitz B, Agostino NR, Walter KA, Hamilton RL, et al. Tumor cells from ultrasonic aspirations of glioblastomas migrate and form spheres with radial outgrowth. Cancer Lett 2007;255:135-44.
    • (2007) Cancer Lett , vol.255 , pp. 135-144
    • Beckner, M.E.1    Jane, E.P.2    Jankowitz, B.3    Agostino, N.R.4    Walter, K.A.5    Hamilton, R.L.6
  • 43
    • 0032756158 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription: Novel targets for anticancer therapeutics
    • Bowman T, Yu H, Sebti S, Dalton W, Jove R. Signal transducers and activators of transcription: Novel targets for anticancer therapeutics. Cancer Control 1999;6:427-35.
    • (1999) Cancer Control , vol.6 , pp. 427-435
    • Bowman, T.1    Yu, H.2    Sebti, S.3    Dalton, W.4    Jove, R.5
  • 47
    • 0037164865 scopus 로고    scopus 로고
    • Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
    • Arnoult D, Parone P, Martinou JC, Antonsson B, Estaquier J, Ameisen JC. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 2002;159:923-9.
    • (2002) J Cell Biol , vol.159 , pp. 923-929
    • Arnoult, D.1    Parone, P.2    Martinou, J.C.3    Antonsson, B.4    Estaquier, J.5    Ameisen, J.C.6
  • 48
    • 0037012040 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment
    • Joseph B, Marchetti P, Formstecher P, Kroemer G, Lewensohn R, Zhivotovsky B. Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment. Oncogene 2002;21:65-77.
    • (2002) Oncogene , vol.21 , pp. 65-77
    • Joseph, B.1    Marchetti, P.2    Formstecher, P.3    Kroemer, G.4    Lewensohn, R.5    Zhivotovsky, B.6
  • 49
    • 31044433498 scopus 로고    scopus 로고
    • Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells
    • Premkumar DR, Arnold B, Jane EP, Pollack IF. Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells. Mol Carcinog 2006;45:47-59.
    • (2006) Mol Carcinog , vol.45 , pp. 47-59
    • Premkumar, D.R.1    Arnold, B.2    Jane, E.P.3    Pollack, I.F.4
  • 50
    • 3042748279 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
    • Konnikova L, Kotecki M, Kruger MM, Cochran BH. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer 2003;3:23.
    • (2003) BMC Cancer , vol.3 , pp. 23
    • Konnikova, L.1    Kotecki, M.2    Kruger, M.M.3    Cochran, B.H.4
  • 51
    • 34047265691 scopus 로고    scopus 로고
    • Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival
    • Shor AC, Keschman EA, Lee FY, Muro-Cacho C, Letson GD, Trent JC, et al. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res 2007;67:2800-8.
    • (2007) Cancer Res , vol.67 , pp. 2800-288
    • Shor, A.C.1    Keschman, E.A.2    Lee, F.Y.3    Muro-Cacho, C.4    Letson, G.D.5    Trent, J.C.6
  • 52
    • 33947225176 scopus 로고    scopus 로고
    • Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: Rationale for patient selection
    • DOI 10.1158/0008-5472.CAN-06-3633
    • Huang F, Reeves K, Han X, Fairchild C, Platero S, Wong TW, et al. Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: Rationale for patient selection. Cancer Res 2007;67:2226-38. (Pubitemid 46424242)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 2226-2238
    • Huang, F.1    Reeves, K.2    Han, X.3    Fairchild, C.4    Platero, S.5    Wong, T.W.6    Lee, F.7    Shaw, P.8    Clark, E.9
  • 53
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA, Haque SJ. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 2002;21:8404-13.
    • (2002) Oncogene , vol.21 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 54
    • 34247154498 scopus 로고    scopus 로고
    • A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
    • Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 2007;26:2435-44.
    • (2007) Oncogene , vol.26 , pp. 2435-2444
    • Iwamaru, A.1    Szymanski, S.2    Iwado, E.3    Aoki, H.4    Yokoyama, T.5    Fokt, I.6
  • 56
    • 27144538568 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
    • Nefedova Y, Nagaraj S, Rosenbauer A, Muro-Cacho C, Sebti SM, Gabrilovich DI. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res 2005;65:9525-35.
    • (2005) Cancer Res , vol.65 , pp. 9525-9535
    • Nefedova, Y.1    Nagaraj, S.2    Rosenbauer, A.3    Muro-Cacho, C.4    Sebti, S.M.5    Gabrilovich, D.I.6
  • 57
    • 33751160860 scopus 로고    scopus 로고
    • Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells
    • Jane EP, Premkumar DR, Pollack IF. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther 2006;319:1070-80.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1070-1080
    • Jane, E.P.1    Premkumar, D.R.2    Pollack, I.F.3
  • 58
    • 33646735616 scopus 로고    scopus 로고
    • Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth
    • Premkumar DR, Arnold B, Pollack IF. Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth. Mol Carcinog 2006;45:288-301.
    • (2006) Mol Carcinog , vol.45 , pp. 288-301
    • Premkumar, D.R.1    Arnold, B.2    Pollack, I.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.