Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells

International Immunology

Volumn 11, Issue 1, 1999, Pages 11-20

  Pound, John D ^a   Challa, Anita ^a   Holder, Michelle J ^a   Armitage, Richard J ^b   Dower, Steven K ^b,e   Fanslow, William C ^b   Kikutani, Hitoshi ^c   Paulie, Staffan ^d   Gregory, Christopher D ^a   Gordon, John ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b AMGEN INC   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d Mabtech AB   (Sweden)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

B cell; CD40 ligand; Germinal center; Receptor; Signalling

Indexed keywords

CD32 ANTIGEN; CD40 ANTIGEN; EPITOPE; GLYCOPROTEIN GP 39; INTERLEUKIN 4; MONOCLONAL ANTIBODY; PHORBOL ESTER;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL CYCLE; CROSS LINKING; DNA SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIGENS, CD40; APOPTOSIS; B-LYMPHOCYTES; BINDING, COMPETITIVE; CD40 LIGAND; CELL ADHESION; CELL CYCLE; EPITOPE MAPPING; EPITOPES; GERMINAL CENTER; HUMANS; IMMUNOLOGIC CAPPING; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS;

EID: 0032926595     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.1.11     Document Type: Article

References (36)

1. Wheeler, K., Pound, J. D., Gordon, J. and Jefferis, R. 1993. Engagement of CD40 lowers the threshold for activation of resting B cells via antigen receptor. Eur J. Immunol. 23:1165.
2. Barrett, T. B., Shu, G. and Clark, E. A. 1991. CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells. J. Immunol. 146:1722.
3. Flores-Romo, L., Estoppey, D. and Bacon, K. B. 1993. Anti-CD40 antibody stimulates the VLA-4-dependent adhesion of normal and LFA-1-deficient B cells to endothelium. Immunology 79:445.
4. Cairns, J. A., Flores-Romo, L., Millsum, M. J., Guy, G. R., Gillis, S., Ledbetter, J. A. and Gordon, J. 1988. Soluble CD23 is released by B lymphocytes cycling in response to interleukin 4 and anti-Bp50 (CDw40). Eur. J. Immunol. 18:349.
5. Armitage, R. J., Fanslow, W. C., Strockbine, L. , Sato, T. A., Clifford, K. N., MacDuff, B. M., Anderson, D. M., Gimpel, S. D., Davis-Smith, T., Maliszewski, C. R., Clark, E. A., Smith, C. A., Grabstein, K. H., Cosman, D. and Spriggs, M. K. 1992. Molecular and biological characterization of a murine ligand for CD40. Nature 357:80.
6. MacLennan, I. C. M., Gulbranson-Judge, A., Toellner, K. M., Casamayor-Palleja, M., Chan, E. Y. T., Sze, D. M.-Y., Luther, S. A. and Orbea, H. A. 1997. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol. Rev. 156:53.
7. Gregory, C. D., Dive, C., Henderson, S., Smith, C. A., Williams, G. T. Gordon, J. and Rickinson, A. B. 1991. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 349:612.
8. Gordon, J. 1995. CD40 and its ligand: central players in B lymphocyte survival, growth and differentiation. Blood 9:53.
9. Knox, K. A. and Gordon, J. 1993. Protein tyrosine phosphorylation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis. Eur. J. Immunol. 23:2578.
10. Holder, M. J., Wang, H., Milner, A. E., Casamayor-Palleja, M., Armitage, R. J., Spriggs, M. K., Fanslow, W. C., MacLennan, I. C. M., Gregory, C. D. and Gordon, J. 1993. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction. Eur. J. Immunol. 23:2368.
11. Mallett, S. and Barclay, A. N. 1991. A new superfamily of cell surface proteins related to the nerve growth factor receptor. Immunol. Today 12:220.
12. Gruss, H. J. and Dower, S. K. 1995. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 85:3378.
13. Bjorck, P. and Paulie, S. 1996. CD40 antibodies defining distinct epitopes display qualitative differences in their induction of B-cell differentiation. Immunology 87:291.
14. Heath, A. W., Wu, W. W. and Howard, M. C. 1994. Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur. J. Immunol. 24:1828.
15. Howard, M. C., Heath, A. W., Ishida, H. and Moore, K. W. 1992. Biological roles of IL-10 and the CD40 receptor Progr. Immunol. VIII:327.
16. Katira, A., Holder, M. J., Pound, J. D. and Gordon, J. 1995. CD40 Workshop Panel Report. In Schlossman, S. F., Boumsell, L., Gilks, W., Harlan, J. M., Kishimoto, T., Morimoto, C., Ritz, J. , Shaw, S., Silverstein, R., Springer, T., Tedder, T. F. and Todd, R. F., eds, Leukocyte Typing V, p. 547. Oxford University Press, Oxford.
17. Fanslow, W. C., Clifford, K. N., Zappone, J., Alderson, M. R. and Armitage, R. J. 1995. CD40 mAb M2 and M3 inhibit CD40 ligand binding and function. In Schlossman, S. F., Boumsell, L., Gilks, W., Harlan, J. M., Kishimoto, T., Morimoto, C., Ritz, J. , Shaw, S., Silverstein, R., Springer, T., Tedder, T. F. and Todd, R. F., eds, Leukocyte Typing V, p. 555. Oxford University Press, Oxford.
18. Fanslow, W. C., Rousseau, A.-M. C., Lofton, T. E., Klinke, R., Ulrich, D. T. and Armitage, R. J. 1998. CD154 (CD40 ligand) workshop panel report. In Kishimoto, T., Kikutani, H., von dem Borne, A. E. G. K., Goyert, S. M., Mason, D. Y., Miyasaka, M., Moretta, L., Okumura, K., Shaw, S., Springer, T. A., Sugamura, K. and Zola, H., eds, Leucocyte Typing VI. White Cell Differentiation Antigens, p. 101. Garland, New York.
19. Fanslow, W. C., Srinivasan, S., Paxton, R., Gibson, M. G., Spriggs, M. K. and Armitage, R. J. 1994. Structural characteristics of CD40 ligand that determine biological function. Semin. Immunol. 6:267.
20. Fanslow, W. C., Anderson, D. M., Grabstein, K. H., Clark, E. A., Cosman, D. and Armitage, R. J. 1992. Soluble forms of CD40 inhibit biologic responses of human B cells. J. Immunol. 149:655.
21. Pound, J. D. and Gordon, J, 1997. Maintenance of human germinal center B cells in vitro. Blood 89:919.
22. Arend, W. P., Malyak, M., Smith, M. F., Jr, Whisenand, T. D. , Slack, J. L., Sims, J. E., Giri, J. G. and Dower, S. K. 1994. Binding of IL-1α, IL-1β, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J. Immunol. 153:4766.
23. Dower, S. K., Titus, J. A., DeLisi, C. and Segal, D. M. 1981. Mechanism of binding of multivalent immune complexes to Fc receptors. 2. Kinetics of binding. Biochemistry 20:6335.
24. Liu, Y.-J., Cairns, J. A., Holder, M. J., Abbot, S. D., Jansen, K. U., Bonnefoy, J.-Y., Gordon, J. and MacLennan, I. C. M. 1991. Recombinant 25-kDa CD23 and interleukin 1a promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis. Eur. J. Immunol. 21:1107.
25. MacDonald, I., Wang, H., Grand, R., Armitage, R. J., Fanslow, W. C., Gregory, C. D. and Gordon, J. 1996. Transforming growth factor-1 cooperates with anti-immunoglobulin for the induction of apoptosis in group I (biopsy-like) Burkitt lymphoma cell lines. Blood 87:1147.
26. Bajorath, J., Marken, J. S., Chalupny, N. J. , Spoon, T. L., Siadak, A. W., Gordon, M., Noelle, R. J., Hollenbaugh, D. and Aruffo, A. 1995. Analysis of gp39/CD40 interactions using molecular models and site-directed mutagenesis. Biochemistry 34:9884.
27. Uckun, F. M., Schieven, G. L., Dibirdik, I. , Chandan-Langlie, M., Tuel-Ahlgren, L. and Ledbetter J. A. 1991. Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny. J. Biol. Chem. 266:17478.
28. Hostager, B. S., Hsing, Y., Harms, D. E. and Bishop, G. A. 1996. Different CD40-mediated signaling events require distinct CD40 structural features. J. Immunol. 157:1047.
29. Goldstein, M. D. and Watts, T. H. 1996. Identification of distinct domains in CD40 involved in B7-1 induction or growth inhibition. J. Immunol. 157:2837.
30. Grammer, A. C., Bergman, M. C., Miura, Y., Fujita, K., Davis, L. S. and Lipsky, P. E. 1995. The CD40 ligand expressed by human B cells costimulates B cell responses. J. Immunol. 154:4996.
31. Wykes, M., Poudrier, J., Lindstedt, R. and Gray, D. 1998. Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells. Eur. J. Immunol 28:548.
32. Bjorck, P., Braesch-Andersen, S. and Paulie, S. 1994. Antibodies to distinct epitopes on the CD40 molecule co-operate in stimulation and can be used for the detection of soluble CD40. Immunology 83:430.
33. Lindhout, E., Lakeman, A. and de Groot, C. 1995. Follicular dendritic cells inhibit apoptosis in human B lymphocytes by a rapid and irreversible blockade of pre-existing endonuclease. J. Exp. Med. 181:1985.
34. + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181:1293.
35. Graf, D., Muller, S., Korthauer, U., van Kooten, C., Weise, C. and Kroczek, R. A. 1995. A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation. Eur. J. Immunol. 25:1749.
36. + T cells with dendritic cells. Eur. J. Immunol. 26:3137.