4-(1H-Imidazo[4,5-f]-1,10-phenanthrolin-2-yl)phenol-based G-quadruplex DNA binding agents: Telomerase inhibition, cytotoxicity and DNA-binding studies

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 3379-3387

  Wei, Chun Ying ^a,b   Wang, Jun Hong ^a   Wen, Ye ^a   Liu, Jie ^a   Wang, Li Hua ^a  

^a SHANXI UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

G quadruplex; Phenanthroline; Promoter; Telomere

Indexed keywords

2 [4 (1H IMIDAZO[4,5 F] 1,10 PHENANTHROLIN 2 YL)PHENOXY] N,N DIMETHYLETHANAMINE; 2 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL] 1H IMIDAZO[4,5 F] 1,10 PHENANTHROLINE; 2 [4 [2 (1 PIPERIDYL)ETHOXY]PHENYL] 1H IMIDAZO[4,5 F] 1,10 PHENANTHROLINE; 4 (1H IMIDAZO[4,5 F] 1,10 PHENANTHROLIN 2 YL)PHENOL; 4 [2 [4 (1H IMIDAZO[4,5 F] 1,10 PHENANTHROLIN 2 YL)PHENOXY]ETHYL]MORPHOLINE; C KIT PROTEIN; C KIT2 PROTEIN; GUANINE QUADRUPLEX; MYC PROTEIN; PHENOL DERIVATIVE; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DNA BINDING; DNA STRUCTURE; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SELECTIVITY; DRUG STABILITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; ONCOGENE; ONCOGENE C KIT2; ONCOGENE C MYC;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CYTOTOXINS; ENZYME INHIBITORS; G-QUADRUPLEXES; G2 PHASE CELL CYCLE CHECKPOINTS; HELA CELLS; HEP G2 CELLS; HUMANS; NUCLEIC ACID DENATURATION; PHENANTHROLINES; PHENOLS; PROTO-ONCOGENE PROTEINS C-KIT; PROTO-ONCOGENE PROTEINS C-MYC; TELOMERASE;

EID: 84877834547     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.059     Document Type: Article

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