Absorption, excretion, and metabolism of a potential GABA-A α2/3 receptor modulator in rats

Xenobiotica

Volumn 41, Issue 5, 2011, Pages 385-399

  Guo, Jian ^a   Davis, Patty C ^a   Gu, Chungang ^a   Grimm, Scott W ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

AZD6280; excretion; mass spectrometry; metabolism

Indexed keywords

4 AMINO 8 (2,5 DIMETHOXYPHENYL)N PROPYLCINNOLINE 3 CARBOXAMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; ANXIOLYTIC AGENT; AZD 6280; CARBON 14; DRUG METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; FEMALE; GENERALIZED ANXIETY DISORDER; MALE; NONHUMAN; RADIOCHROMATOGRAPHY; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

ABSORPTION; ADMINISTRATION, ORAL; AMIDES; ANIMALS; FEMALE; INJECTIONS, INTRAVENOUS; MALE; MASS SPECTROMETRY; RATS; RECEPTORS, GABA-A;

RATTUS;

EID: 79954556386     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.545453     Document Type: Article

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