An integrated strategy for in vivo metabolite profiling using high-resolution mass spectrometry based data processing techniques

Analytica Chimica Acta

Volumn 780, Issue , 2013, Pages 55-64

  Guo, Jian ^a   Zhang, Minli ^a   Elmore, Charles S ^b   Vishwanathan, Karthick ^a  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

High resolution mass spectrometry; High resolution data processing; Metabolite profiling; Techniques

Indexed keywords

BACKGROUND SUBTRACTION; DATA MINING ALGORITHM; DATA PROCESSING TECHNIQUES; HIGH RESOLUTION MASS SPECTROMETRY; HIGH-RESOLUTION DATUM; METABOLITE PROFILING; METABOLOMIC ANALYSIS; TECHNIQUES;

ALGORITHMS; BIOMOLECULES; BODY FLUIDS; DATA MINING; DATA PROCESSING; DEFECTS; ISOTOPES; MASS SPECTROMETRY; PATTERN RECOGNITION; RATS;

METABOLITES;

4 [[4 [(2 HYDROXYETHYL)METHYLCARBAMOYL]PHENYL]QUINOLIN 8 YL METHYLENE] 1 THIAZOL 4 YLMETHYL PIPERIDINIUM; 4 AMINO 8 (2,5 DIMETHOXYPHENYL) N PROPYLCINNOLINE 3 CARBOXAMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; AZ 12488024; AZD 6280; CARBON 14; DELTA OPIATE RECEPTOR AGONIST; DRUG METABOLITE; N (2 HYDROXYETHYL) 4 [QUINOLIN 8 YL [1 (THIAZOL 4 YLMETHYL)PIPERIDIN 4 YLIDENE]METHYL]BENZAMIDE; N (2 HYDROXYETHYL) N METHYL 4 [PIPERIDIN 4 YLIDENE(QUINOLIN 8 YL)METHYL]BENZAMIDE; UNCLASSIFIED DRUG;

ACCURACY; ALGORITHM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DATA MINING; DIGITAL FILTERING; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FECES LEVEL; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; METABOLOMICS; METHYLATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RADIOCHROMATOGRAPHY; RAT;

ANIMALS; AUTOMATIC DATA PROCESSING; BILE; DATA MINING; FECES; HETEROCYCLIC COMPOUNDS, 2-RING; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PIPERIDINES; QUINOLINES; RATS;

RATTUS;

EID: 84877836745     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2013.04.012     Document Type: Article

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