Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 3120-3126

  Li, Yao ^a   Zhao, Chang Po ^a   Ma, Hua Ping ^a   Zhao, Meng Yue ^a   Xue, Ya Rong ^a   Wang, Xiao Ming ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antibacterial activities; FabH inhibitors; Schiff base; Secnidazole derivatives

Indexed keywords

2 (2 METHYL 5 NITRO 1H IMIDAZO 1 YL) N' (2 NITROBENZYLIDENE)ACETOHYDRAZIDE; 2 (2 METHYL 5 NITRO 1H IMIDAZO 1 YL) N' (3 NITROBENZYLIDENE)ACETOHYDRAZIDE; 2 (2 METHYL 5 NITRO 1H IMIDAZO 1 YL) N' (3,4,5 TRIMETHYLBENZYLIDENE)ACETOHYDRAZIDE; 2 (2 METHYL 5 NITRO 1H IMIDAZO 1 YL) N' (4 METHYLBENZYLIDENE)ACETOHYDRAZIDE; 2 (2 METHYL 5 NITRO 1H IMIDAZO 1 YL) N' (4 NITROBENZYLIDENE)ACETOHYDRAZIDE; 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL) N' (3,4,5 TRIMETHYLBENZYLIDENE)ACETOHYDRAZIDE; ANTIINFECTIVE AGENT; FABH INHIBITOR; N' (2 CHLOROBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (2 FLUOROBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (2 METHOXYBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (2,4 DIFLUOROBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (3 FLUOROBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (3 METHOXYBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (3,4 DIMETHOXYBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (4 BROMOBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (4 CHLOROBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (4 FLUOROBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (4 HYDROXYBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; N' (4 METHOXYBENZYLIDENE) 2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ACETOHYDRAZIDE; SCHIFF BASE; SECNIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ELEMENTAL ANALYSIS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS AERUGINOSA; SIMULATION; SPECTROSCOPY; STAPHYLOCOCCUS AUREUS;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHASE, TYPE II; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PSEUDOMONAS AERUGINOSA; SCHIFF BASES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 84877833117     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.023     Document Type: Article

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