Surface display of a massively variable lipoprotein by a legionella diversity-generating retroelement

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 8212-8217

  Arambula, Diego ^a   Wong, Wenge ^a   Medhekar, Bob A ^b   Guo, Huatao ^a   Gingery, Mari ^a   Czornyj, Elizabeth ^a   Liu, Minghsun ^a   Dey, Sanghamitra ^c   Ghosh, Partho ^c   Miller, Jeff F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Accelerated evolution; Bacterial surface display; TAT

Indexed keywords

BACTERIAL PROTEIN; CIS ACTING ELEMENT; LEGIONELLA DETERMINENT TARGET A PROTEIN; LIPOPROTEIN; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANATOMY; ARTICLE; BACTERIAL CELL; BACTERIAL CHROMOSOME; BACTERIAL GENOME; BACTERIAL OUTER MEMBRANE; BACTEROIDES FRAGILIS; BACTEROIDES THETAIOTAOMICRON; CARBOXY TERMINAL SEQUENCE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DIVERSITY GENERATING RETROELEMENT; DNA SEQUENCE; GENE TARGETING; GENOMIC ISLAND; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETROPOSON; SHEWANELLA; TREPONEMA DENTICOLA; TYPE IV SECRETION SYSTEM; VIBRIO;

ACCELERATED EVOLUTION; BACTERIAL SURFACE DISPLAY; TAT;

BACTERIAL PROTEINS; BASE SEQUENCE; CELL MEMBRANE; GENOMIC ISLANDS; LEGIONELLA PNEUMOPHILA; LIPOPROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OPEN READING FRAMES; PROTEIN STRUCTURE, TERTIARY; RETROELEMENTS; SEQUENCE ANALYSIS, DNA; SURFACE PROPERTIES; VIRULENCE;

EID: 84877846517     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1301366110     Document Type: Article

References (30)

1. Gogvadze E, Buzdin A (2009) Retroelements and their impact on genome evolution and functioning. Cell Mol Life Sci 66(23):3727-3742.
2. Doulatov S, et al. (2004) Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements. Nature 431(7007):476-481. (Pubitemid 39329589)
3. AlayyoubiM, et al. (2013) Structure of the essential diversity-generating retroelement protein bAvd and its functionally important interaction with reverse transcriptase. Structure 21(2):266-276.
4. Medhekar B, Miller JF (2007) Diversity-generating retroelements. Curr Opin Microbiol 10(4):388-395. (Pubitemid 47404952)
5. Miller JL, et al. (2008) Selective ligand recognition by a diversity-generating retroelement variable protein. PLoS Biol 6(6):e131.
6. Guo H, et al. (2008) Diversity-generating retroelement homing regenerates target sequences for repeated rounds of codon rewriting and protein diversification. Mol Cell 31(6):813-823.
7. Guo H, et al. (2011) Target site recognition by a diversity-generating retroelement. PLoS Genet 7(12):e1002414.
8. Le Coq J, Ghosh P (2011) Conservation of the C-type lectin fold for massive sequence variation in a Treponema diversity-generating retroelement. Proc Natl Acad Sci USA 108(35):14649-14653.
9. Isberg RR, O'Connor TJ, Heidtman M (2009) The Legionella pneumophila replication vacuole: Making a cosy niche inside host cells. Nat Rev Microbiol 7(1):13-24.
10. Lautner M, Schunder E, Herrmann V, Heuner K (2013) Transfer of genomic islands in Legionella pneumophila. J Bacteriol 195(7):1583-1597.
11. Langille MG, Hsiao WW, Brinkman FS (2010) Detecting genomic islands using bioinformatics approaches. Nat Rev Microbiol 8(5):373-382.
12. Stanley NR, Palmer T, Berks BC (2000) The twin arginine consensus motif of Tat signal peptides is involved in Sec-independent protein targeting in Escherichia coli. J Biol Chem 275(16):11591-11596. (Pubitemid 30237716)
13. De Buck E, et al. (2004) A putative twin-arginine translocation pathway in Legionella pneumophila. Biochem Biophys Res Commun 317(2):654-661. (Pubitemid 38452533)
14. Narita S, Tokuda H (2010) Sorting of bacterial lipoproteins to the outer membrane by the Lol system. Methods Mol Biol 619:117-129.
15. Shruthi H, Babu MM, Sankaran K (2010) TAT-pathway-dependent lipoproteins as a niche-based adaptation in prokaryotes. J Mol Evol 70(4):359-370.
16. Gralnick JA, Vali H, Lies DP, Newman DK (2006) Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1. Proc Natl Acad Sci USA 103(12): 4669-4674.
17. Helbig JH, et al. (2001) Immunolocalization of the Mip protein of intracellularly and extracellularly grown Legionella pneumophila. Lett Appl Microbiol 32(2):83-88. (Pubitemid 32158725)
18. Roy CR, Isberg RR (1997) Topology of Legionella pneumophila DotA: An inner membrane protein required for replication in macrophages. Infect Immun 65(2): 571-578. (Pubitemid 27053227)
19. Miyamoto H, et al. (1993) Protein profiles of Legionella pneumophila Philadelphia-1 grown in macrophages and characterization of a gene encoding a novel 24 kDa Legionella protein. Microb Pathog 15(6):469-484. (Pubitemid 24112088)
20. Matthews M, Roy CR (2000) Identification and subcellular localization of the Legionella pneumophila IcmX protein: A factor essential for establishment of a replicative organelle in eukaryotic host cells. Infect Immun 68(7):3971-3982. (Pubitemid 30434549)
21. Schulze RJ, Zückert WR (2006) Borrelia burgdorferi lipoproteins are secreted to the outer surface by default. Mol Microbiol 59(5):1473-1484.
22. De Buck E, et al. (2005) Legionella pneumophila Philadelphia-1 tatB and tatC affect intracellular replication and biofilm formation. Biochem Biophys Res Commun 331(4): 1413-1420. (Pubitemid 40692513)
23. Rossier O, Cianciotto NP (2005) The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection. Infect Immun 73(4):2020-2032. (Pubitemid 40470800)
24. Kamalakkannan S, Murugan V, Jagannadham MV, Nagaraj R, Sankaran K (2004) Bacterial lipid modification of proteins for novel protein engineering applications. Protein Eng Des Sel 17(10):721-729. (Pubitemid 40143854)
25. Linder ME, Deschenes RJ (2007) Palmitoylation: Policing protein stability and traffic. Nat Rev Mol Cell Biol 8(1):74-84. (Pubitemid 46012016)
26. Kozak NA, et al. (2009) Distribution of lag-1 alleles and sequence-based types among Legionella pneumophila serogroup 1 clinical and environmental isolates in the United States. J Clin Microbiol 47(8):2525-2535.
27. Cazalet C, et al. (2004) Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet 36(11):1165-1173. (Pubitemid 41288965)
28. Petersen TN, Brunak S, von Heijne G, Nielsen H (2011) SignalP 4.0: Discriminating signal peptides from transmembrane regions. Nat Methods 8(10):785-786.
29. Sidhu SS, et al. (2004) Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions. J Mol Biol 338(2):299-310. (Pubitemid 38447087)
30. Dalebroux ZD, Svensson SL, Gaynor EC, Swanson MS (2010) ppGpp conjures bacterial virulence. Microbiol Mol Biol Rev 74(2):171-199.