In vitro and in vivo metabolism of a selective δ-opioid receptor

Drug Metabolism and Disposition

Volumn 39, Issue 10, 2011, Pages 1883-1894

  Guo, Jian ^a   Gu, Chungang ^a   Zhou, Diansong ^a   Elmore, Charles S ^a   Bui, Khanh H ^a   Grimm, Scott W ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[4 [(2 HYDROXYETHYL)METHYLCARBAMOYL]PHENYL]QUINOLIN 8 YLMETHYLENE] 1 THIAZOL 4 YLMETHYLPIPERIDIUM; CARBOXYLIC ACID; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLITE; OPIATE AGONIST; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILE; BILE DUCT; CONTROLLED STUDY; DEALKYLATION; DEMETHYLATION; DOG; DRUG ABSORPTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TRANSFORMATION; FECES; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPECIES DIFFERENCE; TANDEM MASS SPECTROMETRY; URINE;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; BILE; BILE DUCTS; BIOTRANSFORMATION; CATHETERIZATION; CYTOCHROME P-450 CYP3A; DEALKYLATION; DOGS; FECES; FEMALE; HALF-LIFE; HEPATOCYTES; HUMANS; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; RECEPTORS, OPIOID, DELTA; TANDEM MASS SPECTROMETRY;

CANIS FAMILIARIS; RATTUS;

EID: 80053155751     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.040980     Document Type: Article

References (23)

1. Aguila B, Coulbault L, Boulouard M, Léveillé F, Davis A, Tóth G, Borsodi A, Balboni G, Salvadori S, Jauzac P, et al. (2007) In vitro and in vivo pharmacological profile of UFP-512, a novel selective δ-opioid receptor agonist; correlations between desensitization and tolerance. Br J Pharmacol 152:1312-1324. (Pubitemid 350242435)
2. Bausch SB, Garland JP, and Yamada J (2005) The δ opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats. Brain Res 1045:38-44. (Pubitemid 40725218)
3. Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, and Woods JH (2002) Nonpeptidic δ-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology 26:744-755. (Pubitemid 34455027)
4. Burrows GD, Maguire KP, and Norman TR (1998) Antidepressant efficacy and tolerability of the selective norepinephrine reuptake inhibitor reboxetine: a review. J Clin Psychiatry 59 (Suppl 14):4-7. (Pubitemid 28462381)
5. Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, et al. (2000) Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 25:195-200. (Pubitemid 30394992)
6. Guengerich FP (1999) Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39:1-17.
7. Hajós M, Fleishaker JC, Filipiak-Reisner JK, Brown MT, and Wong EH (2004) The selective norepinephrine reuptake inhibitor antidepressant reboxetine: pharmacological and clinical profile. CNS Drug Rev 10:23-44. (Pubitemid 38381173)
8. Hamilton RA, Garnett WR, and Kline BJ (1981) Determination of mean valproic acid serum level by assay of a single pooled sample. Clin Pharmacol Ther 29:408-413. (Pubitemid 11134120)
9. Hughes RD, Millburn P, and Williams RT (1973) Molecular weight as a factor in the excretion of monoquaternary ammonium cations in the bile of the rat, rabbit and guinea pig. Biochem J 136:967-978.
10. Jutkiewicz EM (2006) The antidepressant-like effects of δ-opioid receptor agonists. Mol Interv 6:162-169.
11. Jutkiewicz EM, Torregrossa MM, Sobczyk-Kojiro K, Mosberg HI, Folk JE, Rice KC, Watson SJ, and Woods JH (2006) Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. Eur J Pharmacol 531:151-159. (Pubitemid 43202228)
12. Nieto MM, Guen SL, Kieffer BL, Roques BP, and Noble F (2005) Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the δ opioid receptors. Neuroscience 135:305-313. (Pubitemid 41317370)
13. Papakostas GI, Stahl SM, Krishen A, Seifert CA, Tucker VL, Goodale EP, and Fava M (2008) Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies. J Clin Psychiatry 69:1287-1292.
14. Perrine SA, Hoshaw BA, and Unterwald EM (2006) Delta opioid receptor ligands modulate anxiety-like behaviors in the rat. Br J Pharmacol 147:864-872.
15. Raynor K, Kong H, Chen Y, Yasuda K, Yu L, Bell GI, and Reisine T (1994) Pharmacological characterization of the cloned ≲καππ α∀-, δ-, and ≲μθ∀-opioid receptors. Mol Pharmacol 45:330-334.
16. Saitoh A, Kimura Y, Suzuki T, Kawai K, Nagase H, and Kamei J (2004) Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents. J Pharmacol Sci 95:374-380. (Pubitemid 39037898)
17. Saitoh A, Yamada M, Yamada M, Takahashi K, Yamaguchi K, Murasawa H, Nakatani A, Tatsumi Y, Hirose N, and Kamei J (2008) Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5- dimethyl-4-(2-propenyl)-1- piperazinyl]-(3-methoxyphenyl)methyl]-N,N- diethylbenzamide) in an olfactory bulbectomized rat model. Brain Res 1208:160-169.
18. Saitoh A, Yoshikawa Y, Onodera K, and Kamei J (2005) Role of δ-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats. Psychopharmacology (Berl) 182:327-334. (Pubitemid 41464644)
19. Tejedor-Real P, Micó JA, Smadja C, Maldonado R, Roques BP, and Gilbert-Rahola J (1998) Involvement of α-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model. Eur J Pharmacol 354:1-7. (Pubitemid 28410224)
20. Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, and Woods JH (2006) Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats. Brain Res 1069:172-181. (Pubitemid 43145911)
21. Torregrossa MM, Isgor C, Folk JE, Rice KC, Watson SJ, and Woods JH (2004) The δ-opioid receptor agonist (+)BW373U86 regulates BDNF mRNA expression in rats. Neuropsychopharmacology 29:649-659. (Pubitemid 38402472)
22. 2-COOH)-Bid (UFP-512), a novel selective δ opioid receptor agonist. Peptides 29:93-103.
23. Wright WE and Line VD (1980) Biliary excretion of cephalosporins in rats: influence of molecular weight. Antimicrob Agents Chemother 17:842-846. (Pubitemid 10112535)